Sex versus sweet: Opposite effects of opioid drugs on the reward of sucrose and sexual pheromones.

Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely male sexual pheromones for female mice, we checked the effects of systemic injections of the general opioid antagonist naloxone (1-10 mg/kg) and the agonist fentanyl (0.1- 0.5 mg/kg) in a number of behavioral tests. Naloxone affected neither the innate preference for male-soiled bedding (vs. female-soiled bedding) in 2-choice tests nor the induction of place conditioning using male pheromones as rewarding stimuli, although it effectively blocked the preference for consuming a sucrose solution. In contrast, fentanyl inhibited the preference for male chemosignals without altering sucrose preference. These results suggest that, in macrosmatic animals such as rodents, opioidergic inhibition of sexual behavior might be due, at least partially, to an impaired processing of pheromonal cues and that the hedonic value of sweet-tasting solutions and sexual pheromones are under different opioid modulation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Increased sensitivity to the aversive effects of ethanol in PKCε null mice revealed by place conditioning.

Determining the intracellular signaling pathways that mediate the rewarding effects of ethanol may help identify drug targets to curb excessive alcohol consumption. Mice lacking the epsilon isoform of protein kinase C (PKCε) voluntarily consumed less ethanol than wild-type mice in two-bottle choice and operant self-administration assays. Decreased consumption may reflect either increased or decreased sensitivity to the rewarding effects of ethanol. Alternatively, decreased voluntary consumption may reflect a change in sensitivity to the aversive effects of ethanol. The authors used place conditioning to determine that PKCε null mice have an increased sensitivity to the aversive effects of ethanol but a decreased sensitivity to the rewarding effects of ethanol. Together these data suggest that PKCε null mice voluntarily consume less ethanol because they derive less reward and are more sensitive to the aversive effects of ethanol. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Microlesions of the ventromedial nucleus of the hypothalamus: Effects on sociosexual behaviors in male rats.

Electrolytic microlesions aimed at the dorsomedial portion of the ventromedial nucleus (VMN) of the hypothalamus were generated, and effects on copulation, 50-kHz vocalizations, scent marking, and sexual motivation were measured. Male rats were tested before and after lesions, after castration, and after testosterone replacement. Three control groups were used: One received sham surgery, another received no surgery or testosterone replacement, and a 3rd received lesions primarily outside the VMN. VMN lesions produced impairments in testosterone's ability to restore ultrasonic vocalizations and scent marking, assessed with 2 different test methods. Copulation, sexual motivation, and weight gain were largely unaffected, although some differences were observed in copulatory efficiency. The authors conclude that the integrity of the VMN is important for full expression of sociosexual behaviors in male rats. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Revising memories and forming new connections: A comment on "The reunion process: A new focus in short-term dynamic psychotherapy."

It is both exciting and an honor to have the opportunity to comment on interesting articles in our field. And interesting this one is! It brings together multiple sources of information and ideas to create a revisioning of the therapeutic approach in a way that is stimulating and intriguing. Dr. Sandler (see record 2007-09422-001)presents what he terms a "reunion process," in which he proposes connecting with positive attachment experiences as a way to intervene with patients who, despite "having done the necessary work on the painful memories of attachment failures" face relapse and return of symptoms. His explanations of the process of connecting with positive attachments raise challenging questions about roles and functions of memory, therapeutic techniques and processes, and our explanations for how and why psychotherapy works. In this brief comment, I offer reactions and questions that I hope will be part of the continuing dialogue about this fascinating process we call psychotherapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of vomeronasal organ removal from male mice on their preference for and neural Fos responses to female urinary odors.

Four experiments were conducted to determine whether vomeronasal organ (VNO) inputs in male mice mediate the rewarding properties of estrous female urinary odors. Sexually naive male mice with either an intact (VNOi) or lesioned (VNOx) VNO preferred to investigate female urine over water in Y-maze tests. Subsequently, VNOi males ran significantly more quickly and remained in nasal contact longer with estrous female urine than with male urine, whereas VNOx males investigated these odors equally. In home-cage habituation-dishabituation tests, VNOi males also investigated female urine significantly longer than did VNOx males, although both groups investigated female urine longer than other non-body odors. Finally, female urinary odors induced Fos in the nucleus accumbens core of VNOi males but not of VNOx males. Our results suggest that female urinary odors retain some incentive value in VNOx males. However, once direct nasal contact is made with female urine, VNO inputs further activate forebrain mechanisms that amplify the reward salience of this stimulus for the male mouse. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A rose by any other name: Commentary on Lerner's "Treatment issues in a case of possible multiple personality disorder."

