High-performance liquid chromatographic determination of midazolam in rat brain

The authors tested whether perfectionism dimensions interact with specific stress to predict depression over time. A sample of 103 current and former patients completed measures of perfectionism and depression at Time 1 and measures of stress and depression 4 months later. After controlling Time 1 depression, self-oriented perfectionism interacted only with achievement stress to predict Time 2 depression. Socially prescribed perfectionism did not interact with achievement or social stress to predict Time 2 depression, but it did predict Time 2 depression as a main effect. The results provide support for the contention that perfectionism dimensions are involved in vulnerability to depression over time.     

Perfectionism and depression: Longitudinal assessment of a specific vulnerability hypothesis.

The authors tested whether perfectionism dimensions interact with specific stress to predict depression over time. A sample of 103 current and former patients completed measures of perfectionism and depression at Time 1 and measures of stress and depression 4 months later. After controlling for Time 1 depression, self-oriented perfectionism interacted only with achievement stress to predict Time 2 depression. Socially prescribed perfectionism did not interact with achievement or social stress to predict Time 2 depression, but it did predict Time 2 depression as a main effect. The results provide support for the contention that perfectionism dimensions are involved in vulnerability to depression over time. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Personality, negative social interactions, and depressive symptoms.

Examined the associations among the frequency of negative social interactions, personality traits, and depressive symptoms in university students. 176 Ss completed measures of negative social interactions, sociotropy, autonomy, perfectionism, and depressive symptoms. It was found in the total sample that higher depression symptoms scores were correlated significantly with the frequency of negative social interactions, sociotropy, autonomy, and socially prescribed perfectionism. Additional results indicate that the frequency of negative social interactions accounted for unique variance in depressive symptoms over and above the variance predicted by personality traits, but it did not interact with these personality traits to predict unique variance in depressive symptoms. It was also found that the reported frequency of negative social interactions was correlated positively with socially prescribed perfectionism, sociotropy, and autonomy, especially among women. The current findings are discussed in terms of their implications for specific vulnerability and stress generation models of personality, life events, and depressive symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism dimensions, perfectionistic attitudes, dependent attitudes, and depression in psychiatric patients and university students.

P. L. Hewitt and G. L. Flett's (1991b) model of perfectionism dimensions (i.e., self-oriented, other-oriented, and socially prescribed perfectionism) was compared with A. T. Beck's model (G. P. Brown & A.T. Beck, 2002) of dysfunctional attitudes (i.e., perfectionistic attitudes [PA] and dependent attitudes [DA]) in predicting depression in 70 psychiatric patients and 280 university students. Socially prescribed perfectionism uniquely predicted both PA and DA. Dysfunctional attitudes failed to consistently predict additional variance in depression beyond perfectionism dimensions (and vice versa). Evidence for Hewitt and Flett's specific vulnerability hypothesis and Beck's specific cognitive vulnerability hypothesis was equivocal. Beck's conceptualization of perfectionism as a unitary cognitive style obscures important information by overlooking the distinction between the self-related and socially based features of perfectionism. Hewitt and Flett's conceptualization of perfectionism as 3 distinct personality traits allows for precise conclusions by recognizing the differential contribution of the self-related and socially based features of perfectionism. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism in chronic and state symptoms of depression.

Tested whether perfectionism dimensions uniquely predict chronic unipolar and chronic bipolar symptoms. A sample of 121 patients and former patients (mean age 46.1 yrs) completed the Multidimensional Perfectionism Scale, the General Behavior Inventory, and the Beck Depression Inventory. The results confirm that the perfectionism dimensions are related to chronicity of depression symptoms. Whereas self-oriented perfectionism was uniquely associated only with chronic unipolar symptoms, both socially prescribed and other-oriented perfectionism were uniquely associated with chronic bipolar symptoms. Importantly, these relationships remained significant after controlling for the effects of concurrent state depression. Finally, only socially prescribed perfectionism was uniquely associated with state depression. The results provide support for the position that perfectionism dimensions are important in both chronic. and state depression symptoms, but the perfectionism dimensions may differ in terms of their degree of association with various facets of depressive phenomena. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perfectionism as a predictor of subsequent adjustment: Evidence for a specific diathesis–stress mechanism among college students.

