相转移催化合成增产胺及其类似物

制备增产胺及其类似物的一种改进方法，用相转移催化剂，１－溴－（３，４－二氯苯氧）乙烷与二乙胺在５０％ＮａＯＨ－甲苯中，于９０℃反应１２ｈ，可方便地制得增产胺１ａ，产率９２％。还用这一改进方法制取了４个增产胺类似物１ｂ～ｅ。     

含磷增产胺类似物的合成与生物活性

１－溴－２－（取代苯氧基）乙烷与二硫代磷酸酯钾盐或亚磷酸三甲酯反应，制备了含二硫代磷酸酯基或磷酸酯基的增产胺类似物共１０个新化合物。上述化合物不仅具有与增产胺类似的植物生长调节活性，而且兼具杀菌活性。     

增产胺及其类似物的合成研究

本文报道一种经济简便的制备增产胺及其类似物的改进方法。３．４－二氯苯酚与１，２－二氯乙烷在ＫＯＨ溶液中、在相转移催化剂Ｂｕ＿４Ｂｒ存在下反应，得到１－氯－２－（３，４－二氯苯氧）乙烷２＿ｂ，产率９８％。２＿ｂ与二乙胺的丙酮溶液在封管中反应得到增产胺１．，产率９５％。使用相同的方法还制备了５个具有植物生长调节活性的类似物。     

扁桃酸类杀菌剂的创制及其研究进展

介绍了扁桃酸类杀菌剂的创制及其研究进展,内容涉及双炔酰菌胺的创制过程及各大农药公司近年来以其为先导化合物设计合成的各种类似物及生物活性.扁桃酸类化合物主要用于防治番茄晚疫病、马铃薯晚疫病和葡萄霜霉病等.     

新昆虫抗保激素类似物的合成

一、前言自1967年 Roller 等对天然蚕蛾(Hyal-ophera Cecrapia)的保幼激素进行分离鉴定结构以来,国内外进行了其类似物的合成和应用的大量工作,并集中于经济昆虫的增产以及害虫防治方面的研究,取得良好效果。但是,昆虫保幼激素类似物     

增产菊胺酯对雄性小鼠生殖细胞能量代谢的影响

为了探讨增产菊胺酯对雄性生殖毒作用的机理,本文用酶组织化学的方法研究了染毒后小鼠生殖细胞琥珀酸脱氢酶(SDH)、乳酸脱氢酶(LDH)和Mg~(++)—ATP_(ase)活性均受到抑制,说明增产菊胺酯不仅干扰睾丸细胞有氧代谢及无氧代谢的供能过程,还干扰细胞对能量的利用, 能量代谢障碍可能是增产菊胺酯对雄性生殖细胞毒作用的机理之一。     

0.025%五氟磺草胺可溶性药肥粒剂的研制

[目的]筛选0.025%五氟磺草胺可溶性药肥粒剂(WSG)的配方,为药肥一体化研究提供思路。[方法]探索制备0.025%五氟磺草胺可溶性药肥粒剂的工艺;考察不同润湿分散剂、黏结剂、载体对其理化性能的影响;分析农药成分和肥料养分含量,测定WSG对直播田杂草防效及其增产效果。[结果]利用该工艺制备的WSG,强度高、崩解快,肥料与农药成分之间无拮抗退化作用,防治效果与25 g/L五氟磺草胺OD差异显著,增产效果相当。[结论]药肥一体化是农药企业发展的新方向。     

Mannich碱胺丁苯酮的合成

近年来,国外合成并筛选出一些具有生物活性的Mannich碱。想从中寻找具有抗癌活性的物质,开拓Mannich碱在药学领域的应用范围。在国内,还尚未见到有关的报道。我们参考文献[2]合成了Mannich碱胺丁苯酮[Ambuphenone,即3-二甲胺基-2-二甲胺基甲基-1-(4-甲氧基苯基)丙酮]及其类似物。     

吡啶[3,2-α]咔唑及其类似物的合成

以3-吲哚甲醛及其类似物和3-溴吡啶乙酸乙酯为原料,经过Knoevenagel缩合和Heck反应,得到了一系列的吡啶[3,2-α]咔唑及其类似物,化合物结构经熔点、LC-MS和1H-NMR确证。值得一提的是,这是一种全新的高效的合成吡啶[3,2-α]咔唑及其类似物的方法。     

增产胺的合成与应用

在相转移催化条件下，３，４－二氯苯酚和二乙氨基乙基溴合成增产胺，产率达９４％。田间实验表明，增产胺促进棉花早发，增花增蕾，提高成铃率，从而使皮棉亩产增加了３３．５６％。     

