Quantitative trait loci that modify the severity of spotting in piebald mice

OBJECTIVE: to evaluate the diagnostic and therapeutic role of emergency hemodynamic studies, in the coronary intensive care (UCI). STUDY DESIGN: Retrospective study of--patients (P) submitted to emergency catheterization. PATIENTS: 183 P (152 M and 31 F), mean age 56 +/- 11.5 years, admitted to UCI of Hospital Santa Marta and who had cardiac catheterization performed, between October 88 and November 92. METHODS: Patient clinical files were reviewed. We considered the reasons for emergency cardiac catheterization; final diagnosis; complications in the first 24 hours; catheterization role in the therapeutic orientation. RESULTS: Reasons for hemodynamic study were: coronary artery disease (CAD) in 127 P (69%); aortic dissection in 33 P (18%); valvular disease in 19 P (10%) and other in 4 P (3%). Clinical diagnosis was confirmed in 92% and changed in 8% by hemodynamic study results. Left main coronary artery disease was diagnosed in 6.5% of CAD patients. Coronary artery disease was excluded in 5 P with previous CAD diagnosis, in 19 P with aortic dissection and in 11 valvular patients. 32% of P were sent to emergent surgery: 93% ascending aortic dissection and 20% of CAD, 76% of valvular disease. The hemodynamic study was decisive in the therapeutic option of myocardial revascularization in 77% of P with CAD: 39 emergent PTCA (31%), 13 primary (33%) and 14 P oriented to elective PTCA (11%); 26 emergent surgery and 19 P oriented to elective surgery (15%). The emergency cardiac catheterization mortality rate was 0.5%, and the morbidity 2.7%. CONCLUSIONS: The contribution of Hemodynamic Department to UCI was decisive in the diagnostic and therapeutic orientation of critical patients.     

Influence of background similarity and trait structuring on the perception of a taped therapist.

Examined the effects of the following factors on attraction to a taped therapist: (a) type of s (48 normal 10th-12th graders vs. 32 disturbed adolescents in a residential treatment center), (b) trait structuring (warm vs. Cold), and (c) structured background similarity (therapist had or had not had treatment as an adolescent). Measures obtained following the playing of the taped therapy session reveal that, as with previous samples, normal and disturbed ss were more attracted to a therapist previously described as warm rather than cold. In addition, ss were more attracted to a therapist described as being similar to themselves in treatment background. (23 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reproductive profile of mothers in relation to hemoglobin E genotypes

The reproductive profile of 190 Ahom-Kachari mothers belonging to Mongoloid ethnic stock of Assam has been studied in relation to hemoglobin (Hb) E genotypes. No significant variations have been observed in the reproductive performance between the normal population and abnormal hemoglobin homozygote (HbEE) and heterozygote (HbAE) mothers. However, the reproductive wastage among the hemoglobin homozygote (HbEE) mothers has been observed to be double than the normal hemoglobin (HbAA) and abnormal hemoglobin heterozygote (HbAE) mothers. The reproductive performance parameters have also been compared with the other available studies.     

Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease

A spectrum of disease severity has been observed in patients with Lyme disease, with approximately 60% of untreated individuals developing arthritis. The murine model of Lyme disease has provided strong evidence that the genetic composition of the host influences the severity of arthritis following infection with Borrelia burgdorferi: infected C3H mice develop severe arthritis while infected C57BL/6N mice develop mild arthritis. Regions of the mouse genome controlling arthritis severity and humoral responses during B. burgdorferi infection were identified in the F2 intercross generation of C3H/HeNCr and C57BL/6NCr mice. Rear ankle swelling measurements identified quantitative trait loci (QTL) on chromosomes 4 and 5, while histopathological scoring identified QTL on a unique region of chromosome 5 and on chromosome 11. The identification of QTL unique for ankle swelling or histopathological severity suggests that processes under distinct genetic control are responsible for these two manifestations of Lyme arthritis. Additional QTL that control the levels of circulating Igs induced by B. burgdorferi infection were identified on chromosomes 6, 9, 11, 12, and 17. Interestingly, the magnitude of the humoral response was not correlated with the severity of arthritis in infected F2 mice. This work defines several genetic loci that regulate either the severity of arthritis or the magnitude of humoral responses to B. burgdorferi infection in mice, with implications toward understanding the host-pathogen interactions involved in disease development.     

