双色互变电子墨水微胶囊的制备以及性能研究

十八胺改性的酞菁绿G和经过改性的TiO2作为显示颗粒配制电泳液,使用明胶-阿拉伯树胶复合凝聚法制备了双色互变的电子墨水微胶囊。通过电镜照片证明,改性以后的酞菁绿G颗粒粒径变小,而且它们在四氯乙烯中的分散性能良好。对电泳液进行微胶囊化处理,电泳颗粒在微胶囊中均匀分散,调节搅拌速度以及SDS等条件,获得了表面光滑,大小均一且无粘连的电子墨水微胶囊。在E=20V/μm电场作用下,电子墨水微胶囊实现了双色互变,微胶囊中的电泳颗粒具有良好的电场响应特性。     

复凝聚法制备磁性微胶囊及其磁响应特性

采用复凝聚法,以亲油改性的纳米Fe3O4为磁性颗粒,白油为分散介质,明胶、阿拉伯胶为壁材,在不同工艺条件下制备磁性微胶囊.通过激光粒度分析仪测试微胶囊的粒径及粒径分布,采用光学显微镜和扫描电子显微镜(SEM)观察微胶囊的表面形貌及分散状态,借助磁铁和振动样品磁强计(VSM)测试微胶囊的磁响应性能.结果表明,反应溶液pH=3.8、芯壁比1∶1时,微胶囊收率最高;搅拌速率为600r/min时,微胶囊的粒径分布最均匀;在pH=3.8、芯壁比1∶1、搅拌速率600r/min条件下制备的微胶囊形状规整性及单分散性好,且囊壁透明、表面光滑,具有良好的磁响应性能,可应用于磁泳显示和靶向药物传输领域.     

响应面优化法研究蔗糖苯酚树脂胶粘剂的合成

以蔗糖代替甲醛,在碱性条件下合成了一种环保型蔗糖苯酚树脂胶粘剂.用响应面优化法对蔗糖苯酚树脂的合成条件进行了优化,以树脂黏度作为考察指标,根据中心复合的设计原理对实验进行设计并对结果进行分析.研究了温度、时间、糖酚比和催化剂用量对反应的影响,得到最佳工艺条件为:反应温度95.63℃,反应时间5.26h,糖酚比2.6,催...     

卵磷脂对磁性微胶囊性能的影响

以亲油性的TiO2和Fe3O4为显示颗粒,SDS,span80为乳化剂,变压器油为分散介质,卵磷脂为分散剂,制备了分散性良好的悬浮液.以上述悬浮液为囊芯材料,明胶-阿拉伯树胶为壁材,采用复合凝聚法制备了磁性微胶囊.实验发现,卵磷脂对多相囊芯的稳定和乳化有促进作用,滴酸速度、搅拌速度、SDS及卵磷脂的量影响微胶囊大小及成...     

电子墨水微胶囊的制备及性能研究

微胶囊电泳显示电子墨水技术（EPID）是实现柔性显示的重要技术之一。电子墨水的微胶囊化，在一定范围内有效改善了电子墨水的稳定性问题。本文以联苯胺黄PY14为显色颗粒，分散蓝BF为背景色染料，四氯乙烯和二甲苯为混合溶剂，聚丁烯琥珀酰氨PIBI为电荷控制剂制备电泳显示液。以明胶一阿拉伯树胶为壁材，采用复凝聚法将电泳显示液微胶囊化，制得颗粒饱满圆滑，壁材透射率高，保存时间长，柔韧性好的电子墨水微胶囊。并制作了对比度高，响应快的电泳显示原理型器件。用密度仪测试，显微镜观察，粒度仪测试粒径分布的方法，研究确定了微胶囊制备过程中影响微胶囊形貌的主要因素。     

