铜-镥无机抗菌材料的制备研究

采用溶胶-凝胶法制备出含镥铜型无机抗菌材料。通过单因素实验得到较佳的制备条件,运用傅里叶变换红外光谱仪(FTIR)、X射线衍射仪(XRD)、扫描电镜(SEM)对制备出来的铜-镥无机抗菌材料进行表征;并对不同条件下制备出的材料进行比较。结果表明,在Lu3+浓度为0.005mol/L,反应时间为1h,反应温度为90℃的条件下所制备的材料,结构松散,分散性好;粒径分布为3～6μm,且均一。     

铜、银双组分无机抗菌材料的制备和性能研究

采用溶胶-凝胶法制取白炭黑载体,在一定条件下,将具有杀菌性能的Cu2 、Ag 附着在白炭黑载体上,制得含Cu2 、Ag 双组分杀菌活性成分的无机粉体抗菌材料.运用ICP、粒度分布仪和FTIR等手段对材料中抗菌离子含量、粒度以及抗菌离子与载体的结合方式等进行了表征.并利用菌落计数法对材料的抗菌性能进行研究.结果表明,Cu-Ag双组分抗菌白炭黑中,抗菌离子含量高于单组分抗菌白炭黑;其中,Cu2 是通过离子交换方式结合到白炭黑上的,而Ag 是通过离子交换和吸附两种方式结合到白炭黑上;材料的杀菌率达99%以上;粒径＜7μm且均一.     

银型抗菌白炭黑的改性研究

通过添加表面活性剂和有机溶剂对银型抗菌白炭黑进行改性研究。运用ICP、粒度分布仪对改性后银型抗菌白炭黑中抗菌离子含量、粒度分布进行表征;利用菌落计数法对改性后材料的抗菌性能进行研究;并与未改性的银型抗菌白炭黑进行比较。结果表明,改性后的银型抗菌白炭黑中抗菌离子含量高于未改性前;结构较改性前松散,且分散性好;粒径主要分布在3~6μm且均一;具有较好的热稳定性和光稳定性。     

无机抗菌材料的发展和应用

介绍了离子型抗菌材料、光催化抗菌材料等无机抗菌材料的发展现状、抗菌机理和应用情况等。     

新型无机抗菌材料:载铜蒙脱石及其抗菌机理讨论

以内蒙赤峰蒙脱石为原料合成了载铜蒙脱石,它对革兰氏阴性菌E.coli和革兰氏阳性菌S.faecalis均有很强的抑止和杀灭作用,其抗菌能力大大优于载铜沸石,蒙脱石在载铜反应后矿物表面带有剩余正电荷,它的抗菌能力来自两方面因素,一方面是矿物对带相反电荷的细菌的吸附作用,另一方面是矿物释放出的铜离子对细茵的杀灭作用,这是载铜蒙脱石抗菌能力优于载铜沸石的本质原因。     

新型无机抗菌材料的研究进展

介绍了具有无毒、抗菌功效持久等特点的无机抗菌剂的研究进展,主要介绍其抗菌机理、抗菌特点以及无机抗菌材料的应用领域与前景,提出了该类材料今后的研究和发展方向.     

无机粉体抗菌材料的研究进展

无机抗菌剂由于其独特的性能而成为当前抗菌材料领域的研究开发热点.本文对无机抗菌剂的分类、制备方法、抗菌机理及应用进行了综述,并结合应用现状讨论了无机粉体抗菌材料的发展前景及存在的问题.     

聚氨酯抗菌材料表面等离子体改性研究

本文采用低温等离子体技术，对环丙沙星抗菌生物材料表面进行改性处理。经药物释放动力学的测试和灭菌效果试验表明，该材料具有较长的药物缓释周期和很好的抗菌活性。     

银系无机抗菌材料研究进展

系统论述了国内外银系无机抗菌材料的研究和应用现状,重点介绍了纳米银颗粒和载银型两类无机抗菌材料,包括它们的种类、制备方法、抗菌机理及其在各种制品中的应用等。纳米银无机抗菌材料制备方法主要有物理法、化学法和生物法,载银型无机抗菌材料根据载体不同分为沸石、蒙脱石、可溶性玻璃、羟基磷灰石和磷酸盐等类型。银系无机抗菌材料在医疗用品、陶瓷、塑料、涂料等制品上已得到大量应用,但其潜在毒性和生物安全性还有待进一步关注。最后提出了银系无机抗菌材料还需深入研究的问题和今后的发展前景。     

铜型抗菌白炭黑的改性研究

通过添加表面活性剂和有机溶剂对铜型抗菌白炭黑进行改性研究.并运用ICP、粒度分布仪对改性后铜型抗菌白炭黑中抗菌离子含量、粒度进行了表征;利用菌落计数法对改性后材料的抗菌性能进行了研究;并与未改性的铜型抗菌白炭黑进行比较.结果表明,改性后的铜型抗菌白炭黑中,抗菌离子含量高于未改性前;结构较改性前松散,且分散性好;平均粒径为3μm且均一;杀菌率达99%以上.具有较好的热稳定性和光稳定性.     

