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Dr. Evangelos C. Tatsis Dr. Eva Eylert Dr. Ravi Kumar Maddula Dr. Elena Ostrozhenkova Dr. Aleš Svatoš Prof. Dr. Wolfgang Eisenreich Dr. Bernd Schneider 《Chembiochem : a European journal of chemical biology》2014,15(11):1645-1650
Nudicaulins are unique alkaloids responsible for the yellow color of the petals of some papaveraceaous plants. To elucidate the unknown biosynthetic origin of the skeleton, a 13CO2‐pulse/chase experiment was performed with growing Papaver nudicaule plants. 13C NMR analysis revealed more than 20 multiple 13C‐enriched isotopologues in nudicaulins from the petals of 13CO2‐labeled plants. The complex labeling pattern was compared with the isotopologue composition of a kaempferol derivative that was isolated from petals of the same 13CO2‐labeled plants. The deconvolution of the labeling profiles indicated that the nudicaulin scaffold is assembled from products or intermediates of indole metabolism, the phenylpropanoid pathway, and the polyketide biosynthesis. Naringenin‐type compounds and tryptophan/tryptamine are potential substrates for the condensation reaction finally generating the aglycone skeleton of nudicaulins. 相似文献