Classification of Foot Pressure Images Using Machine Learning Algorithm

Arthritis is an acute systemic disease of a joint accompanied by pain. In developed countries, it mainly causes disability among people over 50 years of age. Rheumatoid Arthritis is a type of arthritis that occurs commonly among elders. The incidence of arthritis is higher in females than in males. There is no permanent diagnosis method for arthritis, but if it was identified in the early stages based on the foot pressure, it can be diagnosed before attaining the critical stage of Rheumatoid Arthritis. The analysis and study of arthritis patients were done using design thinking methodology. Design thinking is a problem-solving methodology that is used to find a solution for the identification of the early stage of arthritis. This process consists of five stages follows Empathy, Define, Ideate, Prototype, and Testing. To define the problem statement, the Empathy was done with the arthritis patients to know the difficulties faced by them. This paper proposes a measurement technique of early measurement of arthritis using a non-invasive technique. It helps us to detect arthritis using a foot pressure pad that was designed with piezoresistive material and the feature classification was done using Weka.     

Identification of novel PAD4 inhibitors based on a pharmacophore model derived from transition state coordinates

1.4 Protein arginine deiminases 4 (PAD4) is an attractive target for the development of novel and selective inhibitors of Rheumatoid Arthritis (RA). F-amidine is known as mechanism-based inhibitor targeting PAD4 and used as inactivators by covalently modifying the active site Cys645. To identify novel structural inhibitors of PAD4, we investigated the flexibility of protein on basis of the transition state geometry of PAD4 inhibited by F-amidine from our previous QM/MM calculation. And a pharmacophore model was generated containing four features (ADHH) using five representative structures from molecular dynamic (MD) simulation on basis of the transition state geometry of PAD4 inhibited by F-amidine. We performed virtual screening using the pharmacophore model and molecular docking methods, resulting in the discovery of two molecules with K_D (dissociation equilibrium constant) values of 112 μM and 218 μΜ against PAD4 through Surface Plasmon Resonance (SPR) experiments. These two molecules could potentially serve as PAD4 inhibitors.     

The role of the abdominal musculature in the elevation of the intra-abdominal pressure during specified tasks

A series of standardized tasks, isometric trunk flexion and extension and maximal Valsalva manoeuvres, were used to evaluate the role of the abdominal musculature in developing an increased intra-abdominal pressure (IAP). Seven male subjects were measured for IAP, myoelectric activity of rectus abdominis (RA), obliquus externus and internus (OE and OI respectively), erector spinae (ES) and isometric trunk torque. IAPs in all experimental conditions were markedly greater than those that occurred while relaxed. In isometric trunk flexion, IAPs were increased with accompanying high levels of activity from the abdominal muscles. In contrast, little activity from the abdominal muscles occurred during isometric trunk extension, although levels of IAP were similar to those found in the isometric flexion condition. With maximal voluntary pressurization (Valsalva manoeuvre) slightly higher levels of IAP than those found in torque conditions were recorded, this pressure being produced with abdominal activities (OE and OI) less than one fourth their recorded maximum. When isometric torque tasks were added to the Valsalva manoeuvre, patterns of muscle activity (RA, OE, OI and ES) were significantly altered. For Valsalva with isometric trunk extension, activity from OE and OI was reduced while IAPs remained fairly constant. These findings indicate that in tasks where an IAP extension moment is warranted, abdominal pressure can be increased without the development of a large counter-moment produced by the dual action of the trunk flexors. Activation of other muscles such as the diaphragm and transversus abdominis is suggested as helping provide control over the level of IAP during controlled trunk tasks.     

The role of the abdominal musculature in the elevation of the intra-abdominal pressure during specified tasks

