Changes in the chemotherapy sensitivity of leukemia L1210 cells during the development of diazan resistance

L 1210 leukemia strain resistant to diazan (L 1210/D1) was studied for its drug sensitivity in comparison with the parent strain. The resistant strain exhibited significantly higher sensitivity to nine drugs: dopan, sarcolysine, apirazidin, cyclophosphane, 6-mercaptopurine, thiophosphamide, rubomycin, vinblastine and vincristine. L 1210/D1 gained cross resistance to four drugs: 1-(2-chloroethyl)-3-(2, 6-dioxy-3-piperidyl)-1-nitrosourea, methotrexate, 5-fluorouracil and ftorafur. The resistant strain sensitivity remained unchanged (in comparison with the parent strain) to seven drugs: degranol, prospidin, nitrosomethylurea, chlorozotocin, deazauridine, bleomycin and L-asparaginase (crasnitine).     

Cytogenetic characteristics of H3 oxide induced myeloid leukemia in Wistar rats

Frequency and spectrum of chromosomal aberrations were studied in hemopoietic cells of Wistar rats myeloid leukaemia induced by the prolonged exposure to tritium oxide. Differences in quantitative and structural damages of chromosomes were revealed by the cytogenetic assessment of eighteen rats with acute myeloid leukaemia (AML) and six rats with chronic myeloid leukaemia (CML). The most characteristic chromosomal aberrations for AML appeared to be rearrangements in chromosomes 1-3. In CML translocations by one of chromosomes 15-20 coupled with defects in the groups of chromosomes 5-10 seemed to be nonrandom.     

FBG传感器和电阻应变仪的振动监测特性

将光纤布拉格光栅（FBG）传感器和电阻应变片固定在等强度梁上,研究了两种传感器的振动监测性能,总结比较了其优缺点。通过固定在等强度梁末端的电机来产生振动,测试了FBG 传感器和电阻应变片监测到随时间变化的振动信号,并分析了振动信号经傅里叶变换（FFT）的频谱图。实验结果表明,FBG 传感器和电阻应变片监测到振动信号的时域图基本一致,但是FBG 传感器监测到振动信号经FFT 变换的频谱图出现较明显的二次谐波和三次谐波,电阻应变仪监测到的频谱图出现的谐波较弱。在实验中还观察到,在有电磁干扰情况下,电阻应变仪监测不到振动信号,而FBG 传感器正常工作,不受电磁干扰。     

苏云金芽孢杆菌工程菌芽孢形态发生的特征

苏云金芽孢杆菌杀虫蛋白的表达及晶体的形成与芽孢的发育有关。本文利用电子显微镜观察了苏云金芽孢杆菌工程菌不同发育时期芽孢的形态结构特点。结果表明，整个芽孢的发育过程依次经历了前芽孢、双层膜芽孢、初生芽孢壁形成、芽孢衣与孢外壁形成以及皮层形成等过程。这与一般芽孢的发育过程不同，即芽孢衣与孢外壁的形成时期早于皮层；另外发现孢外壁包被有膜结构，这表明杀虫晶体蛋白的超量表达可能会影响到芽孢的发育。     

Morphofunctional characteristics of the blast cells in acute myelomonoblastic leukemia

Morphocytochemical and immunological characteristics and indices of the cloning effectiveness were studied in agar cultures. Three types of leukemic cells were found whose ratio in the bone marrow varied in a rather wide range. The lymphoid markers (of cOLL and T-antigens) were detected on blast cells. It is established that histogenetic characteristics of the blast cells determines peculiarities of their growth in the agar culture.     

Effect of androgens on the development of leukemia in AKR-strain mice

A possibility of the androgen's correction of spontaneous and transplanted leukogenesis has been investigated in AKR mice. Prolongation of life was observed in the animals treated with the hormone at early stages of the leukemia development. The obtained results may be related to the stem hemopoietic precursors differentiation change under the testosterone influence manifested by erythropoiesis stimulation and the reduction of granulocytic colonies determined by the growth in the cellulose-acetate membranes (CFUcam).     

