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1.
OBJECTIVE: To determine the prevalence of meniscal protrusion (i.e. location of the outer edge of a meniscus beyond the tibial articular surface), and to determine its relationship with internal derangement, joint effusion, and degenerative arthropathy. DESIGN AND PATIENTS: Sagittal and coronal MR images of 111 abnormal and 46 normal knees were evaluated for the presence of meniscal protrusion. We set 25% as the minimum amount of displacement considered abnormal because this was the smallest amount of displacement we could confidently discern. Presence of meniscal tear, anterior cruciate ligament (ACL) injury, joint effusion, or osteophytosis was also recorded. RESULTS AND CONCLUSION: Normal examinations demonstrated protrusion of the medial meniscus in 6.5% of sagittal images and 15% of coronal images, and of the lateral meniscus in 2% and 13%, respectively. Fisher's exact test demonstrated a statistically significant difference between the normal and abnormal groups for the medial meniscus on both sagittal (P < 0.0001) and coronal (P = 0.01) images, but not for the lateral meniscus in either plane (P > 0.2). A protruding medial meniscus was associated with effusion and osteophytosis (P < 0.05) but not with meniscal or ACL tear (P > 0.1). Posterior protrusion of the lateral meniscus was only associated with ACL injury (P < 0.0001); protruding anterior horns and bodies of lateral menisci were not associated with any of the four abnormalities. It is concluded that the medial meniscus may occasionally protrude more than 25% of its width, but protrusion is more often due to effusion and osteophytes. Protrusion of the posterior horn of the lateral meniscus is associated with ACL insufficiency, while protrusion of the body and anterior horn of the lateral meniscus is a normal variant.  相似文献   

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Unicompartmental knee arthroplasty is an appropriate method of treating selected patients with osteoarthritis of the medial compartment of the knee. The common causes of failure are aseptic loosening, infection, patellofemoral pain, and deterioration in the opposite compartment. Seven cases of a cohort of 32 Robert Brigham unicondylar knee replacements that failed because of early catastrophic wear of the polyethylene tibial component are reported. Possible reasons suggested for failure include inadequate thickness of polyethylene, fusion defects in the polyethylene structure as a result of the sterilization process, increased rotational freedom, and reduced conformity in the design of the prosthesis.  相似文献   

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A retrospective matched-pair comparative analysis was done between 30 total knee arthroplasties following failed high tibial osteotomies and 30 total knee arthroplasties following failed unicompartmental knee arthroplasties. The groups were matched according to age, gender, type of prosthesis, primary disease, and length of followup. A minimum followup of 2 years was required for inclusion in the study, and the average followup was 3.8 years (range, 2-9 years). The Knee Society Knee Score for the high tibial osteotomy group was significantly higher than that for the unicompartmental arthroplasty group. More osseous reconstructions were required in the unicompartmental revisions. Difficulty with exposure was not significantly greater in the osteotomy group. Rates of component loosening were not significantly different between the groups. A failed unicompartmental knee arthroplasty and a failed high tibial osteotomy can be revised successfully to a total knee arthroplasty. The results confirm that revisions after unicondylar arthroplasty and high tibial osteotomy are technically demanding. In this series, the results of total knee arthroplasty following unicompartmental knee arthroplasty approached but did not equal those obtained after high tibial osteotomy.  相似文献   

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We randomised 102 knees suitable for a unicompartmental replacement to receive either a unicompartmental (UKR) or total knee replacement (TKR) after arthrotomy. Both groups were well matched with a predominance of females and a mean age of 69 years. Patients in the UKR group showed less perioperative morbidity, but regained knee movement more rapidly and were discharged from hospital sooner. At five years, two UKRs and one TKR had been revised; another TKR was radiologically loose. All other knees appeared to be clinically and radiologically sound. Pain relief was good in both groups but the number of knees able to flex > or =120 degrees was significantly higher in the UKR group (p < 0.001) and there were more excellent results in this group. Our findings have shown that UKR gives better results than TKR and that this superiority is maintained for at least five years.  相似文献   

