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1.
以氯化亚铁和氢氧化钠为原料,采用双氧水快速氧化氢氧化亚铁的方式,成功制备了δ-FeOOH纳米材料。首次将其应用于催化臭氧氧化,并探究了催化剂投加量、臭氧浓度、萘普生(NPX)初始浓度对目标污染物降解效果的影响。采用X射线衍射仪(XRD)、透射电子显微镜(TEM)、低温N2吸附脱附等温线对催化剂的晶体结构、形貌等进行表征。结果表明,制备的材料纯度高,是厚度约为4 nm的六角片层结构。该材料的BET比表面积达191.73 m2/g,并具有介孔特征。试验制备的材料显著提升了催化臭氧氧化萘普生的能力,反应15 min后TOC的最高去除率为64.5%,与单独臭氧相比提高了38.4%。同时,通过·OH抑制试验,初步探究了可能的纳米δ-FeOOH催化臭氧氧化机理。 相似文献
2.
In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was extended in the presence of diflunisal. In the presence of indomethacin, the lag time did not change. IC(50) values of monophenolase activity were estimated to be 0.112 mM (diflunisal) and 1.78 mM (indomethacin). Kinetic studies of monophenolase activity revealed that both diflunisal and indomethacin were non-competitive inhibitors. For diphenolase activity, IC(50) values were estimated to be 0.197 mM (diflunisal) and 0.509 mM (indomethacin). Diflunisal and indomethacin were also found to be non-competitive diphenolase inhibitors. 相似文献
3.
二氟尼柳嵌入镁铝水滑石的合成表征与研究 总被引：1，自引：0，他引：1
采用共沉淀法、离子交换法和焙烧复原法三种不同方法将二氟尼柳嵌入Mg-Al水滑石层间,得到一种有机-无机复合层状材料.通过XRD、IR、TG-DTA和元素分析等手段对材料表征,结果表明,共沉淀法和离子交换法成功地将二氟尼柳嵌入水滑石,得到的材料层状结构完整、晶相单一,且层间距扩大为1.81～2.14 nm;IR分析表明二氟尼柳嵌入水滑石后,原二氟尼柳分子中的νC=O振动峰消失,在1567 cm(1和1412 cm(1处出现羧酸盐的-COO(对称与不对称吸收谱带;二氟尼柳嵌入水滑石后其分解温度提高了140～180℃.此外,根据表征结果建立了材料超分子结构模型, 即客体二氟尼柳与水滑石层板之间以静电力和氢键相互作用,以双层交替式倾斜地排列于层板之间. 相似文献
4.
Marek J. Pawlik Barbara Miziak Aleksandra Walczak Agnieszka Konarzewska Magdalena Chro ci&#x;ska-Krawczyk Jan Albrecht Stanis&#x;aw J. Czuczwar 《International journal of molecular sciences》2021,22(18)
The term epileptogenesis defines the usually durable process of converting normal brain into an epileptic one. The resistance of a significant proportion of patients with epilepsy to the available pharmacotherapy prompted the concept of a causative treatment option consisting in stopping or modifying the progress of epileptogenesis. Most antiepileptic drugs possess only a weak or no antiepileptogenic potential at all, but a few of them appear promising in this regard; these include, for example, eslicarbazepine (a sodium and T-type channel blocker), lamotrigine (a sodium channel blocker and glutamate antagonist) or levetiracetam (a ligand of synaptic vehicle protein SV2A). Among the approved non-antiepileptic drugs, antiepileptogenic potential seems to reside in losartan (a blocker of angiotensin II type 1 receptors), biperiden (an antiparkinsonian drug), nonsteroidal anti-inflammatory drugs, antioxidative drugs and minocycline (a second-generation tetracycline with anti-inflammatory and antioxidant properties). Among other possible antiepileptogenic compounds, antisense nucleotides have been considered, among these an antagomir targeting microRNA-134. The drugs and agents mentioned above have been evaluated in post-status epilepticus models of epileptogenesis, so their preventive efficacy must be verified. Limited clinical data indicate that biperiden in patients with brain injuries is well-tolerated and seems to reduce the incidence of post-traumatic epilepsy. Exceptionally, in this regard, our own original data presented here point to c-Fos as an early seizure duration, but not seizure intensity-related, marker of early epileptogenesis. Further research of reliable markers of early epileptogenesis is definitely needed to improve the process of designing adequate antiepileptogenic therapies. 相似文献
5.
