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青蒿素及其衍生物对菜青虫的生物活性 总被引:1,自引:0,他引:1
以二氢青蒿素为原料合成了10种双二氧青蒿素醚和5种单二氢青蒿素醚,用常规的非选择性叶碟法测定了质量浓度为1.0 g/L的合成化合物、青蒿素和二氢青蒿素对菜青虫的生物活性.结果表明:双醚对菜青虫的拒食活性最为显著,处理后24、48 h的拒食率分别为85.4%~96.9%和90.9%~98.6%,单醚分别为45.5%~60.6%和50.9%~68.2%,二氢青蒿素为36.6%和42.4%,青蒿素为40.1%和47.0%;双醚同样具有较高的杀虫活性,其处理后96 h的校正死亡率为72.7%~95.5%,单醚为45.4%~54.6%,二氢青蒿素为49.9%,青蒿素的杀虫活性不显著.结合活性数据,初步讨论了青蒿素衍生物的构效关系. 相似文献
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以2,5-二氯苯酚为原料,经与碱试剂反应脱水成盐,Kolbe-Schmitt羧基化,酸化,合成高效除草剂麦草畏的关键中间产物3,6-二氯水杨酸。探索了工业化生产的较佳的工艺条件。 相似文献
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SRNA-4非晶态合金催化双环戊二烯液相加氢反应研究 总被引:3,自引:0,他引:3
采用SRNA-4非晶态合金催化剂对双环戊二烯(DCPD)进行了加氢反应考察,研究了搅拌速度、温度、压力和催化剂浓度各条件对双环戊二烯加氢反应的影响.结果表明DCPD加氢反应为连串反应,中间产物主要为9,10-二氢双环戊二烯(9,10-DHDCPD)和少量1,2-二氢双环戊二烯(1,2-DHDCPD);DCPD易于加氢生成中间产物9,10-DHDCPD,其继续加氢为四氢双环戊二烯(endo-THDCPD)需要较为剧烈的条件.DCPD加氢过程选用两段法,第一段为温度110℃,第二段为130℃,压力均为1.5MPa,催化剂浓度1.18%.非晶态合金(催化剂)对DCPD的加氢反应活性明显高于Raney Ni,可进行1、2位加氢反应生成1,2-DHDCPD,并且催化剂用量少,反应温度和反应压力低,反应时间短,生成副产物少. 相似文献
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超声强化溴化1-乙基-3-甲基咪唑从黄花蒿中提取青蒿素 总被引:1,自引:0,他引:1
利用超声强化[emim]Br(溴化1-乙基-3-甲基咪唑)-水体系从黄花蒿粉末中提取青蒿素. 正交实验和单因素实验结果表明,影响黄花蒿中青蒿素提取因素的显著性次序为液固比>提取时间>提取温度>超声波功率>占空比. 综合考虑单因素实验结果及成本,得出优化工艺条件为黄花蒿原料粒度0.38 mm,液固比50 mL/g,提取时间30 min,提取温度20℃,超声波功率600 W,占空比1.6 s/0.4 s. 在上述条件下青蒿素提取量为4.37 mg/g,提取率为97%. 相似文献
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Four cyclopropene fatty acids, having the double bond of the cyclopropene ring at the 8,9, 9,10, 10,11 and 11,12 positions,
respectively, were tested as inhibitors of stearic acid desaturation by the desaturase enzyme system of hen liver. The first
three were powerful inhibitors, but the last was not. The cyclopropene acids with the 9,10 and 10,11 double bonds were equally
strong inhibitors, while the acid with the 8,9 double bond was less effective. To account for the specificity of those cyclopropene
fatty acids in which the C9 or C10 carbon atom is included in the cyclopropene ring, it is suggested that the conformation
and structure of the CoA derivatives of these acids is such that they can irreversibly occupy the site on the enzyme responsible
for 9,10-desaturation. 相似文献
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Novel, nitrogen-containing heterocyclic chromophores based on either 1,2,4-triazine or an imidazole core were synthesized using a three-component, one-pot reaction under microwave irradiation. Structures were verified by 1H NMR, IR, MS and elemental analyses while crystal structure was determined using X-ray diffraction. The two-photon absorption and two-photon upconverted blue fluorescent emission characteristics were investigated experimentally; preliminary structure–photophysical property relationships were established. Chromophores that contained the imidazole moiety displayed more potent two-photon absorption than compounds based upon 1,2,4-triazine and also exhibited a strong two-photon upconverted blue fluorescent emission peak at around 443–476 nm. Significant enhancement of the two-photon absorption cross-section was achieved by fusing a benzoxazole moiety onto the phenanthro[9,10-d]imidazole ring. 相似文献
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R. A. Grimm A. J. Stirton J. K. Weil 《Journal of the American Oil Chemists' Society》1968,45(12):901-902
9,10-Dichlorostearylamine was prepared by the hydrogenation of 9,10-dichlorostearonitrile, catalyzed by Rh/C, and by the chlorination
of oleylamine hydrochloride. The dichloro amine was surprisingly heat-stable and could be purified by molecular distillation
at 170 C (0.1 mm). Also described are the preparations of 9,10-dichlorostearoyl chloride, 9,10-dichlorostearamide and 9,10-dichlorostearonitrile.