Effect of aseptic inflammation on the course of transplantable leukemia in C-58 strain mice

An investigation was carried out on 59 mice of high leukemic line C-58. It is shown that aseptic inflammation inhibited the leukemic process in mice with transplantable leukemia, stimulated the myeloid sprout of hemopoiesis and suppressed the lymphoid one, and also decreased the spleen and thymus mass.     

On the high-frequency characteristics of substrate resistance in RF MOSFETs

The high-frequency (HF) behavior of substrate components in MOSFETs is studied at different bias conditions for a 0.35 /spl mu/m BICMOS technology in the frequency range up to 10 GHz. It was found that the observed strong bias dependence of the real part of admittance y/sub 22/, Re{y/sub 22/}, is mainly contributed by the channel conductance. A very weak bias dependence of substrate resistance was found after deembedding the measured y/sub 22/ to remove the influence of channel resistance R/sub ds/ and gate-to-drain capacitance C/sub gd/. The results are key to the understanding and modeling of the HF behavior of MOSFET substrate components for RF IC design.     

毛细胞白血病中毛细胞的超微结构特征

应用透射电镜观察6例毛细胞白血病（HCL）患者外周血、骨髓血和脾细胞悬液中毛细胞的超微结构特征。结果显示,毛细胞表面微绒毛较多,呈细长指状或环状,或为粗大细胞突起;胞质内细胞器丰富,偶见核糖体-板层复合体（RLC）。结果提示毛细胞表面的微绒毛是HCL超微病理诊断的重要依据,而RLC是HCL诊断和治疗的参考依据。     

Hemolytic resistance of erythrocytes in the development of experimental tumors

Peculiarities of variations in the mechanical resistance of erythrocytes from mice with tumours were studied depending on the growth stage of tumours (lymphoma NK/Ly and sarcoma S-37). The accumulation of erythrocytes with the increased mechanical resistance at the stage of rapid tumour development (on the 4 to 6th days) was revealed by the kinetic method of ultrasonic haemolysis. Quantitative parameters of ultrasonic haemolytic resistance of erythrocytes from normal and tumour-bearing mice were used as criteria for the red blood cell changes depending on the cell age in blood. The increase of haemolytic resistance at the rapid stage of tumour growth may be caused by a higher number of "young" erythrocytes in blood. Ultrasonic haemolytic resistance increases when there is no changes in the erythrocyte quantity and hemoglobin concentration. The kinetic study of ultrasonic haemolysis of the erythrocytes isolated from peripheric blood permits estimating the reaction of the blood forming organs to the origin and development of tumours.     

Molecular biology characteristics of cattle leukemia virus

The structure and morphogenesis of the cattle leukemia virus, the main biochemical and immunological characteristics and its antigenic relationship with other members of the family Retroviridae are reviewed.     

Temperature and strain sensing characteristics of the tilted fiber Bragg grating

Theoretical and experimental studies on the tilted fiber Bragg grating (TFBG) temperature and strain sensing characteristics are conducted. The TFBG is stuck to the surface of the beam along the axis direction. When the free end of the beam is forced, both the strain and temperature will induce wavelength shifts. The temperature characteristic of TFBG cladding modes is similar to that of the core mode while the strain characteristics of TFBG core mode and cladding modes are different. A novel method to discriminate the temperature and strain simultaneously is put forward based on TFBG sensing characteristics.     

Radiation resistance characteristics of optical fibers

In order to fabricate an optical fiber with an excellent radiation resistance characteristic, we have investigated the radiation resistance characteristics of various types of optical fibers. As a result, two kinds of fiber were found to have an excellent radiation resistance characteristic which can be sufficiently used in the practical application under large doses exceeding1 times 10^{8}R.     