Abstract

A series of standardized tasks, isometric trunk flexion and extension and maximal Valsalva manoeuvres, were used to evaluate the role of the abdominal musculature in developing an increased intra-abdominal pressure (IAP). Seven male subjects were measured for IAP, myoelectric activity of rectus abdominis (RA), obliquus externus and intemus (OE and OI respectively), erector spinae (ES) and isometric trunk torque. IAPs in all experimental conditions were markedly greater than those that occurred while relaxed. In isometric trunk flexion, IAPs were increased with accompanying high levels of activity from the abdominal muscles. In contrast, little activity from the abdominal muscles occurred during isometric trunk extension, although levels of IAP were similar to those found in the isometric flexion condition. With maximal voluntary pressurization (Valsalva manoeuvre) slightly higher levels of IAP than those found in torque conditions were recorded, this pressure being produced with abdominal activities (OE and OI) less than one fourth their recorded maximum. When isometric torque tasks were added to the Valsalva manoeuvre, patterns of muscle activity (RA, OE, OI and ES) were significantly altered. For Valsalva with isometric trunk extension, activity from OE and OI was reduced while IAPs remained fairly constant. These findings indicate that in tasks where an IAP extension moment is warranted, abdominal pressure can be increased without the development of a large counter-moment produced by the dual action of the trunk flexors. Activation of other muscles such as the diaphragm and transversus abdominis is suggested as helping provide control over the level of IAP during controlled trunk tasks.     

Evaluation of methods to assess push/pull forces in a construction task

The objective of the present study was to determine the validity of methods to assess push/pull forces exerted in a construction task. Forces assessed using a hand-held digital force gauge were compared to those obtained using a highly accurate measuring frame. No significant differences were found between the methods, except for peak push forces, for which the forces assessed with the force gauge were significantly lower than those assessed with the measuring frame. When the construction task was reproduced close to the actual workplace by simulation against a fixed object using the force gauge, all exerted forces on the force gauge were significantly lower than those on the measuring frame, except for mean pull forces. When self-reports were compared to the exerted forces on the measuring frame, the construction workers overestimated the exerted push/pull forces by 50%. In conclusion, when applied for direct measurements, the force gauge can be used to validly assess push/pull forces at the workplace.     

Medical diagnosis of rheumatoid arthritis disease from right and left hand Ulnar artery Doppler signals using adaptive network based fuzzy inference system (ANFIS) and MUSIC method

Rheumatoid arthritis (RA) is a multi-systemic autoimmune disease that leads to substantial morbidity and mortality. In this paper, as spectral analysis methods of Multiple Signal Classification (MUSIC) method is used in order to extract the significant features from the right and left hand Ulnar artery Doppler signals for the diagnosis of RA disease. The MUSIC method has been used as subspace method. To extract features from Doppler signals obtained from the right and left hand Ulnar arterial the MUSIC method model degrees of 5, 10, 15, 20, and 25 were used. Then, an adaptive network based fuzzy inference system (ANFIS) was applied to features extracted from the right and left hand Ulnar artery Doppler signals for classifying RA disease. The methods are not new, but the study has a novelty in that the application area of these methods is new. In the hybrid model, the combination of MUSIC and ANFIS yielded classification accuracies of 95% (for a model degree of 20) using the right hand Ulnar artery and classification accuracies of 91.25% (for a model degree of 10) using left hand Ulnar artery Doppler signals in the diagnosis of RA disease. The proposed approach has potential to help with the early diagnosis of RA disease for the specialists who study this subject.     

Effect of wrist position on grip force sense in healthy adults

To achieve a better understanding of the causes of higher rates of musculoskeletal disorders and to develop preventive strategies to decrease the risk of injury and optimally design hand tools, it is necessary to understand the effects of both wrist position and force level on grip force sense. In this study, the effects of both wrist position and force level on grip force sense in healthy males during an ipsilateral force reproduction task were investigated. Twenty healthy subjects were instructed to produce varying levels of target forces (i.e., 10%, 30%, and 50% of maximal voluntary isometric contraction [MVIC]) for five wrist positions (i.e., neutral position, full radial deviation, full ulnar deviation, full‐extension, and full flexion), and to reproduce these forces using the same hand. The results of our study revealed that the absolute error, constant error, and MVIC decreased as the wrist joint angle deviated from the neutral position. Subjects had a more accurate estimation of medium target force (30% MVIC), while low target force (10% MVIC) was overestimated and high target force (50% MVIC) was underestimated, in contrast to most previous studies.     

