Consolidation of Soft Clay Foundations Reinforced by Stone Columns under Time-Dependent Loadings

This paper presents an analytical solution for the consolidation of soft soil foundations reinforced by stone columns under time-dependent loadings. The differential equations of the foundations reinforced by stone columns are obtained including smear and well resistance under arbitrary applied loadings. The closed-form solutions of pore pressure and the overall average degree of consolidations are obtained for some common types of loadings, such as step loading, ramp loading, and cyclic trapezoidal loading. By solving the equations using a semianalytical method, the comparisons agree very well with the existing analytical solutions, which verify the correctness and accuracy of the proposed methods. Using the solutions obtained, some selected charts are presented and the relevant consolidation behavior is investigated and discussed.     

Water Table Fluctuation in the Presence of a Time-Varying Exponential Recharge and Depth-Dependent ET in a Two-Dimensional Aquifer System with an Inclined Base

An analytical solution is presented for water table fluctuation between ditch drains in presence of exponential recharge and depth-dependent evapotranspiration (ET) from groundwater table in a two-dimensional gently sloping aquifer. The groundwater head above the drain is small compared to the saturated thickness of the aquifer. A sound mathematical transformation is devised to transform the two-dimensional groundwater flow equation into a simple form, which makes possible to obtain an analytical solution. The transient midpoint water table variations from the proposed solution compare well with the already existing solutions for horizontal aquifer. A numerical example is used to illustrate the combined effect of depth-dependent ET coupled with a time-varying exponential recharge on the water table fluctuation. The inclusion of a depth-dependent ET in the solution results in water table decline at a faster rate as compared to the case when ET is not considered. With an increase in slope of the aquifer base, water table profiles become asymmetric and the water table divide shifts towards the lower drain. The height of the water table profiles increases on moving away from the boundary of the aquifer and the highest level of the ground water table is obtained in the central portion of the aquifer basin due to the presence of drainage ditches on the aquifer boundary. When the effect of ET is incorporated in combination with recharge, the analytical solution results in accurate and reliable estimates of water table fluctuations under situations subjected to a number of controlling factors. This study will be useful for alleviation of drainage problems of the aquifers receiving surface recharge and surrounded by streams.     

Consolidation of a Double-Layered Compressible Foundation Partially Penetrated by Deep Mixed Columns

Deep mixed columns often penetrate partially into the soft soil as floating columns due to the depth of the end-bearing layer. Partially penetrated soft soil by columns and the underlying compressible soft soil create a double-layered compressible foundation. So far, no reasonable solution is available to estimate the consolidation of such a double-layered foundation. This paper proposes an analytical solution for consolidation of a double-layered compressible foundation partially penetrated by deep mixed columns considering one-side or two-side vertical drainage The Laplace transform method was used to solve the consolidation equation for the double-layered system while Stehfest’s algorithm was used to solve the inverse Laplace transform for time-dependent loading. A consolidation algorithm was used to calculate the time-settlement relationship of an embankment constructed upon the double-layered foundation partially penetrated by deep mixed columns. The calculated settlements were compared well with field measurements.     

实炉底节能连续式加热炉

轧钢生产使用实炉底连续式加热炉加热钢坯，炉内双纵滑管用耐热耐高温材料，无水冷，起到节约水、电的作用，达到节能增效的目的。     

Liquid Metal Heat Transfer in an Inclined Tube Affected by a Longitudinal Magnetic Field

This paper presents results of hydrodynamic and heat transfer investigations in liquid metal flow affected by a longitudinal magnetic field in an inclined tube with respect to tokamak cooling problem.Experimental study has been conducted for the tube with slope 15 to the horizon which corresponds to the conditions oflTER project in case the LM flow faced longitudinal MF.The results obtained in the regimes without the MF,may be interesting for the design of nuclear reactors cooled by LM and metallurgical processes.     