电阻测量分选控制系统的开发

为了满足电阻测量分选自动化控制生产的需求,要求对所有电阻片的阻值进行精确的采集和处理,以及准确地分选控制。由Pc、NI—GPIB卡、Agilent34401A数字万用表,研华PCL-725带隔数字量输入输出卡,加一些机电装置,可以组成一套电阻测量分选控制系统,完成电阻片的分选处理。本文主要讨论了在此平台上开发PC的控制系统,给出分选系统设计原理图,使用VB来实现IEEE488．2对agilent34401A数字万用表的控制和电阻测量值的数据采集,以及通过PCL-725板卡对测量之后的电阻片进行分选控制。     

Hemopoietic precursor cells during the development of carminomycin resistance

A comparative quantitative investigation of colony-forming ability of mouse bone marrow hemopoietic stem cells in the case of ordinary leukemia variant (P-388) and carminomycin-resistant variant (P-388/k) was carried out. Leukemia bearing mice received single injections of increasing doses of carminomycin on the 5th day after transplantation and 24 hours later the bone marrow was investigated for quantity of colony-forming units in the spleen (CFUs). Dynamics investigation of bone marrow cells in the case of P-388 and P-388/k (without treatment) reveals the common tendency to a decrease of these cells in the period before animal death. Sensitivity of colony forming cells (CFUs) to different doses of the antibiotic of mouse bone marrow in both cases (P-388 and P-388/k) was practically the same. Dynamics of CFUs in two populations of cells after a single injection of carminomycin in doses causing the killing of 50% of CFUs showed that the antibiotic inhibited CFUs equally (50%). However this inhibition in case of CFUs with P-388/k leukemia was almost five times longer than in the case of ordinary P-388 one. Based on the investigations conducted the second injection of the antibiotic to mice with P-388/k leukemia on the fifteenth day after the first one may be recommended.     

Photo-sensitive characteristics of negative resistance turn-around occurring in SIPTH

Influences of light irradiation on the negative resistance turn-around characteristics of static induction photosensitive thyristor(SIPTH)have been experimentally and theoretically studied.As the gate current of SIPTH is increased by the light irradiation,the potential barrier in the channel is reduced due to the increase in voltage drop across the gate series resistance.Therefore.SIPTH Can be quickly switched from the blocking state to the conducting state by relatively low anode voltage.The optimal matching relation for controlling anode conducting voltage of SIPTH by light irradiation has also been represented.     

静电感应光电晶闸管负阻转折的光敏特性

Influences of light irradiation on the negative resistance turn-around characteristics of static induction photosensitive thyristor （SIPTH） have been experimentally and theoretically studied. As the gate current of SIPTH is increased by the light irradiation, the potential barrier in the channel is reduced due to the increase in voltage drop across the gate series resistance. Therefore, SIPTH can be quickly switched from the blocking state to the conducting state by relatively low anode voltage. The optimal matching relation for controlling anode conducting voltage of SIPTH by light irradiation has also been represented.     

Static negative resistance in calculated MESFET drain characteristics

Static negative-resistance regions in MESFET drain current-voltage characteristics are sometimes observed in results obtained by computer-modeling techniques. This paper shows that in some cases these negative-resistance regions may be numerically induced by an inappropriate choice of the spatial mesh size used in the calculation. A criterion for choosing a sufficiently small mesh size is given.     

基于重叠多光栅的动态应变传感特性研究

利用重叠多光纤布拉格光栅(FBG)反射谱的时间同 步性,实现了动态或静态应变信号的高速传感与解调。给出了基于光纤F-P 可调谐滤波器(FFP-TF)的重叠多FBG解调系统及其时域重构的实现方法,重叠多FBG在FFP- TF 三角波扫描电压与动态应 变信号测量时产生时域上等间隔分布的传感脉冲,解调系统采用质心法硬件解算并结合平滑 滤波的方法可满足速度与解调精 度的同时测量需要。在重叠双FBG与500Hz FFP-TF扫描速率条件下 可产生2kHz的传感脉冲,动态应变信号的测量 带宽相对于单FBG解调系统提高了4倍,静态条件下的波长偏移小于±4pm。给出了影响重叠多FBG动态应变信号解调结果失真度的影响因素。