Gender differences in psychiatric comorbidity among adolescents with substance use disorders.

The authors examined gender differences in rates of comorbid psychiatric disorders among adolescents with 1 or more psychoactive substance use disorders. Baseline diagnostic data were obtained from 135 adolescents, ages 12 to 19, and their parents-guardians, who participated in a study to develop and efficacy test Integrated Family and Cognitive-Behavioral Therapy. Rates of attention-deficit/hyperactivity disorder and conduct disorder were higher among drug-abusing male adolescents compared with drug-abusing female adolescents. However, high rates of disruptive behavior disorders also characterized drug-abusing female adolescents. Similarly, drug-abusing female adolescents exhibited a higher rate of major depression compared with drug-abusing male adolescents. However, rates of dysthymia, double depression (i.e., major depression and dysthymia), and bipolar disorder were equivalent between genders. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gender IQ differences among psychiatric patients.

Provides evidence against the hypothesis that adult male psychiatric patients are more intelligent than their female peers. 1,187 patients were administered either the Wechsler-Bellevue Intelligence Scales, the Wechsler Adult Intelligence Scale (WAIS), the Wechsler Intelligence Scale for Children—Revised (WISC—R), or the Wechsler Adult Intelligence Scale—Revised. Analyses revealed no significant sex differences except on the WISC—R. Explanations that have been suggested to account for previous observations of discrepant IQ test performance are discussed, and the possibility of regional or institutional biases is noted. (French abstract) (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Locus of control among opiate addicts.

Predicted that because the use of opiates enables the user to exert direct control over reinforcements, opiate addicts would show strongly internal expectancies on Rotter's Internal-External Locus of Control scale, especially on items referring directly to personal control. Item and total score differences between hospitalized addicts (200 each male and 100 each female blacks and whites) and a comparison group of 400 male and 400 female predominantly white undergraduates strongly supported the predictions. Multivariate analyses of addict subgroups disclosed greater internality for culturally favored subgroups (males, whites) than for less favored ones (females, blacks). Contrary to usual assumptions, however, the addicts' strong beliefs in personal control, based on drug effects rather than social learning, may hinder their responsiveness to treatment programs. (21 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Voluntarism and self-reported psychopathology among opiate addicts.

Investigated the relation between voluntary and nonvoluntary treatment application status and MMPI responses of 473 opiate addicts within and across 3 drug treatment settings. Treatment settings represented evaluation conditions occurring prior to admission in a selective program, during routine evaluation in an "open admission" program, and following acceptance to drug treatment. ANOVA comparisons of volunteer and nonvolunteer groups within each program revealed differences in MMPI responding for the selective treatment program and minimal differences for the other programs. Two-factor analyses of covariance performed for combined program samples showed that the treatment program variable was significantly related to S responses, but no significant main effects for voluntarism were found. Treatment applicants to the selective program reported greater psychopathology than Ss in other groups on 7 MMPI scales, but there were few significant scale differences between volunteers and nonvolunteers. Discriminant function analysis using MMPI scores and demographic data showed these variables to be of limited value in discriminating volunteer from nonvolunteer addict clients. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Subgroups among opiate addicts: A typological investigation.

Applied a multivariate correlational clustering technique to the MMPI profiles of 1,500 addicts, subdivided into 10 subsamples (5 for each sex) representing 4 different categories of admission into treatment (civilly committed, volunteers, probationers, prisoners). Within each subsample, 2 homogeneous and replicable profile types were isolated. Type I (33% of all Ss) showed elevations on Scales 2, 4, and 8, suggesting marked subjective distress, nonconformity, and disturbed thinking. The much smaller Type II (about 7% of Ss) showed a single peak on Scale 4. 60% of Ss thus were unclustered. The 2 basic types, however, were effectively discriminated on a variety of other psychometric indices and were consistent with the 2 major profile types found among alcoholics in prior research. (29 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Personality disorder subtypes among opiate addicts in methadone maintenance.

