代谢性骨病骨显像特点探讨

为提高骨显像对临床上各种骨疾患的鉴别诊断能力,本文回顾分析了代谢性骨病在骨显像上的特征表现.临床确诊的142例共6种代谢性骨病:其中甲状旁腺功能亢进症117例;肾性骨病4例;畸形性骨炎16例;成人骨软骨病2例;石骨症2例,脆骨病1例.142例代谢性骨病的骨显像结果可分为四种类型:全身骨摄取显像剂增加(I型);局部骨摄取显像剂增加(Ⅱ型);全身+局部骨摄取显像剂增加(Ⅲ型)和正常骨显像图(Ⅳ型).部分甲旁亢、石骨症、脆骨病和肾性骨病骨显像表现为I型;畸形性骨炎、成人低血磷软骨病和部分甲旁亢骨显像表现为Ⅱ型;表现为I型的代谢骨病患者发生病理性骨折或继发局部骨病变时骨显像表现为Ⅲ型.Ⅳ型骨显像仅发现在早期甲旁亢的患者.各种类型在异常显像骨的部位、骨显像病灶的形状、摄取显像剂的程度等方面均有自身特点,根据这些特点再结合病史及X线结果可有助与骨肿瘤加以区别.     

BH6012二维扫描单光子骨密度仪

本文介绍了ＢＨ６０１２二维扫描单光子骨密度仪的原理，仪器构成，优点和性能指标。     

二膦酸类骨显像剂的研究

研究了１，２－二羟基－１，２－二膦酸乙烷（ＤＨＰＥ）、２，３－二羟基－２，３－二膦酸丁烷（ＤＨＰＢ）及２，４－二羟基－２，４－二膦酸戊烷（ＤＨＰＰ）三种络合物的合成并用＾９９ｍＴｃ标记，研究了影响记率的因素和标记的电佳方法。对这三种络合物进行了小鼠体内生物分布的对比研究，结果表明３种化合物与＾９９ｍＴｃ均能很好地络合，并具有亲骨性。     

~(18)F-FDG PET/CT in diagnosis of skeletal metastases

This work is to evaluate correlated lesions in PET and CT images of patients suffering skeletal metastases so as to improve efficacy of ~(18)F-FDG PET/CT in diagnosing bone metastases. PET and CT images of 25 patients with malignant tumor suspected bone metastases were reviewed independently by three experts. A region of interest was placed over each lesion, and the standardized uptake value (SUV) was calculated at the maximal single pixel value.The t and χ~2 tests were used for statistical analysis. Of the 203 lesions detected on the PET and CT images, 189 were malignant and 14 were benign lesions. PET alone identified 159 malignant lesions and 6 benign lesions, CT alone identified 152 malignant lesions and 11 benign lesions. For PET, the diagnostic sensitivity, specificity and accuracy were 84.1%, 71.4% and 83.3%, respectively, while 80.4%, 71.4% and 83.3% for CT. No significant difference was found between PET and CT in detecting bone metastases (χ~2=0.89, 0.19, 0.59,P>0.05). Statistical difference of positive ratio of PET was found between osteoblastic and osteolytic or mixed lesions (χ~2=47.33, 7.93, both P<0.05).Of the 122 positive lesions on both CT and PET scan, the mean SUV was 5.76±3.41, 8.52±5.37 and 7.78±4.96 in osteoblastic lesions, osteolytic lesions and mixed lesions, respectively. Significant difference was found between osteoblast lesions and osteolytic lesions (t=2.28, P<0.05). PET images alone may leave out half of osteoblastic letions,but combined analysis of PET and CT images gives better diagnosis.     

Survey of radon concentrations in bone-coal mining areas and inside BCCB houses in five provinces

1 Introduction According to the National Investigation of Natu- ral Radioactive Level (abbreviated as “the investiga- tion of levels” below) during 1983-1990, the specific activities of radionuclides in bone-coal are relatively high. It is a man-made activity which may signifi- cantly increase the radioactive level of environment and the public dose, when the local peasants sponta- neously mine the bone-coal, produce bone-coal cinder bricks (BCCB, commonly called as carbide brick) with bo…     

^188Re—HEDP的制备和初步动物实验

用＾１８８Ｗ／＾１８８Ｒｅ发生器淋洗液制备了骨肿瘤治疗＾１８８Ｒｅ－ＨＥＤＰ，＾１８８Ｒｅ－ＨＥＤＰ的最佳标记条件为：５ｍｇＨＥＤＰ，２．０ｍｇＳｎＣｌ２和１ｍｇＶｃ，在ｐＨ２．０的条件下，标记率大于９５％，其体外１２ｈ内稳定性良好，在制备＾１８８Ｒｅ－ＨＥＤＰ时加入辅剂，注射后４ｈ，小鼠股骨摄取为（７．８６±１．６２）％ＩＤ／ｇ，而对照组仅为（１．９２±０．６１）％ＩＤ／ｇ（Ｐ〈０．０１），兔全     

双能X线骨密度仪的原理和结构

本文介绍了骨密度测量的最新方法双能量Ｘ射线吸收法的基本原理，并提出了测量骼质量的计算公式和实现这种方法的结构框图。     

浙江省石煤开发利用对环境的放射性影响

本文报道了石煤开发利用中产生的对环境的放射性影响问题。石煤中U、~(226)Ra含量高,在其生产和利用过程中,如无任何控制措施,可以导致环境放射性污染。调查结果表明:浙江省石煤开发利用区土壤中~(238)U 和~(226)Ra 含量分别比对照区高2.4和2.1倍;陆地γ辐射水平比对照区高44%;石煤渣砖建房室内γ辐射剂量率比对照区高80%;石煤渣砖建房室内氡及其子体浓度最高分别可比一般砖建房高35和42倍,室内氡子体所致居民年附加有效剂量当量为41.2mSv;并导致钱塘江冰系某些局部江段中~(238)U 和~(226)Ra 浓度增加了一个数量级。     

89SrCl2治疗转移性骨肿瘤的应用研究

观察了69例转移性骨肿瘤病人使用^89SrCl2治疗后的镇疼效果、不良反应及不同原发病灶所致骨转移的使用效果。结果表明：治疗69例病人,有32例显效：疼痛完全消失,部分骨转移灶缩小、消失;30例有效：疼痛明显缓解且部分停用或减用止痛剂;7例无效。已死亡的39例除7例无效外,其它病人均有疼痛缓解,停止或减用止痛药物,生活质量明显改善。