新型植物生长调节剂-- 增产胺的应用

本文报道了一种新型植物生长调节剂———增产胺在大豆、甜菜、玉米、小麦等植物的应用 ,以及不同浓度在植物生长时期的喷施对植物产量及质量的影响     

TCDCANa的合成及抗菌抗炎作用研究

以鹅去氧胆酸(CDCA)和牛磺酸为基本原料合成了牛磺鹅去氧胆酸钠(TCDCANa),以萃取和重结晶法提纯,收率63.4%,w(TCDCANa)≥92%,以TLC和IR法确定了其结构。并将牛磺鹅去氧胆酸钠与鹅去氧胆酸钠(CDCANa)进行了抗菌、抗炎和镇咳对比实验。药效实验结果为:TCDCANa和CDCANa均具有抗革兰阳性菌作用(抑菌环直径分别为2.46±0.08cm和1.91±0.13cm),抗炎作用抑制率分别为(79.1±25.4)%和(71.2±23.1)%,镇咳作用减咳率分别为(29.1±5.6)%和(18.2±6.8)%,牛磺鹅去氧胆酸钠与鹅去氧胆酸钠间存在显著性差异。药效实验表明,TCDCANa具明显的镇咳、平喘和抗菌作用,其作用强于CDCANa。     

Wetting properties of homopolymers and copolymers of pentafluorostyrene and methylacrylate and homopolymer blends

Polypentafluorostyrene (PPFS), polymethylacrylate (PMA), and poly(pentafluorostyrene-co-methylacrylate), poly(PFS-co-MA) were prepared and the wetting characteristics of polymer blends of PPFS and PMA were compared with that of poly(PFS-co-MA) via contact angle measurements. The critical surface tension of polypentafluorostyrene was found to be 22.6 dyne/cm, which is comparable to the value reported for polytrifluoroethylene (22 dyne/cm). The critical surface tension of poly(PFS-co-MA) is not linearly related to its composition. The polymer blends of PPFS and PMA exhibit significant surface enrichment of the fluoropolymer. The harmonic-mean method¹ was employed to determine surface tensions of these polymers and many known polymers. It is found that the method produces useful surface tension data provided the contact angle values are derived from testing liquids of dissimilar polarity.     

单偶氮及双偶氮苯咔唑类化合物的合成与表征

以对硝基重氮盐与N-羟基烷基咔唑作原料,用相转移催化剂十二烷基苯磺酸钠(NaDBS),通过重氮偶联反应合成了单偶氮和具有对称结构的双偶氮化合物。单偶氮:3-(4-硝基苯基偶氮基)-N-(6-羟己基)咔唑(收率28.8%)、3-(4-硝基苯基偶氮基)-N-(10-羟癸基)咔唑(收率14.2%);双偶氮:3,3-′2(4-硝基苯基偶氮基)-N-(6-羟己基)咔唑(收率25%)、3,3-′2(4-硝基苯基偶氮基)-N-(10-羟癸基)咔唑(收率11.9%)。并用红外光谱、核磁共振光谱对该4种化合物的结构进行了表征。红外谱图表明生成的产物中含有N N和NO2;核磁共振谱图中,只存在4种氢:化学位移7.1~8.8的咔唑环和苯环氢,化学位移4.3附近的—CH2—O—的氢,化学位移3.61附近的—CH2—N—的氢,以及化学位移在1.2~1.9的脂肪链上的氢。红外谱图中的特征峰及核磁共振谱图中质子的化学位移和数目证明了这4种化合物的结构。     

聚甲基环戊二烯基硅烷及其共聚物的合成与表征

用钠试剂法合成了甲基环戊二烯基二氯硅烷,采用钠缩合法将其均聚,并分别与二甲基二氯硅烷、二苯基二氯硅烷、甲基苯基二氯硅烷及甲基正丁基二氯硅烷进行共聚反应,合成了5种聚硅烷。并用IR、UV、^1H NMR、GPC和荧光光谱对它们进行了表征。     

Lipid characterization and antioxidant status of the seeds and meals of Camelina sativa and flax