Ballistic Impact of Braided Composites with a Soft Projectile

Impact tests using a soft gelatin projectile were performed to identify failure modes that occur at high strain energy density during impact loading. Failure modes were identified for aluminum plates and for composites plates and half-rings made from triaxial carbon fiber braid having a 0/±60° architecture. For aluminum plates, a large hole formed as a result of crack propagation from the initiation site at the center of the plate. For composite plates, fiber tensile failure occurred in the back ply at the center of the plate. Cracks then propagated from this site along the ±60° fiber directions until triangular flaps opened to form a hole. For composite half-rings fabricated with 0° fibers aligned circumferentially, fiber tensile failure also occurred in the back ply. Cracks first propagated from this site perpendicular the 0° fibers. The cracks then turned to follow the ±60° fibers and 0° fibers until rectangular flaps opened to form a hole. Damage in the composites was localized near the impact site, while cracks in the aluminum extended to the boundaries.     

Soft Bedrock Erosion Modeling with a Two-Dimensional Depth-Averaged Model

Many rivers in Taiwan have steep slopes, are subject to typhoon-induced flood flows, and contain soft bedrock that is exposed at many locations and easily erodible. The occurrence of extensive bedrock erosion has been a major threat to river infrastructure at many locations. Soft bedrock erosion, therefore, is an important process to consider for river projects in Taiwan. In this study, bedrock erosion models are reviewed. A specific model is proposed by combining two existing models incorporating both the hydraulic and abrasive scour mechanisms. The proposed bedrock erosion model is incorporated into a two-dimensional mobile-bed model, and the integrated model is tested by simulating bedrock erosion downstream of the Chi-Chi weir on the Choshui River in Taiwan. A calibration study is performed to determine appropriate values of the model parameters based on two and a half years of measured data. The model is then assessed based on a verification study that compares model predictions of bedrock erosion of the same reach to two additional years of measured data. The bedrock erosion model is found to be suitable for the river reach studied. Further improvement, however, is still necessary, which points to potential future research.     

浅谈采用短木桩加土工网碎石垫层处理挡墙软基

结合工程实例，对采用传统的短木桩加新兴的土工合成材料——土工网及碎石垫层构成复合基础，处理河岸挡墙软基进行探讨，该方法在软土层厚度不超过4．0m的条件下，技术可靠，施工简单，工期短，造价低。     

Isolation of a novel gene down-regulated by v-src

We have re-examined the reaction of fast oxidised cytochrome bo with H202 in a stopped-flow spectrophotometer. Monitoring the reaction at 582 nm allows us to observe the formation and decay of a spectroscopically distinct intermediate which accumulates transiently prior to the formation of an oxyferryl species previously characterised in this laboratory (Watmough, N.J., Cheesman, M.R., Greenwood, C. and Thomson, A.J. (1994) Biochem. J. 300, 469-475 [1]). The reaction shows three distinct phases of which the fast and intermediate phases are bimolecular and show a marked pH dependence. Initially these results appeared incompatible with the report that only one equivalent of H202 is required to generate the oxyferryl species (Moody, A.J. and Rich, P.R. (1994) Eur. J. Biochem. 226, 731-737 [21]. However, these data can be reconciled by a branched reaction mechanism whose contributions differ according to the peroxide concentration used.     

Evaluation of a Dike Damaged by Pile Driving in Soft Clay

This paper presents a case study detailing a riverbank dike damaged by pile driving in very soft clay in Shanghai, P.?R. China. Driven piles were designed to support the existing dike to be raised to a higher elevation. The subsoil mainly consisted of very soft clay with its natural moisture content greater than its liquid limit. This paper describes the phenomena of dike movement and crack development during pile driving based on field observations and instrumentation data. Cone penetration tests and vane shear tests were conducted after pile driving to investigate the slip surfaces. Degradation of soil strength was identified as the main cause for the failure of this dike. Slope stability analysis was conducted to back-calculate the degraded undrained shear strength of the clay. The results indicate that the soil strength in the disturbed area due to pile driving approached the level of its remolded strength.     

Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display

Fibroblasts are the major cell type responsible for synthesizing matrix constituents in lung and other connective tissues. Evidence indicates that fibroblasts are heterogeneous, and that subpopulations with some distinct properties are clonally selected and expanded in fibrotic diseases. However, few distinct markers capable of demonstrating the presence of fibroblast subpopulations in tissues have been isolated so far. With the objective of identifying proteins that could detect fibroblast subpopulations, we compared the messenger RNA (mRNA) expression of two cultured human lung fibroblast subpopulations by differential display. Total RNA was obtained, complementary DNA (cDNA) was synthesized, and the polymerase chain reaction (PCR) products obtained with several primer pairs were compared. One 724-bp product, which was strongly expressed by one human lung fibroblast subpopulation, was identified and cloned. This product was poorly expressed by the other lung fibroblast subpopulation. The mRNA for the gene encoding this product was not detectable in human smooth-muscle cells, endothelial cells, or epithelial cells, although it was present in dermal fibroblasts. The mRNA was detected in normal and fibrotic human lungs. Search of the National Center for Biotechnology (NCBI) GenBank DNA database with the sequence obtained from this clone revealed no significant matches. However, a search of the NCBI database of expressed sequence tags (dBEST) revealed five different human expressed sequence tag (EST) clones corresponding to the LR8 cDNA sequence. Six additional mouse and one pig EST clones were identified that showed significant similarity to the human fibroblast cDNA. Composites of the entire coding sequences for the human fibroblast gene product and the mouse homologue were assembled from the respective overlapping EST sequences. The open reading frame identified for each composite sequence predicted protein products of 270 and 263 amino acids for the human and mouse sequences, respectively, which were 52% identical, with three gaps. At the amino acid level, no significant sequence similarity was detected with any other sequences in exhaustive searches of the NCBI DNA and protein databases or the Blocks databases. A PCR product with predicted length and sequence was obtained by using a sense primer upstream to LR8 and an antisense primer within LR8. Our results indicate that this differentially displayed product represents a previously undescribed protein that could be useful for distinguishing fibroblasts, and possibly fibroblast subpopulations, from other cell types in lungs and other tissues.     

Isolation of a fluorophore-specific DNA aptamer with weak redox activity

BACKGROUND: In vitro selection experiments with pools of random-sequence nucleic acids have been used extensively to isolate molecules capable of binding specific ligands and catalyzing self-modification reactions. RESULTS: In vitro selection from a random pool of single-stranded DNAs has been used to isolate molecules capable of recognizing the fluorophore sulforhodamine B with high affinity. When assayed for the ability to promote an oxidation reaction using the reduced form of a related fluorophore, dihydrotetramethylrosamine, a number of selected clones show low levels of catalytic activity. Chemical modification and site-directed mutagenesis experiments have been used to probe the structural requirements for fluorophore binding. The aptamer recognizes its ligand with relatively high affinity and is also capable of binding related molecules that share extended aromatic rings and negatively charged functional groups. CONCLUSIONS: A guanosine-rich single-stranded DNA is capable of binding fluorophores with relatively high affinity and of weakly promoting a multiple-turnover reaction. A simple motif consisting of a three-tiered G-quartet stacked upon a standard Watson-Crick duplex appears to be responsible for this activity. The corresponding sequence might provide a useful starting point for the evolution of novel, improved deoxyribozymes that generate fluorescent signals by promoting multiple-turnover reactions.     

Pancreatic cancer and comparison of a hospital-based tumor registry with a National Cancer Data Base

