Stimulus generalization among schizophrenics and normal subjects.

Compared schizophrenic and normal groups on a stimulus generalization (SG) task and attempted to explore whether differences in SG among schizophrenics were related to the type of reinforcement applied during acquisition or to diagnostic subtype. 48 chronic poor premorbid schizophrenics and 48 normal controls reached criterion on a size discrimination task under either praise or censure conditions and then were administered an SG task. Schizophrenics showed significantly greater SG than normals, but no differences were found between the praised and censured groups or between paranoid and nonparanoid schizophrenics. (19 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Manipulation of indications of disturbed thinking in normal subjects.

Presents data to support a behavioral model of schizophrenia which predicts that "normal" people emit indications of disturbed thinking (IDT) and that the rate of emitted IDT will be affected by environmental manipulations. 2 2 * (presence or absence of reinforcement; use or nonuse of instructions) experiments were conducted with 48 undergraduates. In Exp. I, Holtzman inkblots (HIT) served as the pretest-posttest measure and a word association test (WAT) was used for training; in Exp.II, the WAT was the pretest-posttest measure and HIT was used for training. Results indicates that: (a) both reinforcement and instructions affected IDT rates on both HIT and WAT during training; (b) training results generalized to the pretest-posttest task; and (c) compared to reinforcement, instruction led to a more rapid but less durable increase in IDT. (36 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

One-footed and externally disturbed two-footed postural control in patients with chronic low back pain and healthy control subjects. A controlled study with follow-up

STUDY DESIGN: A study of postural control during one-footed and externally disturbed two-footed stance among healthy control subjects and patients with chronic low back pain at the beginning of a functional back restoration program and 6 months later at follow-up examination. OBJECTIVES: To study postural control cross-sectionally among control subjects and patients with low back pain, and to evaluate the effects of functional restoration on the postural control parameters in a follow-up examination. SUMMARY OF BACKGROUND DATA: Deficits of motor skills and coordination have been reported in association with musculoskeletal disorders. It has been found that patients with chronic low back pain have impaired psychomotor control, but the impairment is reversible with successful low back rehabilitation. It is insufficiently known how functional activation and intensive physical training affect postural control. METHODS: Sixty-one healthy volunteers (32 men, 29 women) and altogether 99 patients with low back pain participated in the study. Sixty-eight patients (33 men, 35 women) had moderate and 31 (18 men, 13 women) had severe low back pain. Postural stability was measured with a force platform. In two-footed stance, vibration stimulation on calf and back muscles was used to disturb the balance. Center point of force-velocity (cm/sec), average position shift in anteroposterior direction (cm), and maximal position shift in lateral direction (cm) were used as the parameters. RESULTS: Reliability of all tests was acceptable. Center point of force-velocity was the most sensitive parameter and the one-footed measurement the most sensitivetest for evaluating postural stability. At the beginning, the patients with severe low back pain had poorer one-footed postural control compared with the control subjects (P = 0.0003). The subgroup of patients with moderate low back pain participated in the restoration program. The outcome of the restoration program was considered good if the disability because of low back pain (Oswestry index) decreased during the restoration program and poor if the disability increased or did not change. The one-footed postural stability remained primarily at the same level as the initial results in the control and good outcome groups, but became significantly poorer in the poor outcome group. The difference between poor outcome and control groups was statistically significant (P = 0.04). CONCLUSIONS: Impaired postural stability seems to be one factor in multidimensional symptomatology of patients with chronic low back trouble. Postural stability is easily disturbed in case of impairment in strength, coordination, or effective coupling of muscles in the lumbar and pelvic area. Patients with chronic low back pain seem to experience impairment in these functions, which should be taken into consideration when back rehabilitation programs are planned.     

Immediate versus delayed visual memory task performance among schizophrenic patients and normal control subjects

In an exploratory study, 10 schizophrenic patients and 10 normal control subjects performed immediate and delayed memory tasks, which were variants of previously developed continuous performance tests. Both tasks required participants to identify five-digit numbers which were repeated. Numbers were presented in series for 500 ms each and separated by a 500-ms time-out period. In the immediate memory task, subjects were to respond if a number was identical to the one that had immediately preceded it. The delayed memory task differed from the first task in that a longer delay (3.5 s) between stimuli was introduced, and during this delay distracter stimuli appeared. While normal control subjects performed accurately on both tasks (exceeding 80% correct detections), schizophrenic patients performed poorly, performing worse on the delayed memory task than on the immediate memory task. Rates of commission errors (responses made to similar, but not identical numbers) were nearly equal between groups on the immediate memory task, but on the delayed memory task normal control subjects made relatively more commission errors while schizophrenic patients made fewer commission errors. No differences in response latencies were observed between subject groups or tasks. This paradigm may prove useful in discriminating subtle differences in immediate and delayed memory capability among psychiatric populations and normal control subjects.     

Comparisons of the restricted association of chronic schizophrenic and normal control subjects.

