HPLC法测定叶酸片溶出度

采用高效液相色谱（HPLC）法进行叶酸片的溶出度测定。采用小杯法,色谱柱为Agilent Hypersil C18（25 cm×4.6 nm,5μm）,流动相为pH=5.0的磷酸盐缓冲液,检测波长为280 nm,流速为1.2 mL/min。结果表明,采用HPLC法测定叶酸片溶出度,分离度好,峰形对称,保留时间短,辅料不干扰,测得叶酸回收率为100.6%,RSD=1.04%（n=9）。该法简便,结果准确。     

HPLC法测定恩替卡韦片的溶出度

为建立HPLC法测定恩替卡韦片溶出度的方法。以0.05mol·L-1磷酸二氢钾溶液(用1mol·L-1的氢氧化钠溶液调节pH值为6.8)1000mL为溶出介质,转速为50r/min,取样时间30min,采用桨法测定恩替卡韦片的溶出度。结果表明恩替卡韦在0.25~0.61μg·mL-1范围内线性关系良好(R=0.9996),平均回收率为100.1%,RSD=0.29%(n=9)。该方法操作简便,结果准确可靠,辅料对溶出度测定无影响,可用于该制剂的质量控制。     

左舒必利片的溶出度测定

建立了左舒必利片溶出度的测定方法。以0.1 mol/L盐酸溶液为溶出介质,采用桨法（50 r/min）20 min取样,使用紫外-可见分光光度法测定溶出度,检测波长为291 nm,考察了溶出曲线,样品溶出度〉90%,该方法可用于左舒必利片的溶出度测定。     

头孢克肟口崩片溶出度测定方法学研究

建立了头孢克肟口崩片溶出度的测定方法。采用紫外分光光法,于波长288 nm处测定本品吸光度,计算本品的溶出度。方法的线性范围为6.05～14.11μg/mL（r=0.999 8）,平均回收率（n=9）为99.9%,RSD=0.18%。本法简便、快速、准确,可较好评价头孢克肟口崩片的质量,为其质量控制提供依据。     

马来酸左旋氨氯地平分散片溶出度测定

建立马来酸左旋氨氯地平(玄宁)分散片溶出度的测定方法.以0.1 mo1/L盐酸溶液为溶出介质,采用浆法(50 r/min)20 min取样,运用紫外-可见分光光度法测定溶出度,检测波长为237 nm,并考察了溶出曲线,样品溶出均一性良好,溶出度均＞90%,该方法可用于马来酸左旋氨氯地平分散片的溶出度的测定.     

独一味分散片的制备及质量控制

目的:利用均匀设计筛选出独一味分散片的最佳处方。方法:通过调节崩解剂的含量、粘合剂的浓度等因素,制备独一味分散片,考查崩解时限、混悬性、溶出度等因素,对处方进行筛选。结果:优化处方为A4B6C3,即维晶纤维素含量为11%,交联聚乙烯吡咯烷酮含量为15%,聚乙烯吡咯烷酮K30浓度为7%。对优选处方的试验表明:崩解时限小于3min,分散均匀性试验能通过2号筛网,混悬性较好,溶出度好。结论:本方法简单、可靠,优选处方的独一味分散片达到中国药典(2010年版)要求。     

膜生物反应器膜污染机理及其防治

介绍了近年来国内外对膜污染产生机理、数学模型及其防治方法的最新研究状况,并对膜污染防治技术研究前沿作了探讨。     

MODELING OF DRUG RELEASE FROM A SWELLABLE MATRIX

In many polymeric controlled release systems (CRSs) the drug release kinetics is mainly ruled by the penetrant absorption characteristics which, in turn, depend on the viscoelastic properties of the polymer/penetrant system. The kinetics of the drug release process can follow either a typical Fickian behavior or a non-Fickian one (anomalous release), depending on the polymer/ penetrant viscoelastic properties. The aim of this work is to model such physical evidences by means of the appropriate flux equations describing the penetrant uptake and the corresponding drug release.

As a main result of our work we prove that, by resorting to the Sarti and Camera-Roda flux equation for the penetrant, and to the Fick flux equation for the drug, it is possible to simulate both Fickian and non-Fickian drug release from swelling CRSs characterized by different viscoelastic properties of the polymer/penetrant system. Furthermore, we demonstrate that the effect of the density gradient developing inside the matrix during the drug release does not sensibly affect the drug release kinetics.     

一种钾钙肥中钾、钙的溶出行为研究

以水和一定浓度的酸溶液为浸取液,测定了钾钙肥中的钾、钙在不同振荡温度、不同振荡时间和不同pH值下的溶出率,并分析其溶出规律;模拟植物吸收养分,测定了钾、钙的累积溶出率,验证了其缓释性,为钾钙肥的使用提供依据.     