The chlorination of oleonitrile is not a simple reaction and the 9,10-dichlorostearonitrile was best prepared by dehydration
of the amide. 相似文献
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The solid state fluorescence of diketopyrrolopyrrole dyes and perylene-3,4:9,10- tetracarboxylic bisimides with alkyl substituents are investigated and compared with noncovalent interactions. The latter are estimated by crystal structure analysis, heats and entropies of fusion and solubilities in organic solvents. Applications of the dyes are discussed. 相似文献
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H. W. Knoche 《Lipids》1971,6(8):581-583
The synthesis ofcis-9,10-epoxyoctadecanoic acid by tissue slices of wheat plants infected withPuccinia graminis tritici (Wheat stem rust) has been investigated further. Synthetic methylcis-9,10-epoxyoctadecanoate and the same ester isolated from incubation in an atmosphere containing18O2, or a medium containing H2
18O, were analyzed by mass spectrometry. These analyses revealed that molecular oxygen was incorporated into the oxirane ring
ofcis-9,10-epoxyoctadecanoic acid.
Presented in part at the AOCS Meeting, Minneapolis, October 1969. 相似文献
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Shoji Watanabe Tsutomu Fujita Kyoichi Suga Satoshi Inoki 《Journal of the American Oil Chemists' Society》1982,59(4):197-199
Carboxylic acids containing the dichlorocyclopropane ring system react with lithium naphthalene to give dechlorinated products.
For example, from the reaction of 9,10-dichloromethylene octadecanoic acid and lithium naphthalene, a mixture of 9,10-nonadecadienoic
acid as a main product and unidentified minor products were obtained. 相似文献
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茚并氧杂蒽类化合物C24H28O5是由邻苯二甲醛和5,5-二甲基-1,3-环己二酮在醋酸溶剂中,于室温下搅拌一步法反应制得,通过单晶X-射线衍射法测定其结构。该晶体属单斜晶系,空间群P2(1),晶胞参数a=1.006 92(11)nm,b=1.021 73(12)nm,c=2.430 6(2)nm,V=2.500 6(5)nm~3,Z=4,晶胞密度Dc=1.247 mg/m~3,吸收系数μ=0.087 mm~(-1),单胞中电子的数目F(000)=1 008,分子量Mr=469.56(单晶中包含一分子溶剂DMF)。晶体结构经全矩阵最小二乘法对各原子参数进行修正,最终得到的偏离因子为R=0.061 9,ωR=0.090 4。在晶体结构中新形成的茚环呈现信封式构象,同时形成的吡喃环显示为扭船式构象。 相似文献
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Dellagreca M Fiorentino LA Monaco P Pinto G Previtera L Zarrelli A 《Journal of chemical ecology》2001,27(2):257-271
9,10-Dihydrophenanthrenes and phenanthrenes, mimics of natural compounds with strong antialgal activity, have been synthesized through cross-coupling by zerovalent Ni of 1-(2-iodo-5-methoxy)-phenylethanol or 2-iodo-5-methoxyacetophenone with iodoxylenes. The synthetic compounds had a hydroxyl or a methoxyl group at C-2 and two methyls in the C ring. Assays on the green alga Selenastrum capricornutum showed that all the compounds, except 2-methoxy-5,7-dimethylphenanthrene, caused strong inhibition of algal growth at 10–4 M. 2-Hydroxy-7,8-dimethyl-9,10-dihydrophenanthrene and 2-methoxy-5,6-dimethylphenanthrene fully inhibited growth at 10–5 M. 相似文献
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The effect of the triglycerides containing 9,10-dihydroxystearic acid (DHS-TG) on the phase transition of polymorphic forms
of normal triglycerides (TG) of sal fat was investigated by differential scanning calorimetry (DSC) under different cooling
and heating modes. Four levels of DHS-TG, 2, 5, 8 and 10%, were used. DHS-TG accelerated the phase transition of lower melting
crystal forms I → II → III of TG obtained under rapid (20°C/min) or slow (2°C/min) rates of cooling. They delayed the phase
transition of crystal form III to IV of TG at 0°C. Also, DHS-TG reduced the heat of fusion (ΔH) of the stable form (V) of
TG obtained after tempering at 0°C and at 26°C. 相似文献