去屑产品的新方向

介绍了头屑形成的原因,包括真菌的增殖、炎症的产生及去屑产品中致痒致干燥成分;综述了去屑产品的新方向,包括使用杀菌剂抑制马拉色菌的过度增殖、添加止痒成分预防头皮炎症的发生、使用具有保湿效果的表面活性剂、使用不易积聚的成分;最后对未来去屑产品的发展趋势进行了展望。     

香波中祛屑剂和防脱剂的应用

分析了头屑和脱发产生的主要原因以及香波中祛屑剂和防脱剂的祛屑、防脱作用机理,对当前香波中使用的祛屑剂、防脱剂的类别,特别是对一些具有祛屑、防脱应用价值的天然植物作了介绍。     

基于图像分析技术的发用产品去头屑功效定量评价研究

为探讨头屑图像分析技术在发用产品去屑功效定量评价中的应用,采用随机、双盲、自身对照的试验设计,基于半头测试的原则,通过头屑图像分析技术以及头屑分级评分方法,对两种市售香波的去屑效果进行评价。头屑图像分析结果清晰显示出,随着去屑香波A和B使用时间的延长,头屑量均逐渐减少,且香波A的去屑效果明显优于香波B,此结果与分级评分法所得结果一致。研究表明,应用头屑图像分析技术定量评价头屑量的变化,可以直观、准确评价发用产品的去屑效果,同时具有易于标准化、科学客观的优势,具有良好的行业推广前景。     

洗发水中去屑剂、有效物和表面活性剂调查

研究考察了78批次去屑洗发水中去屑剂(水杨酸、酮康唑、氯咪巴唑、吡罗克酮乙醇胺盐、二硫化硒和吡啶硫酮锌)的含量和44批次普通洗发水中有效物和表面活性剂的含量,结果表明绝大多数去屑剂和有效物的含量符合标准要求。吡啶硫酮锌是最常用的去屑剂,使用率达52.6%,其次是氯咪巴唑。44批次普通洗发水中有效物、阴离子和非离子表面活性剂的平均含量分别为14.1%、10.3%和2.2%,非知名品牌洗发水的平均有效物和表面活性剂含量低于名牌产品,宾馆用品则低于市售产品。     

Natural Polyphenols Selectively Inhibit β‐Carbonic Anhydrase from the Dandruff‐Producing Fungus Malassezia globosa: Activity and Modeling Studies

Around 50 % of the worldwide population is affected by dandruff, which is triggered by a variety of factors. The yeast Malassezia globosa has been labeled as the most probable causative agent for the onset of dandruff. The β‐carbonic anhydrase (CA) of MgCA was recently validated as an anti‐dandruff target, with its inhibition being responsible for in vivo growth defects in the fungus. As classical CA inhibitors of the sulfonamide type give rise to permeability problems through biological membranes, finding non‐sulfonamide alternatives for MgCA inhibition is of considerable interest in the cosmetic field. We recently screened a large library of human (h) CA inhibitors for MgCA inhibition, including different chemotypes, such as monothiocarbamates, dithiocarbamates, phenols, and benzoxaboroles. Herein, we expanded the research toward new MgCA inhibitors by considering a set of natural polyphenols (including flavones, flavonols, flavanones, flavanols, isoflavones, and depsides) that exhibited MgCA inhibitory activity in the micromolar range, as well as selectivity for the fungal isozyme over off‐target human isoforms. The binding mode of representative derivatives within the MgCA catalytic cleft was investigated by docking studies using a homology‐built model.     

个人洗护用品配方原理及应用技术(Ⅰ)--洗发香波的配方原理及其性能评价

通过介绍洗发香波的配方原理并结合作长期在该领域工作所取得的一些经验和体会来重点阐明：决定洗发香波使用效果(调理效果)的调理剂选择和使用；决定洗发香波品质稳定和货架周期的黏度稳定剂选择和使用；决定洗发香波去屑效果的去屑剂选择和使用；以及如何评价调理剂、去屑剂和黏度稳定剂的使用性能和相关的测试方法介绍。     

Pharmakologie der Hautoberflächenlipide

Pharmacology of Skin Surface Lipids Influence of drugs on the amount and composition of lipids of skin, scalp and hair is reviewed. Drugs can influence the amount of lipids, the liberation of free fatty acids from triglycerides and the ratio of sebaceous gland lipids and epidermal lipids. A reduction in the content of free fatty acids and the amount of lipids is indicative of a favorable influence on Acne vulgaris and Seborrhoea oleosa capitis. A reduction in the amount of epidermal lipids indicates favorable influence on dandruff. A number of drugs show undesirable side effects with respect to the amount and composition of lipids.     

中草药系列洗发香波工艺技术开发

洗发香波属于发用化妆品。中药洗发香波的生产近年来发展较快,产品琳琅满目。介绍了中草药洗发香波的产品现状,中草药在洗发香波中的作用、中草药对洗发香波性能的影响、中草药的制取方法等;研究了洗发香波中表面活性剂的特点和使用方法。通过大量实验,合成了生发防脱发洗发香波、防晒洗发香波、乌发洗发香波、去屑止痒洗发香波等系列中草药洗发香波。     

洗发露去屑效果检测评价方法的建立及应用研究

通过对引起头皮屑的马拉色氏菌菌群进行分离、培养和鉴定试验,建立了洗发露去屑效果的抑菌环试验体外评价方法,为研制新的去屑洗发产品提供一种新的评价手段。     

无机盐复配对马拉色菌的抑菌作用研究

寻找一种无副作用洗发水祛屑和防腐二合一添加剂,通过NaC l与ZnSO4、ZnC l2、MgSO4和MgC l2等无机盐复配体系抑制马拉色菌和化妆品腐败菌的作用表明,当总无机盐含量在8%,NaC l与0.05%的锌盐复配时,能有效地杀死导致产生头皮屑的马拉色菌落和抑制洗发水腐败菌落的生长,抑菌效果达国家优级标准,可以作为洗发产品良好的添加剂。     

