共查询到18条相似文献,搜索用时 218 毫秒
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同时进行发酵和分离的CO2气提、活性碳吸附乙醇发酵动力学研究(二)游离细 总被引:3,自引:0,他引:3
本文研究了游离细胞连续发酵时应用CO2气提、活性炭吸附的乙醇发酵和分离动力学,考察了稀释率和进口葡萄糖浓度对发酵速率的影响,提出了包括CO2汽提乙醇速率的发酵动力学模型,研究了连续发酵时的稳态和动态过程,结果表明,CO2气提有助于减少乙醇对酵母的抑制作用,发酵动力学模型可以较好地关联稳态时的发酵动力学数据,从中获得的模型参数可以用于预测动态过程中底物,微生物及产物的变化规律。对于所研究的过程,存在着最佳稀释率和进口糖浓度以获得最大发酵速率。 相似文献
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研究了应用固定化酵母同时进行发酵和分离的CO2气提的乙醇间歇发酵和连续发酵。从实验结果发现,无论是间歇还是连续操作,无论是改变稀释率还是改变进口底物浓度,在实验范围内,发酵速率都基本上保持常数,即,固定化酵母发酵时,发醇液中少量游离酵母的影响可以忽略,固定化酵母密度在发酵过程中不会发生很大变化。由此而导出的简化模型可以满意地关联稳态操作时的实验数据,并进而推算动态响应曲线。 相似文献
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本文研究了游离细胞连续发酵时应用 CO_2气提、活性炭吸附的乙醇发酵和分离动力学,考察了稀释率和进口葡萄糖浓度对发酵速率的影响,提出了包括 CO_2汽提乙醇速率的发酵动力学模型,研究了连续发酵时的稳态和动态过程,结果表明,CO_2气提有助于减少乙醇对酵母的抑制作用,发酵动力学模型可以较好地关联稳态时的发酵动力学数据,从中获得的模型参数可以用于预测动态过程中底物、微生物及产物的变化规律。对于所研究的过程,存在着最佳稀释率和进口糖浓度以获得最大发酵速率。 相似文献
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恒速流加是一种常见的发酵操作方式。通过对该发酵过程动力学的分析,得到反应器有效体积、稀释率以及过程中细胞浓度、底物浓度、产物浓度随时间的变化关系。且提出在发酵后期系统达到拟稳态。该模型的动力学分析为实验室及工业上的应用奠定了一定的理论基础。 相似文献
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研究了用油醇为萃取剂进行丙酮/丁醇游离细胞间歇和补料间歇萃取发酵过程。结果表明,萃取发酵可以减轻产物对微生物的抑制作用,提高初始底物浓度,增加发酵速率。建立了间歇萃取发酵的动力学模型,该模型能够描述在间歇萃取发酵过程中底物、微生物、产物及pH的变化规律。 相似文献
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研究了应用固定化酵母同时进行发酵和分离的 CO_2气提的乙醇间歇发酵和连续发酵。从实验结果发现,无论是间歇还是连续操作,无论是改变稀释率还是改变进口底物浓度,在实验范围内,发酵速率都基本上保持常数,即,固定化酵母发酵时,发酵液中少量游离酵母的影响可以忽略,固定化酵母密度在发酵过程中不会发生很大变化。由此而导出的简化模型可以满意地关联稳态操作时的实验数据,并进而推算动态响应曲线。 相似文献
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生物发酵甘油生产1,3-丙二醇的自动化控制是其工业化应用亟待解决的关键问题。首先,采用数学函数连续性分析深入研究了克雷伯氏杆菌连续发酵甘油生产1,3-丙二醇过程的多稳态特性。在不同的初始甘油浓度或稀释速率下,系统均会出现多稳态现象,通过双因素分析确定了多稳态出现的临界区域,该区域内部的稳态是不稳定的。之后,基于反馈控制理论和多稳态分析结果,设计优化了受残余甘油和产物浓度影响的稀释速率控制策略。在连续发酵过程中,调整时间从81.27 h缩短到34.11 h,显著提高了发酵初期阶段甘油的利用率;同时甘油转化率由0.478 mmol·mmol-1提高至0.563 mmol·mmol-1,生产强度由85.70 mmol·L-1·h-1提高到101.10 mmol·L-1·h-1,显著提高了生产性能。 相似文献
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发酵蜣螂粉乙醇提取物抗肿瘤活性研究 总被引:1,自引:0,他引:1
目的:研究蜣螂发酵产物经乙醇回流提取对乳腺癌MCF-7细胞、肺腺癌A549细胞的抑制效果。方法:采用新型固体发酵方式对蜣螂粉进行深层加工,再经乙醇回流提取旋蒸后,用MTT法测定不同浓度的发酵蜣螂醇提物对乳腺癌MCF-7细胞和肺腺癌A549细胞的抑制率。结果:发酵蜣螂醇提物对MCF-7和A549具有较好的抑制作用,且作用强度与药物浓度成正比。其IC50分别为1.51和0.94 mg/mL。结论:蜣螂发酵产物醇提物具有一定的抗肿瘤效果,为临床用药提供新思路。 相似文献
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1 INTRODUCTIONInhibition phenomena have frequently been observed in microbial reactions.When thesubstrate concentration in the broth is high enough,the contour curve of the specificgrowth rate of cells is no longer monotonically increasing in a substrate-product phaseplane.The system exhibits a substrate inhibition.Some supersession products can affectthe growth and the yield of the cells as well as the viability of the microorganisms.Forexample,in the case of using Saccharomyces,the ethanol product inhibits the growth 相似文献