The relations among perfectionism, stress, subsequent psychological symptoms, and hopelessness were examined among 215 college students. Hierarchical regression analyses were conducted to determine whether dimensions of perfectionism (P. Hewitt & G. Flett, 1991) predicted psychological symptoms and hopelessness (1 month later), and the extent to which stress scores added incremental validity to these predictions. Results indicated that socially prescribed perfectionism was a significant predictor of both adjustment measures. In addition, stress accounted for a significant amount of additional variance in predicting adjustment beyond perfectionism. Consistent with a diathesis–stress model, a significant Perfectionism × Stress interaction was found in predicting scores on adjustment measures beyond perfectionism and stress. However, this interaction was only found for socially prescribed perfectionism. Results provide support for a specific diathesis–stress mechanism and important implications for developing specific interventions in working with perfectionistic college students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychological distress and the frequency of perfectionistic thinking

Five studies tested the hypotheses that there are individual differences in the frequency of automatic thoughts involving perfectionism and that these thoughts are associated with psychological distress. Research with the Perfectionism Cognitions Inventory (PCI) established that this new measure has adequate psychometric properties, and high PCI scorers tend to spontaneously report perfectionistic thoughts in naturalistic situations. Additional research confirmed that frequent perfectionism thoughts account for unique variance in distress, over and above variance predicted by standard measures of negative automatic thoughts and trait perfectionism measures. Overall, the findings support the view that personality traits involved in depression and anxiety have a cognitive component involving ruminative thoughts and that activation of this cognitive personality component contributes to distress.     

Perfectionism, stress, and social (dis)connection: A short-term study of hopelessness, depression, and academic adjustment among honors students.

This study tested models of perfectionism predicting psychological distress and academic adjustment and moderators and mediators of those associations in 2 successive cohorts of high-achieving university honors students (N = 499). Participants completed measures early and late in the semester. Adaptive (high standards) and maladaptive (self-critical perceptions of inadequacy in meeting performance expectations) dimensions of perfectionism were found to be significantly associated, in generally expected directions, with concurrent and prospective perceived stress, social connectedness, depression, hopelessness, and perceived academic adjustment. However, some perfectionism effects were reduced when earlier psychological distress and adjustment were controlled in analyses predicting later distress and adjustment. Several effects were moderated and at least partially mediated by perceived stress and social connection. The results suggest several counseling implications for high-achieving, perfectionistic students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Acculturative stress, perfectionism, years in the United States, and depression among Chinese international students.

The present study examined whether maladaptive perfectionism (i.e., discrepancy between expectations and performance) and length of time in the United States moderated the association between acculturative stress and depression. Data were collected through online surveys from 189 Chinese international students from China and Taiwan attending a midwestern university. Results from a hierarchical regression showed that there were significant main effects of acculturative stress and maladaptive perfectionism on depression, no significant two-way interactions, and a significant three-way interaction, indicating that acculturative stress, maladaptive perfectionism, and length of time in the United States interacted to predict depression. Low maladaptive perfectionism buffered the effect of acculturative stress on depression only for those who had been in the United States for a relatively longer period of time. Implications for counseling and future research directions are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dimensions of perfectionism in unipolar depression.

We tested the hypothesis that self-oriented perfectionism, other-oriented perfectionism, and socially prescribed perfectionism are related differentially to unipolar depression. The Multidimensional Perfectionism Scale was administered along with measures of depression and anxiety to 22 depressed patients, 22 matched normal control Ss, and 13 anxiety patients. It was found that the depressed patients had higher levels of self-oriented perfectionism than did either the psychiatric or normal control Ss. In addition, depressed patients and anxious patients reported higher levels of socially prescribed perfectionism than did the normal control Ss. The results suggest that various dimensions of perfectionism may play an important role in clinical depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The relationship of perfectionism, depression, and therapeutic alliance during treatment for depression: Latent difference score analysis.

The authors examined the longitudinal relationship of patient-rated perfectionism, clinician-rated depression, and observer-rated therapeutic alliance using the latent difference score (LDS) analytic framework. Outpatients involved in the Treatment for Depression Collaborative Research Program completed measures of perfectionism and depression at 5 occasions throughout treatment, with therapeutic alliance measured early in therapy. First, LDS analyses of perfectionism and depression established longitudinal change models. Further LDS analyses revealed significant longitudinal interrelationships, in which perfectionism predicted the subsequent rate of depression change, consistent with a personality vulnerability model of depression. In the final LDS model, the strength of the therapeutic alliance significantly predicted longitudinal perfectionism change, and perfectionism significantly predicted the rate of depression change throughout therapy. These results clarify the patterns of growth and change for these indicators throughout depression treatment, demonstrating an alternative method for evaluating longitudinal dynamics in therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive specificity and positive-negative affectivity: Complementary or contradictory views on anxiety and depression?