Comments on P. M. Lerner's (see record 1995-18480-001) use of traditional psychoanalytic treatment (PT) on a possible multiple personality disorder patient and his attempt to maintain therapeutic neutrality. Bromberg takes issue with Lerner's clinical approach and conceptualization of PT, seeing both as a fundamental misunderstanding of the basic psychoanalytic situation as a relational milieu. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice.

Estrogens modulate almost all aspects of female behavioral arousal; however, apart from that of sexual behavior, the neurobiology of female arousal remains unclear. Because orexins-hypocretins are neurotransmitters known to be important for behavioral arousal, the authors hypothesized that orexins may be a target for estrogen. Gonadectomized female mice received an intracerebral injection of either phosphate-buffered saline, the neurotoxin saporin (SAP), or the orexin-2-saporin conjugate (OXSAP) in the lateral hypothalamus. SAP- and OXSAP-treated mice were also divided into groups receiving either estradiol capsules or oil capsules. Mice were tested in 3 behavioral tests measuring different modes of arousal: sensory responsiveness, running wheel activity, and fearfulness. OXSAP mice showed decreases in sensory responsiveness and fearfulness concomitant with a reduction in orexin cell number. Estradiol affected all behaviors tested but decreased fearfulness only when combined with OXSAP treatment. These data indicate that estrogens modulate orexins' effects on fearfulness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"The spacing effect: A case study in the failure to apply the results of psychological research": Comment.

F. N. Dempster's (see record 1989-03118-001) recommendation that distributed practice be implemented in the classroom fails to consider such impediments as costs and effects on educators' quality of work life. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Paternal influence on female behavior: The role of Peg3 in exploration, olfaction, and neuroendocrine regulation of maternal behavior of female mice.

Genomic imprinting represents a mechanism through which parent-of-origin effects on offspring development may be mediated. However, investigation of the influence of imprinted genes on behavior has been limited. Here the authors investigate the role of the maternally imprinted/paternally expressed gene, Peg3, in several aspects of behavior using both 129Sv- and B6-Peg3 mutant female mice. Virgin Peg3 females on both genetic backgrounds were less exploratory and had higher rates of defecation with strain-dependent effects on activity levels and olfactory discrimination. Reproductive success, pup retrieval, and postnatal maternal care of pups were reduced in these females whereas indices of maternal aggression were higher among B6 Peg3-KO females. Differences in maternal care were apparent in females caring for biological or cross-fostered offspring and deficits in pup retrieval apparent beyond the immediate postpartum period. Oxytocin receptor binding in the MPOA and LS was reduced in Peg3-KO females. Thus, the authors demonstrate that disruptions to Peg3 influences aspects of female behavior that are critical for mediating maternal effects on offspring development, such as postpartum licking/grooming, and that effects of Peg3 are dependent on the maternal genetic background. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Effects of beta blockade with metoprolol on simple and complex task performance": Erratum.

Reports an error in "Effects of beta blockade with metoprolol on simple and complex task performance" by Siegfried Streufert, Anthony DePadova, Thomas McGlynn, Mary Piasecki and et al (Health Psychology, 1989, Vol 8[2], 143-158). The reference and citations for Merrill, Robbins, Schultz, Streeten, and Elias (1987) were incorrect. The correct reference is: Elias, M. F., Robbins, M. A., Schultz, N. R., Streeten, D. H. P., & Elias, P. K. (1987). Clinical significance of cognitive performance by hypertensive patients. Hypertension, 9, 192-197. (The following abstract of the original article appeared in record 1989-34110-001.) Measured the effect of treatment with the beta-blocker metoprolol on several indicants of task performance in 25 mildly to moderately hypertensive men (aged 24–63 yrs) treated for 2 wks each with drug and placebo, compared with 25 untreated normotensive men (aged 23–64 yrs). Ss responded twice to the Mood Adjective Check List (MACL) and the Stroop Color and Word Test. In addition, Ss participated in 2 parallel decision-making simulations. Results indicate that normotensives and hypertensives on drug or placebo did not differ on MACL and Stroop scores. Comparisons on 12 validated simulation measures showed that treatment with metoprolol aided complex task performance. Treatment improved strategic capacity and the ability to deal effectively with emergencies. Preliminary evidence that treatment with metoprolol might help restore performance capacity that may have been lost due to hypertensive disease was also obtained. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Effects of aerobic exercise on cognitive and psychosocial functioning in patients with mild hypertension": Correction.