On the solution of the three forces problem and its application in optimal designing of a class of symmetric plane frameworks of least weight

Two problems of minimum weight design of plane trusses are dealt with. The first problem concerns construction of the lightest fully stressed truss subject to three self-equilibrated forces applied at three given points. This problem has been solved analytically by H.S.Y. Chan in 1966. This analytical solution is re-derived in the present paper. It compares favourably with new numerical solutions found here by the method developed recently by the first author. The solution to the three forces problem paves the way to half-analytical as well as numerical solutions to the problem of minimum weight design of plane symmetric frameworks transmitting two symmetrically located vertical forces to two fixed supports lying along the line linking the points of application of the forces.     

类风湿性关节炎免疫发病机制的研究进展

类风湿性关节炎(Rheumatoid Arthritis,RA) 是一种以多发性、对称性关节炎症为主,可引起肢体严重畸形的慢性全身性自身免疫性疾病,其发病机制目前尚不完全明确。文章从与类风湿性关节炎发生发展相的免疫细胞( 包括CD4+ T 细胞、B 细胞、先天性免疫细胞)、细胞因子以及微小RNA 等方面对该病发病机制的有关研究进展进行综述。     

Infection risk in patients with rheumatoid arthritis treated with etanercept or adalimumab

Objectives

To compare the risk of infection for rheumatoid arthritis (RA) patients who took etanercept or adalimumab medication in a nationwide population.

Methods

RA patients who took etanercept or adalimumab were identified in the Taiwan's National Health Insurance Research Database. The composite outcome of serious infections, including hospitalization for infection, reception of an antimicrobial injection, and tuberculosis were followed for 365 days. A Kaplan–Meier survival curve with a log-rank test and Cox proportional hazards regression were used to compare risks of infection between the two cohorts of tumor necrosis factor (TNF)-α antagonists users. Hazard ratios (HRs) were obtained and adjusted with propensity scores and clinical factors. Sensitivity analyses and subgroup analyses were also performed.

Results

In total, 1660 incident etanercept users and 484 incident adalimumab users were eligible for the analysis. The unadjusted HR for infection of the etanercept users was significantly higher than that of the adalimumab users (HR: 1.93; 95% confidence interval (CI): 1.09–3.42; p = 0.024). The HRs were 2.04 (95% CI: 1.14–3.65; p = 0.016) and 2.02 (95% CI: 1.13–3.61; p = 0.018) after adjusting for propensity scores and for propensity scores in addition to clinical factors, respectively. The subgroup analyses revealed that HRs for composite infection was significantly higher in patient subgroups of older age, female, as well as patients who did not have DM, COPD, and hospitalization history at the baseline.

Conclusion

In this head-to-head cohort study involving a nationwide population of patients with RA, etanercept users demonstrated a higher risk of infection than adalimumab users. Results of this study suggest the possible existence of an intra-class difference in infection risk among TNF-α antagonists.     

Test-retest reliability of isometric and isoinertial testing in symmetric and asymmetric lifting

The aim of this study was to evaluate test-retest reliability of a dynamometer in measuring lifting strength or force parameters under several combinations of ergonomic factors. Thirteen healthy participants were tested on peak force (PF), related variables and isometric strength (IS) twice, at intervals of 3 months. Correlation coefficients for all parameters in the sagittal plane were 0.60–0.85. Coefficients of variations (CVs) of methodology error for PF in the sagittal plane were 6.2–6.9%. Correlation coefficients and CVs for IS at 90° to the lateral plane were 0.51– 0.54 and 16.6–17.9%, respectively. In paired t-tests of the parameters under all conditions, there was no significant difference between test and retest. In the test and retest, ratings of perceived exertions for the low back and the right arm in isometric lifting were significantly higher than those in dynamic lifting. It was concluded that the test-retest reliability of dynamic forces in the dynamometer was high. The peak force in the sagittal plane was considered reliable. In isometric lifting, isometric strength in the sagittal plane seemed reliable, while that at right angles to the lateral plane was considered to be less reliable.     

Psychophysical study of six hand movements.

