N—十二烷基葡糖基月桂酰胺的合成及其特性研究

在催化剂存在下，以葡萄糖为主要原料，经还原胺化、酰化两步反应合成了新型表面活性剂－－Ｎ－十二烷基葡萄基月桂酰胺。讨论了诸因素对产物收率的影响，正交试验确定了优化合成工艺条件，分析了产物的特性推广应用前景。本文的研究尚未见有文献报道。     

N-十二烷基葡糖基月桂酰胺的合成及其特性研究

在催化剂存在下，以葡萄糖为主要原料，经还原胺化、酰化两步反应合成了新型表面活性剂──N-十二烷基葡萄基月桂酰胺。讨论了诸因素对产物收率的影响，正交试验确定了优化合成工艺条件，分析了产物的特性及推广应用前景。本文的研究尚未见有文献报道。     

含氮姜黄素类似物的合成及其酪氨酸酶抑制效应

通过芳香醛与4-乙酰基吡啶在酸碱条件下催化缩合,合成了4个单羰基姜黄素类似物A1～A4,并研究了其对酪氨酸酶的抑制活性。结果表明,3-(4-羟基-3,5-二甲氧基苯基)-1-(4-吡啶基)-2-烯-1-酮对酪氨酸酶具有强抑制活性,半数抑制浓度（IC50）为45.1μmol/L,是姜黄素（IC50= 97.1μmol/L）的抑制活性的2.2倍。抑制动力学研究表明,3-(4-羟基-3,5-二甲氧基苯基)-1-(4-吡啶基)-2-烯-1-酮对酪氨酸酶的抑制作用类型属于竞争性抑制。     

二氢杨梅素的制备及其对酪氨酸酶的抑制研究

通过正交实验确定超声波提取藤茶中总黄酮的最佳工艺条件,用柱层析-重结晶法从藤茶中分离得到二氢杨梅素。选用L-酪氨酸、L-多巴为底物,分别测定二氢杨梅素对酪氨酸酶的单酚酶、二酚酶的抑制率。结果表明,提取的最佳工艺条件:提取溶剂是体积分数为60%的乙醇,料液比1∶30(g/mL),提取温度40℃,提取时间40 min,总黄酮得率为46.54%。柱层析-重结晶法分离纯化得到的二氢杨梅素得率为41.12%,纯度为99.12%。二氢杨梅素对单酚酶、二酚酶均有显著的抑制作用,抑制率分别可达95.87%,69.01%。     

没食子酸正（异）丁醌的制备及性能研究

对甲苯磺酸为催化剂，用梯度升温法，酸、醇直接酯化合没食子酸正（异）丁酯最佳反应条件为：没食子酸丁酯：没食子酸与催化剂的摩尔比为１：０．０４２，丁醇８０ｍｌ，反应温度１２０－１２５℃，反应时间４ｈ；没食子酸异丁酯；没食子酸与催化剂的摩匀比为１：０．０５３，异丁醇９０ｍｌ，反应温度１１５－１２０℃，反应时间４ｈ，美元酯化率分别为９４％和９１．２％，抗猪油氧化性能为没食子酸异子酯〉没食子酸丁酯。     

苯并咪唑酮类衍生物的合成及生物活性的初步研究

本文以5-氨基苯并咪唑酮与取代苯甲醛(1a～1h)为起始原料,在酸性条件下合成了苯并咪唑酮类衍生物(2a～2h),其结构经~1H NMR、~(13)C NMR表征。初步生物活性测试结果表明该系列部分化合物能抑制酪氨酸酶的活性,部分化合物对乳腺癌也具有一定的抑制作用。     

烷基葡糖苷合成反应的动力学模型与复配性能

在烷基葡糖多苷 (APG)合成反应研究的基础上 ,探讨了葡萄糖与脂肪醇反应直接合成APG的反应机理 ,提出了直接法合成APG时葡萄糖浓度cA 和反应时间t的反应动力学模型为 :ln(cA- 0 0 0 0 2 5 ) =- (Kt +2 0 8)。同时 ,以APG为主要原料〔w(APG) =10 %～ 15 %〕 ,通过多种表面活性剂的复配及添加特效吸附渗透剂 ,研制开发出一种适宜于各种行业工人使用的劳保浴液 ,产品集净洗、调理、护肤、洗发等多种功用于一体。该浴液经推广应用 ,并采用“模糊数学综合评价法”对其质量进行评判 ,证明APG复配产品的质量性能优异     