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B-chronic lymphocytic leukemia (CLL) is characterized by an accumulation of long-lived, resting B cells expressing the Bcl-2 protein. However, less than 10% of the CLL patients shows bcl-2 gene rearrangement in blood cells, using traditional Southern blotting analysis. In the present study, rearrangement of the bcl-2 gene in CLL cells was studied by pulsed-field gel electrophoresis (PFGE). With this method, large DNA fragments (> 50-10,000 kb) could be analyzed. Blood CLL cells from 9 of 9 patients and 2 of 2 CLL cell lines showed rearranged bcl-2 gene. In comparison, healthy blood B cells and lymphoblastoid cell lines (LCLs) established from normal peripheral blood lymphocytes of the patients showed only germ line configuration. Thus, the possibility of restriction fragment length polymorphisms (RFLPs) in this gene could be excluded. The primary cell involved in CLL might be a progenitor B cell that has accidentally rearranged the bcl-2 gene. As a consequence, such cells express stable amount of Bcl-2 protein and do not enter apoptosis. During prolonged survival, such cells may acquire secondary changes including chromosomal translocations and mutations.  相似文献   

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Complete or partial withdrawal of immunosuppression is a desirable goal for physicians managing solid organ transplant recipients and has particular appeal for the management of composite tissue allograft recipients. Experience to date with steroid withdrawal or cyclosporine withdrawal in organ transplant recipients suggests that the risks of acute rejection are minimized with slow tapering of the drugs and when drug withdrawal is attempted many months or years after transplantation. Unfortunately, the full benefits of withdrawing any component of a multidrug immunosuppression regimen can probably be achieved only when the drug is withdrawn relatively early after transplantation. Thus, there is a need for improved immunologic monitoring to facilitate withdrawal of immunosuppression in any setting. Because steroid withdrawal might be particularly advantageous to the recipient of a composite tissue allograft, further experience is needed to determine the safety of steroid withdrawal with newer immunosuppressants such as tacrolimus, mycophenolate mofetil, and sirolimus.  相似文献   

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The role of arthroscopic synovectomy in Rheumatoid arthritis is still in discussion. The evaluation of the available scientific data out of the literature should give a contribution to this discussion. The review of the studies done in only small numbers of patients demonstrates good clinical results for a short or middle lasting follow-up time. The evaluation showed a lot of differences and problems in the study design, amount of usable datas and results. For the scientific rating of the results of arthroscopic synovectomies it is necessary to have prospective studies with sufficient and reliable data on activity of the disease, the pre-, post- and intraoperative findings, standardized surgical procedures and longer lasting follow-up times.  相似文献   

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The authors report on a series of 15 knees in which an extensor mechanism allograft was used to treat a rupture of the patellar tendon associated with a total knee arthroplasty. Nine of the knees have greater than two-year follow-up evaluation (average, 4.1 years; range, 2.3-7 years). Postoperatively, the average flexion was 106 degrees. All but three patients achieved full passive extension. Six of the nine knees had no extensor lag. The average post-operative clinical score for the follow-up group was 78 points. Graft complications include one early graft rupture, one early quadriceps junction failure, and one patellar component loosening. One graft fractured after revision of a metal-backed patella.  相似文献   

15.
STUDY DESIGN: The reactions to sequestrated disc fragments, which were removed surgically from 35 patients, were examined histologically. OBJECTIVES: To elucidate whether or not there is histologic evidence of absorption of sequestrated discs. SUMMARY OF BACKGROUND DATA: Spontaneous disappearance or diminution of lumbar herniated discs in the spinal canal has been recognized, and this could be a possible explanation for relief of symptoms without surgery. The mechanism of this phenomenon is unclear. METHODS: Sequestrated discs removed surgically from 35 patients were examined histologically. RESULTS: In 30 cases, neovascularization was observed at the periphery of the sequestrated discs. Many foamy cells (macrophages) were present in the vascularized areas. In addition, immunohistochemistry revealed that many spindle-shaped, fibroblast-like cells were positive for CD68, a marker of macrophages. No fibrous scar formation was observed in any region. CONCLUSION: These findings suggest that organization is not a main course for this type of herniated disc and that a kind of "absorption" process occurs predominantly in the healing stage.  相似文献   

16.
BACKGROUND: Despite recent advances in diagnosis and treatment, cytomegalovirus (CMV) infection continues to be a common cause of morbidity in liver transplant (LT) recipients. Because CMV infection suppresses cell-mediated immunity, which seems to be important in neutralizing hepatitis C virus (HCV) infection, we assessed the impact of CMV infection on histopathological HCV recurrence after LT. METHODS: The study group was comprised of 43 consecutive LT recipients with at least 6 months of histologic follow-up. Group 1 consisted of the 8 patients who developed CMV viremia after LT; group 2 comprised the 35 patients without CMV viremia. There was no significant difference with regard to age, initial immunosuppression, incidence of rejection, distribution of HCV genotypes, or mean follow-up between the groups. Semiquantitative histopathologic assessment of allograft hepatitis was performed using the Knodell's score. RESULTS: The mean total Knodell score of the final allograft biopsy was significantly greater in group 1 patients (P=0.016), with most of the difference due to periportal/bridging necrosis (P=0.009) and lobular activity subitem (P=0.01) scores. Half of the CMV viremic patients eventually developed allograft cirrhosis as compared with 11% of the CMV-negative patients (P=0.027). Accordingly, the cirrhosis-free actuarial survival by Kaplan-Meier estimates was significantly diminished in the CMV viremic patients. Glycoprotein B genotype analysis of CMV isolates revealed no significant differences between patients who did and those who did not develop allograft cirrhosis. CONCLUSIONS: After LT for chronic HCV, patients who develop CMV viremia incur a significantly greater risk of severe HCV recurrence.  相似文献   