气-液-固滴流床反应器放大中的重要参数及其数学模型

介绍了在滴流床反应器放大过程中所涉及到的物理化学参数和数学模型建立的方法，并对这些参数计算的经验公式进行了综述，为滴流床反应器的模拟、放大提供了理论依据。     

盐酸二甲双胍胃漂浮缓释制剂的制备与释药过程研究

采用湿法制粒压片制备了盐酸二甲双胍胃漂浮缓释片。片剂具有良好的漂浮特性 ,药物释放可延长至 8h以上。片剂的漂浮迟滞时间随羟丙甲基纤维素质量分数的增加而降低 ,片剂密度与十八醇质量分数的关系为 :ρ =1 1 4 6 - 1 2 1 2w。采用单层桨网法对片剂的体外释放实验结果表明 ,药物的体外释放动力学符合 :Q =S[DPCP(2C0 -CP)t] 1 / 2,药物通过扩散和骨架溶蚀共同作用进行释放     

Plume model for sulphur capture in largescale,atmospheric fludized-bed combustors (AFBC)

The established plume model for the atmospheric fluidized-bed combustor is here extended to sulphur capture by bed solids. The model accounts for two mechanisms for sulphur capture: (1) the oxidation of sulphur to SO₂, followed by retention by limestone, all in the oxidizing regions of the combustor; and (2) the retention of released sulphur-hydrogen compounds by solids in the unburned plume rising through the bed. Calculations show that there is a significant difference in sulphur retention efficiency predictions between the plume model with its reducing and oxidizing zones and those models which do not consider the occurrence of plumes of unburned volatiles.     

Cellular-automata and individual-based approaches for the modeling of biofilm structures: Pros and cons

Fresh water shortage is one of the greatest problems of modern society; as a result, water desalination, particularly with membrane processes, is becoming increasingly important, since it makes possible the use of brackish water for potable water, or the reuse of lower-quality water for industrial, irrigation, or other uses. Membrane processes used in water desalination and wastewater treatment are often affected by the degradation of biofouling, in which biofilms play a critical role, thus making biofilm simulation models very relevant. Biofilms are highly complex and heterogeneous systems, containing cells distributed in a non-uniform manner in polymers. Two classes of models, the cellular-automata and the individual-based models, which are used to simulate the growth and development of biofilm structures as a result of microbial growth in different environmental conditions, are presented. After a short review of models presented in the last decade, we identify similarities and differences and present the environmental conditions that can be best simulated with each model type.     

缓释片剂的研究概况

综述了近年来缓释片剂的研究概况。目前上市的缓释片主要包括骨架缓释片、包衣缓释片、多层缓释片等。对缓释片剂的分类与制备、应用的辅料以及质量控制方法进行了介绍。     

基于油田井场的燃油在线监控系统

为了实现对油田井场柴油的实时监控,设计了一种无线式的基于油田井场的燃油在线监控系统。通过现场对柴油油罐进行实时监测,采集数据信号,经由GPRS无线通信传输到数据采集发布系统,并存储到数据库。继而通过Web服务器发布所采集的数据,实现对现场柴油的实时监控。     

炼焦生产技术中的数学模型

炼焦生产是一极其复杂的动态体系 ,该生产体系中的输出量 (诸产物的生成量和品质指标 )与输入量 (原料煤的质量指标和生产工艺指标 )之间受着多种不稳定因素的影响 .近些年 ,人们注重炼焦生产中重要数据的积累和归纳 ,尤其是进行了许多相关的实验研究 .通过对大量生产数据和实验数据的回归分析 ,总结得出了多种重要技术指标之间的数学模型 .较全面地汇总了这类数学模型 ,并根据模型依据和实践应用情况进行了分类和评述 .     

Dissolution of Polydisperse Silica Grains in Glass Melts–Analysis

By combining population balance with mass-transfer-controlled dissolution, a formulation is developed to analyze the dissolution of polydisperse silica grains in glass furnaces. For an initial lognormal distriution of particle sizes, the change in the distribution with respect to a modified time scale is expressed analytically. This paper shows how the formulation can be combined with time-temperature data along various flow path lines in a glass melter to calculate the extent of dissolution in the melter. Calculated results are presented on the dissolution of polydisperse silica grains in a glass melter for which the information on path lines was obtained by using a three-dimensional mathematical model for flow and heat transfer. The effects of maximum particle size of a truncated distribution and the standard deviation on the extent of dissolution are examined.