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二吲哚基甲烷及其其他衍生物是一类具有生物活性的物质,在治疗许多疾病方面很好的作用。以对甲苯磺酰腙和吲哚为底物,过渡金属亚铜盐催化剂,合成了二吲哚基苯基甲烷和其衍生物。并且对反应时间、温度、溶剂等反应条件进行了相应探讨,优化了反应工艺。对反应产物进行了表征,利用NMR和XRD单晶衍射进行了分析检测,确定其结构。此合成方法是一种高效、温和的新方法。 相似文献
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该文报道在琥珀酰亚胺磺酸镧催化下,吲哚、芳香醛和2,2-亚戊基-1,3-二口恶烷-4,6-二酮在无溶剂条件下经超声辐射合成了10个5-[(3-吲哚基)-芳甲基]-2,2-亚戊基-1,3-二口恶烷-4,6-二酮衍生物(3-取代吲哚衍生物)。当催化剂用量为3%(即其物质的量与吲哚物质的量的百分数,下同)时,30℃反应20~60 min,收率为82.4%~98.5%。此外,还探讨了琥珀酰亚胺磺酸镧的催化机理。该方法具有反应条件温和、反应时间短、底物普适性好、收率高及对环境友好等优点。催化剂回收利用4次仍然保持很高的催化活性。 相似文献
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吲哚及其衍生物具有非常重要的生物和药理活性,广泛应用于农业、医药等领域中。因此对吲哚及其衍生物合成方法的研究也越来越多。近年来经过化学家的努力,以2-炔基芳香胺分子内环化和芳香胺类化合物与炔反应来合成吲哚衍生物都取得了很大的进展,成为了重要的合成方法。主要对近十年来这两类方法即2-炔基芳香胺在各种不同催化条件下的分子内环化和各种不同取代的芳香胺类化合物与炔反应合成吲哚衍生物的研究进展进行了综述。 相似文献
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建设创新型国家是我们中华民族的历史责任。“自主创新、重点突破、支撑发展、引领未来”的16字方针应当成为我们未来创新活动的指南。建设创新型国家把自主创新放在首位,并提出了引领未来的高标准要求。钢铁科技创新必须突出重点,抓住创新成果产业化这个关键,支撑起行业和国民经济的发展。 相似文献
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Solid solutions of diphosphates of zinc and copper and of zinc and cobalt were synthesized from mixtures of pure diphosphates at temperatures up to 1000°C. Their X-ray diffractometry patterns varied continuously from one end member to the other. Solid solutions of orthophosphates of composition Zn3−x Cox(PO4 )2, with x = 0.4–1.6, were formed at temperatures up to 950°C; all exhibited the structure of γ-Zn3 (PO4 )2. Solid solutions of orthophosphates of composition Zn3−x Cux (PO4 )2 exhibited more-complex behavior. At 1000°C and copper contents of 20–80 mol%, a phase that is related to Cu3 (PO4 )2, termed here the "ε-phase," predominated. At 850°–950°C and in the region from 20 mol% to ∼33 mol% of copper, the solid solutions (the "η-phase") adopted the structure of graftonite. At 800°–900°C and 10–15 mol% of copper, the solid solutions exhibited a new structure (the "δ-phase"), which we found to be related to the mineral sarcopside. At temperatures 950°C, the solutions that contained 5–15 mol% of copper (the "β-phase") had the structure of β-Zn3 (PO4 )2, whereas at 800°–850°C, solutions with 5 mol% of copper (the "-phase") exhibited the structure of γ-Zn3 (PO4 )2. Attempts to synthesize Cu+ ZnPO4 and Cu+ Cu2+ Zn3 (PO4 )3 were unsuccessful. 相似文献
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相比已经完善丰富的开采和勘探技术,油气的运输以及储存却仍然存在不足之处。我国对能源安全提出更加严格要求的同时,对区域经济的发展规划也有足够重视。因此,保障油气管道的安全则成为了我国能源安全战略的重中之重。在阐释油气管道现阶段在储运安全保障技术发展状况的基础上,分析了现存的问题及解决问题的手段,并指出未来可能使用的目标策略,为今后研究者提供一定程度上的借鉴经验。 相似文献
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膜的污染和劣化及其防治对策 总被引:25,自引:0,他引:25
较为系统地介绍了膜污染和劣化的定义和特点,因膜污染和劣化而造成的膜性能变化,以及如何预防、减少或清除膜污染和劣化的一些通用方法。 相似文献
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The composition and solubility properties of eight ammonium and potassium orthophosphites and hypophosphites were determined to evaluate the potential of these classes of materials for increasing the plant nutrient content of liquid fertilizers. Phase relationships for the systems (NH4)2O-P2O3-H2O, K2O-P2O3-H2O, (NH4)2O-P2O-H2O, and K2O-P2O-H2O were determined along with the crystallographic properties (X-ray and optical) of the solid phases. Toxicity and phosphite response was tested in greenhouse experiments for the compounds. 相似文献
