对羟基苯甘氨酸的合成及拆分技术进展

综述了近年来对羟基苯甘氨酸的合成及拆分技术进展 ,其中包括 5种合成方法 ,4种拆分方法     

手性拆分技术的工业应用

综述了迄今为止在实验室或者工业领域内所采用的手性拆分技术，包括直接结晶拆分法，化学拆分法，动力学拆分法，色谱拆分法以及手性膜拆分法等，指出了各种方法的优缺点，并比较了它们在工业领域中进行规模生产的可能性，共引用文章41篇。     

D-丙氨酸的用途及制备方法

介绍了D－丙氨酸在生理医学，食品工业等方面的应用，及目前它的各种生产方法。并对建立D－丙氨酸的工业生产方法提出了建议。     

D-天冬氨酸的制备和应用

D 天冬氨酸是一种重要的手性化合物,在医药、食品等方面具有重要作用,特别是作为手性药物合成的前体、中间体在医药行业中有着重要的应用前景。目前其制备方法主要是消旋体的拆分,其中酶法拆分最具竞争力。综述了D 天冬氨酸的应用及制备方法,为开展D 天冬氨酸的制备及应用研究提供了一定的依据。     

手性拆分——化学拆分法的研究进展

综述了近年来化学拆分法的研究进展,重点分析了经典成盐拆分法、包结拆分法和组合拆分法三种拆分方法的研究进展以及各个拆分方法的优缺点。并对化学拆分法进行了总结和展望,在未来,随着高端化学品高纯度生产的需求,对于手性化合物的光学纯度要求也越来越高,化学拆分法由于操作简单、成本低、易于大规模生产等优势而广泛应用于对映异构体的拆分,在手性拆分领域将发挥重要、不可替代的作用。     

手性拆分技术进展

对外消旋体实施拆分是获得手性物质的重要途径。本文综述了外消旋体的拆分方法，包括机械拆分法、化学拆分法、生物化学拆分法、色谱拆分法、萃取拆分法、膜拆分法等六大类方法。其中机械拆分法、化学拆分法、生物化学拆分法是目前工业上广泛应用的方法；色谱拆分法、萃取拆分法、膜拆分法以其自身的优点，有望成为手性拆分技术今后的发展方向。     

( S )-氰戊菊酯的制备方法述评

对目前国外（Ｓ）－氰戊炙酯制备的主要方法进行了介绍，并对各种方法的优劣及前景作了进一步的讨论。     

手性物质及其拆分方法

简要介绍了手性化合物的概念和发展情况以及获得手性化合物单一对映体的几种拆分方法。包括:结晶拆分法,化学拆分法,微生物酶拆分法,色谱拆分法,膜拆分法及电泳技术拆分法。并简要介绍了每种方法的应用情况及优缺点。     

薄荷醇手性拆分的研究进展

薄荷醇是工业上应用广泛的一类重要的环萜醇.光学活性的左旋薄荷醇在医药卫生方面可用作清凉剂、止痒剂、杀菌剂等;在香料行业是需求量最大的环状单萜醇,可用作日化香精的调配剂,还能充作多种食品的调味剂;其需求量正大幅度增加,因此寻求一种好的拆分外消旋体薄荷醇的方法是极其重要的.主要综述了目前国内外薄荷醇拆分的一些方法,比较了这些拆分方法的优缺点,其中生物酶法拆分是一个很有发展潜力的方法.     

左旋对羟基苯甘氨酸的拆分技术进展

左旋对羟基苯甘氨酸是一种鞋要的精细化工产品,也是合成多种抗生索的重要中间体,近年来对它的拆分技术研究收到了国内外的广泛关注。文章主要评述了左旋对羟基苯甘氨酸的拆分技术,分析了其拆分方法,并简要评析了它的发展前景及国内外的需求情况、开发情况及各自的优缺点。     

Chemo-enzymatic synthesis of optically active polymeric prodrug of naproxen, ketoprofen and ibuprofen

A combined enzymatic resolution and chemical polymerization strategy has been used to create optically active polymeric prodrugs. (S)-Naproxen, (S)-ketoprofen and (S)-ibuprofen derivatives were obtained in excellent optical purity and high yield by enzymatic resolution after optimization of reaction conditions. Each optically active monomer was subjected to free radical polymerization with methyl methacrylate. The obtained optically active polymeric prodrugs bearing (S)-naproxen, (S)-ketoprofen or (S)-ibuprofen residue were characterized by IR, NMR and GPC. The effect of molar ratio of naproxen vinyl ester to methyl methacrylate on the polymerization was also investigated. This methodology is useful to provide a facile and clean route to optically active macromolecular prodrugs.     

