Effects of alcohol administration on psychophysiological and subjective-emotional responses to aversive stimulation in anxiety-sensitive women.

Examined the effects of anxiety-sensitivity (AS) levels, and 1.00 ml/kg alcohol, on autonomic and subjective-emotional responses to aversive stimulation (i.e., noise bursts). Ss were 30 university women divided into 3 AS groups (high, moderate, and low), on the basis of Anxiety Sensitivity Index (ASI) scores. When sober, high-AS women provided higher emotional arousal ratings while anticipating the noise bursts than did low-AS women. Alcohol dampened the noise burst-anticipation ratings, particularly in the high-AS group. ASI scores were positively correlated with degree of sober skin conductance level (SCL) reactivity and with degree of alcohol dampening of SCL reactivity. Thus, high-AS women may use alcohol to normalize their anticipatory emotional and electrodermal overreactivity to threat. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential sensitivity to alcohol reinforcement in groups of men at risk for distinct alcoholism subtypes

The present study examines the relationship of familial and personality risk factors for alcoholism to individual differences in sensitivity to the positively and negatively reinforcing properties of alcohol. Sixteen sons of male alcoholics with multigenerational family histories of alcoholism (MFH) and 11 men who self-report heightened sensitivity to anxiety (HAS) were compared with 13 age-matched family history negative, low anxiety sensitive men (FH-LAS) on sober and alcohol-intoxicated response patterns. We were interested in the effects of alcohol on specific psychophysiological indices of "stimulus reactivity," anxiety, and incentive reward. Alcohol significantly dampened heart rate reactivity to aversive stimulation for the MFH and HAS men equally, yet did not for the FH-LAS group. HAS men evidenced idiosyncrasies with respect to alcohol-induced changes in electrodermal reactivity to aversive stimulation (an index of anxiety/fear-dampening), and MFH men demonstrated elevated alcohol-intoxicated resting heart rates (an index of psychostimulation) relative to the FH-LAS men. The results are interpreted as reflecting a sensitivity to the "stimulus reactivity-dampening" effects of alcohol in both high-risk groups, yet population-specific sensitivities to the fear-dampening and psychostimulant properties of alcohol in the HAS and MFH groups, respectively.     

Men at high risk for alcoholism: The effect of alcohol on cardiovascular response to unavoidable shock.

Three groups of 12 nonalcoholic men at differing degrees of genetic risk for alcoholism were tested with and without alcohol for their cardiovascular response to an aversive stimulus. A high-risk group consisted of sons of alcoholic fathers with extensive transgenerational family histories of alcoholism. A moderate-risk group included sons of alcoholic fathers whose previous generation was essentially negative for other alcoholic diagnoses. The low-risk group consisted of men with negative family histories for the disorder. Heart rate and digital blood volume amplitude were measured in each subject while resting and during a signaled shock procedure. Results show that the high-risk group was more cardiovascularly reactive to the stressor than the moderate-risk group when sober. Alcohol consumption led to a dramatic reduction in the degree of reactivity in the high-risk group, and it led to increased reactivity in the moderate-risk group. The trend for the low-risk group was similar to the moderate-risk group with no significant differences between the two. The methodology and results are discussed in terms of their relevance in the etiology of alcoholism in high-risk men and in terms of the need for generational controls in studying sons of alcoholics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of alcohol abuse and familial alcoholism on physical health in men and women.

Administered a structured interview measuring 5 categories of physical health (medical history, alcohol-related disorders, trauma history, drug use history, and female-related disorders) to 76 male and 72 female detoxified alcoholics and 50 male and 51 female nonalcoholic controls. Ss were aged 21–62 yrs, and approximately half the Ss had a positive family history (FH) of alcoholism (AC). Results indicate that (1) alcoholics suffer pervasive physical health difficulties, (2) an FH of AC is predictive of health problems in both alcoholics and controls, (3) the effects of alcohol abuse and FH of AC on health are independent and additive, and (4) women may exhibit increased vulnerability to the adverse effects of AC. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Positive and negative associations with alcohol and familial risk for alcoholism.

Considerable evidence indicates that cognitions regarding favorable drinking consequences figure prominently in the development of problem drinking. Because children of alcoholics (COAs) are at particularly high risk for developing drinking problems, the authors hypothesized that they would have higher levels of such cognitions than children of nonalcoholics (CONAs). The authors administered a free-recall task consisting of alcohol, positive, negative, and neutral words to 100 college students and predicted that COAs (n?=?18) would have higher levels of positive associations (measured by contiguous recall) and lower levels of negative associations with alcohol than would CONAs (n?=?82). The results indicated that although COAs had significantly fewer negative associations than CONAs they had statistically comparable levels of positive associations. Early intervention efforts among COAs may be enhanced by placing increased emphasis on alcohol's negative consequences. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive function, cardiovascular reactivity, and behavior in boys at high risk for alcoholism.