Reports an error in the original article by T. W. Pierce et al (Health Psychology, 1993[Jul], Vol 12[4], 286–291). Table 4, which was inadvertently excluded, is provided. (The following abstract of this article originally appeared in record 1993-46609-001.) The effects of 16 wks of physical exercise training on the psychological functioning of 90 patients with mild hypertension were examined. At baseline and after 16 wks of training, patients completed a psychometric test battery that included objective measures of neuropsychological performance and standardized self-report measures of psychosocial functioning. Patients were randomly assigned to 1 of 3 groups: aerobic exercise, strength training and flexibility exercise, or a waiting list control group. After training, there were no group differences on any of the psychological measures, even though patients who engaged in exercise perceived themselves as functioning better in a number of psychological domains. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A study of the logic of empirical arguments in psychological research: "the automaticity of social behavior" as a case study.

This article describes the logical structure of one type of empirical argument commonly used in psychological research. A characteristic flaw in its application is identified and illustrated with an analysis of a number of experiments. Intraindividual as well as social factors that contribute to the flaw's occurrence are discussed. The operation of the social factor is explored with an analysis of citation patterns in the literature. The citation analysis reveals the degree to which the flaw goes unnoticed, in deference to building a consensus of support for broad theoretical claims. The article closes with an outline of the decisions involved in choosing a research strategy and indicates the epistemic consequences of these choices. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice.

This study examined the role of dorsal hippocampal NMDA receptors and PKA activation in 17β-estradiol (E?)-induced enhancement of object memory consolidation. Mice explored two identical objects during training, after which they immediately received intraperitoneal injections of 0.2 mg/kg E?, and bilateral dorsal hippocampal infusions of Vehicle, the NMDA receptor antagonist APV (2.5 μg/side), or the cAMP inhibitor Rp-cAMPS (18.0 μg/side). Retention was tested 48 hours later. The enhanced object memory and increased ERK phosphorylation observed with E? alone was reduced by APV and Rp-cAMPS, suggesting that estrogenic enhancement of object memory involves NMDA receptors and PKA activation within the dorsal hippocampus. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comment: Integrating methodologies in the scientific study of interpersonal psychotherapy: A reaction to "Therapist immediacy in brief psychotherapy: Case study I and case study II".

In this reaction article, the author concentrates on selected methodological components characterizing both Kasper, Hill, and Kivlighan's (see record 2008-13167-001) and Hill, Sim, Spangler, Stahl, Sullivan, and Teyber's (see record 2008-13167-002) respective case studies of therapist immediacy in brief psychotherapy. In tandem, the foci and methodology of these investigations break new ground in the scientific study of interpersonal psychotherapy, and more generally they serve as paradigmatic illustrations of the form that psychotherapy research can take if it is to be truly more meaningful and useful for practitioners. Emphasis is placed on the investigators' integration of single-case research, elements of change process research, and quantitative and qualitative methods in a way that enables highly intensive examination of this core intervention in interpersonal psychotherapy. Specific elements and implications of each of these methodological components are briefly discussed, which also creates a context for addressing the issue of discovery versus verification as this pertains to the present studies. Some underlying philosophical considerations are also briefly touched on along the way. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Finding the "genuine" schizotype: A model and method for resolving heterogeneity in performance on laboratory research.

Heterogeneity in the performance of persons affected with schizophrenia or schizotypic psychopathology on various laboratory tasks has long been recognized, both for its consistency across tasks and studies and for the massive methodological and substantive challenges it poses for experimental psychopathology, genetic, and other investigations. Traditional multivariate techniques, such as factor analysis, discriminant function analysis, and cluster analysis, have all been deemed inadequate for resolving heterogeneity, because of one or another statistical limitation. Here, an objective statistical approach based on a formal statistical model that uses the ubiquitous and well-developed expectation-maximization (EM) algorithm (A. P. Dempster, N. M. Laird, & D. B. Rubin, 1977) is presented, which enables one effectively to partition a group of experimental subjects, in this case identified initially using the well-known Perceptual Aberration Scale (L. J. Chapman, J. P. Chapman, & M. L. Raulin. 1978), in a manner that reduces heterogeneity and allows for the separation of what are termed genuine and false-positive schizotypes. The validity of the parsing strategy was supported by reference to other laboratory indexes of relevance to schizophrenia and schizotypy that were not... (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Productivity Ratings of Psychology Programs Based on Publications in Clinical Journals": Correction.