17.
目的:探讨关节镜清理术对不同分期膝关节骨性关节炎(OA)的临床疗效,为膝关节OA患者关节镜清理术手术时机的选择提供依据.方法:根据Kellgren-Lawrence X线及Outerbridge关节镜分级标准将134例膝关节OA患者分为早期(58例)、中期(28例)和晚期(48例),并对不同时期的膝关节OA患者进行相应清理术治疗.术后平均随访18.6 个月,对早、中、晚期膝关节OA患者的主观满意度、VAS和HSS评分进行术前与术后比较及不同组间的比较.结果:患者主观评定,早期患者满意40例(68.9%),中期患者满意16例(57.1%),晚期患者满意6例(12.5%),即满意患者所占构成比早期及中期患者高于晚期患者( P<0.05),早期患者高于中期患者( P<0.05);早、中和晚期OA患者膝关节VAS评分术后较术前均明显降低( P<0.05),HSS评分术后则较术前明显升高( P<0.05);术后中期和晚期OA患者VAS评分高于早期组( P<0.05),HSS评分低于早期组( P<0.05);术后晚期OA患者VAS评分低于中期组( P<0.05),HSS评分高于晚期组( P<0.05).结论:关节镜清理术对早期及部分中期OA患者术后患者满意度较高,VAS和HSS评分疗效好,提示OA患者应在患病早期及时行关节镜手术治疗.  相似文献   

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Cylinder knee splints afforded significant relief of pain and were not associated with loss of range of motion or muscle strength in 13 of 15 patients. Splints help patients who demonstrate persistent synovitis of the knee, who do not respond to intraarticular injection of steroids, and for whom surgery is not immediately appropriate. The fiberglass polymer used in this study has several advantages over plaster for splints.  相似文献   

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Morselized cancellous allograft was used to fill large femoral and/or tibial defects in 63 patients (63 knees) who had revision surgery for failed arthroplasty between September 1988 and January 1993. Firm seating of the components on a rim of viable bone and rigid fixation with a medullary stem were achieved in all cases. One patient was lost to followup, leaving 62 patients with standard radiographic evaluation at 1 month, 3 months, and yearly intervals postoperatively. Fourteen patients required reoperation between 3 weeks and 37 months after revision surgery for loosening (two patients), wound avulsion (one patient), wound hematoma (two patients), painful wires (four patients), patellar tendon avulsion from the tibial tubercle (two patients), patellar subluxation (one patient), or late onset instability (two patients). A biopsy specimen was taken from the central portion of the allograft in each case. Evidence of healing, bone maturation, and formation of trabeculae was seen in all allografted areas visible on radiograph at 1 year after surgery. No sign of significant bone graft loss had occurred in any case. Likewise, all biopsy specimens, including the 3-week specimen, showed evidence of active new bone formation in the allografted area. Active bone formation was found in and around the allograft pieces, and new osteoid formed directly on dead allograft trabeculae. Vascular stroma was present between the bone fragments deep in the allograft mass. Older biopsy specimens evidenced progressive maturation, and evidence of active osteoclastic activity was absent by 18 months after surgery. All patients but one had significant improvement in their pain score as compared with their preoperative status. Although the complication rate was high (22%), all but one patient achieved lasting fixation to bone, adequate ligament balancing, good range of motion, and minimal to mild pain. Two patients required revision surgery. Both had greatly improved bone stock so that new implants could be applied with minor additional grafting. This method of bone stock reconstitution appears to be reliable when used in conjunction with firm rim seating and rigid intramedullary stem fixation.  相似文献   

20.
The frequent occurrence of degenerative joint disease following complete or partial meniscectomy is well recognized. Meniscal repair has been shown to lead to a lower prevalence of degenerative changes in the knee. Arthroscopically assisted inside-to-outside meniscal repair is a safe, reproducible technique for for salvaging the torn meniscus.  相似文献   

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