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E Pfitzner R J?hne M Wissler E Stoecklin B Groner 《Canadian Metallurgical Quarterly》1998,12(10):1582-1593
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W Feng RC Ribeiro RL Wagner H Nguyen JW Apriletti RJ Fletterick JD Baxter PJ Kushner BL West 《Canadian Metallurgical Quarterly》1998,280(5370):1747-1749
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Steroid receptor coactivator-1 is a histone acetyltransferase 总被引:2,自引:0,他引:2
TE Spencer G Jenster MM Burcin CD Allis J Zhou CA Mizzen NJ McKenna SA Onate SY Tsai MJ Tsai BW O'Malley 《Canadian Metallurgical Quarterly》1997,389(6647):194-198
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CA Berrevoets P Doesburg K Steketee J Trapman AO Brinkmann 《Canadian Metallurgical Quarterly》1998,12(8):1172-1183
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S Nakajima 《Canadian Metallurgical Quarterly》1998,56(7):1717-1721
The 1,25-dihydroxyvitamin D receptor (VDR) belongs to the nuclear hormone receptor family. Mutational analysis revealed that the carboxyl-terminal region between leucine-417 and glutamic acid-420 of the human VDR is essential for the ligand-dependent transactivation. Mutant VDR at this AF-2 region exhibits only weak suppressive effect on the transactivation via the wild type receptor compared to the estrogen and vitamin A receptors, which confer the strong dominant negative effect. Using the AF-2 mutant VDR protein, we demonstrated a 65kD nuclear protein, which binds to the AF-2 region of the human VDR in a ligand dependent manner. 相似文献
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