Synthesis,characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Iron oxide nanoparticles (IONPs) were synthesized by coprecipitation of iron salts in alkali media followed by coating with glycol chitosan (GC-coated IONPs). Both bare and GC-coated IONPs were subsequently characterized and evaluated for their antibacterial activity. Comparison of Fourier transform infrared spectra and thermogravimetric data of bare and GC-coated IONPs confirmed the presence of GC coating on IONPs. Magnetization curves showed that both bare and GC-coated IONPs are superparamagnetic and have saturation magnetizations of 70.3 and 59.8 emu g⁻¹, respectively. The IONP size was measured as ∼8–9 nm by transmission electron microscopy, and their crystal structure was assigned to magnetite from x-ray diffraction patterns. Both bare and GC-coated IONPs inhibited the growths of Escherichia coli ATCC 8739 and Salmonella enteritidis SE 01 bacteria better than the antibiotics linezolid and cefaclor, as evaluated by the agar dilution assay. GC-coated IONPs showed higher potency against E. coli O157:H7 and Staphylococcus aureus ATCC 10832 than bare IONPs. Given their biocompatibility and antibacterial properties, GC-coated IONPs are a potential nanomaterial for in vivo applications.     

Synthesis,characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Abstract

Iron oxide nanoparticles (IONPs) were synthesized by coprecipitation of iron salts in alkali media followed by coating with glycol chitosan (GC-coated IONPs). Both bare and GC-coated IONPs were subsequently characterized and evaluated for their antibacterial activity. Comparison of Fourier transform infrared spectra and thermogravimetric data of bare and GC-coated IONPs confirmed the presence of GC coating on IONPs. Magnetization curves showed that both bare and GC-coated IONPs are superparamagnetic and have saturation magnetizations of 70.3 and 59.8 emu g^?1, respectively. The IONP size was measured as ～8–9 nm by transmission electron microscopy, and their crystal structure was assigned to magnetite from x-ray diffraction patterns. Both bare and GC-coated IONPs inhibited the growths of Escherichia coli ATCC 8739 and Salmonella enteritidis SE 01 bacteria better than the antibiotics linezolid and cefaclor, as evaluated by the agar dilution assay. GC-coated IONPs showed higher potency against E. coli O157:H7 and Staphylococcus aureus ATCC 10832 than bare IONPs. Given their biocompatibility and antibacterial properties, GC-coated IONPs are a potential nanomaterial for in vivo applications.     

Synthesis of Ag modified vanadium oxide nanotubes and their antibacterial properties

Vanadium oxide nanotubes (VO_x-NTs) modified by highly dispersed Ag nanoparticles have been synthesized via a facile silver-mirror reaction. The crucial factors that affected the preparation of the Ag modified vanadium oxide nanotubes (Ag/VO_x-NTs) have been also studied. The dispersion and structure of Ag nanoparticles in the obtained materials were characterized by transmission electron microscopy (TEM), electron diffraction (ED) and X-ray diffraction (XRD). The results showed the distribution and size of the formed Ag particles were greatly influenced by the concentration of AgNO₃ solution. Typically, Ag nanoparticles were well dispersed on the VO_x-NTs with the size range from 3 to 10 nm. The corresponding antibacterial tests demonstrated the as-synthesized Ag/VO_x-NTs exhibited strong antibacterial activity against Escherichia coli (E. coli).     

可控降解抗感染材料的合成和表征

在聚己内酯(PCL)与六亚甲基二异氰酸酯(HDI)缩合体系中加入抗菌药物环丙沙星(CF),制备CF嵌入聚氨酯(PU)主链的聚氨酯前药CFPU。用UV、FTIR、H-NMR表征其结构;GPC法测定分子量;UV法测定载药率;摸索影响其分子量和载药率的主要因素;并用琼脂稀释法测定其胆固醇酯酶(CE)降解液对金黄色葡萄球菌的抗菌活性。结果表明,确已成功制得目标产物;PCL浓度和HDI加料方式分别对其平均分子量和载药率有较大影响;而其CE降解液对金黄色葡萄球菌具有抗菌活性。因此,当其用作医用内植物的涂层材料时,能被炎症组织所分泌的CE可控降解为这种具抗菌活性的降解液,从而可发挥抗感染作用。     

主链型偶氮苯改性聚芳酰胺的合成及表征

在以N,N二甲基乙酰胺为溶剂,三乙胺为酸吸收剂的条件下,将自制的反式-4,4'-偶氮苯二甲酰氯与对苯二胺进行低温缩聚反应,合成了1种新型的反式偶氮苯聚芳酰胺.用红外光谱、示差热扫描量热分析,热重分析,偏光显微镜,紫外光谱对其结构及性能进行了表征.合成的聚合物表现出了一定的结晶性能,聚合物的稀溶液呈现出溶致液晶行为.     

