Programming saccadic eye movements.

This article addresses questions about the preparatory processes that immediately precede saccadic eye movements. Saccade latencies were measured in a task in which subjects were provided partial advance information about the spatial location of a target fixation. In one experiment, subjects were faster in initiating saccades when they knew either the direction or amplitude of the required movement in advance compared to a condition with equal uncertainty about the number of potential saccade targets but without knowledge of the parameters required to execute the movement. These results suggest that the direction and amplitude for an upcoming saccade were calculated separately, and not in a fixed serial order. In another experiment, subjects appear to have programmed the saccades more holistically—with computations of direction and amplitude parameters occurring simultaneously. The implications of these results for models of eye movement preparation are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adaptive modification of saccadic eye movements.

Experiments are reported in which the target for a saccadic eye movement was displaced during the saccade. Ss adapted to the displacement by altering the amplitudes of subsequent saccades to compensate for it. Analysis of kinematic details of the saccade trajectories revealed that the adaptation did not arise from a simple remapping of perceived target locations. Instead, the adaptation appeared to be accomplished by a change in the gain of the saccadic system. The gain change arose primarily from a change in the magnitude of the force pulse for the saccade, not a change in the duration of the pulse. These results have implications for the mechanisms that underlie saccades in normal situations. In particular, people can separately adjust the magnitudes and durations of the force pulses used to produce saccades. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perception of everyday visual environments during saccadic eye movements

Subjects were required to execute saccadic eye movements in the horizontal plane which passed through primary gaze. During the saccades, visual images were projected onto a screen which subtended 40 degrees horizontaloy and 26 degrees vertically and was centered on primary gaze. Content, contrast, and intensity of the stimulus patterns and level of illumination of the laboratory background were manipulated to maximise pattern recognition. Little or no detail of the projected images could be discerned under any conditions. Only horizontal laminations were perceived as blurs of appropriate colour. It is concluded that there is no useful perception of the everyday environment during saccades.     

Decrease in saccadic performance after many visually guided saccadic eye movements in monkeys

PURPOSE: To investigate the influence of repeated saccades and of background illumination on the metrics and dynamics of visually guided targeting saccades. METHODS: Eye movements were measured by magnetic search coil technique in seven trained monkeys (Macaca mulatta) while they performed many visually guided saccades in the dark or in dim background light. RESULTS: After 2000 to 7000 saccades in the dark, peak eye velocity on the average decreased by 20%, saccadic gain decreased slightly by 4.5%, and saccadic latency increased by 15%. All parameters also showed increased variability. In contrast, when testing was done in dim light, there was little to no change in average saccadic metrics and latency. CONCLUSIONS: The changes in saccadic metrics and dynamics in the dark do not reflect a change of the ocular plant but may reflect a change in the cortical or cerebellar influences on the brain stem burst generator linked to the monkeys attentional state. Background light mostly prevents this change.     

Influences of chorion type on saccadic eye movements in twins

PURPOSE: The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS: Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of amplitude-peak velocity exponential equation (main sequence) were quantified. RESULTS: Intraclass correlations of saccadic parameters differed significantly from zero for monochorionic and dichorionic MZ twins. The within-pair mean squares were significantly less, and intraclass correlations were significantly higher in monochorionic than in dichorionic twins for latency and were similar for other saccadic parameters (accuracy, slope of main sequence, and peak velocity for 15 degrees saccades). CONCLUSIONS: These findings confirmed previous reports that saccadic parameters of MZ twins are significantly correlated and indicated that similarity of these parameters seen in MZ twins may be driven both by genetic and by prenatal environmental factors.     

Visual masking and visual integration across saccadic eye movements.

Studied visual masking and visual integration across saccadic eye movements in 4 experiments. In a 5th experiment, 4 randomly chosen dots from a 3?×?5 dot matrix were presented in 1 fixation, and 4 different dots from the matrix were presented in a 2nd fixation. Ss reported the location of the missing dot. When the 1st display was presented just before the saccade (as in Exps I–III), Ss accurately specified the missing dot location when the dots were presented to the same region of the retina but not when they were presented in the same place in space. When the 1st display was presented well before the saccade (as in Exp IV), Ss performed poorly regardless of retinal or spatial overlap. Results indicate the existence of a short-lived retinotopic visual persistence but provide no support for a spatiotopic visual persistence capable of fusing the contents of successive fixations. It is concluded that transsaccadic integration depends instead on an abstract memory that accumulates position and identity information about the contents of successive fixations. Results are discussed in relation to the work by M. L. Davidson et al (see record 1974-10245-001). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Auditory stimulus detection is not suppressed during saccadic eye movements

Auditory detection and pitch discrimination thresholds were measured during saccades and during periods of fixation. The accuracy of auditory localisation under these two conditions was also measured. These thresholds were unaffected by whether the sound was presented during a saccade or during periods of steady fixation: there is no evidence for saccadic suppression of auditory processing.     