Boys (average age?=?12.1 years) from families with an extensive history of paternal alcoholism differed from controls of similar age and IQ on measures of cognitive function, cardiovascular reactivity, and parent-rated conduct problems. High-risk boys performed most poorly on neuropsychological tests of frontal lobe function. According to tests of temporal organization and conditional associate learning, control over working memory was the frontal subfunction primarily affected. A mental arithmetic task also elicited greater heart rate increases and peripheral vasoconstriction among high-risk boys than among controls. After controlling for group status, significant correlations remained between frontal lobe test scores and disruptive behavior and between cardiovascular hyperreactivity and anxiety levels. The possible contribution of these findings to alcohol abuse was discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of alcohol and cognitive set on sexual arousal to deviant stimuli.

48 undergraduate male social drinkers were randomly assigned to 1 of 2 expectancy set conditions in which they were led to believe that the beverage they were administered contained alcohol or no alcohol. For half of the Ss in each expectancy condition, the beverage was an alcoholic malt liquor; the others drank a nonalcoholic malt beverage. After their drinks, changes in penile tumescence (PT) in response to normal and deviant tape recordings and to self-generated fantasy were measured physiologically by a mercury-in-rubber strain gauge. The cognitive set (expectancy) significantly increased PT in response to the various erotic recordings. Alcohol did not significantly influence levels of sexual arousal. Ss who believed they had consumed an alcoholic beverage evidenced significantly more arousal to the forcible rape recording and to the sadistic stimuli than Ss who believed that they had consumed a nonalcoholic beverage, regardless of the actual contents of the beverage. The cognitive set, as well as the alcohol, significantly influenced heart rate, skin temperature, and subjective reports of sexual arousal. Self-report measures of sexual arousal were positively correlated with PT. Mosher Forced-Choice Guilt Inventory scores were not significantly correlated with PT, although the Sex Guilt subscore was negatively correlated with the subjective measure of sexual arousal for the heterosexual intercourse and forcible rape tapes. (35 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Emotional conditioning to masked stimuli: Expectancies for aversive outcomes following nonrecognized fear-relevant stimuli.

The role of conscious awareness in human Pavlovian conditioning was examined in 2 experiments using masked fear-relevant (snakes and spiders; Experiments 1 and 2) and fear-irrelevant (flowers and mushrooms; Experiment 1) pictures as conditioned stimuli, a mild electric shock as the unconditioned stimulus, and skin conductance responses as the primary dependent variable. The conditioned stimuli were presented briefly (30 ms) and were effectively masked by an immediately following masking stimulus. Experiment 1 demonstrated nonconscious conditioning to fear-relevant but not to fear-irrelevant stimuli. Even though the participants could not recognize the stimuli in Experiment 2, they differentiated between masked stimuli predicting and not predicting shocks in expectancy ratings. However, expectancy ratings were not related to the conditioned autonomic response. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of hypercholesterolemic men and women at high risk for atherosclerosis. Study of risk factors and response to pravastatin treatment

BACKGROUND: Ornithine decarboxylase (ODC; EC 4.1.1.17) is the first rate-limiting enzyme in the biosynthesis of polyamines. ODC protein has a characteristic amino acid sequence, the PEST sequence, which is related to the enzyme's rapid degradation. ODC cDNA prepared from human hepatoma tissues has been reported to show nonsense or missense mutations. METHODS: We examined somatic mutations of ODC cDNA by RT-PCR-SSCP analysis and mRNA expressions by RT-PCR in 50 colorectal cancer tissues to investigate the involvement of ODC gene alterations in colorectal cancers. RESULTS: Increased expression of the ODC gene was observed in 36 cases (86%) out of the 42 examined by RT-PCR. In one case, a missense mutation was found in the cancer tissue but not in normal mucosa. The missense mutation from Asp to Asn at codon 424, in the PEST region, possibly stabilizes the ODC protein. In colorectal cancer, replication error and a germline mutation in hMSH2 gene were observed. CONCLUSIONS: The missense mutation at codon 424 is speculated to be a cause of stabilization and a passenger mutation owing to the mutator phenotype. Since only one of 50 colorectal cancers exhibited a missense mutation of the ODC gene, mutations in ODC gene are not frequent in colorectal cancer. The increased expression of the ODC gene was noted in 86% of colorectal cancer tissues by RT-PCR, however, it was not due to point mutations in ODC coding exons.     

