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1.
Soyeong Ahn Tae-Hee Han Kathleen Maleski Jinouk Song Young-Hoon Kim Min-Ho Park Huanyu Zhou Seunghyup Yoo Yury Gogotsi Tae-Woo Lee 《Advanced materials (Deerfield Beach, Fla.)》2020,32(23):2000919
Although several transparent conducting materials such as carbon nanotubes, graphene, and conducting polymers have been intensively explored as flexible electrodes in optoelectronic devices, their insufficient electrical conductivity, low work function, and complicated electrode fabrication processes have limited their practical use. Herein, a 2D titanium carbide (Ti3C2) MXene film with transparent conducting electrode (TCE) properties, including high electrical conductivity (≈11 670 S cm−1) and high work function (≈5.1 eV), which are achieved by combining a simple solution processing with modulation of surface composition, is described. A chemical neutralization strategy of a conducting-polymer hole-injection layer is used to prevent detrimental surface oxidation and resulting degradation of the electrode film. Use of the MXene electrode in an organic light-emitting diode leads to a current efficiency of ≈102.0 cd A−1 and an external quantum efficiency of ≈28.5% ph/el, which agree well with the theoretical maximum values from optical simulations. The results demonstrate the strong potential of MXene as a solution-processable electrode in optoelectronic devices and provide a guideline for use of MXenes as TCEs in low-cost flexible optoelectronic devices. 相似文献
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Jason R. McCarthy Ethan Korngold Ralph Weissleder Farouc A. Jaffer 《Small (Weinheim an der Bergstrasse, Germany)》2010,6(18):2041-2049
The synthesis and utility of a multimodal theranostic nanoagent based upon magnetofluorescent nanoparticles for the treatment of inflammatory atherosclerosis is described. These particles are modified with near‐infrared fluorophores and light‐activated therapeutic moieties, which allow for the optical determination of agent localization and phototoxic activation at spectrally distinct wavelengths. The resulting agent is readily taken up by murine macrophages in vitro and is highly phototoxic, with an LD50 of 430 pM . Intravenous administration results in the localization of the nanoagent within macrophage‐rich atherosclerotic lesions that can be imaged by intravital fluorescence microscopy. Irradiation of the atheroma with 650 nm light activates the therapeutic component and results in eradication of inflammatory macrophages, which may induce lesion stabilization. Importantly, these agents display limited skin photosensitivity, are highly efficacious, and provide an integrated imaging and therapeutic nanoplatform for atherosclerosis. 相似文献
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Multifunctional pDNA‐Conjugated Polycationic Au Nanorod‐Coated Fe3O4 Hierarchical Nanocomposites for Trimodal Imaging and Combined Photothermal/Gene Therapy
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Yang Hu Yiqiang Zhou Nana Zhao Fusheng Liu Fu‐Jian Xu 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(18):2459-2468
It is very desirable to design multifunctional nanocomposites for theranostic applications via flexible strategies. The synthesis of one new multifunctional polycationic Au nanorod (NR)‐coated Fe3O4 nanosphere (NS) hierarchical nanocomposite (Au@pDM/Fe3O4) based on the ternary assemblies of negatively charged Fe3O4 cores (Fe3O4‐PDA), polycation‐modified Au nanorods (Au NR‐pDM), and polycations is proposed. For such nanocomposites, the combined near‐infrared absorbance properties of Fe3O4‐PDA and Au NR‐pDM are applied to photoacoustic imaging and photothermal therapy. Besides, Fe3O4 and Au NR components allow the nanocomposites to serve as MRI and CT contrast agents. The prepared positively charged Au@pDM/Fe3O4 also can complex plasmid DNA into pDNA/Au@pDM/Fe3O4 and efficiently mediated gene therapy. The multifunctional applications of pDNA/Au@pDM/Fe3O4 nanocomposites in trimodal imaging and combined photothermal/gene therapy are demonstrated using a xenografted rat glioma nude mouse model. The present study demonstrates that the proper assembly of different inorganic nanoparticles and polycations is an effective strategy to construct new multifunctional theranostic systems. 相似文献
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Photothermal Therapy: Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu2−xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer (Adv. Mater. 40/2016)
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Shaohua Zhang Caixia Sun Jianfeng Zeng Qiao Sun Guanglin Wang Yong Wang Yan Wu Shixue Dou Mingyuan Gao Zhen Li 《Advanced materials (Deerfield Beach, Fla.)》2016,28(40):8788-8788
7.