Jean Leandro dos Santos Vanessa Moreira Michel Leandro Campos Rafael Consolin Chelucci Karina Pereira Barbieri Pollyana Cristina Maggio de Castro Souto Márcio Hideki Matsubara Catarina Teixeira Priscila Longhin Bosquesi Rosangela Gon?alves Peccinini Chung Man Chin 《International journal of molecular sciences》2012,13(11):15305-15320
Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adverse effects such as gastric ulceration and cardiovascular events. Among the molecular modifications strategies, the prodrug approach is a useful tool to discover new safe NSAIDs. The 1-(2,6-dichlorophenyl)indolin-2-one is a diclofenac prodrug which demonstrated relevant anti-inflammatory properties without gastro ulceration effect. In addition, the prodrug decreases PGE2 levels, COX-2 expression and cellular influx into peritoneal cavity induced by carrageenan treatment. Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac. This prodrug is a new nonulcerogenic NSAID useful to treat inflammatory events by long-term therapy. 相似文献
6.
2-萘甲醚(1)在无水AlCl3催化下与丙酰氯反应得6-甲氧基-2-丙酰萘(2),(2)在原甲酸三乙酯、硫酸下采用聚苯乙烯二醋酸碘苯催化进行1,2-芳基迁移重排得2-(2-(6-甲氧基萘基))丙酸乙酯(3),(3)在氢氧化钠水溶液中水解、酸化得萘普生(4)。总收率约47.4%(以2-萘甲醚计)。试验研究了影响合成2-(2-(6-甲氧基萘基))丙酸乙酯(3)的多种因素,如:硫酸的用量、原甲酸三酯的用量以及聚苯乙烯碘苯的回收利用。 相似文献
7.
Age-related macular degeneration (AMD) is central vision loss with aging, was the fourth main cause of blindness in 2015, and has many risk factors, such as cataract surgery, cigarette smoking, family history, hypertension, obesity, long-term smart device usage, etc. AMD is classified into three categories: normal AMD, early AMD, and late AMD, based on angiogenesis in the retina, and can be determined by bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E)-epoxides from the reaction of A2E and blue light. During the reaction of A2E and blue light, reactive oxygen species (ROS) are synthesized, which gather inflammatory factors, induce carbonyl stress, and finally stimulate the death of retinal pigment epitheliums (RPEs). There are several medications for AMD, such as device-based therapy, anti-inflammatory drugs, anti-VEGFs, and natural products. For device-based therapy, two methods are used: prophylactic laser therapy (photocoagulation laser therapy) and photodynamic therapy. Anti-inflammatory drugs consist of corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs). Anti-VEGFs are classified antibodies for VEGF, aptamer, soluble receptor, VEGF receptor-1 and -2 antibody, and VEGF receptor tyrosine kinase inhibitor. Finally, additional AMD drug candidates are derived from natural products. For each medication, there are several and severe adverse effects, but natural products have a potency as AMD drugs, as they have been used as culinary materials and/or traditional medicines for a long time. Their major application route is oral administration, and they can be combined with device-based therapy, anti-inflammatory drugs, and anti-VEGFs. In general, AMD drug candidates from natural products are more effective at treating early and intermediate AMD. However, further study is needed to evaluate their efficacy and to investigate their therapeutic mechanisms. 相似文献
8.
