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1.
Capaldi Elizabeth D.; Hunter Martin J.; Privitera Gregory J. 《Canadian Metallurgical Quarterly》2004,118(6):1400
The present research addresses whether rats can express odor aversions to the odor of taste stimuli. In Experiment 1, saccharin or salt were either mixed in distilled water, so the rats could taste and smell them, or presented on disks attached to the tubes' metal spouts so the rats could only smell them. Aversions were established to taste stimuli under both conditions. The results of Experiment 2 indicate that conditioning was to the odor of the tastes when they were presented on disks in Experiment 1, hence both taste and odor aversions were established by means of "taste" stimuli. Taste aversion learning thus may more properly be termed flavor aversion learning, with flavor referring to both taste and odor components. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
Ossenkopp Klaus-Peter; Parker Linda A.; Limebeer Cheryl L.; Burton Page; Fudge Melissa A.; Cross-Mellor Shelley K. 《Canadian Metallurgical Quarterly》2003,117(1):105
Pairing a novel taste with provocative vestibular stimulation results in conditioned taste aversions in both rats and humans. Vestibular system involvement in gustatory conditioning was examined in sham-lesioned or labyrinthectomized rats. Three conditioning trials consisted of 30 min access to a saccharin (0.1%) solution followed by 30 min of rotation (70 rpm) or sham rotation. In a taste reactivity test with saccharin, rotated sham-lesioned rats, but not labyrinthectomized rats, exhibited increased oral rejection reactions compared with control rats. When conditioned with lithium chloride, both labyrinthectomized and sham-lesioned rats displayed robust conditioned rejection reactions. The finding that normal vestibular function is necessary in obtaining rotation-induced conditioned taste aversions supports the face and construct validity of a rat model of motion sickness. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
In 2 experiments, rats received flavor-aversion conditioning in which the unconditioned stimulus (US) was an orally consumed solution of lithium chloride (LiCl). The resulting aversion was not attenuated by giving preexposure to injections of LiCl, although such preexposure did attenuate aversions established using injected LiCl as the US (Experiment 1). This outcome suggests that blocking by injection-related cues is responsible for the US-preexposure effect observed in this situation. Experiment 2 confirmed this interpretation by showing that presenting such cues (by giving an injection of saline) at the time that the LiCl was drunk resulted in an attenuation of conditioning in animals preexposed to injections of LiCl. The US-preexposure effect obtained in these experiments can be explained solely in terms of blocking by injection cues, although other mechanisms may contribute to the effect seen in other flavor-aversion paradigms. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Conducted 3 experiments with a total of 131 male Wistar rats. Results indicate that (a) a single preexposure to a distinctive flavor resulted in both a retardation of aversion learning (if the flavor was later paired with toxicosis) and a preference for this flavor (if the flavor was not paired with toxicosis); (b) preexposure-induced preferences were retained over a 24-day period and were not attributable to thirst reduction consequent upon ingestion; and (c) Ss evidenced a preference for a preexposed solution by subsequently ingesting relatively great amounts of this solution when it was the only fluid available (as well as by choosing it over an alternative, simultaneously available solution). Results are discussed in terms of a "learned safety" interpretation of the deleterious effects of flavor preexposure on flavor-aversion learning. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
In the separated arms conditioned cue preference (CCP) task rats are trained by confining them in one arm of an eight-arm radial maze with food and in another arm on the opposite side of the maze with no food on alternate days. After two such trials, rats prefer the food-paired arm when allowed to move freely between the two arms, neither of which contains food. However, if the rats are preexposed to the maze by exploring it without food before training, no preference is observed and at least 4 training trials are required to produce a CCP, suggesting that unreinforced preexposure to the maze latently inhibits acquisition. If this interpretation is correct, preexposure should reduce the size of the preference acquired with both 2 and 4 training trials. In Experiment 1, this prediction was replicated for 2 training trials; however, with 4 training trials, eliminating preexposure also eliminated the CCP. A previous finding that basolateral amygdala lesions impair the CCP with preexposure and 4 training trials was replicated in Experiment 2, but similar lesions had no effect on the CCP in nonpreexposed rats given 2 training trials. In contrast, lesions of the central nucleus impaired the 2 training trial CCP but had no effect on the 4 training trial CCP. This double dissociation suggests that the BLA-mediated 4 training trial CCP may be due to learning about the reward features of the maze space, while the central-nucleus-mediated 2 training trial CCP may be due to a conditioned approach response. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
6.