Transparent,Flexible, and Conductive 2D Titanium Carbide (MXene) Films with High Volumetric Capacitance
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Chuanfang Zhang Babak Anasori Andrés Seral‐Ascaso Sang‐Hoon Park Niall McEvoy Aleksey Shmeliov Georg S. Duesberg Jonathan N. Coleman Yury Gogotsi Valeria Nicolosi 《Advanced materials (Deerfield Beach, Fla.)》2017,29(36)
2D transition‐metal carbides and nitrides, known as MXenes, have displayed promising properties in numerous applications, such as energy storage, electromagnetic interference shielding, and catalysis. Titanium carbide MXene (Ti3C2Tx ), in particular, has shown significant energy‐storage capability. However, previously, only micrometer‐thick, nontransparent films were studied. Here, highly transparent and conductive Ti3C2Tx films and their application as transparent, solid‐state supercapacitors are reported. Transparent films are fabricated via spin‐casting of Ti3C2Tx nanosheet colloidal solutions, followed by vacuum annealing at 200 °C. Films with transmittance of 93% (≈4 nm) and 29% (≈88 nm) demonstrate DC conductivity of ≈5736 and ≈9880 S cm?1, respectively. Such highly transparent, conductive Ti3C2Tx films display impressive volumetric capacitance (676 F cm?3) combined with fast response. Transparent solid‐state, asymmetric supercapacitors (72% transmittance) based on Ti3C2Tx and single‐walled carbon nanotube (SWCNT) films are also fabricated. These electrodes exhibit high capacitance (1.6 mF cm?2) and energy density (0.05 µW h cm?2), and long lifetime (no capacitance decay over 20 000 cycles), exceeding that of graphene or SWCNT‐based transparent supercapacitor devices. Collectively, the Ti3C2Tx films are among the state‐of‐the‐art for future transparent, conductive, capacitive electrodes, and translate into technologically viable devices for next‐generation wearable, portable electronics. 相似文献
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Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu2−xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer
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Shaohua Zhang Caixia Sun Jianfeng Zeng Qiao Sun Guanglin Wang Yong Wang Yan Wu Shixue Dou Mingyuan Gao Zhen Li 《Advanced materials (Deerfield Beach, Fla.)》2016,28(40):8927-8936
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Photothermal Therapy: Metabolizable Ultrathin Bi2Se3 Nanosheets in Imaging‐Guided Photothermal Therapy (Small 30/2016)
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Hanhan Xie Zhibin Li Zhengbo Sun Jundong Shao Xue‐Feng Yu Zhinan Guo Jiahong Wang Quanlan Xiao Huaiyu Wang Qu‐Quan Wang Han Zhang Paul K. Chu 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(30):4158-4158
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Wei Sun Xiaodong Zhang Hao‐Ran Jia Ya‐Xuan Zhu Yuxin Guo Ge Gao Yan‐Hong Li Fu‐Gen Wu 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(11)
Herein, water‐dispersible carbon nano‐onion clusters (CNOCs) with an average hydrodynamic size of ≈90 nm are prepared by simply sonicating candle soot in a mixture of oxidizing acid. The obtained CNOCs have high photothermal conversion efficiency (57.5%), excellent aqueous dispersibility (stable in water for more than a year without precipitation), and benign biocompatibility. After polyethylenimine (PEI) and poly(ethylene glycol) (PEG) modification, the resultant CNOCs‐PEI‐PEG have a high photothermal conversion efficiency (56.5%), and can realize after‐wash photothermal cancer cell ablation due to their ultrahigh cellular uptake (21.3 pg/cell), which is highly beneficial for the selective ablation of cancer cells via light‐triggered intracellular heat generation. More interestingly, the cellular uptake of CNOCs‐PEI‐PEG is so high that the internalized nanoagents can be directly observed under a microscope without fluorescent labeling. Besides, in vivo experiments reveal that CNOCs‐PEI‐PEG can be used for photothermal/photoacoustic dual‐modal imaging‐guided photothermal therapy after intravenous administration. Furthermore, CNOCs‐PEI‐PEG can be efficiently cleared from the mouse body within a week, ensuring their excellent long‐term biosafety. To the best of the authors' knowledge, the first example of using candle soot as raw material to prepare water‐dispersible onion‐like carbon nanomaterials for cancer theranostics is represented herein. 相似文献
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Su Hyun Hong Robert A. Falconer Paul M. Loadman Jason H. Gill Rosalinda Castaneda Florette K. Hazard Ling Tong Olga D. Lenkov Dean W. Felsher Jianghong Rao Heike E. Daldrup‐Link 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(3):566-575