Abdollah Karami Reem Shomal Rana Sabouni Sana Z. M. Murtaza Mehdi Ghommem 《加拿大化工杂志》2023,101(5):2660-2676
In this work, TiO2 and ZnO were incorporated successfully into a MIL-53(Al) metal–organic framework (MOF) to form nanocomposites via a facile post-modification technique. The hybrid MIL-53(Al)@TiO2 and MIL-53(Al)@ZnO were characterized by several characterization tests. The X-ray diffraction (XRD), Fourier-transform infrared (FTIR), and field-emission scanning electron microscopy (FE-SEM) analyses showed evidence of the successful incorporation of TiO2 and ZnO within the MIL-53(Al) framework. The thermal gravimetric analysis (TGA) analysis demonstrated the excellent thermal stability of MIL-53(Al)@TiO2 and MIL-53(Al)@ZnO, while diffuse reflectance spectroscopy (DRS) determined the direct optical band gaps of MIL-53(Al)@ZnO and MIL-53(Al)@TiO2 to be 3.24 and 3.34 eV, respectively. The composites were also tested for the photocatalytic degradation of diclofenac (DCF) as a micropollutant. The DCF degradation efficiency of the photocatalysts was ranked in the following order: MIL-53(Al)@TiO2 > MIL-53(Al) > TiO2 > ZnO > MIL-53(Al)@ZnO. The incorporation of TiO2 enhanced the optical properties of MIL-53 (Al), which was confirmed with the superior photodegradation efficiency of MIL-53(Al)@TiO2 (>85% in 2 h) as compared to the pristine MIL-53(Al) (around 80% in 2 h). The improvement in the photodegradation of the hybrid-MOF is mostly associated with the possible dual function of the adsorption and photodegradation mechanisms. The reusability of MIL-53(Al) and its composites was inspected over 3 cycles of photodegradation experiments with DCF. The photocatalytic activity of MIL-53(Al)@TiO2 remained unchanged (>90%), while for MIL-53(Al) and MIL-53(Al)@ZnO a slight drop was observed over three cyclic degradation experiments. Fluorescence measurements revealed that the hydroxyl radical is an important reactive oxygen species produced by all the photocatalysts that aid in the photodegradation of DCF. Furthermore, the kinetic modelling of the photoreaction identified a second-order kinetics for all catalysts. Experiments with scavengers showed that hydroxyl radicals played a major role in the photocatalytic process, and it was found that only 2 h of treatment was sufficient to obtain a considerable chemical oxygen demand (COD) reduction of 58%. 相似文献
9.
Alberto Galisteo Fatin Jannus Amalia García-García Houssam Aheget Sara Rojas Jos A. Lupiaez Antonio Rodríguez-Diguez Fernando J. Reyes-Zurita Jos F. Quílez del Moral 《International journal of molecular sciences》2021,22(10)
A series of diclofenac N-derivatives (2, 4, 6, 8c, 9c, 10a-c) were synthesized in order to test their anti-cancer and anti-inflammatory effects. The anticarcinogen activity has been assayed against three cancer cell lines: HT29, human colon cancer cells; Hep-G2, human hepatic cells; and B16-F10, murine melanoma cells. First, we determined the cytotoxicity of the different compounds, finding that the most effective compound was compound 8c against all cell lines and both compounds 4 and 6 in human Hep-G2 and HT29 cell lines. Compounds 4 and 8c were selected for the percentage of apoptosis determination, cell cycle distribution, and mitochondrial membrane potential measure because these products presented the lowest IC50 values in two of the three cancer cell lines assayed (B16-F10 and HepG2), and were two of the three products with lowest IC50 in HT29 cell line. Moreover, the percentages of apoptosis induction were determined for compounds 4 and 8c, showing that the highest values were between 30 to 60%. Next, the effects of these two compounds were observed on the cellular cycle, resulting in an increase in the cell population in G2/M cell cycle phase after treatment with product 8c, whereas compound 4 increased the cells in phase G0/G1, by possible differentiation process induction. Finally, to determine the possible apoptosis mechanism triggered by these compounds, mitochondrial potential was evaluated, indicating the possible activation of extrinsic apoptotic mechanism. On the other hand, we studied the anti-inflammatory effects of these diclofenac (DCF) derivatives on lipopolysaccharide (LPS) activated RAW 264.7 macrophages-monocytes murine cells by inhibition of nitric oxide (NO) production. As a first step, we determined the cytotoxicity of the synthesized compounds, as well as DCF, against these cells. Then, sub-cytotoxic concentrations were used to determine NO release at different incubation times. The greatest anti-inflammatory effect was observed for products 2, 4, 8c, 10a, 10b, and 9c at 20 µg·mL−1 concentration after 48 h of treatment, with inhibition of produced NO between 60 to 75%, and a concentration that reduces to the 50% the production of NO (IC50 NO) between 2.5 to 25 times lower than that of DCF. In this work, we synthesized and determined for the first time the anti-cancer and anti-inflammatory potential of eight diclofenac N-derivatives. In agreement with the recent evidences suggesting that inflammation may contribute to all states of tumorigenesis, the development of these new derivatives capable of inducing apoptosis and anti-inflammatory effects at very low concentrations represent new effective therapeutic strategies against these diseases. 相似文献
10.
萘普生是一种广泛应用于人类日常生活中的消炎药,其经人体使用后大量进入水体环境对水体生物产生影响。该文采用由三种不同填料组成的水平流和复合垂直流生物活性滤床类型比较分析对萘普生的不同去除效果。结果表明：在水力负荷为0．1m^3／（m2·d）、进水萘普生浓度为1149．7-1652．9μg（平均浓度为1523．3μg／L）条件下,以汽块砖为填料的水平流生物活性滤床对萘普生的去除效果最佳,去除率达到49．61％。目前,生物活性滤床正逐步成为处理生活污水中萘普生的一种有效方法。 相似文献
11.