In two experiments, rats received preexposure to one type of food followed by autoshaping in which presentation of one lever was associated with the preexposed food, and presentation of another lever with a novel type of food pellet. In both it was found that acquisition of the leverpress response occurred more readily on the lever associated with the novel food. This example of the US (unconditioned stimulus) preexposure effect is not to be explained in terms of the development of competing responses during preexposure. Explanations in terms of blocking by contextual cues and of habituation to the US are considered. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
7.
Rats in a state of salt need prefer a flavor that has previously been paired with saline (Exp 1). In Exp 2 and 3, rats exposed to 2 saline concentrations, presented either concurrently or on separate trials, and each paired with a different flavor, showed a preference for the flavor that had been associated with the stronger saline. This effect was substantial, however, only in those rats that had experienced the concurrent exposure schedule. This effect cannot be attributed to a difference in the strength of within-compound associations produced by the 2 preexposure schedules (Exp 4). It is suggested that concurrent preexposure can engage a learning process that enhances the discriminability of the preexposed stimuli. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Robinson Jasper; Whitt Emma J.; Horsley Rachel R.; Jones Peter M. 《Canadian Metallurgical Quarterly》2010,124(5):587
We report that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization. After surgery, rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B). Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B. Sham rats' generalization was greater when preexposure was to both A and B than when preexposure was to B only. That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing. Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
24 Long-Evans hooded rats lacking gustatory neocortex and 24 normal rats were familiarized to either hydrochloric acid or quinine hydrochloride solutions during free-drinking trials. Ss were subsequently trained to avoid either the familiar or the novel taste stimulus, using a balanced design, by pairing the to-be-associated taste with ip injections of apomorphine hydrochloride. Balanced, nonpaired presentations of the other taste solution and water were also presented. Normal Ss learned to avoid the novel taste more efficiently than the familiar taste. Ss with gustatory neocortex lesions did not differentiate novel from familiar tastes. They learned aversions to both in a manner highly similar to the aversion learning of familiar tastes by the normal group. Therefore, results demonstrate that Ss lacking gustatory neocortex displayed an associative deficiency only when they were trained on novel stimuli. This suggests that gustatory neocortex lesions disrupt the conditionability of taste stimuli by reducing or eliminating responses to taste novelty. This interpretation is supported by the absence of a "neophobic" response in the lesioned rats to the first presentation of a taste stimulus. (26 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
Rats were given exposure either to an odor (almond) or a compound of odor plus taste (almond plus saline), prior to training in which the odor served as the conditioned stimulus. It was found, for both appetitive and aversive procedures, that conditioning was retarded by preexposure (a latent inhibition effect), and the extent of the retardation was greater in rats preexposed to the compound (i.e., latent inhibition to the odor was potentiated by the presence of the taste). In contrast, the presence of the taste during conditioning itself overshadowed learning about the odor. We argue that the presence of the salient taste in compound with the odor enhances the rate of associative learning, producing a rapid loss in the associability of the odor. This loss of associability will generate both overshadowing and the potentiation of latent inhibition that is observed after preexposure to the compound. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
11.
Novel tastes are more effective than familiar tastes as conditioned stimuli (CSs) in taste aversion learning. Parallel to this, a novel CS-unconditioned stimulus (US) pairing induced stronger Fos-like immunoreactivity (FLI) in insular cortex (IC), amygdala, and brainstem than familiar CS-US pairing, suggesting a large circuit is recruited for acquisition. To better define the role of IC, the authors combined immunostaining with lesion or reversible inactivation of IC. Lesions abolished FLI increases to novel taste pairing in amygdala, suggesting a role in novelty detection. Reversible inactivation during taste preexposure increased FLI to familiar taste pairing in amygdala and brainstem. The difference between temporary inactivation, which blocked establishment of "safe" taste memory, and lesions points to a dual role for IC in taste learning. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
12.
Neuronal activity of the auditory thalamus, amygdala, cingulate cortex, and substantia nigra was recorded during the administration of a behavioral test for latent inhibition (LI) or the retardation of behavioral conditioning because of preexposure of the conditional stimulus (CS). Following CS preexposure, both the preexposed CS and a control CS predicted avoidable footshock. LI occurred as significantly fewer avoidance conditioned avoidance responses after the preexposed CS than after the control CS. Attenuation of neuronal responses to the preexposed CS, or neural LI, occurred in all monitored areas. One group of subjects (Oryctolagus cuniculus) then received context extinction, and additional groups experienced novel context exposure or handling. Context extinction enhanced behavioral responding to the preexposed CS, eliminating LI. Context extinction also eliminated cingulate cortical neural LI by enhancing posterior cingulate cortical responses to the preexposed CS and attenuating anterior cingulate cortical responses to the control CS. Present and past results are interpreted to indicate that LI is (a) a failure of response retrieval and/or expression mediated by interfering CS-context associations and (b) a product of interactions of the posterior cingulate cortex and the hippocampus. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
13.
