一款祛痘精华的功效研究

通过体内和体外两种途径对一款自主研发祛痘精华产品的祛痘效果进行研究。首先通过微生物抑菌试验,检验其配方中功效成分对痤疮丙酸杆菌的抑制作用;而后经体外抗炎试验,检验功效成分对炎症的抑制作用;最后通过对该祛痘精华进行人体功效评价,观察其祛痘效果。试验结果表明,此款祛痘精华祛痘效果明显,体内和体外试验两种途径均可作为评价化妆品祛痘功效的手段,二者结合可互相印证。     

复方山茶花精华油的制备及护肤功效

目的：制备一款复方山茶花精华油,并对其护肤功效进行考察。方法：按配方比例制备山茶花精华油,参考国家标准,检测精华油理化性质,斑贴试验观察其皮肤刺激性,人体试用试验对其保湿、润肤功效进行评价。结果：制得精华油理化性质符合润肤油国家标准要求;精华油对人体皮肤安全性高,无明显不良反应;定时保湿性能考察显示精华油配合精华水或精华水、乳使用,能显著提高护肤品补水保湿效果,配合使用精华油组比单独使用精华水、乳组,用后120 min皮肤水分含量高10;28天试用试验也显示精华油配合精华水、乳使用,可使皮肤平均水分、油分、弹性都有所提高,志愿者使用后感觉皮肤滋润性改善较大。结论：该山茶花精华油理化性能良好,皮肤安全性高,配合水、乳使用可提高护肤品的保湿性、滋润性,具有一定的开发前景。     

一款祛痘化妆品的效果评估

通过两种方法对国内某品牌安心祛痘精华露的祛痘效果进行研究。首先通过微生物抑菌试验,检验其配方内功效剂的实际抑菌情况,从而验证功效剂的祛痘效果;接着通过对安心祛痘精华露进行人体功效评价,再次验证其祛痘效果。以上两种方法均可以明显反映出该化妆品的祛痘功效,说明此款祛痘化妆品的祛痘效果真实有效,同时,说明微生物抑菌试验及人体功效试验可作为评价化妆品祛痘功效的手段,且相互佐证。     

大学生面部痤疮问题的解决与效果评价

通过对238例大学生痤疮患者进行调查问卷和初次皮肤指标测试,结合化妆品市场调研及文献检索得出包括祛痤疮化妆品选用及生活习惯改善在内的有针对性的痤疮改善方案。将痤疮志愿者分为"遵从建议组"和"遵从建议配合使用化妆品组"分别改善1个月后再次进行皮肤测试并对各项皮肤生理指标进行分析,结果表明两组痤疮患者面部情况均得到了改善且配合使用化妆品组改善情况更佳。     

一款提亮精华的功效评价

制备一款提亮精华,并对其进行提亮功效评价.选择30名20～45岁的合格受试者,持续在面部使用提亮精华56天,分别在使用前、使用后第28天和第56天时测试相应皮肤部位的黑色素含量MI值、明度L*值、暗黄度ITA°值.实验结果显示,使用精华56天后,皮肤的MI值、L*值和ITA°值均具有显著性差异(P<0.05);同时,对...     

美白面膜临床功效测试与分析

对自研美白面膜产品进行临床功效测试,评价其美白效果。选择32名有效健康志愿者作为研究对象,每隔2 d使用一次美白面膜,连续8周,同时停用其他美白护肤品或面膜。分别于使用前0周及使用后2,4和8周,测试志愿者面部含水量、黑红度、L~*值和b~*值,并拍摄VISIA的正面、左侧和右侧面部图片。分析结果显示,使用美白面膜,能够显著提高皮肤含水量,提高皮肤亮度L~*值和皮肤ITA°值,降低皮肤黑度和黄度b~*值,同时还能够降低皮肤毛孔、皱纹及纹理分值,即美白面膜具有良好的美白、使皮肤细腻、减少皮肤皱纹和纹理的功效。     