重金属对大肠杆菌生长繁殖的影响研究

汞、镉、铅、砷、铬等是工业废物中常见的重金属。本论文采用琼脂扩散法,寻求对大肠杆生长繁殖无影响的重金属界点浓度,以此为大肠杆菌的重金属的抗性、浓缩研究及大肠杆菌的驯化及其生物治理应用等方面的深入探讨提供实验依据。     

Mapping a quantitative trait locus involved in melanotic encapsulation of foreign bodies in the malaria vector, Anopheles gambiae

A Plasmodium-refractory strain of Anopheles gambiae melanotically encapsulates many species of Plasmodium, whereas wild-type mosquitoes are usually susceptible. This encapsulation trait can also be observed by studying the response of refractory and susceptible strains to intrathoracically injected CM-Sephadex beads. We report the results of broad-scale quantitative trait locus (QTL) mapping of the encapsulation trait using the bead model system. Interval mapping using the method of maximum likelihood identified one major QTL, Pen1. The 13.7-cM interval containing Pen1 was defined by marker AGH157 at 8E and AGH46 at 7A on 2R. Pen1 was associated with a maximum LOD score of 9.0 and accounted for 44% of the phenotypic variance in the distribution of phenotypes in the backcross. To test if this QTL is important for encapsulation of Plasmodium berghei, F2 progeny were infected with P. berghei and evaluated for degree of parasite encapsulation. For each of the two markers that define the interval containing Pen1, a significant difference of encapsulation was seen in progeny with at least one refractory allele in contrast with homozygous susceptible progeny. These results suggest that Pen1 is important for melanotic encapsulation of Plasmodium as well as beads.     

Influence of vitamin E acetate on stratum corneum hydration

The influence of vitamin E (tocopherol, CAS 10191-41-0) on stratum corneum hydration was tested in O/W and W/O emulsions. Additionally, the O/W emulsion was used in an in vivo/in vitro method to gravimetrically obtain evidence concerning the water-binding capacity of the stratum corneum. In the W/O emulsion, 2.5%, 5%, and 7.5% vitamin E were compared. With both types of emulsions, vitamin E increased the stratum corneum hydration statistically significantly (p = 0.0002). In addition, we could provide evidence of an enhanced water-binding capacity after treatment with vitamin E (p = 0.05). For the hydrating effect of vitamin E. its concentration is of importance. The optimum concentration turned out to be 5%.     

Conceptual note on state, trait, and the state–trait distinction.

Discusses the conceptual bases of the state–trait distinction and suggests that the distinction, though more complex than previously appreciated, is conceptually viable. B. P. Allen and C. R. Potkay's (see record 1982-09834-001) contention that the state–trait distinction is arbitrary is rejected. Rather than attempting to reduce the state–trait distinction to a single dimension, the author proposes 4 overlapping but distinct dimensions as underlying current professional uses of the distinction: duration, continuous vs reactive manifestation, concreteness vs abstractness, and situational causality vs personal causality. Parallels are drawn between these dimensions and aspects of the broader concepts of occurrence and disposition, and the concepts of state and trait are described as applications in psychology of these broader concepts. It is argued that a clearer understanding of the concepts of state and trait will facilitate theory and research. (42 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influence of age on the vitamin E requirement for resolution of necrotizing myopathy

Weanling rats were fed either a vitamin E-deficient diet or the deficient diet supplemented with vitamin E or the antioxidant ethoxyquin. Ethoxyquin was not effective in preventing the elevation in platelet number or percent aggregation. However, ethoxyquin was as effective as vitamin E in maintaining body weight, testes weight, pigmentation of the incisors and in preventing myopathy, observed either histologically or by an elevation in plasma glutamic oxalacetic transaminase (GOT) activity. Removal of ethoxyquin from the diet after 19 weeks of feeding resulted in a rapid onset of myopathy. These observations permitted us to study the requirement for vitamin E at various ages without the complication of any cumulative pathological effects of vitamin E deficiency. Ethoxyquin was deleted from the diet at 8, 20, 44 and 64 weeks of age. The requirement for vitamin E to reduce plasma GOT and pyruvate kinase (PK) activity was measured at 12, 24, 48 and 68 weeks of age. The requirement for vitamin E did not change significantly during this time period.     

The referents of trait inferences: The impact of trait concepts versus actor–trait links on subsequent judgments.

The authors investigated the hypothesis that when trait inferences refer to abstract behavior labels they act as a general interpretation frame and lead to assimilation in subsequent judgments of an ambiguous target, whereas when they refer to a specific actor–trait link they will be used as a scale anchor and lead to contrast. Similar to G. B. Moskowitz and R. J. Roman's (see record 1992-31124-001) study, participants who were instructed to memorize trait-implying sentences showed assimilation, and participants who were instructed to form an impression of the actors in these sentences showed contrast. However, exposure to trait-implying sentences that described actors with real names and were accompanied with photos of the actors resulted in contrast under both memorization and impression instructions (Experiment 1). Furthermore, contrast ensued when trait-implying sentences were accompanied with information that suggested a person attribution, whereas assimilation ensued when that information suggested a situation attribution, independent of processing goals (Experiment 2). These findings are interpreted as support for referent-based explanations of the consequences of trait inferences. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

分段冷却对HRB400E相变过程及微观组织的影响

 HRB400E吐丝后的冷却过程决定了其微观组织组成。通过Gleeble-3500热模拟试验机模拟了HRB400E不同的冷却工艺,分析了不同冷却工艺条件下的膨胀量曲线和微观组织。试验结果表明：冷却速率和冷却速率突变温度对试验钢的最终组织组成有非常大的影响,2个参数的合理搭配,可以控制得到一定数量的贝氏体;贝氏体体积分数随突变温度的降低和冷却速率的提高呈现上升的趋势。     

Influence of purified apoprotein E on platelet activation induced by serotonin

In what ways can a premenopausal woman be pregnant after a breast carcinoma's treatment? A survey organized in 1985 by the French Gynecologic Association gave us the opinion of 316 gynecologists: 50% of them disagreed with this pregnancy because of an accrued risk of relapse. 68 observations were collected including 41 of full term pregnancies; the survival curves were, in each group, similar to those of the controls at the same stage. The interruption doesn't improve the prognosis. This confirms the whole of the published series: a subsequent pregnancy doesn't seem to affect the prognosis of a breast carcinoma; it is important to take the contraception into account so that this pregnancy shall be really desired.     