Obtained 11 types of restricted associations and free associations from 24 chronic schizophrenics and 24 normal controls equated for age and education. The associations of schizophrenics were more variable than those of normal Ss, especially on tasks which most restricted the choice of responses. Agreement in responding between normal and schizophrenic Ss was markedly lower when compared with that between high- and low-creative Ss, or with 1-yr, test-retest data. Repetition of responses given to the same stimuli under different instructions was markedly higher for schizophrenic than normal Ss, and thus the degree of task and response differentiation was reduced. The restricted associations overlapped with free associations more markedly for schizophrenic than for normal Ss, but the general structure of a conceptual semantic space was about the same for both groups. It is argued that when explicit constraint in tasks of verbal associations is high, schizophrenic Ss, more than normals, impose a low degree of implicit constraint on their verbal behavior; when the external constraint is low, they increase their implicit constraint. (26 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Creativity in manic-depressives, cyclothymes, their normal relatives, and control subjects.

Studies of creativity and affective illness typically focus on eminent individuals in specific fields. This is the first study to select subjects solely by diagnosis, and then evaluate their overall creative accomplishments. Seventeen manic-depressives, 16 cyclothymes, and 11 normal first-degree relatives were compared with 33 controls with no personal or family history of major affective disorder, cyclothymia, or schizophrenia; 15 controls were normal and 18 carried another diagnosis. Peak creativity was assessed by raters blind to subjects' diagnosis with the use of the Lifetime Creativity Scales. Orthogonal contrasts showed (a) creativity to be significantly higher among the combined index subjects (manic-depressives, cyclothymes, and normal relatives) than among controls (p?p?     

Preferred interpersonal distance as a function of locus of control orientation in chronic schizophrenics, nonschizophrenic patients, and normals.

Used a new instrument, the Comfortable Interpersonal Distance scale, to reassess the relationship between psychopathology and interpersonal distance. It was predicted that, since schizophrenics are more external than normals and since externality has been shown to be related to greater preferred distance from others, 20 female schizophrenics theoretically should prefer greater distance, in general, from interpersonal stimuli. 20 female nonschizophrenic patients were included as controls for the "externalizing" effects of hospitalization. Results show that schizophrenics were more external than nonschizophrenics, who were more external than 20 normals. Preferred distance from interpersonal stimuli as measured by the Comfortable Interpersonal Distance scale was greatest for schizophrenics and least for normals. Implications for future research and treatment of schizophrenic patients are discussed. (16 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perceived maternal nurturance and control of process schizophrenics, reactive schizophrenics, and normals.

Attempted to compare the amount of maternal nurturance and control as measured by A. B. Heilbrun (see 38:5) in 3 S groups 33 male process schizophrenics, 33 male reactive schizophrenics, and 198 normal male undergraduates. Ss were administered the "Parent Attitude Research Instrument . . . measuring control and the Parent-Child Interaction Rating Scale . . . measuring nurturance." Results support the hypothesis "of nurturance differences being present between the mothers of process schizophrenics and mothers of reactive schizophrenics" and "the process-reactive distinction in regard to differences in prior family interaction." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Heterogeneity of plasma glucagon. Circulating components in normal subjects and patients with chronic renal failure

Plasma immunoreactive glucagon (IRG) concentrations were measured in 36 patients with chronic renal failure (CRF) and 32 normal subjects. In addition, the components of circulating IRG were analyzed by gel filtration in the fasting state and after physiological stimuli. Fasting IRG was elevated (P less than 0.001) in CRF patients (534 +/- 32 pg/ml) compared with the levels found in healthy subjects (113 +/- 9 pg/ml). Oral glucose suppressed plasma IRG in CRF patients from a basal level of 568 +/- 52 to a nadir of 354 +/- 57 pg/ml (120 min). This degree of suppression (38%) was comparable to that found in normal subjects (basal = 154 +/- 20 to 100 +/- 23 pg/ml) at 120 min (35%). Intravenous infusion of arginine (250 mg/kg) resulted in a 71% rise in IRG in CRF patients and a 166% increase in normal subjects. Gel filtration of fasting plasma from CRF patients showed three major peaks. The earliest (A) was found in the void volume (mol wt greater than 40,000) and constituted 16.5 +/- 4.7% of the elution profile. The middle peak (B) eluted just beyond the proinsulin marker (approximately 9,000 mol wt) and constituted the largest proportion of the elution profile (56.5 +/- 3.4%). The third peak (C) coincided with the standard glucagon and [125I]glucagon markers (3,485 mol wt) and comprised 27.0 +/- 4% of the IRG profile. In contrast, only peaks A and C were found in fasting plasma of normal subjects (53.6 +/- 10.4% in A and 46.4 +/- 10.4 in C). After oral glucose, glucagon immunoreactivity in the 3,500 mol wt peak (C) was markedly suppressed, while the B peak in patients with CRF declined to a lesser extent. The A peak in both groups was unchanged. After an arginine infusion only the C peak increased in both groups of subjects. Gel filtration of plasma in 3 M acetic acid gave similar profiles to those obtained in glycine albumin buffer. Exposure of serum to trypsin indicated that the B and C peaks were digestible, while the A peak was resistant to the action of the enzyme. In one sample, peak C increased after a 2-h exposure of serum to trypsin. We conclude that circulating IRG in normal subjects and patients with CRF is heterogenous. The hyperglucagonemia of renal failure is largely due to an increase in IRG material of approximately 9,000 mol wt, consistent with proglucagon, although the 3,500 mol wt component is also considerably elevated (threefold). The significance of circulating IRG levels should be interpreted with caution until the relative biological activity of the three components is established.     