没食子酸及其衍生物的生理活性及研究现状

介绍了没食子酸的来源以及常见的提取方法,如酸水解法、碱水解法、发酵法和生物酶法,综述了没食子酸常见衍生物的种类和它们的主要作用;没食子酸及其衍生物显著的抗氧化、抗菌、抗肿瘤等生理活性。介绍了没食子酸及其衍生物在农业、化妆品、医药领域的应用。     

没食子酸微晶纤维素酯的合成工艺研究

用可再生资源微晶纤维素为原料,在催化剂的作用下,与含抗氧化基团的没食子酸作用,合成一种新型没食子酸酯。考察了对甲苯磺酸、十二烷基苯磺酸、磷钨酸三种催化剂对产物的影响,以酯化度为考察目标,对合成时间、温度、催化剂用量、没食子酸和微晶纤维素用量比等因素进行考察,确定最佳合成条件为:没食子酸和微晶纤维素的反应物配比(GA∶MCC)为4∶1时,以磷钨酸为催化剂,催化剂用量为相对于没食子酸质量的10%,在温度120℃下,反应10 h,没食子酸微晶纤维素酯的酯化度最高。通过红外检测,合成产物红外谱图中1680 cm-1处有酯中C=O伸缩振动吸收峰,证明没食子酸与微晶纤维素不是机械混合而是化学合成。     

癸基葡糖苷的合成与性能研究

在酸性介质中，采用直接催化法合成了淀粉基表面活性剂癸基葡糖苷，确定了合成工艺条件，产物收率≥９３．５％。性能测试结果表明，癸基葡糖苷具有表面张力低、起泡和润湿性能优良等特点，是一种新型的非离子表面活性剂。     

三乙酰没食子酰氯制备工艺的研究

以没食子酸与乙酸酐反应,生成三乙酰没食子酸(TAGA),再与SOCl2反应,制备目的产物三乙酰没食子酰氯(TAGC)。结果表明,TAGA合成最佳原料摩尔比为1∶4∶4,产率基本在87%左右,TAGC合成最佳原料摩尔比为1∶3,产率基本在95%左右。实验方法稳定可行,且操作简单,污染小,可用于工业生产。     

没食子酸制备三乙酰基没食子酰氯工艺研究

以没食子酸与乙酸酐合成三乙酰没食子酸(TAGA),进而以N,N-二甲基甲酰胺(DMF)为催化剂,与SOCl2酰氯化反应合成三乙酰没食子酰氯(TAGC),考察了溶剂、反应物配比、催化剂加入量、浴温及反应时间对产率的影响。结果表明,二氯甲烷反应效果最好,优化工艺条件为:TAGA与SOCl2摩尔比为1∶3,催化剂加入量1.2%,浴温60℃,反应时间3 h。在此条件下,TAGC产率可达92.9%。     

对甲基苯磺酸催化合成三乙酰没食子酸

以没食子酸与乙酸酐为原料,对甲基苯磺酸作催化剂,合成三乙酰没食子酸,考察了原料配比、催化剂用量、反应时间、反应温度对产品的影响。结果表明,酰化反应较佳的工艺条件是：n（没食子酸）∶n（乙酸酐）∶n（对甲基苯磺酸）=1∶2∶0.5,反应时间为1.5 h,反应温度为60℃,此时三乙酰没食子酸的收率为77.58%。     

从没食子酸结晶母液中回收没食子酸的萃取工艺

引言没食子酸又名五倍子酸,是一种应用很广泛的化工原料[1],可用作食品抗氧化剂、着色剂、净化剂、防腐剂等[2],且具有抗肿瘤、抗炎、抗突变等多种生物学作用[3]。没食子酸是单宁酸的水解产物,国内厂家大多数以含水解单宁的植物五倍子、塔拉为原料生产没     

Development of gallic acid sensors based on polyimide-modified platinum electrode

A series aromatic polyimide (PI) membranes in the form of permselective films was synthesised from different dianhydrides with two diamine monomers for gallic acid (GA) measurement. The obtained PI films were examined by Spectroscopic techniques, Scanning Electron Microscopy (SEM) and thermal analysis techniques and then used to fabricate the selective films on the modified electrode. Because of their excellent film properties, as the permselective polymeric membranes were used for determination of GA in the presence of various interferences and real sample. The PI-1-modified Pt electrode showed a very high R-value (0.9935) and reproducibility for GA determination, as well as high selectivity.     