Reports an error in the original article "Productivity Ratings of Psychology Programs Based on Publications in Clinical Journals" by Charles J. Golden, Sally Kuperman, and David Osmon (Professional Psychology, 1980, Vol. 11, No. 5, pp. 797-806). In Table 10 on page 804, Larue D. Carter Hospital, Indianapolis, Indiana, is incorrectly listed as a general hospital. It is a state mental hospital. (The following abstract of this article originally appeared in record 1981-28771-001.) Sought to identify the relative standing of clinical psychology programs by evaluating their frequency of publication in the major clinical journals. In addition, the relative contribution of university programs, hospital programs, medical centers, and other institutions to the clinical literature was investigated. It was found that although American Psychological Association (APA)-approved university clinical programs are responsible for the largest number of articles in the sample examined, (14 journals for the years 1975, 1976, and 1977), 6 of every 10 articles were published either by non-APA-approved academic programs or by individuals in other institutional settings. The general reputation of universities did not reflect their productivity in the clinical journals. The article includes an analysis of the major sources of publication in the clinical literature and an evaluation of the meaning of these findings for clinical psychology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Individual differences in the "Greek effect" on risky drinking: The role of self-consciousness.

Although the environmental influence of Greek affiliation on drinking has been established, little is known about intrapersonal characteristics that make individuals susceptible to this influence. Self-consciousness (attending to one's self) was hypothesized to represent dispositional vulnerability to environmental influence. The potential moderating effect of self-consciousness on the relation between Greek involvement and drinking was examined longitudinally among college students (N = 319). The effect of Greek status was moderated by private and public self-consciousness and by gender. Specifically, non-Greek members' drinking was not influenced by self-consciousness. However, sorority members increased drinking as private self-consciousness increased, whereas fraternity members increased drinking as private and public self-consciousness decreased. These findings indicate that the "Greek effect" interacts with individual characteristics to affect drinking. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Phase attraction in sensorimotor synchronization with auditory sequences: Effects of single and periodic distractors on synchronization accuracy.

Four experiments showed that both single and periodic distractor tones affected the timing of finger taps produced in synchrony with an isochronous auditory target sequence. Single distractors had only small effects, but periodic distractors occurring at various fixed or changing phase relationships exerted strong phase attraction. The attraction was asymmetric, being stronger when distractors preceded target tones than when they lagged behind. A large pitch difference between target and distractor tones (20 vs. 3 semitones) did not reduce phase attraction substantially, although in the case of continuously changing phase relationships it did prevent complete capture of the taps by the distractors. The results support the hypothesis that phase attraction is an automatic process that is sensitive primarily to event onsets. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Maternal Stress and Pituitary-Adrenal Manipulations During Pregnancy in Rats: Effects on Morphology and Sexual Behavior of Male Offspring"; Corrections to Chapman and Stern.

Reports an error in the original article by Robert H. Chapman and Judith Stern (Journal of Comparative and Physiological Psychology, 1978, Vol. 92[6], pp. 1074-1083). On p. 1081, paragraph 2, line 27, "handling" should read "group housing." Reference Note 3 should be a Reference entry: Dunlap, J. L., Zadina, J. E., & Gougis, G. Prenatal stress interacts with prepubertal social isolation to reduce male copulatory behavior. (The following abstract of this article originally appeared in record 1980-08973-001.) Investigated whether the demasculinizing and feminizing effects of prenatal stress (i.e., stress applied to the mother during pregnancy) in rats reported previously by I. L. Ward (1972) are mediated by activation of the maternal pituitary-adrenal axis. Neither whole-body restraint, with or without hyperthermia, nor ACTH treatment during the last third of gestation had any reliable effect on masculine or feminine sexual behavior in male Sprague-Dawley offspring, although these treatments produced maternal pathology and evidence of maternal adrenocorticoid release. Significant littermate similarity was found for almost every morphological and behavioral measure. Failure to control for the litter variable may account for many previously reported effects of prenatal stress on sexual behavior in rats. The discrepancy between the present and earlier findings is discussed in terms of methodological and theoretical considerations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)