一款针对熬夜型皮肤的护肤精华功效研究

对一款针对熬夜型皮肤所设计的护肤精华开展人体功效研究，从仪器探头测量、图像采集、医生评估及受试者自评等多个维度进行评价。筛选日常有熬夜习惯（经常每晚12点后睡觉）的受试者，分别对其皮肤角质层水分含量、皮肤经表皮失水率（TEWL）、皮肤血红素含量、皮肤颜色（红-绿）值a*值、皮肤油脂含量以及痤疮体积等进行分析，结合皮肤科医生评估及受试者自我评估对该精华进行功效及安全性评价。结果显示，熬夜受试者连续使用该护肤精华7天后皮肤的出油情况及痤疮体积得到了显著改善；连续使用28天后，皮肤角质层水分含量、TEWL值、血红素含量、皮肤颜色皆有改善，与使用前相比均有显著性差异（P<0.05），证明该护肤精华具有保湿、修护、舒缓、控油和祛痘多重功效，可高效解决熬夜人群皮肤干燥敏感等问题；医生评估未出现任何不良反应，且整个测试过程中无受试者感到不适，表明该产品温和无刺激，具有良好的安全性，适合熬夜人群脆弱肌肤使用。     

云南白茶提取物的控油功效评价

为研究化妆品原料云南白茶提取物抑制皮肤油脂分泌的功效,选取25位18～37岁面部皮脂较多的志愿者,测试区域为前额。随机左右侧分区使用对照样品或受试样品,按要求在样品使用前、使用后4 h和6 h进行测试。利用无创仪器SM815型皮肤油脂测试仪与VC20 Plus型皮肤表面纹理分析系统相结合的检测方法,测试皮肤皮脂分泌情况。分别测试受试者前额皮肤使用前后整体油脂面积、平均油脂斑点大小、油脂含量变化率的情况。结果显示使用含有云南白茶提取物的样品之后,相对于使用对照样品的区域,能减少皮肤整体油脂面积和平均油脂斑点大小,两组之间存在显著性差异。     

两款祛痘化妆品的效果评价

对两款祛痘化妆品进行功效评价。通过抑菌试验测试产品对痤疮丙酸杆菌的抗菌活性;选择62名受试者,分组按要求持续使用化妆品4周,测试皮肤油脂分泌量和痘痘在使用产品前后的变化情况。结果表明,产品具有较好的抑菌效果;使用产品四周后,皮肤油脂分泌量和痘痘的体积、高度、数量与初始值比较都明显下降,且具有显著性差异(P0.05)。抑菌试验和人体功效评价试验相结合,是评价祛痘类化妆品功效的一种有效手段。     

一款美白产品的功效研究

制备一种美白精华乳,并对其美白和保湿功效进行研究。选择24名女性志愿者,按要求在前臂内侧持续使用美白精华乳8周,测试皮肤相应位置的MI值、L*值、ITA°值、皮肤角质层水分含量的变化情况。结果表明,使用化妆品8周后,皮肤的MI值、L*值、ITA°值和水分含量与初始值之间具有显著性差异(P<0.05),表明产品具有一定的美白和保湿功效。     

Effect of chromatic components on facial skin whiteness

Although the color measurement of facial skin becomes more common in dermatology and cosmetics, little is known about the relationship between subjective color perception and colorimetric values in facial skin. In this study, the possible relationships among perceived whiteness and the metric lightness, chroma and hue angle of Japanese females' facial skin color were investigated. First, the perceived brightness of the facial skin of Japanese females was evaluated visually and compared with metric lightness, chroma and hue angle, and the effect of hue and chroma on the perceived brightness was discussed. Second, a psychophysical experiment on the whiteness of the facial images and synthesized skin color plate images was conducted for examining the effect of hue and chroma on the perceived whiteness more precisely and independently. The results of two experiments showed that in regard to the facial skin color of the Japanese female, metric lightness disagrees with perceived whiteness or brightness in a narrow lightness range. The reddish facial skin color appeared brighter or whiter than that of a yellowish one in high lightness regions, and the low‐chroma facial skin color appeared brighter or whiter than a high‐chroma one. However, in the color plate images, a change in perceived whiteness by hue could not be confirmed, and the change in perceived whiteness by chroma was weaker than that from facial images. These results indicated that a higher‐level process of face recognition affected whiteness perception, and the criterion of facial skin whiteness was determined by facial skin color distribution. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2011;     

含兵豆籽和红木籽提取物精华液控油及改善毛孔的功效

为研究含兵豆籽和红木籽提取物的精华液对改善人体面部油脂、角质层水分、毛孔的作用,选取了33名年龄为18～40岁、油性肤质、面部毛孔等级为1～3级的受试者,每天早晚使用含兵豆籽和红木籽提取物的精华液,持续使用4周.使用VISIA、Sebumeter SM815、Corneometer CM825仪器测试使用前后面部油脂、...     