Influence of client preparation and problem severity on attitudes and expectations in child psychotherapy.

Assessed the effects of client preparation and problem severity on children's and parents' understanding, attitudes, and expectations of child psychotherapy. 38 children (aged 6–12 yrs) with 1 of their parents served as Ss. Half of the children and parents received preparation information, and the other half were not prepared. Following preparation vs no-preparation procedures, children and parents completed questionnaires assessing problem severity, knowledge of and attraction to therapy, and prognostic expectations. Parents completed the Child Behavior Checklist, and therapists rated problem severity and expectations for treatment outcome. Results indicate that preparation increased children's and parents' knowledge of therapy, attraction–receptivity to therapists and treatment, and expectations for therapy outcome. Children and parents were found to be quite attracted and receptive to psychotherapy and to have very positive expectations for treatment outcome. Findings indicate that therapists saw the children's problems as more severe and had lower prognostic expectations than did children and parents. No relation was found between problem severity and attraction–receptivity to treatment or expectations for treatment outcome. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On the evaluative factor in the trait scales of Peabody's study of trait inferences.

In 2 factor analyses of trait inferences, an analysis of antecedent terms and an analysis of trait scales, D. Peabody (see record 1968-03876-001) did not find an evaluative factor. S. Rosenberg and K. Olshan (see record 1971-04168-001) criticized Peabody's analysis of antecedent terms, having found an evaluative dimension by the use of distance measures. The present reanalysis of Peabody's data also yielded a clearly evaluative dimension in the trait scales. The resulting factors, except the evaluative one, were identical to Peabody's antecedent term factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influence of heat treatment on the mechanical properties of an Fe E 460 TMCP steel

Welding is always accompanied by a heat treatment of the base metal. The heat affected zone (HAZ) of multilayer welded joints often shows different microstructures along the fusion line due to varying heat treatments. In order to investigate the mechanical properties of single microstructures weld simulation treatment was applied. The influence of weld simulation parameters such as heating rate and peak temperature was checked in a preliminary step. Several weld simulation treatments finally were used to explain the behaviour of real welded joints. A comparison of fracture mechanics test results from weld simulated microstructures and from real HAZ's shows good agreement for equal heat treatment conditions.     

Influence of prostaglandin E1 on cerebral mechanisms involved in the control of fluid balance

Br- has been used as a nuclear magnetic resonance (NMR) probe to study the reversible association of alpha-chymotrypsin and an Hg-labelled substrate (4-bromomercuriocinnamic acid, BrHgCin) which rapidly exchanges Br-. T1 was measured for 79Br and 81Br, using a pulse spectrometer. Values of the parameters that determine T1, Obs in aqueous solutions of KBr (pH=5.5) containing alpha-chymotrypsin and BrHgCin are reported. It is found that the rate of Br exchange is diffusion-limited and faster than the rate of reorientation of the BrHgCin-alpha-chymotrypsin complex. The rate constant for the formation of the covalent BrHgCin-alpha-chymotrypsin complex determined by this technique agrees well with previously published data. The rapid rate of Br exchange with the complex, however, is incompatible with the side chain of BrHgCin being entirely buried in a nonpolar pocket on the enzyme but compatible with the side chain being exposed to the solution. The contribution to the NMR signal from the non-covalent complex is negligible.     

Influence of apolipoprotein E polymorphism in alcoholic cirrhosis

OBJECTIVE: To assess whether the polymorphism of apolipo-protein E was associated with the development of alcoholic cirrhosis and could influence the severity of liver injury evaluated by the Child-Pugh score. METHOD: We investigated 75 alcoholic patients with a histological diagnosis of cirrhosis, with negative HBV, HCV serology and a control group of 54 subjects. Polymorphism of apolipoprotein E was performed using PCR. RESULTS: There was no difference for the allele frequency and the genotype in the cirrhotic group and the control group. Cirrhotic patients with allele epsilon 2 had higher concentration of albumin (P = 0.01) and a higher level of apolipoprotein AII (P < 0.05) than those with allele epsilon 3. They also had a higher concentration of apolipoprotein AI than cirrhotic patients with allele epsilon 3 and epsilon 4 (P = 0.01). There was a statistical difference between the three genotype groups for prothrombin time (P = 0.01). There was no statistical difference between the three genotype groups for Child-Pugh score. CONCLUSIONS: Polymorphism of apolipoprotein E was not associated with the development of alcoholic cirrhosis. However patients with allele epsilon 2 had better hepatocellular function.