反相高效液相色谱法测定去屑香波中去屑止痒剂Octopirox的含量

采用反相高效液相色谱法测定了香波中去屑止痒剂Octopirox。在Symmetry C18(5um,4.6mmi.d.X250mm)色谱柱上,以[乙腈：水（含0.02mol磷酸和0.5mmolEDTA二纳）]=70：30的溶液为流动相,流速为0.8mL/min,紫外检测波长为305nm,柱温为35℃下检测,样品用流动相搅拌、超声提取,回收率为97.2%-98.3%,样品测试相对偏差为0.1%-0.4%。具有操作简便,分析速度快和重复性好等特点。     

天然蛋白去屑止痒剂在化妆品中的应用与展望

概述了头皮屑及其形成的机理,同时介绍了新型去屑止痒剂——天然蛋白去屑止痒剂的产品性能及其在日化行业中的应用情况,并对该产品在日化行业中的应用进行了展望。     

无患子洗发香波的配制与性能研究

以无患子提取液作配制功能成分配制洗发香波,其与洗发香波中的其他组分相容性好,能有效地提高洗发香波的调理性能,尤其能增强去屑、抗菌、止痒效果。测试的各项理化指标达到或超过国家标准。经比较,无患子洗发香渡的总体性能稍高于国内普通的中草药洗发香波,与国外名牌洗发香波相比具有药理作用。     

含去屑止痒剂甘宝素香波的流变性研究

通过实验,研究了pH值、氯化钠对含甘宝素香波的流变性的影响关系,结果表明w（甘宝素）=0.8%,w（氯化钠）=0%,pH值为5.0时,香波体系的粘度最佳。关键词     

Über die Wirkung von Haarwässern auf die Kopfhaut- und Haarlipide unter besonderer Berücksichtigung des Wirkstoffes Dexamethason und der Grundlage Isopropylalkohol

Action of Hair Lotions on Scalp and Hair Lipids with Special Consideration of the Active Substance Dexamethason and Isopropyl Alcohol as the Base Five standardized hair washes have been carried out at weekly intervals on 14 male test persons. In the 2nd and 3rd week 70% isopropyl alcohol was applied as a hair tonic every second day. In the 4th and 5th week the same procedure was followed but 0.01% dexamethasone was added to the isopropyl alcohol. In the 1th, 3rd and 5th week gravimetrical and thin layer chromatographical lipid analyses were performed on the 7th day after hair washing immediately before the next wash. Isopropyl alcohol causes a great decrease in the free fatty acids to the advantage of the triglycerides. Dexamethasone induces a reduction in the epidermal lipids contained in the mixture of scalp and hair lipids. It may thus be assumed that dexamethasone in the above composition is suitable for the treatment of dandruff.     

Analyse von Cremes und Lotionen unter besonderer Berücksichtigung von Sonnenschutzpräparaten

Analysis of Creams and Lotions with Respect to Sun Protecting Products At first the analysis of creams and lotions by saponification is described. The unsaponifiable and the saponifiable matter as well as the acid aqueous fraction are further analized by GC. Without saponification the separation can be done by HPLC using columns with silica gel as stationary and n-hex-ane/ethylacetate (97:3) as liquid phase. Hydrocarbons, fatty acid esters, triglycerides and fatty alcohols can be separated from each other and from emulsifiers on basis of nonionic ethoxylated surfactants and quantitatively determined. By the same method also the uv-absorbers of water free or emulsified suntan preparations can be identified and determined. This can be done in one working operation, if a uv/vis-spectrophotometer and a differential refractometer are arranged one after another. For the separation and determination of the uv-absorbers of suntan preparations which are water soluble also a HPLC method is used but with reversed phase column and methanol/water as eluens.     

去屑洗发产品调查分析

通过对国内去屑类洗发产品现状、去屑剂使用种类及安全性、发展趋势进行调查比较,获得国内去屑类洗发产品去屑剂的使用情况,对健康发展规范化妆品行业提出了监管建议。     

Praxisnahe Bestimmung von Wärmeübergangskoeffizienten an Körpern unterschiedlicher Geometrie

A simple method is presented by which the mean heat transfer coefficient at arbitrary geometries in a steady flow field can be determined. It is based on the measurement of the time dependent temperature and an evaluation that takes into account the conservation of thermal energy. For spheres of various sizes the method is exemplified demonstrating that the results agree well with those from the heat transfer literature.     

头皮屑发生机理及头皮生物化学变化研究进展

综述了头皮脂膜与微生态、头皮屏障功能以及头皮生物化学变化等研究成果,总结出头皮屑人群与健康人群在头皮微生态、头皮皮脂分泌、皮脂组分及屏障相关蛋白质和脂质等方面的差异。推断皮脂分泌、屏障受损、微生态失衡这三种主要因素之间可能的相互作用关系,为更加科学有效的去屑洗发剂的研发提供新思路。     

Einfluß von Wachsen auf Haft- und Gleitreibung

Influence of Waxing on Adhering and Sliding Friction A new method has been developed for determining the adhering and sliding friction. By this method, the influence of the films of caring agents on the nonskid properties can be determined very accurately. Novel finding of the present work is that by multiple measurements and mathematical-statistical evaluation valid statements can be made on the nonskid properties of floors. Furthermore, it could be shown that, in the rule, ester waxes have a positive effect on the nonskid properties.