Gender identity and gender role in schizophrenia.

22 recently admitted individuals with affective disorders, 23 recently admitted schizophrenics, 21 long-term schizophrenics, and 21 noninstitutionalized controls demonstrated intact gender identity and gender-role adoption, as measured by the Embedded Figures Test and the MMPI Masculinity and Femininity scale, respectively. The 2 schizophrenic groups, in contrast with the 2 control groups, demonstrated a confused gender-role adoption, as measured by the Bem Sex-Role Inventory, and they tended to choose more opposite-sex roles on the Role Preference Test. Length of hospitalization correlated with Role Preference Test scores, but only for females. Multiple administration of the Bem inventory revealed that all groups were aware of differences in gender roles; all groups noted that their parents would have been more pleased had they adopted sex-appropriate gender roles. Noninstitutionalized controls and recently admitted schizophrenics believed the ideal patient was significantly more feminine than masculine; long-term schizophrenics and those with affective disorders possessed a knowledge more typical of females than of males. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Information processing, social skill, and gender in schizophrenia

The relationships among information processing, social skill, and gender in individuals with chronic schizophrenia were investigated. Although there were no gender differences in information processing, social skill, or negative symptoms, performance on information-processing tasks was related to various indices of social skill (e.g., paralinguistic skill) for female, but not male, inpatients. This pattern of results remained after statistical controls were applied for age, illness chronicity, and positive symptoms.     

Electrodermal nonresponding, premorbid adjustment, and symptomatology as predictors of long-term social functioning in schizophrenics.

The hypothesis that electrodermal nonresponsiveness to orienting stimuli delineates a core group of "Kraepelinian" type schizophrenics was tested by following up social functioning outcome over a 2-year period in 37 schizophrenics. Good social functioning outcome required both some self-supporting ability in the job market and a minimal social life. The prior assessments included monitoring of electrodermal responses to a series of moderately intense tones, ratings of reported and observed symptoms during an interview, and ratings of premorbid adjustment on the basis of an interview with a close relative. Electrodermal nonresponding, poor premorbid adjustment, and negative symptomatology predicted poor social functioning during the second follow-up year, but the relationship to nonresponding pertained exclusively to a group of 15 first-episode patients. Discriminant analysis showed that electrodermal nonresponding and symptoms were the only independent predictors of outcome. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Anhedonia, positive and negative affect, and social functioning in schizophrenia

This study examines the relationship between anhedonia and the trait dimensions of positive affect (PA) and negative affect (NA) in schizophrenia. The relationship between poor social functioning in schizophrenia and these individual differences in affectivity is also examined. Schizophrenia outpatients (n = 37) and normal controls (n = 15) were assessed at a baseline evaluation and again approximately 90 days later. Consistent with the hypothesized decrease in hedonic capacity in schizophrenia, patients reported significantly greater physical and social anhedonia and less PA than controls. However, the schizophrenia group also reported significantly greater NA and social anxiety than did controls. In support of the dispositional view of these individual differences in affectivity, trait measures demonstrated test-retest reliability, and group differences between the schizophrenia group and controls were stable over the 90-day followup period. Within the schizophrenia group, physical and social anhedonia were comparably negatively correlated with trait PA; however, social but not physical anhedonia was significantly positively correlated with NA and social anxiety. Poor social functioning in the schizophrenia group was associated with greater physical and social anhedonia and greater NA and social anxiety. Alternatively, greater trait PA was related to better social functioning. These findings indicate that schizophrenia is characterized by both low PA and elevated NA and that these affective characteristics are a stable feature of the illness. The results also suggest important links between affect and social functioning in schizophrenia.     

Affective and social-behavioral correlates of physical and social anhedonia in schizophrenia.

The association between scales measuring physical and social anhedonia, self-reports of affective response to emotion-eliciting films, and role play measures of social skill was evaluated in patients with schizophrenia, schizoaffective disorder, and bipolar affective disorder. It was hypothesized that patients with schizophrenia would report significantly greater anhedonia than the bipolar patients and that higher scores on the anhedonia scales (AHSs) would be related to attenuated reports of the experience of positive affect and poorer social skill. Patients with schizophrenia and schizoaffective disorder did not differ in ratings of anhedonia, but both groups had higher physical and social AHSs than did bipolar patients. Higher scores on the physical AHS, but not the social AHS, were related to attenuated reports of positive affect following viewing of affect-eliciting films in schizophrenia-schizoaffective disorder patients. Neither AHS was related to role play measures of social skill performance for any patient group. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Long-term use of the female condom among couples at high risk of human immunodeficiency virus infection in Zambia

A comparison of course and outcome in schizophrenics and patients with unipolar affective disorders revealed significant differences not only between the two groups but also between first hospitalized and rehospitalized patients within each group. While schizophrenics fared worse in almost all parameters at the end of the 14-year follow-up period, within each group overall course and outcome were also poorer for rehospitalized versus first hospitalized patients. The poorest course was shown by rehospitalized schizophrenics. Future studies on course and outcome should differentiate between first and rehospitalized patients.     