烟用甜味接装纸三氯蔗糖甜味稳定性影响因素研究

目的 考察烟用甜味接装纸中影响三氯蔗糖的稳定性的因素,为制备出更稳定的甜味接装纸提供参考。方法 通过模拟卷烟过程中,卷烟机的辊子与接装纸的摩擦,以及烫金温度对甜味接装纸甜味稳定性的影响来探究影响甜味接装纸甜味稳定性的原因,同时,通过调整光油的性质和品牌、甜味剂用量、扫描电镜探究光油对三氯蔗糖甜味接装纸甜味稳定性的影响。结果 水性光油的衰减周期为75 d,衰减率最大为78.64%,醇性光油为溶剂的甜味接装纸衰减周期大于105 d,衰减率最大值为15.34%,立美特光油作溶剂比使用其他品牌光油在甜味剂衰减上要更加缓慢,最大衰减率为16.70%。以醇性光油作为溶剂时,甜味剂用量为12 kg/t的甜味与水性光油为溶剂时的甜味剂用量为8 kg/t的甜味接装纸甜味相近。结论 温度是造成以水性光油为溶剂的甜味接装纸甜味损失的重要原因,烘箱法可以作为一种快速检测甜味接装纸甜味衰变过程的检测方法。醇性光油为溶剂的甜味接装纸具有很好的稳定性,通过表征分析,醇性光油将甜味剂包裹,唾液不断将包裹住的甜味剂不断释放,甜味渐渐明显。     

明胶-阿拉伯树胶基电子墨水微胶囊的制备及其显示性能

以明胶-阿拉伯树胶为壁材,Span80为稳定剂,四氯乙烯为分散介质,聚甲基丙烯酸甲酯(PMMA)表面改性的TiO2为显示颗粒,采用复凝聚法制备了红白显示电子墨水微胶囊,研究了SDS对所制备电子墨水微胶囊的影响,并将微胶囊涂覆在ITO玻璃上,制成电子墨水显示原型器件.在直流电场驱动下,电子墨水显示原型器件实现了文字显示.     

微胶囊的制备与应用

概述了微胶囊的发展及其应用，介绍了界面聚合法、原位聚合法、水（油）中相分离法、溶液干燥法、气相表面聚合法、喷雾干燥法造次我种微胶囊的制备方法及其原理，并就其应用中应注意的问题提出了建议。     

毒死蜱/脲醛树脂微胶囊的制备工艺优化及缓释动力学

随着人们健康与环保意识的不断加强,农药施用量大、效率低、高残留等问题日益受到人们的重视,对农药进行微胶囊化,有助于有效解决当前农药使用过程中所面临的问题。采用脲醛树脂作为壁材,以十二烷基硫酸钠为乳化剂,采用原位聚合法制备毒死蜱/脲醛树脂微胶囊。研究了乳化剂种类和用量、pH值、酸化时间对微胶囊粒径及其分布的影响,并进一步探讨微胶囊的载药量、包封率及释放动力学。结果表明,采用3%(质量分数)的十二烷基硫酸钠为乳化剂,在酸化时间为90min、酸化终点pH值为2.5、搅拌速度为1 200r/min、芯壁比为1∶3、固化温度为60℃时,所制备的毒死蜱/脲醛树脂微胶囊的粒径分布窄,平均粒径约为113μm,载药量达53%以上,包封率达62%以上。毒死蜱/脲醛树脂微胶囊的缓释性能及动力学研究结果显示,所制备的毒死蜱/脲醛树脂微胶囊的缓释效果明显,10天内能释放90%的药物,释放过程遵循Fick扩散机理。可见,制备的毒死蜱/脲醛树脂微胶囊具有较高的载药量、较好的包封率以及缓释性能,可进一步开发为新型的农药制剂,并为开发缓释农药新剂型提供理论支持与实践参考。     