BACKGROUND: The Commission on Cancer of the American College of Surgeons has called upon institutions providing cancer care to compare practice patterns and outcomes with the National Cancer Data Base (NCDB). Using data from the Virginia Mason Tumor Registry (VMTR), we sought to compare our pancreatic cancer care patterns with those reported nationally, while critically evaluating the accuracy and usefulness of our registry. METHODS: A review of the 906 computerized patient files in the VMTR from 1973 to 1995 was performed, with more detailed data on patients from the last 5 years retrieved from 224 manual abstracts. These data were compared with the 1991 NCDB for pancreatic cancer. RESULTS: The percent of cases according to AJCC stage in the NCDB (n = 9,715) versus the VMTR (n = 149), respectively, with cases of unknown stage excluded, were stage I 22% versus 22%, stage II 9% versus 12%, stage III 17% versus 28% (P <0.05) stage IV 52% versus 38% (P <0.05). One-third of the cases in the VMTR 1991 to 1995 were of unknown stage; number of cases with unknown stage for NCDB was 26.6%. The percent of surgical procedures for the NCDB (n = 7,802) versus the VMTR (n = 224), respectively, was pancreatectomy 14% versus 11%, local excision 1% versus 0%, no cancer-directed surgery 83% versus 89% (P <0.05), unknown 2% versus 0% (P <0.05). The actuarial relative survival rates for the 1991 NCDB versus 1987 to 1995 VMTR was 3-year 18% versus 38%, and 5-year 14% versus 35%. CONCLUSIONS: In comparison with the NCDB, VMTR may have fewer stage IV pancreatic cancers, but improvement is needed in decreasing the number of patients for whom the stage is unknown, as many of these likely represent late stage disease. We have a similar resection rate and a higher survival compared with the NCDB, but a mechanism is not in place to statistically compare our survival data with those of the NCDB. Even though all accredited hospitals are required to have a tumor registry, our data were difficult to compare with those of the NCDB because of coding and reporting deficiencies and inability to statistically compare survival data. Before our practice patterns and outcomes can be compared with national standards, both the VMTR and the NCDB must have standardized data collection and better access to the data.     

First clinical experience with a new concentrate system for dialysis with dry sodium chloride

Clinical investigation of a new concentrate system for preparing the acid concentrate in bicarbonate dialysis was performed to evaluate handling, safety aspects, and correct mixing of the final dialysis fluid. The system is characterized by an acid concentrate prepared from two components: a cartridge containing 1.1 kg dry sodium chloride and a concentrate bag with 500 ml of a highly concentrated solution of electrolytes (KCl, MgCl2, CaCl2) and acetic acid. The investigation comprised a total of 142 treatments. The concentrate system was well accepted by the clinical staff and considered safe and easy to handle. Marginal deviations in electrolyte concentration of the dialysis fluid relative to set values were observed, but were considered to lack biologic or clinical relevance. The new concentrate system will facilitate the handling of dialysis concentrates and provide a convenient means for individual tailoring of the dialysis fluid composition.     

Analysis of Soft Fibers with Kinematic Constraints and Cross-Links by Finite Deformation Beam Theory

This paper presents a hybrid analytical–computational mechanics formulation for an arbitrarily curved Timoshenko beam undergoing planar finite deformation and subjected to kinematic constraints in the form of fixed displacement and cross-linking. On the basis of an analytical reduction of the governing equations, the system reduced to a single nonlinear differential equation coupled with integral equations associated with translational constraints. An effective numerical formulation of the problem with general distributed and pointwise constraints is shown to be possible by using a simple finite-element procedure. To illustrate the efficiency and accuracy of the method, several examples are introduced to study both stable and bifurcation problems and a system of interacting fibers with different types of cross-link constraints. Because of the reduction of discretization error and the dimension of the matrix system, the proposed formulation is likely to be an attractive computational platform for modeling large-scale multifiber problems, as in fibrous microstructure simulations and other applications.     

Base dynamics in a UUCG tetraloop RNA hairpin characterized by 15N spin relaxation: correlations with structure and stability

Intramolecular dynamics of guanine and uracil bases in a 14-nt RNA hairpin including the extraordinarily stable UUCG tetraloop were studied by 15N spin relaxation experiments that are sensitive to structural fluctuations occurring on a time scale of picoseconds to nanoseconds. The relaxation data were interpreted in the framework of the anisotropic model-free formalism, using assumed values for the chemical shift anisotropies of the 15N spins. The rotational diffusion tensor was determined to be symmetric with an axial ratio of 1.34 +/- 0.12, in agreement with estimates based on the ratio of the principal moments of the inertia tensor. The model-free results indicate that the bases of the G x U pair in the tetraloop are at least as rigid as the interior base pairs in the stem, whereas the 5'-terminal guanine is more flexible. The observed range of order parameters corresponds to base fluctuations of 19-22 degrees about the chi torsion angle. The results reveal dynamical consequences of the unusual structural features in the UUCG tetraloop and offer insights into the configurational entropy of hairpin formation.     