Dwyer Dominic M.; Boakes Robert A.; Hayward Andrew J. 《Canadian Metallurgical Quarterly》2008,122(5):1051
Conditioned taste aversions (CTA) based on lithium chloride (Experiment 1), amphetamine (Experiment 2), and wheel running (Experiment 3) were examined using the analysis of the microstructure of licking to measure the palatability of the taste serving as the conditioned stimulus (CS). Pairing saccharin with amphetamine reduced saccharin intake without reducing the size of licking clusters, initial lick rate, or the distribution of inter-lick intervals (ILIs) within a cluster. By contrast, pairing saccharin with lithium or wheel-running reduced saccharin intake as well as lick cluster size, initial lick rate, and the distribution of ILIs within a cluster. As lick cluster size, initial lick rate, and ILI distribution can be used as indices of stimulus palatability, the current results indicate that taste aversions based on either lithium or activity reduced the palatability of the CS. This suggests that aversions based on both lithium and wheel running involve conditioned nausea to the CS taste. The absence of similar changes in licking microstructure with amphetamine-based CTA is consistent with other evidence indicating this does not involve nausea. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
14.
Stevenson Richard J.; Miller Laurie A.; Thayer Zoe C. 《Canadian Metallurgical Quarterly》2008,34(5):1183
Certain odors have tastelike qualities when sniffed. To the extent that these qualities are akin to real taste experiences, impairment in perception of odor-induced tastes should be accompanied by taste impairment, and vice versa. Twelve patients were selected with possible odor-induced taste impairments or general taste impairments via a screening test, along with a further 6 patients with a probable taste impairment (insular lesion). These 18 patients, along with 19 normal controls, completed a battery of odor, taste, visual control, and neuropsychological tests to assess impairments in odor-induced taste perception and general taste perception. Four patients had an odor-induced taste impairment and were also impaired on taste perception. A further analysis, using regression on the whole sample, indicated that taste impairments were associated with odor-induced taste abnormalities independent of other predictors. This pattern also held for the patient group alone. The insular patients also exhibited both taste and odor-induced taste impairments. This study is the first to demonstrate a relationship between impaired taste perception and the perception of odor-induced tastes and suggests that both may rely on certain common neural substrates. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
15.
Mitchell Chris; Kadib Raja; Nash Scott; Lavis Yvonna; Hall Geoffrey 《Canadian Metallurgical Quarterly》2008,34(4):475
In Experiment 1a, participants were exposed, over a series of trials, to separate presentations of 2 similar checkerboard stimuli, AX and BX (where X represents a common background). In one group, AX and BX were presented on alternating trials (intermixed), in another, they were presented in separate blocks of trials (blocked). The intermixed group performed to a higher standard than the blocked group on a same-different test. A superiority of intermixed over blocked exposure was also evident in a within-subject design (Experiment 1b) and when the test required discrimination between a preexposed stimulus and the background (e.g., AX vs. X), even if the background changed between preexposure and test (AY vs. Y) (Experiment 2). In Experiment 3, the intermixed/blocked effect was observed when, in preexposure, stimulus presentations were alternated with the background alone (e.g., AX/X). This suggests that the perceptual learning effect is not the consequence of inhibitory associations between unique features but to increased salience of those features. Experiment 4 confirmed this finding and also ruled out an account of the effect in terms of trial spacing. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
16.
Rats exposed to a footshock show conditional fear when reexposed to the shock context. Immediate presentation of shock after placement in the context significantly reduces this fear. Preexposure to the context in the absence of shock, coupled with a minimum preshock interval during training, overcomes this immediate shock deficit. Because rats learn about the context during preexposure and express that learning after being reinforced, the context preexposure effect is an aversive analogue of latent learning. The authors examined the effect of the N-methyl-D-aspartate (NMDA) receptor antagonist D,L-2-amino-5-phosphovalerate (APV) on the facilitatory effect of context preexposure. Rats were preexposed to a chamber after APV administration. The next day they were placed in the same chamber without drug and received shock 35 s later. APV blocked the facilitatory effect of preexposure. Therefore NMDA receptors are important for contextual latent learning. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
17.