花色苷微胶囊的制备及其理化性质研究

目的 针对花色苷易降解不稳定等问题,采用复合壁材对花色苷进行微胶囊化处理以提高其加工稳定性。方法 以蓝莓花色苷为芯材,改性玉米淀粉/明胶作为复合壁材,利用真空冷冻干燥法制备花色苷微胶囊。以花色苷的包埋率为评价指标,考察壁芯比、改性玉米淀粉/明胶的质量比、包埋温度和包埋时间对包埋率的影响。通过傅里叶变换红外光谱(FTIR)、扫描电镜(SEM)、热重分析(TGA)对其进行表征并测定其抗氧化性。结果 当壁芯比为8∶1、改性玉米淀粉/明胶质量比为1∶2、包埋温度为60 ℃、包埋时间为40 min时,制备的微胶囊具有更高的包埋率。FTIR结果表明花色苷被成功地包埋。制备的微胶囊呈不规则的片层结构,整体表现光滑,表面无团聚现象。微胶囊化后的花色苷热稳定性、抗氧化能力均有所提高。结论 所制备的花色苷微胶囊具有热稳定性高、抗氧化性强、壁材间相容性好等特点,在食品工业化应用方面具有巨大潜力。     

纳米微球在生物医药领域的应用

纳米微球技术是近年来在生物技术应用中最为热门的前沿技术之一。各种微球产品的应用给生物技术研究带来了新的课题,形成了众多新的研究领域。从生物技术的发展现状和未来方向出发,对纳米微球在生物医药研究中几个重要领域的应用前案进行了综述。     

Preparation of Polymeric Microcapsules: Formulation Studies

Air-filled microcapsules were prepared by freeze-drying different oil-in-water emulsions containing biodegradable polyester as the wall-forming material. The aim of this work was to find an acceptable formulation with respect to the microcapsule suspension and the stability of the emulsion during the production process. The influence of various formulation parameters (concentrations of mannitol, polymer, and surfactant; pH; oil-in-water phase ratio) was investigated in a factorial design. The results were treated by ordinary least-square (OLS) regression and partial least-square regression (PLSR). In a previous work, air-filled microcapsules were successfully made using human serum albumin as the surfactant in the emulsion . In the present work, a new block copolymer based on poly(ethylene glycol) (PEG) was implemented as the surfactant to replace human serum albumin. It was found that the new block copolymer is a suitable replacement for human serum albumin. The concentration of the polymer in water and the concentration of the surfactant in the oil phase and the interaction between these variables had a significant influence on the stability of the emulsion at 60°C. A surfactant concentration of approximately 2% (w/v) in water was necessary when the concentration of the wall-forming polymer was below 5% (w/v) in (-)-camphene. The concentration of the polymer in the oil phase influenced the yield, measured as the volume concentration of particles in suspension per milligram of polymer added and as acoustic effect per milligram of polymer. Low levels of polymer concentration in (-)-camphene (<5% w/v) gave the highest yield. Excess polymer in the oil phase did not form microcapsules, but precipitated in the suspension or was included in the wall of the microcapsules. Addition of mannitol protected the microcapsules from being destroyed during freeze-drying and resulted in freeze-dried products with few cracks, little shrinkage, and higher suspension yield.     

Phenylpropanolamine HCl Microcapsules: Preparation and release studies

Microcapsules of phenylpropanolamine HCL were prepared by three techniques, viz. coacervation-phase separation, air suspension, and pan coating, using different polymers and/or waxes as wall-forming materials.

Formulations showed reasonable dissolution behaviour, viz. microcapsules prepared by air suspension with polymer level of 20% polyvinyl acetate copolymer (PVAC) associated with 40% carnauba wax (II) and microcapsules prepared by pan coating with polymer level of 25% Rodopace^R (III), were evaluated for their absorption rates by demonstrating their toxicities compared to pure grug (I) by the LD₅₀ method. Toxicity assessment showed close agreement between the increase in lethal dose and the decrease in dissolution rate and revealed that Formula III has more prolonged action than Formulae II and I.     