The Millon Clinical Multiaxial Inventory was administered to 196 men and 113 women newly admitted to methadone maintenance. The distribution of participants among Axis I subtypes was no elevation (18.8%), drug-alcohol abuse only (25.2%), affective disturbance (31.7%), and psychotic symptoms(l7.2%); among Axis II subtypes it was no elevation (10.4%), narcissistic-antisocial (36.2%), dependent (16.2%), withdrawn-negativistic (12.6%), histrionic (7.4%), and severe personality disorder (8.4%). Women were more likely to be assigned to histrionic, dependent, and severe personality disorder subtypes. Proportionately more Black participants were assigned to drug-alcohol only, psychotic symptoms, narcissistic-antisocial, and severe personality disorder subtypes. The proportion retained in treatment at 18 mo was higher for withdrawn (.51) and histrionic (.33) than other Axis II subtypes (range?=?.13–.22). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Attributions and relapse in opiate addicts.

Investigated whether attributions of opiate addicts would predict both their ability to abstain from future use and their reactions to abstinence violations. Measures of generalized beliefs about responsibility for positive and negative outcomes and specific attributions about relapse episodes were elicited from 80 addicts at the time of admission for inpatient detoxification and treatment. Addicts who at admission attributed to themselves greater responsibility for negative outcomes and who attributed relapse episodes to more personally controllable factors were subsequently (at 6-mo follow-up) more likely either to be completely abstinent or to contain the effects of temporary lapses into opiate use. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gender differences in psychiatric illness and treatments: a critical review

Controversy exists about the causation of gender differences long observed in the prevalence of mental disorders. Recent epidemiological, biochemical, and genetic research has shed further light upon both their etiologies and treatments. Both controversies and research are reviewed and critically examined.     

Changes in HIV risk behaviors among cocaine-using methadone patients

Cocaine use among methadone patients has been related to higher prevalence of HIV risk behaviors. HIV risk behaviors for cocaine-using patients in methadone treatment (N = 207) were examined for two time periods, the current month in-treatment and the month previous to treatment admission. All needle-related and sexually-related risk behaviors (except for needle hygiene) significantly and substantially declined over the average two year time interval. Several variables were associated with needle and sexual risks in multivariate regression analyses. Dropping apparent opiate use underreporters from the analyses did not alter the results. From a harm reduction perspective, high priority should be given to retaining cocaine-using patients in methadone maintenance, intensifying in-program services for those with anti-social personality, bipolar disorder or alcoholism, as well as increasing access to needle exchanges and free condoms.     

Leisure of opiate addicts at posttreatment follow-up.

Follow-up data for 1,174 opiate addicts were used to examine leisure reported prior to an interview conducted approximately 6 yrs after admission to treatment for drug abuse. Comparisons of self-reported leisure for the pre- and posttreatment follow-up periods showed an overall shift toward more positive, socially accepted leisure activities at follow-up; more free time was spent with family and with friends who did not use drugs. In addition, positive leisure at follow-up, as well as more positive changes in leisure over time, were related to favorable outcomes on drug use, criminality, and productive activities measures during the year before the follow-up interview. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Withdrawal in opiate addicts in an internal medicine hospital unit

Withdrawal of opiates drug addicts in Internal Medicine is unusual in France. Four main preliminary conditions are requested: 1--Drug addict preparation and self motivation, 2--Inter and intra institution team collaboration, 3--Opening the hospital towards community agencies, 4--Hospital staff recruited on volunteer basis. Within two years (1992-1993), 210 opiates drug addicts were hospitalized for withdrawal. Two third were males, median age was 27, median years of addiction was 7. Thirty percent were seropositive for HIV, 70% for HCV. Hospitalisation lasted 7 days for heroin addicts and 10 days for morphin, codein or buprenorphin addicts. Successful withdrawn was observed for 70% patients but six months after withdrawal, only 15% remained abstinent.     

Gender differences among pathological gamblers seeking treatment.

This study investigated gender differences among treatment-seeking pathological gamblers. During treatment intake, 115 pathological gamblers completed the Addiction Severity Index (ASI; A. T. McLellan et al., 1985), including a section on gambling severity, as well as the South Oaks Gambling Screen (H. R. Lesieur & S. B. Blume, 1987). When age and income were controlled, gender differences emerged in ASI gambling, alcohol, and legal scores. Men initiated gambling, began gambling regularly, tried to stop gambling, and first entered gambling treatment at a younger age than women. Women were more likely to be living with someone with a gambling or drinking problem but themselves had fewer alcohol and legal problems. Results suggest that gender differences exist in the initiation of gambling dysfunction and its psychosocial correlates. Understanding these differences may assist in developing treatments that address differential needs of male and female pathological gamblers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A test of the voluntarism hypothesis among nonvolunteering opiate addicts who voluntarily return to treatment.