Skin conductance basal level and reactivity in schizophrenia as a function of chronicity, premorbid adjustment, diagnosis, and medication.

Examined the skin conductance basal level and GSR of 384 male schizophrenics divided into subgroups according to chronicity, premorbid adjustment, diagnosis, and medication. 10 male psychiatric aides served as normal controls. Results indicate that basal level differences between schizophrenic subgroups or between schizophrenics and normals were mainly due to long-term institutionalization. The novelty of the experimental situation, as contrasted with the usual minimal stimulation domicile of the chronic patient, resulted in extensive responsivity not exhibited by the acute schizophrenic, other hospitalized patients, or normals. An interaction of premorbid adjustment and diagnosis within the chronicity subgroups was also found. The GSR differences between schizophrenic subgroups were primarily due to begin on or off medication, and this was mainly evident in the premorbid adjustment grouping. The results of an examination of social censure stimulus effects were not supportive of a social censure hypothesis. (35 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Eye tracking in patients with unipolar and bipolar affective disorders in remission.

Examined patients (20–66 yrs old) with a history of recurrent affective disorder on a variety of smooth-pursuit and saccadic eye-tracking tasks and on psychomotor analogs of these tasks. The 25 unipolar and 24 bipolar Ss were compared to 24 schizophrenics; all Ss were in remission. Results indicate that the performance of the 2 affective-disorder groups was not significantly different from that of the controls on any of these tasks. Smooth-pursuit tracking error was greater for Ss receiving Li and for those with a higher frequency of prior episodes of the disorder. When the pursuit eye movements of these Ss were compared to those of the schizophrenics, the latter produced more tracking error than both affective-disorder groups but significantly so only with respect to unipolar Ss. Although findings are consistent with the interpretation that tracking dysfunction is not a trait characteristic of affective disorders, further investigations contrasting remitted patients with bipolar and schizophrenic disorders are needed to determine the specificity of deviant tracking to schizophrenia. (38 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expectancy changes in depression and schizophrenia.

Does the learned helplessness model of depression apply to clinically depressed patients and is it specific to depression? Changes in expectancy following success and failure in skill and chance tasks were assessed for depressed nonschizophrenics (unipolar depressives), depressed schizophrenics, nondepressed schizophrenics, and normal controls (32 Ss, aged 18–50 yrs). Unipolar depressives showed smaller changes in expectancy of future success after failure in the skill task than did the controls and both schizophrenic groups. Depressed schizophrenics did not show smaller expectancy changes than nondepressed schizophrenics. The learned helplessness model has been tested primarily in populations with subclinical depression; the present results provide partial support for learned helplessness as a model of one type of severe clinical depression and suggest that learned helplessness is not a general feature of psychopathology. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social comparison, self-stereotyping, and gender differences in self-construals.

Four studies examined gender differences in self-construals and the role of social comparison in generating these differences. Consistent with previous research, Study 1 (N=461) showed that women define themselves as higher in relational interdependence than men, and men define themselves as higher in independence/agency than women. Study 2 (N=301) showed that within-gender social comparison decreases gender differences in self-construals relative to a control condition, whereas between-genders comparison increases gender differences on both relational interdependence and independence/agency. Studies 3 (N=169) and 4 (N=278) confirmed these findings and showed that changing self-construal changes gender differences in social dominance orientation. Across the 4 studies, strong evidence for the role of in-group stereotyping as mediator of the effect of gender on self-construal was observed on the relational dimension but not on the agentic dimension. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Ventilatory response at the onset of voluntary exercise and passive movement in endurance runners

In order to address basic mechanisms behind a reduced averaged P300 wave in schizophrenia and depression, 17 unmedicated schizophrenic and 11 unmedicated depressive subjects were tested in an 'oddball paradigm' against healthy controls matched for gender and age. The amplitude distributions of single trials' maximum positive deflections after stimulation (P300) for both target and nontarget stimuli were determined, which served as a basis for calculating the discrimination index d'. This index characterizes differences in the electrophysiological responses to target and nontarget stimuli of a subject being engaged in a discrimination task. As a main result d' was significantly lower for schizophrenics than for their controls. Directly compared to depressive subjects, schizophrenics also depicted a statistically significant decrease of the discrimination index, which could not be explained by differences in age. Although the averaged P300 signals did not show any significant differences between the two diagnostic groups, the approach of calculating d' on the basis of single trial analysis differentiated between schizophrenics and depressives. In conclusion, schizophrenic patients revealed different functional features when generating event-related potentials in an 'oddball paradigm' compared to healthy controls and depressives.     