石蜡微胶囊的制备及改性研究进展

目的概述石蜡相变材料微胶囊在相变温控、能量利用和热交换等主要应用领域内的研究状况,并对未来的应用与发展进行展望,旨在为石蜡微胶囊的改性研究提供一定思路。方法通过分析和总结近年来国内外有关石蜡微胶囊材料的文献,主要从石蜡微胶囊材料的制备方法和改性手段等方面对目前的石蜡微胶囊材料进行综述。结果石蜡微胶囊的壁材结构和芯材成分对石蜡微胶囊的热性能有非常重要的影响,通过对壁材和芯材的改性,提升了石蜡微胶囊的热性能。结论石蜡微胶囊的改性能够实现更高热性能的目标,达到更多热应用的要求,具有很大的发展潜力,在主要应用领域内能得到更加广泛的应用,但仍存在着一些亟待解决的问题。     

含微胶囊的抗菌淀粉膜制备工艺及性能研究

目的研究一种含微胶囊的抗菌淀粉膜制备工艺,并对其性能进行评价。方法以淀粉作为成膜基材,加入具有抗菌性的微胶囊,以及明胶、甘油、CaCl_2等助剂,采用流延法制备出含微胶囊的抗菌淀粉膜。将淀粉/甘油/明胶的质量比、微胶囊含量、CaCl_2含量、干燥温度作为影响因素,进行正交试验,选取膜的水溶性、力学性能、抗菌性能作为指标,对其性能进行检测和综合评价。结果当淀粉/甘油/明胶质量比为6∶3∶1,微胶囊质量分数为20%,CaCl_2质量分数为2%,干燥温度为50℃时,薄膜具有较好的综合性能。结论通过加入丁香精油微胶囊,制得的淀粉基薄膜具有抗菌性。     

界面聚合法制备十二醇相变微胶囊的工艺及性能

为了解决低温相变材料稳定性差、不易储存运输等问题,以六亚甲基二异氰酸酯(HDI)、1,3-丙二胺为壁材单体,以相变温度较低、相变潜热较高的十二醇为芯材,通过界面聚合法制备了低温相变微胶囊.由于十二醇具有反应活性,本工作研究了不同结构异氰酸酯作为壁材单体的适应性,探索了1,3-丙二胺水溶液的pH值对微胶囊形貌的影响.在1,3-丙二胺水溶液的pH值为9.0的情况下,制备的微胶囊粒径约2.0μm,芯材载量为79.8％,熔融温度为24.47℃,熔融热焓为142.3 J/g.相比于原位聚合法,界面聚合法制备的微胶囊有更好的致密性,在甲醇中的渗透率下降了40％,提高了十二醇相变材料的稳定性,有效改善了其泄漏、储存运输等方面的问题.     

Preparation of Acetaminophen Microcapsules by Coaservation-Phase Separation Method

In this study, it was aimed to prepare prolonged action microcapsules of acetaminophen with short biological half-life by a non-solvent addition method which is one of the conservation-phase separation techniques.

For this purpose, the three different particle size ranges of acetaminophen (0.088-0.177 mn, 0.250-0.354 mn, 0.420-0.500 mn) were used. The solution of polyisobuthylene in cyclohexane as a non-solvent and Eudragit RS and Eudragit RL as coating polymers were also used. The prepared mi crosapsules were compressed by a hydraulic press using different types of direct tableting agents such as Ludipress, Avicel PH 101 and Lactose EP D 30. Dissolution rates of each tablet containing 160 mg of microencapsulated acetaminophen were examined by continuous flow-through cell method

The results of this study showed that the release rate of drug from microcapsules prepared with Eudragit RS was lower than that of microcapsules prepared with Eudragit RL. However different particle size ranges of drug didn't affect significantly the release rate; but different types of direct tableting agents were effective on the release rate of drug.     

异噻唑啉酮微胶囊的制备表征及释放行为

以二异氰酸酯(TDI)、聚乙二醇4000(PEG)、二羟甲基丙酸(DMPA)和三乙胺(TEA)为原料,制备可水乳化的聚氨酯(WPU).以合成的WPU为囊壁、以异噻唑啉酮衍生物(Sea-nine 211)为囊芯,通过乳化自组装得到防污剂Sea-nine 211微胶囊,用红外光谱、粒径分布和扫描电镜对胶囊进行表征,并采用分...