Spectrophotometric measurement of human skin colour

This article focuses on human skin colour. Three different colour measuring instruments were used: a tele‐spectroradiometer, a de:8° and a 45°:0° spectrophotometers. They were used to measure 47 subjects who were divided into four skin groups: Chinese, Caucasian, South‐Asian, and Dark. Eight locations for each subject were measured. The spectral reflectance results were first compared. They all showed the “W” shape between the 550 nm and 580 nm as found by the other studies. Those from the tele‐spectroradiometer had an increase from 600 nm while the others were flatter. The colorimetric data calculated from the spectral measurements revealed similar patterns to describe the colour distribution of each skin group. It was found that two scales: whiteness‐depth, and blackness‐vividness could well describe these distributions. The results also showed systematic differences between the four ethnic groups, between eight body locations, between two genders, and between the measurements from the three instruments.     

Semiochemicals and Social Signaling in the Wild European Rabbit in Australia: I. Scent Profiles of Chin Gland Secretion from the Field

The European rabbit (Oryctolagus cuniculus) uses the secretion of the chin gland in the maintenance of social status. Previous work has concentrated on secretion collected directly from the animal. In this study, the analysis was conducted by collecting scent marks made by free-ranging animals. Scent marks were found to be concentrated at the center of the area controlled by a social group, and at the boundaries between two adjacent social groups. Only the mark from dominant animals could be identified. Marks were also collected from the skin of rabbits, where they had been placed by the dominant individual. The mark found on the head of a subordinate animal may, in the future, be used to identify the dominant animal of the social group, who placed the mark.     

Whiteness and fluorescence of fabrics

A method was devised for measuring the whiteness of fabrics containing optical brighteners. It is simple in operation and gives excellent agreement with the visual appraisal by 27 observers of the whiteness for fabrics with different values for their fluorescence, lightness, yellowness or blueness, and redness or greenness. The fabrics contained different quantities of various blues and optical brighteners. Apart from duplicates it requires only four measurements for each surface, viz., lightness, tristimulus amber and blue reflectance, and the tristimulus blue part of the fluorescent light. Yellowness or blueness, redness or greenness, fluorescence effect on the whiteness, whiteness without fluorescence, and whiteness including fluorescence are calculated from the measurements. The method also indicates which fabrics cannot be called “near white” because they are too gray or too strongly colored. It can be adapted to different compositions of the incident light with regard to the relative intensity of the ultraviolet and visible portions.     

Effects of different bleaching application durations on enamel in terms of tooth color,microhardness, and surface roughness

The aim of this research was to assess the color differences (?E₀₀), Vickers microhardness, whiteness index, and surface roughness values of different durations of bleaching the enamel. One hundred and eight teeth were utilized for color evaluation, roughness, and microhardness (n = 36). Teeth were assigned to three groups (n = 12) based on the durations of the bleaching application. Bleaching agent was applied for 20 minutes in group 1, 40 minutes in group 2, and 60 minutes in group 3. The color was measured with a Vita Easyshade Advance 4.0 spectrophotometer before applying the bleach, and 24 hours, 7, and 14 days after bleaching application. The CIEDE2000 and whiteness index for dentistry values were calculated. The microhardness and surface roughness values were obtained before application and 7 and 14 days after application. Data were analyzed using two-way ANOVA and post-hoc LSD tests Group 3 had the largest color and whiteness changes. The whiteness index for dentistry values were statistically significantly increased, considering baseline measurements within all groups (P < .05). For the Vickers micohardness values, in group 3, a statistically significant difference was observed among baseline, and 7 days after application (P < .05). However, the surface roughness values showed no significant difference in any measurement (P > .05). According to this research in all groups, effective whitening was accomplished. Based on the results evaluated for whiteness, color alteration, microhardness, and roughness, the optimal bleaching duration of application was in 40 minutes.     