The present study describes the synthesis of silica and magnetic nanoparticle-decorated graphene oxide (GO-MNPs-SiO2) and its application as an adsorbent for the removal of naproxen from wastewater. Nanocomposite was characterized utilizing FT-IR spectroscopy, FESEM microscopy, EDX and XPS spectroscopy. Under the optimum conditions, a high adsorption capacity (31 mg g?1) was obtained toward naproxen at pH 5. The adsorption process was evaluated using isotherms; the Freundlich isotherm suggested a multilayer adsorption pattern for naproxen. Free energy confirmed a physisorption mechanism between naproxen and adsorbent. Lastly, the field application was performed in wastewater which obtained high removal efficiency percentages (83–94%). 相似文献
12.
Raquel da Ana Joel Fonseca Jacek Karczewski Amlia M. Silva Aleksandra Zieli&#x;ska Eliana B. Souto 《International journal of molecular sciences》2022,23(20)
The complexity of the eye structure and its physiology turned ocular drug administration into one of the most challenging topics in the pharmaceutical field. Ocular inflammation is one of the most common ophthalmic disorders. Topical administration of anti-inflammatory drugs is also commonly used as a side treatment in tissue repair and regeneration. The difficulty in overcoming the eye barriers, which are both physical and chemical, reduces drug bioavailability, and the frequency of administration must be increased to reach the therapeutic effect. However, this can cause serious side effects. Lipid nanoparticles seem to be a great alternative to ocular drug delivery as they are composed from natural excipients and can encapsulate both hydrophilic and lipophilic drugs of different sources, and their unique properties, as their excellent biocompatibility, safety and adhesion allow to increase the bioavailability, compliance and achieve a sustained drug release. They are also very stable, easy to produce and scale up, and can be lyophilized or sterilized with no significant alterations to the release profile and stability. Because of this, lipid nanoparticles show a great potential to be an essential part of the new therapeutic technologies in ophthalmology to deliver synthetic and natural anti-inflammatory drugs. In fact, there is an increasing interest in natural bioactives with anti-inflammatory activities, and the use of nanoparticles for their site-specific delivery. It is therefore expected that, in the near future, many more studies will promote the development of new nanomedicines resulting in clinical studies of new drugs formulations. 相似文献
13.
Elzner S Schmidt D Schollmeyer D Erkel G Anke T Kleinert H Förstermann U Kunz H 《ChemMedChem》2008,3(6):924-939
(S)-Curvularin and its 13-, 14-, and 16-membered lactone homologues were synthesized through a uniform strategy in which a Kochi oxidative decarboxylation and ring-closing metathesis reactions constitute the key processes. In the evaluation of the anti-inflammatory effects of the synthesized compounds in assays using cells stably transfected with a human iNOS promoter-luciferase reporter gene construct, the 14- and 16-membered homologues showed a slightly higher inhibitory effect towards iNOS promoter activity than curvularin itself. However, the larger ring homologues also exhibited higher cytotoxicity, manifest in downregulated eNOS promoter activity. In contrast, the di-O-acetyl and 4-chloro derivatives of (S)-curvularin showed higher inhibitory efficiency towards induction of the iNOS promoter and less negative effect on eNOS promoter activity than curvularin. 相似文献
14.
Hueng-Chuen Fan Herng-Shen Lee Kai-Ping Chang Yi-Yen Lee Hsin-Chuan Lai Pi-Lien Hung Hsiu-Fen Lee Ching-Shiang Chi 《International journal of molecular sciences》2016,17(8)
Epilepsy is a common neurological disorder worldwide and anti-epileptic drugs (AEDs) are always the first choice for treatment. However, more than 50% of patients with epilepsy who take AEDs have reported bone abnormalities. Cytochrome P450 (CYP450) isoenzymes are induced by AEDs, especially the classical AEDs, such as benzodiazepines (BZDs), carbamazepine (CBZ), phenytoin (PT), phenobarbital (PB), and valproic acid (VPA). The induction of CYP450 isoenzymes may cause vitamin D deficiency, hypocalcemia, increased fracture risks, and altered bone turnover, leading to impaired bone mineral density (BMD). Newer AEDs, such as levetiracetam (LEV), oxcarbazepine (OXC), lamotrigine (LTG), topiramate (TPM), gabapentin (GP), and vigabatrin (VB) have broader spectra, and are safer and better tolerated than the classical AEDs. The effects of AEDs on bone health are controversial. This review focuses on the impact of AEDs on growth and bone metabolism and emphasizes the need for caution and timely withdrawal of these medications to avoid serious disabilities. 相似文献
15.
