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研发了一套血流介导皮肤荧光光谱(FMSF)检测系统,该系统可以非侵入性地检测人体皮肤内烟酰胺腺嘌呤二核苷酸(NADH)荧光光谱的动态变化;对该系统中的荧光探头进行了仿真设计,以提高NADH荧光的收集效率.首先构建人体7层皮肤结构模型,采用蒙特卡罗(Monte-Carlo)方法模拟组织中光子的传输规律;然后探究了收集光纤的纤芯直径、激发光纤与收集光纤的近边缘距离、光纤探头与皮肤之间的距离等对荧光光谱检测的影响;最后根据模拟结果研制了一套光纤探头,并将其应用于皮肤NADH荧光光谱检测系统中.结果 表明:采用该系统结合闭塞后反应性充血可以在体检测NADH荧光光谱,光谱强度呈现一种明显的动态变化.与现有技术相比,基于FMSF技术的皮肤NADH检测方法具有测量速度快、无创等优势,为研究线粒体能量代谢及糖尿病等相关疾病提供了先进的技术手段. 相似文献
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使用Monte Carlo模拟方法和器件振荡特性测试研究了异质谷间转移电子器件的直流隧穿特性和射频振荡性能与器件结构参数之间的关系.理论计算结果与实验数据间吻合得很好.在此基础上提出了通过电性能测试来分析器件结构参数的新方法.使用逐层化学腐蚀C-V测试测定了有源层的掺杂分布.通过低场电阻测量确定了量子阱的宽度.最后从器件振荡特性与Monte Carlo模拟曲线的对照中得出了掺杂接口的浓度.由此建立了器件结构参数的一套完整的测试分析方法.使用这套测试监控方法,已成功地研制出MBE和MOCVD工艺的高效、大功率振荡器件. 相似文献
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本文采用计算机Monte Carlo模拟方法研究雷达广义符号检验法(GS)检测器及其两种简化形式在Weibull杂波中的性能。给出了模拟计算的定量结果,详细讨论了Weibull杂波形状参数、目标起伏特性和检测器参数对雷达性能的影响。 相似文献
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王建国 《光纤与电缆及其应用技术》2003,(3):17-19,32
讨论了单模光纤的偏振模色散PMD,包括PMD与单模光纤的几何尺寸及应力的非圆对称的关系模间耦合的影响。PMD具有瞬时统计特性以及采用Monte Carlo模拟软件对光缆产品的PMDQ进行估算。 相似文献
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创新设计了一款操作灵活、方便、适于生物医学原位检测的反射式近红外(NIR)光纤探头,通过将自聚焦透镜耦合到NIR光纤探头的顶端,并对探头结构、光纤排布进行全新设计,使光纤探头具有更高的测量精度和收集效率。通过耦合傅里叶变换近红外光谱仪对蔗糖样本进行NIR光谱采集,发现该反射式NIR光纤探头具有高效便捷的特点以及较高的光谱重复性和信噪比。采用该光纤探头对犬膝关节股骨端关节软骨进行NIR光谱离体原位检测,这些光谱数据经一阶导数2次多项式21点Savitzky-Golay平滑预处理后再进行主成分分析和Fisher判别分析。模型初始案例和交互验证案例正确识别率分别为97.62%、90.47%,样本预测集的识别率达96.43%,证明了采用该NIR光纤探头进行NIR光谱原位检测的有效性及骨关节炎识别的可行性,可为骨关节炎的临床诊断奠定实验基础。 相似文献
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在对薄膜材料热光效应和热膨胀特性研究的基础上,综合运用光学薄膜法布里-珀罗腔(Fabry-Perot)干涉理论,采用MATLAB 编程设计了纳米薄膜光纤法布里-珀罗传感器的仿真分析程序,模拟了薄膜型光纤法布里-珀罗传感探头反射光谱随温度变化的波长漂移特性,分析了不同材料热光效应和热膨胀特性对温度特性的影响权重,并进行了实验验证。验证结果表明,传感探头测试光谱的温度变化特性与仿真特性一致,纳米薄膜光纤法布里-珀罗传感器的理论仿真可用于选择纳米薄膜材料及筛选温度敏感且镀制容差大的膜系,对传感探头的研制具有指导意义。 相似文献
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拉曼光谱技术以其多组分同时探测、分子指纹特性等优点被广泛应用于多个领域,但其较低探测灵敏度严重限制了此技术的进一步发展。为了提高拉曼光谱技术粉末样品原位分析能力,提出了一种基于石英管增强的高灵敏度拉曼光纤探头。探头采取内镀金属空芯光纤用于光信号的传输,有效减小了背景信号对拉曼光谱的影响;探头底端采用石英管设计,增大采样体积和收集效率,提高了拉曼光谱的探测灵敏度。理论分析了石英管拉曼光谱技术可提高粉末样品的探测灵敏度,详细介绍了探头的设计和实现,进一步评估探头的性能,结果表明:相较于球透镜拉曼探头,拉曼信号强度(NaHCO3)增强2.92倍。为模拟实际应用场景,采用光纤拉曼探头成功获得了容器中不同深度粉末样品(Na2SO4和NaHCO3)的拉曼光谱信息。文中设计的石英管增强拉曼探头具有外径尺寸小(外径仅为2 mm)、灵敏度高等优点,可对深层次粉末样品进行探测,为现场粉末样品原位分析提供了一种新途径。 相似文献
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哺乳动物组织体中光能流率测量 总被引:4,自引:1,他引:3
本文使用自行设计的光纤探针深度计,实现了哺乳动物组织体中光能流率的精确测定,并结合后向散射反射率的测量结果,利用Monte Carlo模型的部分结论,计算出了猪肉和牛肉组织的光学特性参数。 相似文献
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用实验方法测量了用熔拉或腐蚀的方法制备的光纤探针的传输效率随光纤圆锥角的变化关系,作出传输效率曲线,通过测定光纤探针传输效率的实验,我们看到:在小锥角的情况下,用熔拉法制备的光纤探针与腐蚀的方法制备的光纤探针的传输效率基本相同。在大锥角的情况下,用腐蚀法制备的光纤探针传输效率高于熔拉的方法制备的光纤探针的传输效率。在锥角为50.4°时,腐蚀的光纤探针传输效率为78.8%,熔拉的光纤探针传输效率为76.6%。在相同的条件下,两者的传输效率的差别随入射光波长的增加而下降。 相似文献
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McShane MJ Rastegar S Pishko M Coté GL 《IEEE transactions on bio-medical engineering》2000,47(5):624-632
A Monte Carlo simulation of photon propagation through human skin and interaction with a subcutaneous fluorescent sensing layer is presented. The algorithm will facilitate design of an optical probe for an implantable fluorescent sensor, which holds potential for monitoring many parameters of biomedical interest. Results are analyzed with respect to output light intensity as a function of radial distance from source, angle of exit for escaping photons, and sensor fluorescence (SF) relative to tissue autofluorescence (AF). A sensitivity study was performed to elucidate the effects on the output due to changes in optical