Research on the voluntarism hypothesis, which holds that self-reported psychopathology is greater on MMPI clinical scales among addicts who enter treatment on their own volition than among those who do not, has been plagued by differences in treatment settings, types of voluntarism, and lack of experimental designs. Experimental design deficiencies were corrected in the present study, where MMPI scores of 20 former nonvolunteering addicts who voluntarily returned for treatment were compared with 20 matched addicts who had volunteered on both 1st and 2nd admissions. The voluntarism hypothesis was supported. Former nonvolunteers evidenced significantly higher MMPI scores on 2nd admission for scales F, Mf, Pt, Sc, and Si. Volunteers did not significantly differ between 1st and 2nd admissions. Findings underscore the necessity for continuing to improve methods in addiction research. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gender differences in rates and correlates of suicidal behaviour amongst child psychiatric outpatients

A key early event of newt limb regeneration is the local dedifferentiation of cells to form dividing progenitor cells. This involves the plasticity of differentiation and the ability to re-enter the cell cycle. In culture, differentiated newt myotubes are able to re-enter S-phase in response to serum stimulation. Here, we analyzed the intracellular and extracellular requirements for this process. Cell cycle re-entry depends on the phosphorylation of the retinoblastoma protein, which is a key regulator of the G1-S transition. This is in contrast to mammalian myotubes, which are refractory to serum stimulation and cannot phosphorylate retinoblastoma protein in response to serum. The serum factor responsible for this phosphorylation appears to be distinct from common polypeptide growth factors and is enriched in crude preparations of bovine thrombin. Fractionation and analysis of this preparation indicate that the factor is regulated by thrombin and plasmin proteolysis. These results indicate that factors involved in acute responses to wounding such as clotting may be important initiators of the regenerative response.     

Gender differences in negative affectivity among university faculty members.

Negative affectivity (NA) and Type A behavior were assessed in a sample of 96 male and female university teachers. In general, female Ss scored lower than did male Ss on NA. The difference between men and women on the NA component of hostility was quite profound. A small yet significant Gender–TABP (Type A behavior pattern) interaction effect was found in which high Type A women exhibited less NA (principally in the form of trait anxiety) than did high Type A men. Because NA has been related to both psychological and physical health complaints, some speculations are offered concerning physical and psychological health differences between men and women (at least within university faculties). The possibility is also raised of there being different psychological and physical consequences for being high on anger and/or Type A in women vs men. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gender differences in substance use among Mexican American school-age children

This study identified differences in gender between and among fourth, fifth, and sixth grade Mexican American students for use of four specific "minor" substances: cigarettes, beer, wine/liquor, and marijuana. Minor substances are believed to serve as a "gateway" to more intense and frequent use of minor and major substances. Students (N = 2,216; males 52% and females 48%) were surveyed to ascertain information pertaining to their substance use. The chi-square statistic found significant gender differences at the fourth and fifth grade for use of minor substances. Patterns of initiation of minor substance use by gender and grade are discussed in the context of substance use stage theory. Overall, results support the need for further research emphasizing within group variations in the substance use of singular ethnic groups.     

Drug use patterns and gender differences among heroin addicts hospitalized for detoxification