A major drawback with current cancer therapy is the prevalence of unrequired dose‐limiting toxicity to non‐cancerous tissues and organs, which is further compounded by a limited ability to rapidly and easily monitor drug delivery, pharmacodynamics and therapeutic response. In this report, the design and characterization of novel multifunctional “theranostic” nanoparticles (TNPs) is described for enzyme‐specific drug activation at tumor sites and simultaneous in vivo magnetic resonance imaging (MRI) of drug delivery. TNPs are synthesized by conjugation of FDA‐approved iron oxide nanoparticles ferumoxytol to an MMP‐activatable peptide conjugate of azademethylcolchicine (ICT), creating CLIO‐ICTs (TNPs). Significant cell death is observed in TNP‐treated MMP‐14 positive MMTV‐PyMT breast cancer cells in vitro, but not MMP‐14 negative fibroblasts or cells treated with ferumoxytol alone. Intravenous administration of TNPs to MMTV‐PyMT tumor‐bearing mice and subsequent MRI demonstrates significant tumor selective accumulation of the TNP, an observation confirmed by histopathology. Treatment with CLIO‐ICTs induces a significant antitumor effect and tumor necrosis, a response not observed with ferumoxytol. Furthermore, no toxicity or cell death is observed in normal tissues following treatment with CLIO‐ICTs, ICT, or ferumoxytol. These findings demonstrate proof of concept for a new nanotemplate that integrates tumor specificity, drug delivery and in vivo imaging into a single TNP entity through attachment of enzyme‐activated prodrugs onto magnetic nanoparticles. This novel approach holds the potential to significantly improve targeted cancer therapies, and ultimately enable personalized therapy regimens. 相似文献
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Photosensitizer‐Conjugated Albumin−Polypyrrole Nanoparticles for Imaging‐Guided In Vivo Photodynamic/Photothermal Therapy
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Xuejiao Song Chao Liang Hua Gong Qian Chen Chao Wang Zhuang Liu 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(32):3932-3941
Conjugated polymers with strong absorbance in the near‐infrared (NIR) region have been widely explored as photothermal therapy agents due to their excellent photostability and high photothermal conversion efficiency. Herein, polypyrrole (PPy) nanoparticles are fabricated by using bovine serum albumin (BSA) as the stabilizing agent, which if preconjugated with photosensitizer chlorin e6 (Ce6) could offer additional functionalities in both imaging and therapy. The obtained PPy@BSA‐Ce6 nanoparticles exhibit little dark toxicity to cells, and are able to trigger both photodynamic therapy (PDT) and photothermal therapy (PTT). As a fluorescent molecule that in the meantime could form chelate complex with Gd3+, Ce6 in PPy@BSA‐Ce6 nanoparticles after being labeled with Gd3+ enables dual‐modal fluorescence and magnetic resonance (MR) imaging, which illustrate strong tumor uptake of those nanoparticles after intravenous injection into tumor‐bearing mice. In vivo combined PDT and PTT treatment is then carried out after systemic administration of PPy@BSA‐Ce6, achieving a remarkably improved synergistic therapeutic effect compared to PDT or PTT alone. Hence, a rather simple one‐step approach to fabricate multifunctional nanoparticles based on conjugated polymers, which appear to be promising in cancer imaging and combination therapy, is presented. 相似文献
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Lei Rong Hui‐Zhen Jia Si Chen Xiang‐Ji Liu Guo‐Feng Luo Ren‐Xi Zhuo Xian‐Zheng Zhang 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(3):599-608
Graphene oxide (GO)‐based theranostic nanohybrid is designed for tumor induced imaging and potential combinational tumor therapy. The anti‐tumor drug, Doxorubicin (DOX) is chemically conjugated to the poly(ethylenimine)‐co‐poly(ethylene glycol) (PEI‐PEG) grafted GO via a MMP2‐cleavable PLGLAG peptide linkage. The therapeutic efficacy of DOX is chemically locked and its intrinsic fluorescence is quenched by GO under normal physiological condition. Once stimulated by the MMP2 enzyme over‐expressed in tumor tissues, the resulting peptide cleavage permits the unloading of DOX for tumor therapy and concurrent fluorescence recovery of DOX for in situ tumor cell imaging. Attractively, this PEI‐bearing nanohybrid can mediate efficient DNA transfection and shows great potential for combinational drug/gene therapy. This tumor induced imaging and potential combinational therapy will open a window for tumor treatment by offering a unique theranostic approach through merging the diagnostic capability and pathology‐responsive therapeutic function. 相似文献