The Mandible Ameliorates Facial Allograft Rejection and Is Associated with the Development of Regulatory T Cells and Mixed Chimerism

Vascularized composite allografts contain various tissue components and possess relative antigenicity, eliciting different degrees of alloimmune responses. To investigate the strategies for achieving facial allograft tolerance, we established a mouse hemiface transplant model, including the skin, muscle, mandible, mucosa, and vessels. However, the immunomodulatory effects of the mandible on facial allografts remain unclear. To understand the effects of the mandible on facial allograft survival, we compared the diversities of different facial allograft-elicited alloimmunity between a facial osteomyocutaneous allograft (OMC), including skin, muscle, oral mucosa, and vessels, and especially the mandible, and a myocutaneous allograft (MC) including the skin, muscle, oral mucosa, and vessels, but not the mandible. The different facial allografts of a BALB/c donor were transplanted into a heterotopic neck defect on fully major histocompatibility complex-mismatched C57BL/6 mice. The allogeneic OMC (Allo-OMC) group exhibited significant prolongation of facial allograft survival compared to the allogeneic MC group, both in the presence and absence of FK506 immunosuppressive drugs. With the use of FK506 monotherapy (2 mg/kg) for 21 days, the allo-OMC group, including the mandible, showed prolongation of facial allograft survival of up to 65 days, whereas the myocutaneous allograft, without the mandible, only survived for 34 days. The Allo-OMC group also displayed decreased lymphocyte infiltration into the facial allograft. Both groups showed similar percentages of B cells, T cells, natural killer cells, macrophages, and dendritic cells in the blood, spleen, and lymph nodes. However, a decrease in pro-inflammatory T helper 1 cells and an increase in anti-inflammatory regulatory T cells were observed in the blood and lymph nodes of the Allo-OMC group. Significantly increased percentages of donor immune cells were also observed in three lymphoid organs of the Allo-OMC group, suggesting mixed chimerism induction. These results indicated that the mandible has the potential to induce anti-inflammatory effects and mixed chimerism for prolonging facial allograft survival. The immunomodulatory understanding of the mandible could contribute to reducing the use of immunosuppressive regimens in clinical face allotransplantation including the mandible.     

Long‐term changes in Japanese women's facial skin color

It has been suggested that skin color changes not only with advancing age but also with the times. The purpose of this study was to investigate changes in Japanese women's facial skin color over 25 years, as well as the changes in skin pigmentation that affect skin color. First, skin color changes in terms of Munsell color values were investigated. A total of 3181 Japanese women residing in the greater Tokyo area were enrolled, and datasets were collected using spectrophotometers, designated as the 1991, 2001, 2005, and 2015 data. The mean Munsell hue, value, and chroma were calculated for each measurement year. Next, the concentrations of melanin and hemoglobin were calculated from spectral data, to investigate changes in skin pigmentations. Finally, Monte Carlo simulations were performed to verify that the suggested changes in skin pigmentations brought about skin color changes. As a result, skin color significantly changed toward high lightness, low saturation, and high yellowness from the 1991 data to the 2001 data. From the 2005 to 2015 data, the skin color distribution shifted toward lower saturation and increased redness. In addition, the concentration of hemoglobin decreased significantly from the 1991 data to the 2001 data, while the melanin concentration decreased significantly from the 2005 data to the 2015 data.     

Exploring the efficacy of AHA–BHA infused nanofiber skin masks as a topical treatment for acne vulgaris

This study investigates the efficacy of AHA–BHA infused nanofiber skin masks as a topical treatment for acne vulgaris. The skin is a vital organ that functions as a barrier to protect the body from external substances. In recent years, there has been a growing emphasis on skin treatment research. Hyaluronic acids (HAs) are commonly used in cosmetic and drug formulations to regulate excessive skin cornification, making them promising candidates for acne treatment. The introduction of HAs in dermatology has revolutionized the field of skin care, and they are used to treat various skin disorders, such as acne, ichthyosis, keratoses, warts, psoriasis, and photoaged skin. The antiaging benefits of HA have gained considerable attention in cosmetic dermatology, resulting in a surge in cosmetic products and skin care systems that contain HA. The study found that AHA–BHA-infused nanofiber skin masks are effective in treating acne vulgaris. The nanofiber masks were found to reduce inflammation, sebum production, and acne lesions. The study suggests that AHA–BHA-infused nanofiber skin masks could be a promising topical treatment for acne vulgaris.