The role of gender differences in the reduction of etiologic heterogeneity in schizophrenia

Recent research has shown a resurgence of interest in the study of gender differences in schizophrenia. Accumulated evidence suggests that, compared with women, men have a higher incidence of schizophrenia, earlier age of onset, poorer course and medication response, poorer premorbid social and intellectual functioning, fewer affective symptoms, lower family morbid risk of schizophrenia and affective disorders, more evidence of obstetric complications in their mothers, and greater structural brain abnormalities. The roles of estrogen, neurodevelopment, and family history of affective disorder are evaluated as co-contributors to the observed gender differences in schizophrenia. Particular emphasis is given to evaluating the hypothesis that men are more prone to a hypothesized poor-prognosis, neurodevelopmental subtype of schizophrenia, for which early environmental brain insults play an important etiologic role, whereas women may be more prone to a hypothesized good-prognosis, affective subtype that is genetically related to the affective disorders. This hypothesis is evaluated in terms of (a) its ability to account for gender differences in schizophrenia, (b) its ability to link differences in clinical presentation to proposed differences in etiology; and (c) its potential to generate testable predictions for future schizophrenia research.     

Schizophrenia and the scanning cognitive control: A reevaluation.

In recent studies it has been inferred from performance on perceptual tasks, that paranoid schizophrenics showed extensive scanning and nonparanoid schizophrenics showed minimal scanning. Eye movements during free-search and size-judgment tasks were recorded for 14 paranoid and 14 nonparanoid schizophrenics, 14 psychotic depressives, and 14 control Ss. Medicated Ss showed lower eyemovement rate and fixation rate than nonmedicated Ss and controls, but there were no significant differences due to schizophrenia. There was a significant interaction between patient type and medication for size-judgment means, but all such differences were reduced to nonsignificance by training. Even after training, Ss showed greater variability in size judgments than controls. Results failed to support the notion of extensive or minimal scanning behavior of schizophrenics. Errors by the psychotic patients in making size judgments were not correlated with scanning behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Production of associative sequences in process-reactive schizophrenic and nonschizophrenic groups.

A previous study (Judson & Katahn, 1960) disclosed significant differences between process-reactive schizophrenics in the recall of friends' names over a 10-minute interval. The differences were greater than would have been expected from their recall of animal names and IQ scores. This was interpreted as reflecting a special restriction in interpersonal relationships in a generally impoverished relationship with the environment. The present study sought to extend the findings and employed both schizophrenic and nonschizophrenic patients. Both the process-reactive dimension and diagnostic category made significant independent and interacting contributions to the recall of friends' names, that is, the material with social connotations, but not to the recall of animal names. By subgroups, the rank order of recall from least to greatest, was process schizophrenics, process nonschizophrenics, reactive schizophrenics, reactive nonschizophrenics. The process-reactive distinction thus proved meaningful for nonschizophrenic as well as schizophrenic patients on this material. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social competence as a process-reactive dimension with schizophrenics, alcoholics, and normals.

Investigated the effect of the level of social competence on the performance of a paired discrimination task involving social censure cues for groups of male hospitalized schizophrenics, alcoholics, and normals. Previous studies finding differences between process and reactive schizophrenics had not controlled for the social competence level of the normal controls. 24 Ss from each diagnostic category were divided equally among groups of low, middle, and high social competence levels. Low social competence Ss discriminated maternal censure stimuli more poorly than middle or high socially competent groups. Psychiatric diagnosis had no significant effect on performance. Results do not support the social censure theory of schizophrenia and suggest that there has been confounding between social competence level and diagnosis in previous process-reactive research. (18 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Family study of schizophrenia and personality.