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填料-橡胶的化学和物理作用及补强ⅡN330,SiO2,n-SiO2和n-SiO2/KH-846与NR 总被引:1,自引:0,他引:1
研究了填料-橡胶的相互作用。发现N330-NR间的相互作用。n-SiO2(粒径:15nm)/KH-846-NR间的相互作用,都是化学作用占优势(>80%),化学作用对补强的贡献率都大于90%;无偶联剂KH-846时,n-SiO2和SiO2(粒径:15.8nm)与NR都无化学作用,只有物理交联,由于隔离作用,都降低硫化体系与橡胶相互作用的化学交联密度,但n-SiO2的物理交联密度是SiO2的2.6倍,对补强的贡献是SiO2的1.9倍,也是n-SiO2/KH-846体系的61%。 相似文献
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Michael P. Badart Emma M. Barnes Andrew P. Cording Selena C. L. Gilmer Ian D. Billinghurst Veera V. Shivaji R. Edupuganti Prof. Guillaume Lessene Abigail R. Bland Rebekah L. Bower Zohaib Rana Scott A. Ferguson Helen K. Opel Reading Prof. Gregory M. Cook Prof. Rhonda J. Rosengren Prof. Kurt L. Krause Dr. Allan B. Gamble Prof. John C. Ashton Dr. Bill C. Hawkins 《ChemMedChem》2021,16(8):1308-1315
A second-generation enantiospecific synthesis of spiroleucettadine is described. The original reported antibacterial activity was not observed when the experiment was repeated on the synthetic samples; however, significant anti-proliferative activity was uncovered for both enantiomers of spiroleucettadine. Comparison of the optical rotational data and ORD-CD spectra of both enantiomers and the reported spectrum from the natural source have not provided a definitive answer regarding the absolute stereochemistry of naturally occurring spiroleucettadine. Efforts then focussed on alteration at the C-4 and C-5 positions of the slightly more active (−)-spiroleucettadine. Ten analogues were synthesised, with three analogues found to possess similar anti-proliferative profiles to spiroleucettadine against the H522 lung cancer cell line. 相似文献
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Tetraalkynylated and Tetraalkenylated Benzenes and Pyridines: Synthesis and Photophysical Properties
Peter Ehlers Ani Hakobyan Antje Neubauer Stefan Lochbrunner Peter Langer 《Advanced Synthesis \u0026amp; Catalysis》2013,355(9):1849-1858
Tetra(arylalkynyl)pyridines and tetra(arylalkenyl)pyridines and their benzene analogues were prepared by palladium‐catalyzed cross‐coupling reactions from the commercially available chlorinated substrates in good to excellent yields. The photophysical properties of selected compounds were investigated and compared to each other. Very good fluorescence quantum yields were observed, especially for the pyridine derivatives. 相似文献
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绿色火炸药及相关技术的发展与应用 总被引:12,自引:1,他引:11
综述了绿色火炸药及其生产工艺、销毁以及回收利用方面具有“绿色”特征的改进和应用研究成果。绿色火炸药包括洁净固体推进剂、无铅双基推进剂、TPE发射药、无毒发射药、无铅点火药和起爆药。绿色制造技术包括N2O5作硝化剂的含能硝基化合物化学合成,过硝酸盐作硝化剂、微生物作催化剂的生物合成技术,连续化柔性制造技术,基于双螺杆混合成型火炸药生产技术,火炸药生产中挥发性污染物的安全消除技术和纳米复合含能材料的Sol-Gel制备技术。绿色销毁和回收利用技术包括销毁产品的熔盐氧化技术、摧毁含含能化合物废水的光催化技术以及火炸药的回收再利用(R^3)技术。评述了上述火炸药及相关技术的最新状况和发展方向,附参考文献25篇。 相似文献