Reversible adhesive based on gallic acid modified acrylate

An inexpensive adhesive bearing polyphenol groups was synthesized in this work. In order to obtain the desired adhesive, gallic acid (3,4,5-trihydroxybenzoic acid) was chosen as the functional compound to modify hydroxyl acrylate copolymer. The rheology and creep properties of the adhesive expressed that its cohesive strength and fatigue resistance were both increased. The resultant adhesive presented a better bonding strength to different substrates, such as steel, polypropylene (PP) and polytetrafluoroethylene (PTFE). In addition, reversible adhesion could be stimulated by modulating the temperature. Shear strength for PP was not less than 0.5 MPa, furthermore that for steel was no less than 4 MPa and the maximum achieved 6 MPa.     

Photocatalytic ozonation of gallic acid in water

Aqueous solutions of gallic acid have been treated with five different oxidation‐radiation processes: visible and ultraviolet A radiation (VUVA), TiO₂ adsorption, ozonation, VUVA/TiO₂ photocatalysis and VUVA/O₃/TiO₂ photocatalytic ozonation. With the exception of VUVA radiation and TiO₂ adsorption, ozone and photolytic processes allow for the total removal of gallic acid in a period between 50 and 90 min. The time taken to achieve 100% gallic acid conversion depends on the oxidation process applied, photocatalytic ozonation being the most effective technique. Throughout the process, oxalic and formic acids were identified as byproducts. Some other unidentified compounds probably related to pyruvic, malonic and maleic acids were also detected. The appearance of these compounds can be justified from direct reactions of both hydroxyl radical and ozone in water. Only photocatalytic ozonation leads to total mineralisation of the organic matter in less than 90 min. The photocatalyst used, TiO₂, showed good activity and stability (no leaching was observed) after five consecutive photocatalytic ozonation runs with the same semiconductor‐catalyst mass. Copyright © 2006 Society of Chemical Industry     

聚天冬氨酸的合成及性能研究

以马来酸酐和氨合成聚天冬氨酸(PASP),探讨了物料比、反应温度对PASP收率的影响,评价了PASP的水溶性、生物降解性和防垢性能。结果表明,在原料马来酸酐与氨的物质的量比为1.0∶1.2条件下,温度为200℃时,PASP的收率为95.22%,分子量22 000,水溶性好;在26~28℃条件下降解30 d后,3%浓度PASP溶液的相对粘度为1.013,有较好的生物降解性;当Ca2+为400 mg/L,Ba2+为200 mg/L,pH=7.0,50~60℃恒温8 h,PASP用量为15 mg/L时,对碳酸钙、硫酸钡、硫酸钙的阻垢率接近100%。     

High performance biocompatible cellulose‐based microcapsules encapsulating gallic acid prepared by inverse microsuspension polymerization

In this study, the preparation of biocompatible cellulose‐based microcapsules encapsulating gallic acid (GA), an important antioxidant of Bambara groundnut extracts, by water‐in‐oil inverse microsuspension polymerization was studied. GA and carboxymethyl cellulose (CMC) were selected as core and shell materials, respectively. For high encapsulation efficiency, CMC was firstly modified (modified‐CMC (m‐CMC)) with 3‐(trimethoxysilyl)propyl methacrylate (MPS) as a silane coupling agent. It was subsequently polymerized with methacrylic acid (MAA) monomer through a radical route, forming a PMAA grafted m‐CMC (m‐CMC‐g‐PMAA) biocompatible polymer shell. Using CMC:MPS in a ratio of 75:25 (w/w %), highly water‐soluble m‐CMC containing a C=C bond for further radical polymerization was obtained. After inverse microsuspension polymerization at various ratios of m‐CMC:MAA, highly stable spherical m‐CMC‐g‐PMAA microcapsules encapsulating GA were formed in all ratios. It was observed that the encapsulation efficiency increased with increase in MAA content. m‐CMC:MAA in a ratio of 33:67 (w/w%) presented the highest encapsulation efficiency which may due to the increase of hydrophilicity of the aqueous phase. It also presented rapid release and non‐cytotoxic characteristics, suited for use in cosmetic products. © 2018 Society of Chemical Industry     

没食子酸环氧树脂/蓖麻油酸多胺体系固化动力学及性能

以蓖麻油和三乙烯四胺为原料合成蓖麻油酸多胺固化剂(COAPA),再将其与没食子酸环氧树脂(GAER)混合组成全生物基GAER/COAPA固化体系,采用非等温差示扫描量热法(DSC)对其固化反应过程进行了研究,确定了固化体系最佳质量配比为7:3(GAER:COAPA),获得了最佳固化工艺温度参数;利用Kissinger方...