This study represents a continuation of a series of psychophysical studies on repetitive motions of the wrist and hand conducted at the Liberty Mutual Research Center for Safety and Health. The purpose of the study was to quantify maximum acceptable forces of six motions performed on separate days but within the context of the same experiment. The six motions were wrist flexion with a power grip, wrist extension with a power grip, wrist flexion with a pinch grip, wrist extension with a pinch grip, ulnar deviation with a power grip, and a handgrip task (with a power grip). A psychophysical methodology was used in which the subject adjusted the resistance on the handle and the experimenter manipulated or controlled all other variables. Thirty-one subjects performed the six tasks at repetition rates of 15, 20 and 25 motions/min. Subjects performed the tasks for 7 h per day, 5 days per week, for 4 weeks. The subjects were instructed to work as if they were on an incentive basis, getting paid for the amount of work performed. Symptoms were recorded by the subjects during the last 5 min of each hour. The results revealed that maximum acceptable torques ranged from 11 to 19% of maximum isometric torque depending on frequency and motion. Maximum acceptable torques for the tasks that could be compared with previous studies showed the same patterns of response. However, the selected forces were substantially lower using the mixed protocol. A table of maximum acceptable torques and forces is presented for application in the field.     

Psychophysical study of six hand movements

This study represents a continuation of a series of psychophysical studies on repetitive motions of the wrist and hand conducted at the Liberty Mutual Research Center for Safety and Health. The purpose of the study was to quantify maximum acceptable forces of six motions performed on separate days but within the context of the same experiment. The six motions were wrist flexion with a power grip, wrist extension with a power grip, wrist flexion with a pinch grip, wrist extension with a pinch grip, ulnar deviation with a power grip, and a handgrip task (with a power grip). A psychophysical methodology was used in which the subject adjusted the resistance on the handle and the experimenter manipulated or controlled all other variables. Thirty-one subjects performed the six tasks at repetition rates of 15, 20 and 25 motions/min. Subjects performed the tasks for 7 h per day, 5 days per week, for 4 weeks. The subjects were instructed to work as if they were on an incentive basis, getting paid for the amount of work performed. Symptoms were recorded by the subjects during the last 5 min of each hour. The results revealed that maximum acceptable torques ranged from 11 to 19% of maximum isometric torque depending on frequency and motion. Maximum acceptable torques for the tasks that could be compared with previous studies showed the same patterns of response. However, the selected forces were substantially lower using the mixed protocol. A table of maximum acceptable torques and forces is presented for application in the field.     

Characterization of DNA hybridization kinetics in a microfluidic flow channel

In this investigation we report on the influence of volumetric flow rate, flow velocity, complementary DNA concentration, height of a microfluidic flow channel and time on DNA hybridization kinetics. A syringe pump was used to drive Cy3-labeled target DNA through a polydimethylsiloxane (PDMS) microfluidic flow channel to hybridize with immobilized DNA from the West Nile Virus. We demonstrate that a reduction of channel height, while keeping a fixed volumetric flow rate or a fixed flow velocity, enhances mass transport of target DNA to the capture probes. Compared to a passive hybridization, the DNA hybridization in the microfluidic flow channel generates higher fluorescence intensities for lower concentration of target DNA during the same fixed period of time. Within a fixed 2 min time period the fastest DNA hybridization at a 50 pM concentration of target DNA is achieved with a continuous flow of target DNA at the highest flow rate and the lowest channel height.     

Human strength: measurements of maximum isometric forces in industry

Within the framework of an on-going research project, the maximum isometric forces of staff working in production were measured for nine test conditions representative for manual material handling (n=3600), The technique for the measurement of maximum human forces depending on body posture, the test set-up, and the procedures used for data analysis plus the preliminary group results (n=1245) are described. The results show a marked influence of the initial grip height on the maximum forces achievable for the lifting of a stacking case with both hands. Under comparable grip height and type of grip, small differences between the lifting forces with one or with two hands exist. In comparison to males, females clearly have lower maximum isometric forces than is generally supposed.     

Designs and concept reliance of a fully automated high-content screening platform

High-content screening (HCS) is becoming an accepted platform in academic and industry screening labs and does require slightly different logistics for execution. To automate our stand-alone HCS microscopes, namely, an alpha IN Cell Analyzer 3000 (INCA3000), originally a Praelux unit hooked to a Hudson Plate Crane with a maximum capacity of 50 plates per run, and the IN Cell Analyzer 2000 (INCA2000), in which up to 320 plates could be fed per run using the Thermo Fisher Scientific Orbitor, we opted for a 4 m linear track system harboring both microscopes, plate washer, bulk dispensers, and a high-capacity incubator allowing us to perform both live and fixed cell-based assays while accessing both microscopes on deck. Considerations in design were given to the integration of the alpha INCA3000, a new gripper concept to access the onboard nest, and peripheral locations on deck to ensure a self-reliant system capable of achieving higher throughput. The resulting system, referred to as Hestia, has been fully operational since the new year, has an onboard capacity of 504 plates, and harbors the only fully automated alpha INCA3000 unit in the world.     