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Photothermal Therapy: Multifunctional Fe5C2 Nanoparticles: A Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography‐Guided Photothermal Therapy (Adv. Mater. 24/2014)
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Jing Yu Ce Yang Jingdingsha Li Yichen Ding Lei Zhang Muhammad Zubair Yousaf Jian Lin Rui Pang Lanbin Wei Lili Xu Fugeng Sheng Changhui Li Gongjie Li Lingyun Zhao Yanglong Hou 《Advanced materials (Deerfield Beach, Fla.)》2014,26(24):4187-4187
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A Smart Responsive Dual Aptamers‐Targeted Bubble‐Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging
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Feifei Zhao Jie Zhou Xiangjie Su Yuhui Wang Xiaosa Yan Shaona Jia Bin Du 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(20)
The absence of targeted, single treatment methods produces low therapeutic value for treating cancers. To increase the accumulation of drugs in tumors and improve the treatment effectiveness, near‐infrared 808 nm photothermal responsive dual aptamers‐targeted docetaxel (DTX)‐containing nanoparticles is proposed. In this system, DTX and NH4HCO3 are loaded in thermosensitive liposomes. The surface of liposomes is coated with gold nanoshells and connected with sulfydryl (SH? ) modified AS1411 and S2.2 aptamers. The nanosystem has good biocompatibility and uniform size (diameter about 200 nm). The drug is rapidly released, reaching a maximum amount (84%) at 4 h under 808 nm laser irradiation. The experiments conducted in vitro and in vivo demonstrate the nanosystem can synergistically inhibit tumor growth by combination of chemotherapy, photothermal therapy, and biological therapy. Dual ligand functionalization significantly increases cellular uptake on breast cancer cell line (MCF‐7) cells and achieves ultrasound imaging (USI) at tumor site. The results indicate that this drug delivery system is a promising theranostic agent involving light‐thermal response at tumor sites, dual ligand targeted triplex therapy, and USI. 相似文献
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Multifunctional Fe5C2 Nanoparticles: A Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography‐Guided Photothermal Therapy
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Jing Yu Ce Yang Jingdingsha Li Yichen Ding Lei Zhang Muhammad Zubair Yousaf Jian Lin Rui Pang Lanbin Wei Lili Xu Fugeng Sheng Changhui Li Gongjie Li Lingyun Zhao Yanglong Hou 《Advanced materials (Deerfield Beach, Fla.)》2014,26(24):4114-4120
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Liang Cheng Xianwen Wang Fei Gong Teng Liu Zhuang Liu 《Advanced materials (Deerfield Beach, Fla.)》2020,32(13):1902333
2D nanomaterials with unique nanosheet structures, large surface areas, and extraordinary physicochemical properties have attracted tremendous interest. In the area of nanomedicine, research on graphene and its derivatives for diverse biomedical applications began as early as 2008. Since then, many other types of 2D nanomaterials, including transition metal dichalcogenides, transition metal carbides, nitrides and carbonitrides, black phosphorus nanosheets, layered double hydroxides, and metal–organic framework nanosheets, have been explored in the area of nanomedicine over the past decade. In particular, a large surface area makes 2D nanomaterials highly efficient drug delivery nanoplatforms. The unique optical and/or X-ray attenuation properties of 2D nanomaterials can be harnessed for phototherapy or radiotherapy of cancer. Furthermore, by integrating 2D nanomaterials with other functional nanoparticles or utilizing their inherent physical properties, 2D nanomaterials may also be engineered as nanoprobes for multimodal imaging of tumors. 2D nanomaterials have shown substantial potential for cancer theranostics. Herein, the latest progress in the development of 2D nanomaterials for cancer theranostic applications is summarized. Current challenges and future perspectives of 2D nanomaterials applied in nanomedicine are also discussed. 相似文献
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Co9Se8 Nanoplates as a New Theranostic Platform for Photoacoustic/Magnetic Resonance Dual‐Modal‐Imaging‐Guided Chemo‐Photothermal Combination Therapy
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Xiao‐Rong Song Xiaoyong Wang Shu‐Xian Yu Jianbo Cao Shi‐Hua Li Juan Li Gang Liu Huang‐Hao Yang Xiaoyuan Chen 《Advanced materials (Deerfield Beach, Fla.)》2015,27(21):3285-3291