properties, thickness of tissue layers, thickness of the sensor layer, and both tissue and sensor quantum yields. The optical properties as well as the thickness of the stratum corneum, epidermis, (tissue layers through which photons must pass to reach the sensor) and the papillary dermis (tissue distal to sensor) are highly influential. The spatial emission profile of the SF is broad compared that of the tissue fluorescence and the ratio of sensor to tissue fluorescence increases with distance from the source. The angular distribution of escaping photons is more concentrated around the normal for SF than for tissue AF. The information gained from these simulations will be helpful in designing appropriate optics for collection of the signal of interest. 相似文献
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概述了反射式光纤传感器的发展。讨论了这类光纤传感器理论分析中所采用的纤端出射光场光强径向均匀分布的假设。给出了纤端出射场的光通量分布函数,并以全光路补偿反射式光纤探头为例,建立了补偿机理的理论分析方法,给出了传感特性调制函数的解析表达式。最后,简要分析了这类光纤传感器的温度稳定性问题。 相似文献
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A kind of fluorescence fiber-optic thermometer is devised based on the solid-state ruby fluorescence material. The characteristics of fluorescence material absorption and emission are analyzed, and the fiber-optic temperature measurement probe in ruby is developed. This system is particularly adaptable to the temperature measurement in the range of 20℃ to 600℃. During the experiment, this method is proved to be useful to temperature measurement with high resolution and precision. 相似文献
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A kind of fluorescence fiber-optic thermometer is devised based on the solid-state ruby fluorescence material. The characteristics of fluorescence material absorption and emission are analyzed, and the fiber-optic temperature measurement probe in ruby is developed. This system is particularly adaptable to the temperature measurement in the range of 20 ℃ to 600 ℃. During the experiment, this method is proved to be useful to temperature measurement with high resolution and precision. 相似文献
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By accurately measuring the displacement between the roller surface and the optical fiber probe relative to a null position, we can test the roller wear. The whole testing method and system were introduced. Each part of the testing system was illustrated. And also a novel fiber-optic sensor with three probes in equal transverse space is adopted. Using this sensor, the effects of fluctuations in the light source, reflectivity changing of target surface and the intensity losses in the fiber lines are automatically compensated. This method offers such advantages as non-contact, no electromagnetic interference, simplicity, low cost, high sensitivity, good accuracy and stability. 相似文献
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GUOYuan WANGYu-tian HAOBing 《半导体光子学与技术》2004,10(4):275-277
By accurately measuring the displacement between the roller surface and the optical fiber probe relative to a null position, we can test the roller wear. The whole testing method and system were introduced.Each part of the testing system was illustrated. And also a novel fiber—optic sensor with three probes in equal transverse space is adopted. Using this sensor, the effects of fluctuations in the light source, reflectivity changing of target surface and the intensity losses in the fiber lines are automatically compensated. This method offers such advantages as non—contact, no electromagnetic interference, simplicity, low cost, high sensitivity, good accuracy and stability. 相似文献