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染料合成中芳胺类化合物是重要的中间体,在染料的合成中往往按不同要求在氮原子上接不同的烷基,通称芳胺N-烷基化。在芳香族伯胺上氮有二个氢原子可以被进行烷基化。实践中往往需要单烷基化物,因而选择合成路线是极重要的。通常芳胺N-烷基化采用溴代烷作烷基化剂,或在硫酸催化下用醇作烷基化剂。它们反应的转化率低,选择性差,且前者原料昂贵,要损失作为反应媒介的溴素,后者反应需要加 相似文献
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芳胺与N,N-双(2-氯乙基)胺盐酸盐在微波辐射下反应合成N-芳基哌嗪盐酸盐,得到一系列的重要中间体(3a~3g),所有的化合物结构经IR、1H NMR、MS表征确证。以苯基哌嗪盐酸盐的微波合成为例,考察了微波辐照时间、辐射温度、原料投料比等三个方面对苯胺转化率或主产物收率的影响。得到优化合成条件:微波辐射反应时间为20 min,微波辐射反应温度为120℃,芳胺与N,N-双(2-氯乙基)胺盐酸盐的摩尔比为1∶0.9。与传统加热方法制备N-芳基哌嗪盐酸盐相比,微波辐射下反应速度至少是常规合成方法反应速度的20倍。 相似文献
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N-烷基化反应是合成精细化工中间体的一种重要工艺,其合成方法很多,所得产品可应用于诸多领域。其中,以卤代烷烃、烷基醇、羧酸酯、磺酸酯作为烷基化试剂的取代N-烷基化反应是非常有用的反应类型,也是近期专利申请的热点课题之一。本文对取代型N-烷基化反应专利技术进行了概述。 相似文献
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用5,5-二溴丙二酸亚异丙酯作溴化试剂,室温下与 N-烷基或 N,N-二烷基芳胺在二氯甲烷中反应,可区域选择地生成对位产物。产率55~93%。 相似文献
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以N,N-二甲基丙烯酰胺和芳胺类化合物为原料,盐酸为促进体系,经过分子间的高区域选择性加成,成功地构建出了3-(芳胺)-N,N-二甲基丙酰胺衍生物。采用1H-NMR、13C-NMR和熔点对目标产物进行了表征。研究表明该方法具有原料便宜易得、原子经济、后处理操作简单和产品纯度高等优点,为3-(芳胺)-N,N-二甲基丙酰胺衍生物的高效、快速合成提供了一条可选的策略。 相似文献
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芳胺N-单烷基化定向控制工艺进展 总被引:7,自引:1,他引:7
芳胺N-单烷基化产物是重要的精细化工产品。本文讨论了金属及其氧化物催化、沸点分子筛催化及相转移催化定向控制合成N-单烷基芳胺的方法及进展情况,并比较了各自的优缺点和发展前景。 相似文献
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The intermediate Schiff base was detected by GC–MS in the reductive alkylation of nitro aromatic compounds catalysed by Raney nickel, supporting the proposed reaction mechanism. The influence of substituents and alkylating agents-alcohols on the reaction were studied and the results showed that both the position and properties of the substituents and the structures of the alcohols used have a significant effect on the N-alkylation. Steric hindrance is the main factor which inhibits N-alkylation and causes side reactions. High yields of N-monoalkyl arylamines were obtained with nitro compounds having para- or meta- substituents and with straight chain alcohols, except for methanol. 相似文献
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Kunling Xu Yuan Zhang Xiaorong Chen Lei Huang Rui Zhang Jun Huang 《Advanced Synthesis \u0026amp; Catalysis》2011,353(8):1260-1264
A convenient and highly selective platinum nanocatalyst was developed for the hydrogenation of nitro aromatics into the corresponding anilines at room temperature under ambient pressure. The platinum catalyst was highly active and selective for the hydrogenation of nitro aromatic compounds. Reducible groups such as aldehyde, ketone and nitrile were untouched during the hydrogenation of the corresponding nitro compounds, and the corresponding anilines were obtained quantitatively. 相似文献
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取代苯胺的生物降解性研究 总被引:4,自引:0,他引:4
以BOD5/CODCr值表征有机物的生物降解性,对影响取代苯胺生物降解性的因素进行了研究,结果表明,随着浓度的升高,取代苯胺的生物降解性降低,BOD5/CODCr的对数值与浓度对数值成线性关系,在较宽的pH值范围内,部分取代苯胺的生物降解性变化不大,盐浓度的增大对取代苯胺的生物降解产生明显的抑制作用。 相似文献
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手性醇是重要的医药中间体与精细化工品,立体选择性羰基还原酶催化制备手性醇具有重要的研究与应用价值,受到国内外科学家和工程师的高度关注。本文主要围绕羰基还原酶的发现与分类、催化羰基还原反应的活性与立体选择性机制、酶的筛选挖掘与分子改造技术、辅酶还原型烟酰胺腺嘌呤二核苷酸(磷酸)的再生方法、羰基还原酶催化合成手性醇医药中间体与精细化学品技术开发与应用等方面展开综述。重点阐述了羰基还原酶催化制备降血脂、抗细菌或病毒感染、抗肿瘤、抗抑郁症、抗癫痫等重要疾病治疗药物中间体及脂肪族、芳香族手性醇精细化工品的国内外技术进展与应用,为高效能立体选择性生物催化剂的创制和手性化合物的生物合成提供理论借鉴和成功范例。 相似文献
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Malai Haniti S.A. Hamid PaulA. Slatford Jonathan M.J. Williams 《Advanced Synthesis \u0026amp; Catalysis》2007,349(10):1555-1575
Alcohols can be temporarily converted into carbonyl compounds by the metal‐catalysed removal of hydrogen. The carbonyl compounds are reactive in a wider range of transformations than the precursor alcohols and can react in situ to give imines, alkenes, and α‐functionalised carbonyl compounds. The metal catalyst, which had borrowed the hydrogen, then returns it to the transformed carbonyl compound, leading to an overall process in which alcohols can be converted into amines, compounds containing C C bonds and β‐functionalised alcohols. 相似文献
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Audrey Holes Alexandra Eusebi Daniel Grosjean David T. Allen 《Aerosol science and technology》2013,47(6):516-526
ABSTRACT The composition of aerosol generated in the photooxidation of 1,3,5-trimethylbenzene was investigated in a smog chamber experiment. The relative concentrations of alcohols, carboxylic acids, organonitrates, carbonyl groups, nitroaromatics, aliphatic C—H and aromatic C—H in the aerosol were estimated through analysis of infrared spectra. Based on model compound calibrations it was estimated that a typical molecule in the aerosol contained three carbonyl groups, six aliphatic C—H bonds, and one hydroxyl group. Small amounts of organic acids (one molecule in ten) and organonitrates (one molecule in four) were observed. About 5–10 wt% of the aerosol mixture was aromatic and these structures contained nitro and hydroxyl groups. This information on aerosol chemical functionality was coupled with gas-phase chemistry mechanisms to propose potential aerosol formation pathways. 相似文献
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The oxidation of primary and secondary alcohols to their corresponding carbonyl compounds proceeds with high efficiency under molecular oxygen in the presence of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and tungsten oxide/alumina (WO3/Al2O3). The method is environmentally benign, because the reaction requires only molecular oxygen as the terminal oxidant and gives water as a side product. Various aromatic, alicyclic, and aliphatic alcohols can be converted to their corresponding carbonyl compounds in excellent yields. It is noteworthy that the oxidative transformation of the alcohols proceeds chemoselectively in the presence of other functional groups. In addition, a plausible catalytic pathway is proposed. 相似文献