An exponential model of isometric muscular fatigue as a function of age and muscle groups.

Despite the recommendations that an important design criterion is not to exceed 15% of an operator's maximum voluntary contraction (MVC) with any muscle that must be used for a long period of time, many tasks involve the exertion of much higher forces coupled with long-term contractions. Many studies have investigated the force-time relationship of isometric muscle contractions to determine the endurance time of a given relative force. To date, however, direct studies of muscle performance throughout fatiguing tasks have not been conducted to the same degree. This research was concerned with studying the effects of different muscle groups (biceps vs quadriceps) of subjects with different age groups (20-29 vs 50-59 years of age) on long-term muscular isometric contractions at different levels of %MVC (20%, 40%, 60%, 80%, and 100% MVC), and modelling the functional data to describe the time course of strength decrement. The data revealed that the time course of strength decrement was best modelled by the function: [formula: see text] An experiment, using 20 subjects with each subject performing 10 conditions (two muscle groups x five levels of %MVC), showed that this function accounted for over 95% of the variance of strength decrement. All parameter estimates were statistically significant.     

Use of social network sites among depressed adolescents

Social network sites (SNSs) are relatively new phenomena, and the relationship between SNSs and psychopathology remains unclear. The purpose of this study was to evaluate the type of SNSs depressed adolescents use and the incidence of depressive disclosure on SNSs among them. The study was designed to be cross-sectional. The sample consisted of 53 adolescents diagnosed with depressive disorder, as confirmed by K-SADS-PL, and 55 non-depressed adolescents. The Children’s Depression Inventory, Social Anxiety Scale and Social Network Use Questionnaire were administered. The primary finding was that the amount of time spent on the Internet and on SNSs was significantly higher among depressed adolescents than non-depressed adolescents. Additionally, depressed adolescents reported significantly higher disclosure of anhedonia, worthlessness, guilt, loss of concentration, irritability and thoughts of suicide on SNSs. The intensity of the depression sharing was significantly higher in the depressed group. Depressed young people use social networks to express their symptoms. Adolescents’ disclosure on social networks may be able to guide relatives, friends and mental health professionals.     

A multidisciplinary framework to support the design of injection mold tools

The design of injection mold tools is a complex process for which market pressures demand ever-shorter development time and higher quality level. Thus, it is considered imperative to adopt new methods and tools to support the design process, in order to achieve a more effective mold design solution. Based on this assumption, a multidisciplinary framework was developed, centered on Design for Six Sigma methodology and reinforced with a set of highly valued techniques, namely: the European Customer Satisfaction, the Axiomatic Design and the Multidisciplinary Design Optimization. As a result, a platform was built to support the design of any mold tool without undercuts, which tackles the design of an injection mold as a fully integrated multidisciplinary optimization problem, oriented by customer preferences and their impositions. A set of specific analysis sub-modules is integrated through an overseeing optimization code system, responsible for the numerical simulation of the injection process. This platform was validated through the comparison with an existing mold, whose results attained highlight the great potential of the proposed framework to achieve mold design improvement. In particular, the value of mold solutions generated led to a global improvement on mold performance by 5 %.     

Human strength: measurements of maximum isometric forces in industry

Abstract

Within the framework of an on-going research project, the maximum isometric forces of staff working in production were measured for nine test conditions representative for manual material handling (n = 3600). The technique for the measurement of maximum human forces depending on body posture, the test setup, and the procedures used for data analysis plus the preliminary group results (n = 1245) are described. The results show a marked influence of the initial grip height on the maximum forces achievable for the lifting of a stacking case with both hands. Under comparable grip height and type of grip, small differences between the lifting forces with one or with two hands exist. In comparison to males, females clearly have lower maximum isometric forces than is generally supposed.