Synthesis and characterization of ZnO tetrapods for optical and antibacterial applications

ZnO tetrapods have been grown by sublimation process employing thermal evaporation at 950 °C on quartz substrate. The grown ZnO tetrapods exhibited noteworthy microstructure, phase formation, emission bands and antibacterial performance. A detailed micro- and nano- analysis supported with analytical measurements elucidated the faceted tetrapod growth with hexagonal wurzite crystal structure of ZnO. Each arm of the tetrapod revealed a facetted hexagonal cross-section with uniform length and diameter. The photolumiscence spectra showed engrossing optical properties with pre-dominant green emission completely overwhelming the near band edge (NBE) UV peak. These fascinating tetrapod objects responded well for antibacterial activity against Escherichia coli and Staphylococcus aureus.     

Synthesis and characterization of inorganic fullerene-like WSe2 material

Abstract

Lately M0S₂ and WS₂ fullerene-like nanoparticles, generically termed inorganic fullerene-like (IF) materials, were reproducibly obtained by gas phase^4,6 and solid state⁶ reactions and the growth mechanism of such structures was elucidated⁶. the present work deals with the synthesis of IF-WSe₂ from tungsten oxide and selenium vapors. Thermodynamic calculations of the sulfidization and selenization processes are provided, and indicate salient differences between the two processes. Notwithstanding, the growth model of IF-WSe₂ is similar to that of sulfide fullerene-like material. the IF-WSe₂ was characterized by X-ray powder diffraction, transmission electron microscopy and high resolution transmission electron microscopy.     

新型药物载体材料——端羟基聚(丙交酯-co-对二氧环己酮)的合成与表征

聚乳酸(PLA)作为药物载体材料存在因疏水性强而导致的药物释放速率难控以及在循环系统中停留时间短等问题.研究表明,在PLA中引入乙醇酸(GA)可提高材料降解速率,引入聚乙二醇(PEG)则可延长共聚物在循环系统中的停留时间.研究以丙交酯(LA)和对二氧环己酮(PDO)为主要原料,在辛酸亚锡-乙二醇共引发体系的存在下,通过熔融开环聚合制备出了端羟基聚(丙交酯-co-对二氧环己酮)(HO-P(LA-co-PDO)-OH).这种同时具有PLA、GA和EG结构单元的大分子二醇可望成为一种降解速率可控、在循环系统中停留时间可调的新型药物载体材料.采用DSC、~1H NMR、~(13)C NMR和GPC-MALLs等对其结构和热学性能进行了表征.分子量检测结果表明,HO-P(LA-co-PDO)-OH的分子量随原料中PDO/LA摩尔比的减小而增大.     

Synthesis and characterization of inorganic fullerene-like WSe2 material

Lately M0S₂ and WS₂ fullerene-like nanoparticles, generically termed inorganic fullerene-like (IF) materials, were reproducibly obtained by gas phase^4,6 and solid state⁶ reactions and the growth mechanism of such structures was elucidated⁶. the present work deals with the synthesis of IF-WSe₂ from tungsten oxide and selenium vapors. Thermodynamic calculations of the sulfidization and selenization processes are provided, and indicate salient differences between the two processes. Notwithstanding, the growth model of IF-WSe₂ is similar to that of sulfide fullerene-like material. the IF-WSe₂ was characterized by X-ray powder diffraction, transmission electron microscopy and high resolution transmission electron microscopy.     

Synthesis and characterization of dextran-capped silver nanoparticles with enhanced antibacterial activity

Dextran-capped silver nanoparticles were synthesized by reducing silver nitrate with NaBH4 in the presence of dextran as capping agent. The characters of silver nanoparticles were investigated using UV-Vis spectrophotometer, nano-grainsize analyzer, X-ray diffraction, and transmission electron microscopy. Results showed that the silver nanoparticles capped with dextran were in uniform shape and narrow size distribution. Moreover, compared with polyvinylpyrrolidone (PVP)-capped silver nanoparticles, the dextran-capped ones possessed better stability. Antibacterial tests of these silver nanoparticles were carried out for Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Results suggested that the dextran-capped silver nanoparticles had high antibacterial activity against both Gram-positive and Gram-negative bacteria. In addition, the cytotoxicity in vitro of the dextran-capped silver nanoparticles was investigated using mouse fibrosarcoma cells (L929). The toxicity was evaluated by the changes of cell morphology and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Results indicated that these silver nanoparticles had slight effect on the survival and proliferation of L-929 cells at their minimal inhibitory concentration (MIC). After modified by dextran, the physiochemical properties of the silver nanoparticles had been improved. We anticipated that these dextran-capped silver nanoparticles could be integrated into systems for biological and pharmaceutical applications.