Chemo-enzymatic synthesis and sustained release of optically active polymeric prodrugs of chlorphenesin

Optically active polymeric prodrugs containing saccharides were prepared via a facile procedure combining enzymatic resolution with chemical polymerization. Polymerizable optically active chlorphenesin derivatives were obtained in excellent optically purity (ee > 99.9%) and high yield (∼50%) in short time (∼4 h) by lipase-catalyzed resolution after optimization of reaction conditions. Then, polymerizable optically active monomer was copolymerized with different polymerizable glycolipids using free radical polymerization method. The obtained optically active polymeric prodrugs bearing (R)-chlorphenesin residue were characterized by IR, NMR and GPC. In vitro released studies showed that the cumulative released optically pure chlorphenesin (ee = 88-92%) from the polymeric prodrug (VADG) was from 19.3% to 34.3% in pH 7.4, pH 5.4 and pH 1.2 after 7 days. The cumulative liberation rate of optically active polymeric prodrugs (ee = ∼88%) with different glycolipids was from 26.4% to 38.5% in pH 1.2.     

扁桃酸的拆分和手性扁桃酸的合成研究进展

综述了扁桃酸拆分和手性扁桃酸合成的研究进展,对非对映体盐结晶法、萃取法、色谱法、电泳法、酶催化法拆分消旋扁桃酸的原理、工艺和特点进行了评述,并介绍了生物转化法、电化学法和直接化学法合成手性扁桃酸的研究状况。其中非对映体盐结晶法是目前工业生产手性扁桃酸的重要方法,而生物转化法合成手性扁桃酸具有良好的工业应用前景。     

不对称转换法制备D-型氨基酸的研究进展

D-型氨基酸对生命科学的研究具有重大意义。不对称转换是光学活性化合物制备中越来越重要的一个分支。通过几种典型D-型氨基酸的制备工艺，概述了不对称转换的最新研究和应用进展，讨论了反应过程并对其大规模工业应用的前景进行了展望。     

Practical Considerations in Kinetic Resolution Reactions

This review provides a critical analysis of catalytic kinetic resolution reactions from a practical perspective, asking the question of when, if ever, is kinetic resolution the best option for the synthesis of an optically active target. A series of crucial conditions are identified, and it is postulated that if all of them are met, then indeed kinetic resolution can be highly practical. A variety of catalytic kinetic resolution processes are evaluated in the context of these criteria, with particular emphasis on catalyst availability, substrate scope, availability of the racemic substrate and of alternative methods for accessing enantiopure substrate or product, and key experimental considerations. It is found that several catalytic systems have been developed that offer almost unbeatable methods for the preparation of useful chiral building blocks.     

旋光性氰醇的酶催化合成

综述了酶催化立体选择性合成及动力学折分制备旋光性氰醇的几种方法。     

生物催化制备光学活性4-氯-3-羟基丁酸酯研究进展

综述了生物催化制备光学活性4-氯-3-羟基丁酸酯(CHBE)的研究进展,介绍了生物催化外消旋体拆分和不对称还原方法制备光学活性CHBE的研究现状,重点阐述了反应介质选择、辅助底物和添加剂的选择、细胞热处理等一些控制不对称还原4-氯-3-氧代丁酸酯(COBE)立体选择性的方法。对生物催化制备光学活性CHBE的工业化前景进行了展望。     

Enantioselective Synthesis of 4‐(Dimethylamino)pyridines through a Chemical Oxidation‐Enzymatic Reduction Sequence. Application in Asymmetric Catalysis

Enantiomerically pure 4‐(dimethylamino)‐3‐(1‐hydroxyalkyl)pyridines and 4‐(dimethylamino)‐3‐[hydroxy(phenyl)methyl]pyridine have been prepared through efficient chemoenzymatic routes. For this purpose different lipases and oxidoreductases have been tested in the preparation of optically active 4‐chloro derivatives and baker’s yeast was found to be an excellent catalyst for the bioreductions of the corresponding ketones. Their applications as enantioselective nucleophilic catalysts have been studied, important catalytic properties were observed in the stereoselective construction of quaternary centers.     

Simple process for preparation of optically active methacrylates polymer with controlled molecular weight

Novel optically active methacrylates polymer with controlled molecular weight have been prepared simply by opening ring reaction of poly(glycidyl methacrylate) and S-(−)-α-methylbenzylamine. The structure of the novel optically active methacrylates polymer was characterized by FT-IR, and chiroptical properties of the polymer were characterized by polarimeter and circular dichroism spectrum. Thermogravimetry analysis and differential scanning calorimetry were employed to examine the thermal properties of the polymer. This preparation process was simple and the racemization of optically active monomers in preparation can be avoided. The molecular weight of optically active methacrylates polymer could be controlled by molecular weight of poly(glycidyl methacrylate) prepared by atom transfer radical polymerization.     

手性扁桃酸光学拆分研究进展

介绍了手性扁桃酸的各种拆分方法,讨论了各种方法的优缺点。以手性苯甘氨酸丁酯为拆分剂的方法操作简单、收率较高,适于工业化生产。