Aging and movement: Variability of force pulses for saccadic eye movements.

Age-related differences in the trajectories of saccadic eye movements were examined. Younger and older adult subjects produced saccades to predictable target locations. Detailed features of the movements were examined such as the time of peak acceleration and the variability in the magnitude of the peak velocity. These and other measures reveal important details of the force pulses underlying the eye movements and the mental mechanisms that control them. Although minor differences were apparent between the eye movements of younger and older adults, the general patterns were the same across age groups. These results suggest that fundamental details of the brain mechanisms involved in the control of movement are the same for younger and older adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Manual asymmetries and saccadic eye movements in right-handers during single and reciprocal aiming movements

The aim of the present study was to establish whether gracile afferents to the inferior olive are topographically organized and whether such inputs coincide with the location of cells that output to the hindlimb C1 zone in the cerebellar posterior lobe. Small injections (n=15) of the anterograde tracers Fluoro-Ruby or biotinylated dextran amine were made into gracile, resulting in anterograde labelling often distributed in partially separate, rostrocaudally directed columns within the lateral half of the contralateral rostral dorsal accessory olive (rDAO). In 12 cases, anterograde labelling was also located within the caudolateral medial accessory olive. Evidence for a topographical organization was obtained, suggesting that medial gracile targets only the most lateral part of rDAO, whereas lateral gracile also targets more medial parts. Gracile injections centred dorsally also resulted in more extensive terminal fields in rDAO than similar sized injections centred ventrally which may relate to the representation of the distal hindlimb in dorsal gracile (e.g., Millar and Basbaum, 1975). Injections of retrograde tracer (green beads) into the C1 zone in the ipsilateral caudal paramedian lobule (7 cases), resulted in retrograde cell labelling in the middle one-third of contralateral DAO in two columns that fused caudally. The proportion of labelled cells that overlapped with anterograde labelled terminals was related to the dorsoventral locus of the gracile injection site: gracile injections centred dorsally produced the largest degree of overlap and therefore, potentially, the greatest functional convergence. In summary, the results suggest that a topographical organization is present within the gracilo-olivo-cerebellar projection which is discussed in relation to the functional organization of the olivocerebellar system.     

Stable individual differences across images in human saccadic eye movements.

Individual differences in eye movements during picture viewing were examined across image format, content, and foveal quality in 3 experiments. Experiment 1 demonstrated that an individual's fixation durations were strongly related across 3 types of scene formats and that saccade amplitudes followed the same pattern. In Experiment 2, a similar relationship was observed for fixation durations across faces and scenes, although the amplitude relationship did not hold as strongly. In Experiment 3, the duration and amplitude relationships were observed when foveal information was degraded and even removed. Eye movement characteristics differ across individuals, but there is a great deal of consistency within individuals when viewing different types of images. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Attentional bias to brief threat-related faces revealed by saccadic eye movements.

According to theories of emotion and attention, we are predisposed to orient rapidly toward threat. However, previous examination of attentional cueing by threat showed no enhanced capture at brief durations, a finding that may be related to the sensitivity of the manual response measure used. Here we investigated the time course of orienting attention toward fearful faces in the exogenous cueing task. Cue duration (20 ms or 100 ms) and response mode (saccadic or manual) were manipulated. In the saccade mode, both enhanced attentional capture and impaired disengagement from fearful faces were evident and limited to 20 ms, suggesting that saccadic cueing effects emerge rapidly and are short lived. In the manual mode, fearful faces impacted only upon the disengagement component of attention at 100 ms, suggesting that manual cueing effects emerge over longer periods of time. Importantly, saccades could reveal threat biases at brief cue durations consistent with current theories of emotion and attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Transformation of sensory signals into commands for saccadic eye movements: a neural network study