Effects of conditioned aversive stimuli presented during tonic immobility in guinea pigs.

The duration of and susceptibility to tonic immobility were measured in 3 groups of albino and pigmented guinea pigs (N = 27) while a train of intense tone bursts was presented. In 1 group, the tone bursts had been previously associated with painful shock stimuli. The 2nd group had previously experienced the tone bursts alone, and the 3rd group had previously received shocks without the train of tone bursts. Results indicate that both groups which had previously received shock exhibited increased susceptibility to immobilization, and the no-shock group showed a decline in duration when tone bursts were presented. Results could not be easily interpreted to support the fear hypothesis. Explanations involving "sensitization" and "learned helplessness" are proposed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Sensitivity" of depressed individuals to aversive stimuli.

Conducted 2 studies to test the hypothesis that depressed individuals are more sensitive to aversive stimuli than nondepressed individuals. Undergraduates were classified into depressed, psychiatric control, and normal control groups (n = 24) on the basis of therapist ratings, interview techniques, and MMPI subscale scores. Autonomic response (skin resistance) to aversive stimulation was studied both before, during, and after Ss were given a mild electric shock. Adaptation over repeated presentations of the same aversive situation was also studied. It was found that depressed Ss showed a significantly greater autonomic response during, but not before or after, the presentation of the aversive stimulus. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of ethanol on temporal recovery of auditory-evoked potentials in individuals at risk for alcoholism

The present investigation examined the effects of placebo (P), low dose (LD), and high dose (HD) ethanol on auditory event-related potential (AEP) recovery functions in a group of males at high risk to develop alcoholism (HR; n = 23, mean = 22.3 years) and a low risk (LR; n = 27, mean = 23.0 years) control group. Condition order was randomized, with one condition (P, LD, or HD) per day and a minimum 1-day interval between conditions. For each subject, both blood alcohol levels (BALs) measured via breathalyzer, and event-related potentials recorded with the entire 10/20 International System, were assessed prior to and at mean intervals of 20, 60, 90, and 130 min after P, LD, or HD administration. A series of binaural auditory stimuli with randomly interposed interstimulus intervals of 0.5, 1.0, and 10.0 sec were used to elicit the N100 and P200 components of the AEP. Between-groups comparisons indicated that ethanol elicited risk group differences in recovery functions not present at baseline. The differences were manifested in the HR group as larger decrements in P200 amplitude during the ascending blood alcohol curve (acute sensitivity) and more rapid returns of both N100 and P200 to baseline levels during the descending blood alcohol curve (acute tolerance). These findings support Newlin and Thomson's (1990) Differentiator Model, suggesting that LR and HR individuals are differentially sensitive to the effects of ethanol.     

Personal control over aversive stimuli and its relationship to stress.

Reviews experimental research relating types of personal control to the experience of stress. 3 main types of personal control may be distinguished: (a) behavioral (direct action on the environment), (b) cognitive (the interpretation of events), and (c) decisional (having a choice among alternative courses of action). Each type of control is related to stress in a complex fashion, sometimes increasing it, sometimes reducing it, and sometimes having no influence at all. It may be generally said that the relationship of personal control to stress is primarily a function of the meaning of the control response for the individual, i.e., the stress-inducing or stress-reducing properties of personal control depend upon the nature of the response and the context in which it is embedded and not just upon its effectiveness in preventing or mitigating the impact of a potentially harmful stimulus. (66 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Paradoxical autonomic responses to aversive stimuli in the developing rat.

The goals of this research were to determine (1) the change in heart rate elicited by aversive auditory stimuli in the laboratory rat at different ages and (2) the autonomic origins of those changes at each age. The results of the 1st 2 experiments showed that aversive white noise stimuli elicited cardiac deceleration in preweanling (16-day-old) rats and cardiac acceleration in weanling (23-day-old), periadolescent (30-day-old), and adult (60-day-old) rats. Subsequent experiments showed that (1) the decrease in heart rate elicited by the noise stimulus in preweanling rats was mediated by parasympathetic activation of the heart, (2) the stimulus-elicited increase in heart rate elicited by the noise in periadolescent rats was mediated by parasympathetic withdrawal of the heart, and (3) the noise-induced increase in heart rate in adult rats was primarily mediated by sympathetic activation of the heart. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of aversive stimuli on reaction time in schizophrenia.

