老胡同，纽约客

Grifted安家在北京南锣鼓巷,它有个好听的中文名字：贵福天地。 和南锣鼓巷大多数小店一样,Grifted也是木质雕花油漆大门,很有仿古做旧的感觉,推门进去却是另一片天地：浓墨重彩的玩偶、设计独特的T恤、各种各样色彩艳丽的包装纸,具有浓郁中国特色的雨具……全都由店主PP亲自设计并手工制作。     

栋梁在五道营

京味儿十足的南锣鼓巷被城市的喧嚣侵蚀,相隔不远的五道营胡同不知何时却生长出丝丝缕缕文艺气息。相比南锣鼓巷的日益繁华,五道营显得更加宁静。即使白天,也能分明听到蛐蛐儿的叫声。三位新锐设计师南朗、Charles也选择将一个专为独立设计师服务的showroom——＂栋梁设计品牌店＂开在了五道营胡同。     

栋梁在五道营

京味儿十足的南锣鼓巷被城市的喧嚣侵蚀,相隔不远的五道营胡同不知何时却生长出丝丝缕缕文艺气息.相比南锣鼓巷的日益繁华,五道营显得更加宁静.即使白天,也能分明听到蛐蛐儿的叫声.三位新锐设计师南朗、Charles也选择将-个专为独立设计师服务的showroom--"桥梁设计品牌店"开在了五道营胡同.     

手艺引领社区新风尚

<正>为社区手工艺人免费提供出售作品的店铺,把收益和让区公益事业相结合,北京为南锣鼓巷街道办探索出的"社区工艺坊"模式不失为一举多得的好办法。南锣鼓巷是北京有名的古街区,老北京文化和时尚创意文化在这里互相融合,催生了街道两旁各种特色小店,成为一道让游客流连忘返的风景。在这些店铺中,有一家位于古街北口的"社区工艺坊"显得与众不同,不仅因为店里的商品均为寄售,还因为在租金高昂、一铺难求的南锣鼓巷,在店里寄售商品的人不用交一分钱租金。     

品读

<正>书店朴道草堂书店在北京,南锣鼓巷永远都是热闹的,而隐弊在南锣鼓巷帽儿胡同里的朴道草堂书店却安静得让人很容易错过它。书店分室内外两部分,室内有沙发区和桌椅区,室外有枣树和凉椅。店内另有两间包间,读者可以在包间内看书、观鱼。书店的装修风格偏欧美化,但店内的原木桌子麻布装饰以及看似随意实则精心摆放在书架上的     

人人都有肚脐眼

每个人的内心深处都种着一颗童心的种子,在每一个生活不被人注意的角落,偷偷地生根发芽。 怀着这样的情绪走进北京南锣鼓巷的“肚脐眼”,分外有感觉。     

水火土熔炼的陶坊

在南锣鼓巷，有一间陶坊，总能让遇见它的人记住它。青砖灰瓦的门头不甚张扬，两只大红灯笼在微风中摇曳出几分老北京的韵味。     

人人都有肚脐眼

每个人的内心深处都种着一颗童心的种子,在每一个生活不被人注意的角落,偷偷地生根发芽。怀着这样的情绪走进北京南锣鼓巷的"肚脐眼",分外有感觉。小店里有一面墙画着可爱的涂鸦,戴红领巾的小学生、课程表、课间操……几乎每个路过的年轻人都会忍不住探着脑袋去瞄那些涂鸦,然后跑进去翻看店里款式多样的T恤。这家主打个性T恤、     

创可贴8

北京历史悠久的街区在哪儿？很多人肯定会说南锣鼓巷，这里完整地保存着元大都里坊的历史遗存。每～处宅院都诉说着老故事，每一条胡同都积淀着京味文化，吸引了众多国内外游客前来观光游览。     

分享1200万的感动 三星M8910U使用手记

北京阴霾了多日的天空终于放晴,这个冬天里难得的好天气,对于长期蜗居在一米格子中的我,身体和心情都需要放到阳光里晒一晒。穿着厚厚冬装,走进被冬日暖阳照射着的南锣鼓巷。没有了夏日的熙来攘往,却凭添了一份和这里更加对味的清闲和慵懒。看着结伴而来的外乡游客用大大小小的照相机在老巷中拍照留念,我不禁有几分偷笑。今天我只带着新买的三星M8910U手机,看看能否与他们试比高呢。     

Aluminum,Arsenic, Beryllium,Cadmium, Chromium,Cobalt, Copper,Iron, Lead,Mercury, Molybdenum,Nickel, Platinum,Thallium, Titanium,Vanadium, and Zinc: Molecular Aspects in Experimental Liver Injury