The purpose of this study was to determine whether the abnormal characteristics observed in relatives of schizophrenics represent variations in normal personality. Relatives (N?=?340) of patients with schizophrenia, affective disorder, and medical or surgical conditions were personally interviewed about psychiatric symptoms and completed the Multidimensional Personality Questionnaire. Relatives who were themselves ill had elevated scores on some scales. Relatives of schizophrenics had normal scores on all personality scales, but relatives of affectively ill probands differed from other relatives on Well-Being and measures of Negative Emotionality. When schizophrenic probands were subtyped by symptoms, relatives of emotionally blunted schizophrenics were found to have slightly lower scores on Social Closeness than did relatives of controls. Overall, these results suggest that schizophrenia is unrelated to normal personality. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Physical anhedonia and schizophrenia.

Assessed the relation of anhedonia to schizophrenia using 69 schizophrenics and 54 psychiatric control outpatients from 3 mental health centers. In addition to indexes of schizophrenia, each S was given the Physical Anhedonia Scale, a measure of premorbidity, and a vocabulary test. Measures of chronicity and education were also included. ANOVAs indicated no significant differences in anhedonia among 4 diagnostic groups: paranoid schizophrenics, nonparanoid schizophrenics, unipolar affective psychiatric control Ss, and other psychiatric control Ss. Intercorrelations showed that anhedonia was negatively related to premorbid social status, years of education and vocabulary, but it was not significantly related to hospitalization. Data do not support the hypothesis that anhedonia is a consistent sign of schizophrenia but are compatible with the notion that anhedonia is the consequence of such liabilities as psychiatric disturbance, poor premorbid status, low educational level, and low verbal ability. (10 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Conformity and achievement-related characteristics of depressed patients.

Conformity and achievement-related characteristics of 10 hospitalized depressed patients and 11 matched acute schizophrenics were studied in an Asch-type conformity situation, and by the use of self-report inventories. It was found that in the conformity situation, depressed Ss showed a greater tendency to conform to social pressure than did the controls. When conformity and achievement were assessed by the use of self-reports, the results were either nonsignificant or opposite to those found in the conformity situation. The results were compared with recent theory and research dealing with cyclical affective disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of surface modifiers on the electrode reactions and conformation of cytochrome c3 adsorbed on a silver electrode

Higher rates of left-handedness and atypical lateralization in schizophrenics paired with findings of morphological abnormalities in cerebral asymmetry suggest that the normal patterns of hemisphere specialization for processing verbal and spatial information may be anomalous in schizophrenics. The small number of studies that have addressed this question have produced inconsistent findings and varied with subtype diagnosis, gender, type of task employed, task difficulty, and control of handedness. Conflicting research findings also may be due to confounding from the heterogeneity of the schizophrenic construct and variability in clinical symptoms across patients. The present study was designed to control for factors that may have confounded earlier studies. Because the study used perceptual measures, the relationship between symptoms of perceptual aberration and hemisphere advantages was examined using Chapman et al.'s (1978) Perceptual Aberration Scale (PAS). Fifteen male schizophrenic patients and 14 male controls were administered tachistoscopic letter and facial recognition go/no-go reaction time tasks. Left hemisphere advantages were found for both controls and schizophrenics on the letter task. Right hemisphere advantages were found for controls on the facial task but not schizophrenics. Instead, a strong negative correlation was found between schizophrenics' PAS scores and hemisphere advantages (r = -0.685, p < 0.007). Further analysis identified a subgroup of schizophrenics with perceptual aberration who exhibited reversed left hemisphere advantages that increased as the PAS scores increased. Additional research is needed to determine whether this subgroup of schizophrenics constitutes a meaningful subtype with a distinct disease process that disrupts the development of normal cerebral lateralization. The findings provide further evidence for the importance of examining relationships between schizophrenics' performance on cognitive measures and their symptom patterns.     

Pharmacotherapy of schizophrenia and affective disorders: Behavioral correlates of diagnostic and demographic variables.

Time sampled observations of objectively defined ward behaviors in 116 schizophrenic, affective, and schizoaffective patients during baseline and medication periods revealed that schizophrenics displayed less scanning, social interaction, participation, and laughing/smiling. S. E. Tureff's (1978) Observational Record of Inpatient Behavior was used. The behavioral measures were relatively insensitive to demographic variables and strongly dependent on environmental context, but the measures did not change greatly over time for the major diagnostic categories, in spite of pharmacological interventions that included therapeutic doses of antipsychotic, antidepressant, and antimanic drugs. However, within diagnostic categories, patient clusters were extracted on the basis of amount and direction of behavior change, and for the affective patients, differential change was predictable from baseline response frequencies. Findings are discussed in terms of their potential usefulness for exploring dose-response and rate-dependence effects of psychotropic drugs in clinical populations and in terms of their potential for contributing to the resolution of the responder–nonresponder controversy in pharmacopsychiatry. (51 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)