Transfer learning in chronic schizophrenics.

Compared reversal shift, where the assignment of stimuli to categories changed but the relevant dimension did not change, and extradimensional shift, where a different dimension was made relevant after training. 28 chronic schizophrenics were trained to the same consecutive correct response criterion in a 3-choice form or color discrimination and shifted to 1 of 4 possible transfer tasks. It was found that (a) extradimensional shift took more trials and errors to criterion than reversal shift, and (b) more perseveration as compared to other errors were made by the total sample. The need for a uniform methodology and an evaluation of S selection factors when investigating the performance of schizophrenics is discussed. (23 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perceptual recognition in chronic and acute schizophrenics.

Compared schizophrenic and normal groups on their speed in recognizing the identity of pictorial stimuli which gradually came into sharper focus from an initially blurred appearance. The chronic schizophrenic group (N = 20) showed slower recognition than the acute schizophrenic (N = 20) or normal groups (N = 40), but the groups did not differ in amount of prerecognition hypotheses or time of 1st response. The differences in perceptual recognition speed seem related to certain clinical differences between the acute and chronic schizophrenic, particularly with regard to the impact of external perceptual stimuli vs. internally generated ideation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of distraction on performance of obese and normal subjects.

Conducted 2 experiments with male undergraduates to determine whether, while working on tasks requiring concentration, overweight Ss (n = 60) would be more distracted than normals (n = 60) by competing, irrelevant material. In measures of proof-reading accuracy and reaction-time latency, overweight Ss were more disrupted than normals by interesting, emotionally toned material, while they performed better than normals when there were no distracting events. Overweight Ss also thought about the tasks more than normals when there was no distraction, suggesting that differences in attention to the tasks may have produced the obtained effect. These findings are considered within the context of the heightened responsiveness of the obese to a wide range of external cues. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Short-term memory impairment in chronic schizophrenics.

Assessed the short-term memory capacities of 4 chronic, schizophrenic and 4 nonschizophrenic psychiatric patients who served as controls. The information to be remembered was presented both visually and verbally and was later probed for after a variable interval by either visual or verbal cues. Schizophrenics and controls did not differ with respect to which type of cue retrieved more of the information, suggesting that the modality in which the information was stored was the same for both groups. However, schizophrenics were markedly inferior to controls regarding both the initial acquisition of information and the maintenance of it in storage. (French summary) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Electrodermal base level, tonic arousal, and adaptation in chronic schizophrenics.

Electrodermal arousal was studied at rest and during repetitive stimulation in chronic schizophrenics who were rated at either extreme of the Montrose Rating scale (MRS), either receiving a phenothiazine or no drugs, and in a control normal sample. Resting base level was significantly higher among Hi than Lo MRS, and among Nondrug than Drug patients: no patient sample was reliably below Control level. Nondrug patients showed no impairment in tonic arousal relative to Controls, even when such patients showed impaired phasic response (though the drug was seemingly associated with diminished tonic response). Considerable independence was demonstrated between phasic and tonic electrodermal functions. Unlike Controls (or Drug patients), Nondrug patients showed a general heightening of electrodermal arousal during repetitive innocuous stimulation. A vigilance hypothesis was offered suggesting that sensitivity to the general demands of the environment remains high among chronic patients, even where there may be a reduction in the input of specific items of information from that environment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-concept, mother concept, and food aversions in emotionally disturbed and normal children.

Self-concept was measured via an adjective check list and a self-rating task (child asked to compare himself to others on traits); mother-child relationship was inferred from responses to specific cards of the Blacky test and a story completion test; food aversion was measured from a food preference list. In general, the self-concept and mother-concept were related and there was an inverse relation between these and food aversion. From Psyc Abstracts 36:04:4FF09D. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Prospective study of fluoxetine treatment and suicidal behavior in affectively ill subjects

A complementary DNA clone preferentially expressed in the gastrointestinal tract was obtained from a rat stomach library. The protein coded by the clone had a single carbohydrate recognition domain having conserved motifs for beta-galactoside binding and showed 67% amino acid identity with human galectin-2. The recombinant protein synthesized in Escherichia coli could bind to an asialofetuin column and was eluted with beta-galactopyranoside. From these observations, we named the protein rat galectin-2 coded by the cDNA. The rat galectin-2 was predominantly expressed in the epithelial cells of stomach. Thus this protein may form a mucin layer cross-linking with the beta-galactoside moiety of glycoproteins.     

Effect of diet on urinary MHPG excretion in depressed patients and normal control subjects

The authors studied the effect of a catecholamine-controlled diet on the urinary level of 3-methoxy-4-hydroxyphenylglycol (MHPG) of 6 depressed patients and 6 normal volunteers. The normal subjects showed no change in MHPG levels on or off the diet; the depressed patients showed a significant increase in MHPG while off the diet.