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A dynamic model for a continuous extractive fermentation process is proposed. Using this model and the Iterative Dynamic Programming algorithm, optimal operating profiles are identified for process start-up from conventional fermentation operation. Under the optimal operating profile, profit during the transient operation accumulates at a rate approaching that of steady state operation. A sensitivity analysis investigating the effect of economic variations on the overall profit function shows that optimization of manipulated variable profiles primarily reduces the impact of substrate cost, so that the profit function approaches a linear function of the product value. 相似文献
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为提高乙醇生产发酵强度,提出了同步汽提闪蒸乙醇发酵新过程。该过程集合了闪蒸发酵和汽提发酵的优点,在发酵的同时能更有效地在位分离乙醇,从而提高发酵强度。通过与普通发酵、闪蒸发酵、汽提发酵等过程进行间歇实验比较,同步闪蒸汽提发酵过程具有发酵强度高的优势;而且,采用耐高温酵母高温发酵、提高通气量、闪蒸罐的进料流速可进一步提高其发酵强度。该过程简单、高效,具有工业应用的潜力。 相似文献
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Dr.‐Ing. Hans‐Jürgen Henzler 《化学,工程师,技术》2012,84(9):1469-1481
The continuous fermentation offers in comparison to the discontinuous process a number of advantages. These include the long‐term operation with a largely constant substrate, cell mass and product concentrations and high plant productivity. In contrast there is a more sophisticated technique and the need to secure long‐term sterility. First of all the basics of the continuous fermentation for starting operation and steady‐state operation are treated. A consistently applied dimensionless formulation of the relevant relationships enables a compact and very clear presentation of the basic laws for the cell mass and product formation. The special features of the continuous fermentation with and without cell retention and fundamental aspects of the continuous fermentation with cell retention are discussed. 相似文献
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Gerda H. Schoutens Ruud P. Guit Gerard J. Zieleman Karel Ch. A. M. Luyben Nico W. F. Kossen 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1986,36(12):565-576
Continuous fermentations using Clostridium spp. DSM 2152 immobilised in calcium alginate beads to produce butanol and isopropanol from glucose were carried out in a fluidised bed reactor with liquid recycle (FBR, 10.9 dm3 working volume, 41 % solids) and in a gas lift loop reactor (GLR, 11.4 dm3 working volume, 32% solids). In the FBR in-situ produced non-coalescing gas bubbles had a negligible influence on the fluidisation pattern and the steady state results of the fermentation were in accordance with those predicted by a reactor model. The FBR was operated reliably for 5 weeks without decrease of activity. The GLR behaved as a three phase reactor because of the recycled fermentation gas. The steady state fermentation results were as predicted by the GLR model. Scale up to a 50 m3 FBR and a 65 m3 GLR led to development of a plug flow with recycle model for the FBR and a stirred tank model for the GLR. On the basis of overall reactor performance and ease of integration with a simultaneous product recovery the FBR is preferred to the GLR for application in a large scale butanol/isopropanol process using immobilised Clostridia spp. 相似文献
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原油负压稳定工艺的轻烃收率受到多个参数的影响。利用HYSYS流程模拟软件对常规负压稳定工艺进行了模拟,并分析了稳定塔操作压力及温度对轻烃收率的影响。在常规工艺基础上,引入气提技术,通过HYSYS模拟发现气提技术可以提高原油稳定深度,增加轻烃收率,同时研究了气提气量及组分对轻烃收率的影响。 相似文献