This report describes the distribution and localization of thrombomodulin (TM) in the rat eye by light and electron microscopic immunocytochemistry. In addition to the endothelium of the entire vasculature, TM was found on the non-vascular structures lining the cavities of the posterior and anterior chambers and the limbus. TM was localized on the basal, lateral, and apical plasma membranes of the inner and outer ciliary epithelium, and the posterior iris epithelium in which there was no polarized expression of TM. In the anterior chamber, TM was localized on the luminal surface of the corneal endothelium, but was negative on the anterior border layer of the iris, which is composed of a discontinuous layer of fibroblasts and collagen fibers. Thus, TM was present at sites of cell-to-cell contact. TM was also present on the endothelia of the trabecular meshwork and the Schlemm's canal in the limbus. TM was localized not only on the luminal plasma membrane, but also on the cytoplasmic giant vacuoles in the endothelial cells of the Schlemm's canal. These findings extend the importance of anticoagulant mechanisms to the systems of secretion, circulation, and drainage of the aqueous humor.     

Quantitative evaluation of saccadic and smooth pursuit eye movements. Is it reliable?

PURPOSE: The authors evaluated the reliability of the coefficients of the (1) amplitude/duration and (2) amplitude/peak velocity relationships of the mean precision values and the mean latency values (saccadic eye movements) and the coefficients of the target velocity/gain relationship (smooth pursuit eye movements). They computed test-retest maximum variability limits for these parameters. METHODS: After a 1-week interval, saccadic and smooth pursuit eye movements were recorded twice from 20 healthy subjects; 12 of these subjects underwent a third recording session. The estimate of the intraclass coefficient of reliability, R, was adopted to evaluate the reliability of eye movement quantitative analysis. RESULTS: The data demonstrated that the reliability was fairly good for the amplitude/peak velocity relationship, was good for the precision, and was excellent for the amplitude/duration, the target velocity/gain relationships, and the latency. CONCLUSIONS: Quantitative analysis of both saccadic and smooth pursuit eye movements is reliable. One statistic used to estimate reliability, ie, the within-subjects mean square value, also enables the determination of test-retest normal variability values for both the variances and the differences of measurements.     

Saccadic eye movements in Graves' disease

PURPOSE: To describe the saccades made by patients with Graves' disease (GD) and to attempt to distinguish these objectively and quantitatively from the saccades in control subjects. METHODS: In 12 euthyroid patients with GD, the saccades of both eyes were recorded simultaneously with electromagnetic search coils. Subjects were asked to alternate their gazes between two fixed targets that were 10 degrees, 20 degrees, 30 degrees, or 40 degrees apart along each horizontal or vertical meridian. The data from the patients with GD and those from the similarly recorded group of 12 control subjects were examined in two ways. First, the difference in saccadic sizes between the two eyes was assessed. Second, the saccadic dynamics--that is, the maximum velocity and the saturation constant of the main sequence--were determined for each eye. Repeated measurement analysis of variance was used to test observed differences between the two groups. Finally, through exact logistic regression analysis, classification of the saccades as those of a patient with GD or of a control subject was carried out. RESULTS: The saccades of patients with GD were generally less conjugate than those of control subjects (P < 0.05). On average, the maximum main sequence velocities in patients with GD were lower than in control subjects (P < 0.05). The saccades of patients with GD were well differentiated from those of control subjects. CONCLUSIONS: The saccades in GD may differ markedly from normal saccades, and the two can be reliably distinguished.     

Speed and accuracy of saccadic eye movements: Characteristics of impulse variability in the oculomotor system.

Dynamic characteristics observed in the trajectories of saccadic eye movements revealed systematic variability of the force pulses used to move the eyes. This variability causes saccades to exhibit a linear speed–accuracy trade-off: As the average distance and duration of saccades toward specified target points increase, the standard deviations of saccadic-movement endpoints increase linearly with the saccades' average velocity. The linear trade-off, and other observed stochastic properties of saccades, may be attributed to noise in neuromotor processes and may be described in terms of an impulse-variability model originally designed for characterizing limb movements. According to the model, both eye and limb movements are controlled through stochastic force and time parameters that govern movement kinematics. Such an account may promote a unified conceptual framework for understanding a wide range of motor behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)