Kiefer Stephen W.; Morrow Nancy S.; Metzler Christine W. 《Canadian Metallurgical Quarterly》1988,102(5):733
Rats with ablations of the gustatory neocortex (Experiment 1) and rats with olfactory bulb ablations (Experiment 2) were compared with normal rats for aversion generalization to both single taste solutions (sucrose, sodium chloride, quinine hydrochloride, hydrochloric acid) and compound taste solutions (pairs of the four single tastants) following alcohol aversion training. All rats acquired equal and strong alcohol aversions. Control rats showed consistent aversion generalization to both the sucrose plus quinine and the sucrose plus hydrochloric acid solutions; no significant generalization occurred to the single tastants except a weak generalization to sucrose in Experiment 2. Rats with gustatory neocortical ablations failed to show aversion generalization to any of the taste solutions. Rats with olfactory bulbectomies displayed the same aversion generalization functions as control rats but exhibited significantly faster extinction of the alcohol aversion than did the trained control rats. Results from the present experiments suggest that during alcohol aversion learning, rats lacking gustatory neocortex use odor cues (no taste generalization), whereas rats lacking olfactory bulbs utilize taste cues (normal taste generalization). (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
18.
Four experiments employed a taste aversion conditioning procedure appropriate for both neonatal and adult rats to investigate the ontogeny of extended retention. In Exp I, 200 outbred albino rats trained at 1, 10, 20, or 60 days of age were tested for retention of the taste aversion 25 days later. At testing, only those Ss conditioned when 20 or 60 days old demonstrated significant taste aversions. Exps II and III, with 190 Ss, established that Ss 14–25 days old and older were able to retain significant taste aversions following a 25-day retention interval. 80 younger Ss did, however, acquire and retain the aversion for several days and showed a gradual retention loss over progressively longer retention intervals (Exp IV). Findings suggest that preweanling rats demonstrate initial consolidation, storage, and retrieval of conditioned taste aversions. It is only after this initial period that retention deficits become evident. (29 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
19.
S Idell U Pendurthi S Pueblitz K Koenig T Williams LV Rao 《Canadian Metallurgical Quarterly》1998,79(3):649-655
Female Long-Evans rats were given 20-min access to saccharin followed by injections of alcohol and cocaine, alone and in combination. Although there was no significant interaction between alcohol and cocaine when cocaine was given intraperitoneally (IP), aversions induced by the drug combination when cocaine was administered subcutaneously (SC) were significantly greater than those induced by either drug alone. Further, the aversions induced by the combination were significantly greater than the summed effects of the individual drugs administered alone, indicating a synergistic interaction between cocaine and alcohol. It was suggested that this synergism might result from a summation of the effects of alcohol, cocaine, and cocaethylene, a unique and toxic metabolite of cocaine produced when alcohol is coadministered. To assess the role of cocaethylene in the present design, additional taste aversion assessments were performed in which saccharin was paired with either IP or SC injections of cocaethylene. Although cocaethylene was found to induce aversions, the summed changes in consumption from baseline produced by cocaine, alcohol, and cocaethylene were significantly less than the changes produced by cocaine and alcohol in combination. These results indicate that the synergistic interaction between cocaine and alcohol in the present design cannot be attributed solely to summation of the effects of the individual drugs and the metabolite cocaethylene. Additional mechanisms by which cocaethylene might contribute to the synergistic interaction between cocaine and alcohol, as well as the role pharmacokinetic interactions between cocaine and alcohol might have in the interaction, were discussed. 相似文献
20.
Rats failed to acquire aversions to odor stimulus, which was followed 30 min later by an unconditioned stimulus (US). However, when the odor stimulus was accompanied by a taste stimulus, they acquired odor aversions as well as taste aversions. In this phenomenon, referred to as a taste-potentiated odor aversion, lesions of the amygdala disrupted both taste and odor aversions, whereas lesions of the parvicellular part of ventroposteromedial thalamic nucleus (VPMpc) or insular cortex (IC) disrupted taste aversion but attenuated only odor aversion. These results suggest that both taste and odor stimuli are associated with US in the amygdala and that taste inputs delivered to the amygdala through the IC and/or VPMpc play an important role in potentiation of odor aversion. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献