Four different antioxidant activity assays including 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS), 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and oxygen radical absorption capacity (ORAC), and thiobarbituric acid reactive substances were performed on the methanolic and ethyl acetate extracts of Camelina seeds (CS), flaxseeds (FS), Camelina meal low fat (CMLF, 9.9% fat), Camelina meal high fat (CMHF, 24.6% fat), and flaxseed meal (FSM, 2.7% fat). In addition, the fatty acid profile, and phenolic, tocopherol, flavonoid, and glucosinolate contents of CS, FS, CMLF, CMHF, and FSM were studied. The major fatty acid was α‐linolenic acid (C18:3 n‐3) which was 33.2, 29.4, 30.2, 60.1, and 39.3% in CS, CMLF, CMHF, FS, and FSM, respectively. The methanolic extract of CMLF showed the highest values of ABTS, DPPH and FRAP and the highest content of phenolic compounds, flavonoids, and glucosinolates. The methanolic and ethylacetate extracts of CMHF showed the highest values for ORAC and α‐ and γ‐tocopherols. The ethylacetate extracts of seeds and meals of Camelina sativa and flax showed lower values for antioxidant activity, phenolic compounds, and flavonoids than the methanolic extracts. In general, Camelina and FS meals showed higher antioxidant activities, and phenolic and flavonoid contents than their respective seeds. Practical applications: Camelina sativa seeds (CS) and flaxseeds (FS) are rich sources of omega 3 oils. Their by‐products after oil extraction are an attractive source of proteins, lipids, fiber, and natural bioactive compounds such as antioxidants. These by‐products may be used to improve nutritional value and prevent lipid oxidation in feed or food systems.     

丙烯酸松香加成物与GMA酯化物的合成与表征

以丙烯酸松香加成物（RA）和甲基丙烯酸缩水甘油酯（GMA）为单体,三乙胺为催化剂,对苯二酚为阻聚剂,在有机溶剂甲苯中合成了RA与GMA酯化物（RAG）,采用单因素和正交试验对酯化反应进行优化。通过傅里叶变换红外光谱（FT-IR）、凝胶渗透色谱（GPC）、黏度计、核磁共振氢谱（¹H NMR）和热重（TG）对酯化物进行了分析与表征。结果表明,RA与GMA酯化物较优合成条件为n_GMA：n_RA=2：1,三乙胺用量为RA质量的0.5%,120℃下反应4 h,该条件下合成的酯化物为深黄棕色澄清液体,酯化率为99.5%,数均相对分子质量为547,重均相对分子质量为848,25℃下测得其质量分数51%甲苯溶液的黏度为10 mPa·s。FT-IR和¹H NMR分析表明成功合成了RA与GMA酯化物。TG分析表明酯化物热稳定性高于丙烯酸松香加成物。     

松香/GMA酯化物的自聚与共聚

利用松香与甲基丙烯酸缩水甘油酯(GMA)进行酯化反应,得到酯化产物(RG),然后进行了RG的自聚反应和与苯乙烯的共聚反应.利用红外光谱对产物结构进行表征,热重分析产物的热稳定性,差示扫描量热法测试产物的玻璃化转变温度,研究单体配比、反应温度、引发剂种类对RG与苯乙烯共聚反应产物分子量及其分布的影响.实验结果表明:成功合成了自聚物和共聚物;偶氮二异丁腈是共聚和自聚反应较优的引发剂;与苯乙烯共聚反应中,随着温度的升高,共聚物分子量增加,分子量分布变窄,随着苯乙烯用量的增大,共聚物分子量下降,分子量分布变宽;自聚物和共聚物的初始分解温度相近,但共聚物最大分解温度较高;共聚物的玻璃化转变温度高于自聚物.     

Comparison of the chemical properties of iron and cobalt porphyrins and corrins

Density functional calculations have been used to compare various geometric, electronic and functional properties of iron and cobalt porphyrin (Por) and corrin (Cor) species. The investigation is focussed on octahedral M(II/III) complexes (where M is the metal) with two axial imidazole ligands (as a model of b and c type cytochromes) or with one imidazole and one methyl ligand (as a model of methylcobalamin). However, we have also studied some five-coordinate M(II) complexes with an imidazole ligand and four-coordinate M(I/II) complexes without any axial ligands as models of other intermediates in the reaction cycle of coenzyme B12. The central cavity of the corrin ring is smaller than that of porphine. We show that the cavity of corrin is close to ideal for low-spin Co(III), Co(II), and Co(I) with the axial ligands encountered in biology, whereas the cavity in porphine is better suited for intermediate-spin states. Therefore, the low-spin state of Co is strongly favoured in complexes with corrins, whereas there is a small energy difference between the various spin states in iron porphyrin species. There are no clear differences for the reduction potentials of the octahedral complexes, but [Co(I)Cor] is more easily formed (by at least 40 kJ mole(-1)) than [Fe(I)Por]. Cobalt and corrin form a strong Cobond;C bond that is more stable against hydrolysis than iron and porphine. Finally, Fe(II/III) gives a much lower reorganisation energy than Co(II/III); this is owing to the occupied d(z2) orbital in Co(II). Altogether, these results give some clues about how nature has chosen the tetrapyrrole rings and their central metal ion.