A principal factor analysis, conducted on a mixed psychiatric outpatient sample (N?=?470) identified both common and specific dimensions underlying anxiety and depression. Although an initial single-factor extraction accounted for a significant proportion of variance in cognitive and symptom measures of anxiety and depression, a two-factor solution, in which anxiety and depression formed separate dimensions, proved to be the better solution. Multivariate analyses of variance (MANOVAs) performed on pure depressed, pure anxious, and mixed anxious/depressed subgroups provided evidence of a specific cognitive profile for anxiety and depression. The mixed subsample evidenced greater severity, a mixed cognitive and symptom profile, and character traits that may indicate increased vulnerability to psychological disturbance. Results are discussed in terms of A. T. Beck's (1976) cognitive content-specificity hypothesis and the positive-negative affect model (D. Watson and A. Tellegen; see record 1986-00110-001). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-esteem as a mediator between perfectionism and depression: A structural equations analysis.

This study of college students (N?=?464) examined the association between adaptive and maladaptive dimensions of perfectionism and 2 mental health outcomes (self-esteem and depression). Confirmatory factor analysis was used to develop and assess the measurement model used in this study. Structural equations modeling was used to test a mediational model derived from prior theory and research. Analyses supported the existence of 2 perfectionism factors. Path models revealed that adaptive perfectionism was not directly or indirectly (through self-esteem) associated with depression. Maladaptive perfectionism was negatively associated with self-esteem and positively associated with depression. Self-esteem also buffered the effects of maladaptive perfectionism on depression. Distinguishing adaptive from maladaptive perfectionism is discussed in the context of recommendations for practice and future research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A preliminary study of perfectionism and loneliness as predictors of depressive and anxious symptoms in Latinas: A top-down test of a model.

In the present study, we used a top-down approach to examine perfectionism and loneliness as additive sociocognitive predictors of depressive and anxious symptoms in a sample of 121 Latina college students. Consistent with expectations, we found perfectionism and loneliness to be associated with both depressive and anxious symptoms. In addition, results of conducting hierarchical regression analyses indicated that certain dimensions of perfectionism, especially doubts about actions, accounted for significant variance in both depressive and anxious symptoms. Moreover, the inclusion of loneliness as a predictor was found to predict additional unique variance in both depressive and anxious symptoms beyond what was accounted for by perfectionism. Implications of the present findings for future research on negative affective conditions in Latinas are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

DSM-III-R personality disorders in a mood and anxiety disorders clinic: prevalence, comorbidity, and clinical correlates

This study examined the prevalence, comorbidity, and clinical correlates of personality disorders in an outpatient sample (N = 352) with anxiety and depression. Subjects were diagnosed using the Structured Clinical Interview for DSM-III-R (SCID) on Axes I and II, and they also completed interview and self-report measures of symptoms. Subjects with a personality disorder were less likely to be married, more likely to be single or divorced, had lower family incomes, had more severe symptoms of both anxiety and depression, and had a greater number of lifetime Axis I diagnoses. Subjects with dysthymic and bipolar disorders were more likely, and subjects with panic disorder uncomplicated by agoraphobia were less likely to have a personality disorder compared to the rest of the sample. The most prevalent personality disorders were Avoidant, Obsessive-Compulsive, Paranoid, and Borderline. Paranoid co-occurred with Narcissistic, and Borderline co-occurred with Histrionic personality disorder significantly more often than chance and base rates would predict.     

Granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor in the treatment of acute myeloid leukemia and acute lymphoblastic leukemia

To explore the role of perfectionism across anxiety disorders, 175 patients with either panic disorder (PD), obsessive compulsive disorder (OCD), social phobia, or specific phobia, as well as 49 nonclinical volunteers, completed two measures [Frost, R. O., Marten, P., Lahart, C., & Rosenblate, R., (1990). The dimensions of perfectionism. Cognitive Therapy and Research, 14, 449-468; Hewitt, P. L., & Flett, G. L., (1991). Perfectionism in the self and social contexts: Conceptualization, assessment and association with psychopathology. Journal of Personality and Social Psychology, 60, 456-470.] that assess a total of nine different dimensions of perfectionism. Relative to the other groups, social phobia was associated with greater concern about mistakes (CM), doubts about actions (DA), and parental criticism (PC) on one measure and more socially prescribed perfectionism (SP) on the other measure. OCD was associated with elevated DA scores relative to the other groups. PD was associated with moderate elevations on the CM and DA subscales. The remaining dimensions of perfectionism failed to differentiate among groups. The clinical implications of these findings are discussed.     

The structure and temporal stability of the Child and Adolescent Perfectionism Scale.

In this study, the authors examined the factor structure and temporal stability of the Child and Adolescent Perfectionism Scale (CAPS; G. L. Flett, P. L. Hewitt, D. J. Boucher, L. A. Davidson, & Y. Munro, 1997) in 2 samples of adolescents (15–16 years old). In Sample 1 (n = 624), confirmatory factor analysis did not support a 2-factor structure (self-oriented and socially prescribed perfectionism). As in B. T. McCreary, T. E. Joiner, N. B. Schmidt, & N. S. Ialongo (2004), reanalysis suggested a 3-factor solution (i.e., socially prescribed perfectionism, self-oriented–Striving perfectionism, self-oriented–Critical perfectionism). The authors validated their 3-factor model in an independent replication sample (Sample 2; n = 514) and confirmed that the 3-factor structure was invariant across gender and time (test–retest over 6 months). Taking these analyses together, the authors concluded that their discriminant 3-factor structure is robust. Theoretical and clinical implications are discussed. More research on the predictive validity of the CAPS is suggested. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Personality predictors of mood related to dieting

The clinical utility of a model of normal emotional functioning (vs. psychopathology) and the moderating effects of neuroticism (N) and extraversion (E) on mood were examined during a 6-week weight-loss trial. Participants were 40 obese women who completed measures of negative affect (NA) and positive affect (PA) weekly during the diet and measures of anxiety and depression (Beck Depression Inventory [BDI]) at pre-, mid-, and postdiet. Results indicated that (a) average NA and PA were each uniquely related to postdiet BDI scores, (b) N was significantly related to NA during the diet and postdiet BDI scores, and (c) N and E interacted to predict PA during the diet. The results suggest that assessment of personality and normal mood variation may be useful additions to weight-loss intervention and research.     

The multidimensional structure of perfectionism in clinically distressed and college student samples.

Confirmatory factor analysis was used to evaluate 2 multidimensional measures of perfectionism (R. 0 Frost, P. Marten, C. Lahart, & R. Rosenblate, 1990; P. L. Hewitt & G. L. Flett, 1991). On a first-order level, support was found for Hewitt and Flett's (1991) original 3-factor conceptualization of perfectionism, although only for an empirically derived 15-item subset. Support was also obtained for 5 of the 6 dimensions proposed by R. O. Frost et al. (1990), but the model only displayed good fit when a refined scale containing 22 of the original 35 items was used. A second-order analysis found evidence for 2 higher-order factors of adaptive and maladaptive perfectionism. Perfectionism dimensions correlated in expected directions with personality domains, symptom distress, and academic achievement. The brief measures of perfectionism also retained the construct-related validity displayed by the full-item versions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Convergence of two systems for assessing specific traits of personality disorder.

Two samples of normal-range individuals (N?=?237) completed the Schedule for Nonadaptive and Adaptive Personality (L. A. Clark, 1993a) and the Dimensional Assessment of Personality Pathology—Basic Questionnaire (W. J. Livesley & D. Jackson, in press), each of which assesses traits relevant to personality disorder. Convergence between the 2 instruments was examined at both the level of broad factors and the level of specific scales that had been matched previously on a conceptual basis (L. A. Clark & W. J. Livesley, 1994). Four of 5 higher order factors resembled dimensions of the 5-factor approach to personality, and a strong convergent and discriminant pattern was found between matched scales of the 2 instruments. Moreover, considerable specific trait variance remained after nonspecific (higher order) variance was accounted for. The results are interpreted as supporting a replicable structure of maladaptive personality traits at both levels of the hierarchy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)