基于FLAC~(3D)数值模拟的某钨矿缓倾斜矿体采场矿柱稳定性研究

针对采用全面采矿法的矿山,其采场矿柱的位置与尺寸留设一直是矿山安全高效生产关注的问题。通过对某钨矿缓倾斜矿脉采场回采过程中的矿柱留设进行数值模拟研究,采用FLAC3D三维有限元数值模拟软件建立采空区、围岩单元模型。根据采场周围应力、应变的计算结果显示,整个采空区顶板沉降均匀,顶板围岩位移呈拱形分布,开挖区间中部位移值略大于两侧,采场布置3排矿柱可以保障整个采空区的稳定性,为矿山采场开挖及采空区稳定提供科学依据。     

First experiences with a new infrared thermometry device in mammary gland diagnosis

A parasitology survey was conducted in five villages in North Sumatra, Indonesia. A total of 3,207 blood smears, 2,066 stool specimens and 969 sera were examined. Sixty (1.9%) inhabitants had malaria (Plasmodium vivax 41, P. falciparum 19), and 20 had Brugia malayi microfilaraemia. The most common intestinal helminths were Trichuris trichiura (87%), Ascaris lumbricoides (75%) and hookworm (58%). Other helminths found in low numbers were Enterobius vermicularis, Strongyloides stercoralis, Taenia sp., Fasciolid, Dicrocoeliid and Echinostoma sp. eggs. Entamoeba coli (25%) was the most common intestinal protozoa followed by Endolimax nana (8%), Entamoeba histolytica (7%), Giardia lamblia (6%), Iodamoeba bütschlii (5%), Entamoeba hartmanni (1%) and Chilomastix mesnili (1%). The amoeba prevalence rate was 31 per cent. Testing of sera for Entamoeba histolytica and Toxoplasma gondii antibodies by the indirect haemagglutination test demonstrated positive reactors in 13 per cent and nine per cent of the population respectively. The greatest number of seropositives for Toxoplasma gondii was at elevations of sea level to five meters and the lowest number at elevations of 5OO-1,000 meters.     

First degree atrioventricular block caused by a calcified tumor of the atrioventricular septum

First degree atrioventricular block occurred in a 69-year-old patient with a calcified atrioventricular septum tumour. The patient suffered several episodes of syncope and the only abnormality found in the routine clinical work-up was a remarkable first degree atrioventricular block. The echocardiogram, computed tomography (CT) and the magnetic resonance imaging (MRI) procedure showed a calcified tumour in the posterior part of the left ventricle, between the left atrium and left ventricle, just beneath the aortic root spreading to the interventricular septum. It was suggested that the first degree atrioventricular block was caused by the tumour. The symptoms were relieved by implantation of permanent cardiac pacemaker.     

Isolation of a ribozyme with 5'-5' ligase activity

BACKGROUND: Many new ribozymes, including sequence-specific nucleases, ligases and kinases, have been isolated by in vitro selection from large pools of random-sequence RNAs. We are attempting to use in vitro selection to isolate new ribozymes that have, or can be evolved to have, RNA polymerase-like activities. As phosphorimidazolide-activated nucleosides are extensively used to study non-enzymatic RNA replication, we wished to select for a ribozyme that would accelerate the template-directed ligation of 5'-phosphorimidazolide-activated oligonucleotides. RESULTS: Ribozymes selected to perform the desired template-directed ligation reaction instead ligated themselves to the activated substrate oligonucleotide via their 5'-triphosphate, generating a 5'-5' P1,P4-tetraphosphate linkage. Deletion analysis of one of the selected sequences revealed that a 54-nucleotide RNA retained activity; this small ribozyme folds into a pseudoknot secondary structure with an internal binding site for the substrate oligonucleotide. The ribozyme can also synthesize 5'-5' triphosphate and 5'-5' pyrophosphate linkages. CONCLUSIONS: The emergence of ribozymes that accelerate an unexpected 5'-5' ligation reaction from a selection designed to yield template-dependent 3'-5' ligases suggests that it may be much easier for RNA to catalyze the synthesis of 5'-5' linkages than 3'-5' linkages. 5'-5' linkages are found in a variety of contexts in present-day biology. The ribozyme-catalyzed synthesis of such linkages raises the possibility that these 5'-5' linkages originated in the biochemistry of the RNA world.