16.
Paula Ossowicz-Rupniewska Joanna Klebeko Ewelina
wi&#x;tek Karolina Bilska Anna Nowak Wiktoria Duchnik &#x;ukasz Kucharski &#x;ukasz Struk Karolina Wenelska Adam Klimowicz Ewa Janus 《International journal of molecular sciences》2022,23(8)
Modifications of (RS)-2-[4-(2-methylpropyl)phenyl] propanoic acid with amino acid isopropyl esters were synthesised using different methods via a common intermediate. The main reaction was the esterification of the carboxyl group of amino acids with isopropanol and chlorination of the amino group of the amino acid, followed by an exchange or neutralisation reaction and protonation. All of the proposed methods were very efficient, and the compounds obtained have great potential to be more effective drugs with increased skin permeability compared with ibuprofen. In addition, it was shown how the introduction of a modification in the form of an ion pair affects the properties of the obtained compound. 相似文献
17.
LI Maoting WANG Lifei SUN Qiang ZHANG Zhihai LIANG Jiangbin YANG Xiaosheng WEN Haizhao 《化工之友》2008,(30)
目的观察药物或局部封闭治疗枕大神经卡压症的疗效。方法对86例枕大神经卡压症的患者先给予药物治疗,疗效差的病例再给予封闭治疗。结果单纯药物治疗的疗效为40.7%,而局部封闭治疗的疗效为90.2%。结论枕大神经卡压症容易误诊,本组病例的误诊率为53.5%;枕大神经卡压症先给予药物治疗,疗效差者给予局部封闭治疗可以获得满意的疗效。 相似文献
18.
Gabrielle Raiche-Marcoux Alexis Loiseau Clo Maranda Audre Poliquin Elodie Boisselier 《International journal of molecular sciences》2022,23(24)
Eye drops represent 90% of all currently used ophthalmic treatments. Only 0.02% of therapeutic molecules contained in eye drops reach the eye anterior chamber despite their high concentration. The tear film efficiently protects the cornea, reducing access to the target. Thereby, the increase in the drug bioavailability and efficiency must come from the mucoadhesion optimization of the drug delivery system. The gold nanoparticles, used as a drug delivery system in this study, already showcased ultrastable and mucoadhesive properties. The goal was to study the gold nanoparticles’ ability to release two specific ophthalmic drugs, flurbiprofen and ketorolac. The parameters of interest were those involving the loading conditions, the gold nanoparticles properties, and the release experimental conditions. The drug release was measured using an in vitro model based on dialysis bags coupled with UV–visible spectroscopy. Gold nanoparticles showed an ability to release different molecules, whether hydrophobic or hydrophilic, in passive or active drug release environments. Based on these preliminary results, gold nanoparticles could represent a promising drug delivery system for ketorolac and flurbiprofen when topically applied through eye drops. 相似文献
19.
含解磷菌螯合微量元素肥在番茄上的施用效果 总被引：1，自引：0，他引：1
以螯合微量元素肥为对照,研究了含解磷菌螯合微量元素肥在番茄上的施用效果。结果表明,施用含解磷菌螯合微量元素肥的番茄茎粗、叶厚以及叶绿素含量均较对照处理稍高,但差异性未达到显著性水平(P0.05);5次糖度值数据跟踪显示,施用含解磷菌螯合微量元素肥的番茄糖度均高于对照处理,糖度较对照处理提高了3.50%~7.72%;施用含解磷菌螯合微量元素肥的番茄单果质量略高于对照处理,且与对照相比,施用含解磷菌螯合微量元素肥处理的番茄增产率达到22.12%。 相似文献
20.
目前 ,国内外丁苯羟酸的合成工艺存在着不适合大规模工业化生产的缺点 ,因此中昊宣化有限公司技术中心充分利用本企业的原料优势———乙醛酸下游产品对羟基苯乙酸开创了合成丁苯羟酸的新工艺。以对羟基苯乙酸为原料 ,经溴代反应、酯化反应以及置换反应等 3步合成工艺 ,再经甲醇重结晶得到丁苯羟酸精品 ,总收率为 5 6 % (以对羟基苯乙酸计 )。同时 ,还介绍了丁苯羟酸的质量指标、市场需求以及发展前景 相似文献