Experimental liver injury with hepatocelluar necrosis and abnormal liver tests is caused by exposure to heavy metals (HMs) like aluminum, arsenic, beryllium, cadmium, chromium, cobalt, copper, iron, lead, mercury, molybdenum, nickel, platinum, thallium, titanium, vanadium, and zinc. As pollutants, HMs disturb the ecosystem, and as these substances are toxic, they may affect the health of humans and animals. HMs are not biodegradable and may be deposited preferentially in the liver. The use of animal models can help identify molecular and mechanistic steps leading to the injury. HMs commonly initiate hepatocellular overproduction of ROS (reactive oxygen species) due to oxidative stress, resulting in covalent binding of radicals to macromolecular proteins or lipids existing in membranes of subcellular organelles. Liver injury is facilitated by iron via the Fenton reaction, providing ROS, and is triggered if protective antioxidant systems are exhausted. Ferroptosis syn pyroptosis was recently introduced as mechanistic concept in explanations of nickel (Ni) liver injury. NiCl₂ causes increased iron deposition in the liver, upregulation of cyclooxygenase 2 (COX-2) protein and mRNA expression levels, downregulation of glutathione eroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1), nuclear receptor coactivator 4 (NCOA4) protein, and mRNA expression levels. Nickel may cause hepatic injury through mitochondrial damage and ferroptosis, defined as mechanism of iron-dependent cell death, similar to glutamate-induced excitotoxicity but likely distinct from apoptosis, necrosis, and autophagy. Under discussion were additional mechanistic concepts of hepatocellular uptake and biliary excretion of mercury in exposed animals. For instance, the organic anion transporter 3 (Oat3) and the multidrug resistance-associated protein 2 (Mrp2) were involved in the hepatic handling of mercury. Mercury treatment modified the expression of Mrp2 and Oat3 as assessed by immunoblotting, partially explaining its impaired biliary excretion. Concomitantly, a decrease in Oat3 abundance in the hepatocyte plasma membranes was observed that limits the hepatic uptake of mercury ions. Most importantly and shown for the first time in liver injury caused by HMs, titanium changed the diversity of gut microbiota and modified their metabolic functions, leading to increased generation of lipopolysaccharides (LPS). As endotoxins, LPS may trigger and perpetuate the liver injury at the level of gut-liver. In sum, mechanistic and molecular steps of experimental liver injury due to HM administration are complex, with ROS as the key promotional compound. However, additional concepts such as iron used in the Fenton reaction, ferroptosis, modification of transporter systems, and endotoxins derived from diversity of intestinal bacteria at the gut-liver level merit further consideration.     

THERMOPLASTIC,FLEXIBLE, AND RECYCLABLE COMPOSITES,DESIGN, PREPARATION,AND CHARACTERIZATION

Glass fiber reinforced composites based on thermosets are the traditional materials used for many applications due to their good mechanical properties. The non-recyclability of these materials has led to the necessity to develop thermoplastic composites and industrial processes for their manufacture [1]. The present paper deals with the preparation of thermoplastic pre-pregs unidirectionally reinforced with Twarn® and their mechanical characterization.     

DUO-ICP-AES测定精对苯二甲酸中的钴、铬、铁、锰、钼、镍、钛

采用DUO-ICP-AES同时测定精对苯二甲酸中钴、铬、铁、锰、钼、镍、钛,并对仪器的分析线选择、背景校正、入射功率、雾化器压力、辅助气流量、冷却气流量、蠕动泵转速的影响及共存元素的干扰、硝酸铯灰化助剂等因素进行了详细的研究。方法的检测限:钴0.0097 mg/L;铬0.0021 mg/L;铁0.0078 mg/L;锰0.0012 mg/L;钼0.0027 mg/L;镍0.016 mg/L;钛0.0027 mg/L,回收率和精密度分别为93.0%～99.5%和0.37%～3.2%。该方法快速简便,具有良好的精密度和准确度,适用于进出口精对苯二甲酸的日常检验。     

Pd-, Ni-, Fe-, and Co-Catalyzed Cross-Couplings Using Functionalized Zn-, Mg-, Fe-, and In-Organometallics

The development of new methods for preparing polyfunctional organometallics has made a broad range of such reagents available for various transition metal-catalyzed cross-couplings. An overview of the most general preparation methods will be presented. Applications to practical cross-coupling procedures will be covered, emphasizing the functional group compatibility and the reaction scope.