OBJECTIVE: To evaluate the role of genetic testing in screening for hereditary hemochromatosis to help guide clinicians, policymakers, and researchers. PARTICIPANTS: An expert panel was convened on March 3, 1997, by the Centers for Disease Control and Prevention (CDC) and the National Human Genome Research Institute (NHGRI), with expertise in epidemiology, genetics, hepatology, iron overload disorders, molecular biology, public health, and the ethical, legal, and social implications surrounding the discovery and use of genetic information. EVIDENCE: The group reviewed evidence regarding the clinical presentation, natural history, and genetics of hemochromatosis, including current data on the candidate gene for hemochromatosis (HFE) and on the ethical and health policy implications of genetic testing for this disorder. CONSENSUS PROCESS: Consensus was achieved by group discussion confirmed by a voice vote. A draft of the consensus statement was prepared by a writing committee and subsequently reviewed and revised by all members of the expert group over a 1-year period. CONCLUSIONS: Genetic testing is not recommended at this time in population-based screening for hereditary hemochromatosis, due to uncertainties about prevalence and penetrance of HFE mutations and the optimal care of asymptomatic people carrying HFE mutations. In addition, use of a genetic screening test raises concerns regarding possible stigmatization and discrimination. Tests for HFE mutations may play a role in confirming the diagnosis of hereditary hemochromatosis in persons with elevated serum iron measures, but even this use is limited by uncertainty about genotype-phenotype correlations. To address these questions, the expert group accorded high priority to population-based research to define the prevalence of HFE mutations, age and sex-related penetrance of different HFE genotypes, interactions between HFE genotypes and environmental modifiers, and psychosocial outcomes of genetic screening for hemochromatosis.     

Gender differences in correlates of disablement among the elderly in Egypt

Abnormal mechanical stress on pulmonary structures is associated with increased airway resistance and impaired gas exchange as a result of increased airway smooth muscle (ASM) deposition. Using an in vitro system with cultured ASM cells, we have demonstrated that cyclic deformational strain increases ASM cellular myosin and myosin light chain kinase. To determine if these contractile protein increases were accompanied by ultrastructural changes in cells indicating phenotypic modulation, cells subjected to strain were compared to cells grown under static conditions by transmission electron microscopy (TEM) and fluorescent staining. The strained ASM cells oriented perpendicular to the strain direction were more elongated and contained more actin stress fibers than identical cells grown under physically static conditions. The stress fiber bundles were thicker and reorganized parallel to the long axis of the cell. Marked increases in the numbers and lengths of focal adhesions between the cell membrane and the substratum were found by both TEM and immunostaining for talin. Mechanical strain thus increases organization of cytoskeletal elements in cultured ASM cells. Similar effects in vivo may serve to promote the expression of the contractile phenotype of cultured ASM cells independent of other in vivo factors and alter cell contractility. Increased organization of cytoskeletal elements might also increase the efficiency of signal transduction from the extracellular matrix into the cell interior.     

Gender differences in alcohol and other drug use among young adults

This article describes gender differences in alcohol and other drug (AOD) use and misuse in a representative sample of young women and men in the United States. Data were drawn from the National Longitudinal Survey of Youth (NLSY) and focus on gender differences in prevalence and patterns of AOD use in African American, Hispanic, and White young adults ages 19 to 24 years old. Findings are summarized and implications for prevention are presented.     

Psychiatric comorbidity among hospitalized AIDS patients vs. non-AIDS patients referred for psychiatric consultation

This study evaluated the clinical performance of a new resin modified glass ionomer cement, Geristore (Den-Mat Corp., Santa Maria, Calif.), for the bonding of orthodontic brackets and its effect on certain caries-associated microorganisms. This cement has been shown to possess increased mechanical properties and long-term fluoride release. There were 716 brackets bonded in 40 patients (17 males and 23 females), with a split-mouth technique and a composite resin, Phase II (Reliance, Itasca, III.), as a control. Bond failures were recorded up to 1 year. Plaque scores and plaque samples were taken from the area of the bonding adhesive in 20 patients, before, at 1 week, and 5 months after the placement of brackets. The plaque samples were investigated for the presence of Streptococcus mutans and lactobacilli. The overall bond failure rate was found to be 8.9% for Geristore and 3.1% for Phase II (p < 0.05). Labially, there was no significant difference (p > 0.05) in bond failure rate: 3.8% for Geristore and 1.7% for Phase II. The proportions of S. mutans and lactobacilli in plaque taken from around Geristore cement were reduced at 1 week and 5 months, when compared with Phase II resin, and this reduction was statistically significant (p < 0.05) at 1 week. Results of this study suggest that Geristore may be of use in the labial segments, especially in caries prone patients, in whom demineralization at debond may present an esthetic and restorative problem several years after treatment.