"… the experiment was to assess the motivational role of aversive stimuli in modifying the performance of normal and… schizophrenic… males… [on] a visual reaction time task… . During… [one] series Ss responded under… experimental conditions… [part of which] involved the use of intense noise as an aversive stimulus. None of the experimental conditions appreciably altered the performance of normal Ss. However, schizophrenic Ss performing under… [conditions involving noise] displayed greater improvement than control Ss." 22 refs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of alcohol and expectancies on verbal aggression in men and women.

In Exp I, 48 male and 48 female heavy social-drinking undergraduates were assigned to beverage (vodka [.75 ml/kg] and tonic or only tonic) and beverage-expectancy (alcohol or tonic) conditions. Ss were provoked by a confederate's unfavorable evaluation and allowed to retaliate. In Exp II, Exp I was repeated using 44 males and 45 females and higher doses of ethanol (1.12 and 1.10 ml/kg, respectively, for males and females). In Exp III, an experimenter criticized 62 male drinkers (.9 ml/kg ethanol) who later evaluated the experimenter's job performance on a questionnaire for his employer. Results show that for Ss at higher doses and males at the lower dose, those expecting alcohol were significantly less aggressive and at higher doses felt happier than did Ss expecting only tonic. Actual alcohol consumption increased aggression only for females at the lower doses. It is concluded that alcohol by its pharmacologic action alone does not necessarily increase aggression at either a low or a moderately high dose. It is suggested that many of the reinforcements of alcohol use are due to the drinkers' cognition rather than the pharmacologic action of alcohol itself. (43 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential subjective and psychophysiological responses to socially and nonsocially generated emotional stimuli.

Sociality may determine the subjective experience and physiological response to emotional stimuli. Film segments induced socially and nonsocially generated emotions. Comedy (social positive), bereavement (social negative), pizza scenes (nonsocial positive), and wounded bodies (nonsocial negative) elicited four distinct emotional patterns. Per subjective report, joy, sadness, appetite, and disgust were elicited by the targeted stimulus condition. The social/nonsocial dimension influenced which emotional valence(s) elicited a skin conductance response, a finding that could not be explained by differences in subjective arousal. Heart rate deceleration was more responsive to nonsocially generated emotions. Taken together, these findings suggest that sociality affects the physiological profile of responses to emotional valence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dimensionality of subjective response to a selection of complex aversive stimuli.

[Correction Notice: An erratum for this article was reported in Vol 6(4) of Canadian Journal of Behavioural Science Revue canadienne des Sciences du comportement (see record 2007-01479-014). An error was made in the printing of Figure 1 (page 261). The correct Figure is provided in this erratum.] Investigated the dimensionality of subjective responses to a variety of stressor stimuli using a multidimensional scaling procedure with 30 undergraduates as Ss. Results indicate that the subjective perception of these stimuli was multidimensionally determined but with only 1 inter-S viewpoint about the obtained dimensionality. Stimulus projections on 2 dimensions were significantly correlated with scaled values of a unidimensional stress scale and were found not to be independent of a subjective attention scale. Speculations about the nature of the obtained dimensional structure, along with possible implications for assessing mechanisms of coping with stress, are discussed briefly. (French summary) (41 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Meta-analysis of P300 amplitude from males at risk for alcoholism.

The P3(00) event-related brain potential (ERP) is used to study the development of alcoholism by comparing males who have a positive family history of alcoholism with control Ss who have no such familial history. Meta-analysis indicated that overall, P3 amplitudes were obtained from males with family histories of alcoholism compared to controls. Moderator analysis indicated that paradigms using difficult visual tasks yielded the most reliable effects. Furthermore, no differences in outcomes were obtained among studies that recruited positive family history Ss exclusively from among individuals whose fathers had received treatment for alcoholism as compared with other studies. These findings are discussed in the context of using ERPs as an evaluative tool in the study of psychopathology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Familial risk for alcoholism and self-reported psychopathology.

Three groups of young men varying in familial alcoholism risk (high density, high risk [HDHR]; low density, high risk [LDHR]; and low risk [LR]) were compared on the 11 clinical scales of the Personality Assessment Inventory. Significant group differences were found on 9 scales, with scores of the HDHR group exceeding those of the other 2 groups. No differences were found between the LDHR and LR groups. When the proportion with pathological scores per scale was examined, significant group differences were still revealed on 7 scales. The HDHR group exceeded the other 2 groups, but the LDHR group also exceeded the LR group on several scales. These findings support the need to more finely characterize familial alcoholism risk than is provided by the typical high-risk-low-risk dichotomy. Finally, statistically controlling for normal variations in response style reduced the number of group differences, although the same patterns persisted. (PsycINFO Database Record (c) 2010 APA, all rights reserved)