Intelligent Approach for Clustering Mutations’ Nature of COVID-19 Genome

In December 2019, a group of people in Wuhan city of Hubei province of China were found to be affected by an infection called dark etiology pneumonia. The outbreak of this pneumonia infection was declared a deadly disease by the China Center for Disease Control and Prevention on January 9, 2020, named Novel Coronavirus 2019 (nCoV-2019). This nCoV-2019 is now known as COVID-19. There is a big list of infections of this coronavirus which is present in the form of a big family. This virus can cause several diseases that usually develop with a serious problem. According to the World Health Organization (WHO), 2019-nCoV has been placed as the modern generation of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) coronaviruses, so COVID-19 can repeatedly change its internal genome structure to extend its existence. Understanding and accurately predicting the mutational properties of the genome structure of COVID-19 can form a good leadership role in preventing and fighting against coronavirus. In this research paper, an analytical approach has been presented which is based on the k-means cluster technique of machine learning to find the clusters over the mutational properties of the COVID-19 viruses’ complete genome. This method would be able to act as a promising tool to monitor and track pathogenic infections in their stable and local genetics/hereditary varieties. This paper identifies five main clusters of mutations with as best in most cases in the coronavirus that could help scientists and researchers develop disease control vaccines for the transformation of coronaviruses.     

Intelligent Decision Support System for COVID-19 Empowered with Deep Learning

The prompt spread of Coronavirus (COVID-19) subsequently adorns a big threat to the people around the globe. The evolving and the perpetually diagnosis of coronavirus has become a critical challenge for the healthcare sector. Drastically increase of COVID-19 has rendered the necessity to detect the people who are more likely to get infected. Lately, the testing kits for COVID-19 are not available to deal it with required proficiency, along with-it countries have been widely hit by the COVID-19 disruption. To keep in view the need of hour asks for an automatic diagnosis system for early detection of COVID-19. It would be a feather in the cap if the early diagnosis of COVID-19 could reveal that how it has been affecting the masses immensely. According to the apparent clinical research, it has unleashed that most of the COVID-19 cases are more likely to fall for a lung infection. The abrupt changes do require a solution so the technology is out there to pace up, Chest X-ray and Computer tomography (CT) scan images could significantly identify the preliminaries of COVID-19 like lungs infection. CT scan and X-ray images could flourish the cause of detecting at an early stage and it has proved to be helpful to radiologists and the medical practitioners. The unbearable circumstances compel us to flatten the curve of the sufferers so a need to develop is obvious, a quick and highly responsive automatic system based on Artificial Intelligence (AI) is always there to aid against the masses to be prone to COVID-19. The proposed Intelligent decision support system for COVID-19 empowered with deep learning (ID2S-COVID19-DL) study suggests Deep learning (DL) based Convolutional neural network (CNN) approaches for effective and accurate detection to the maximum extent it could be, detection of coronavirus is assisted by using X-ray and CT-scan images. The primary experimental results here have depicted the maximum accuracy for training and is around 98.11 percent and for validation it comes out to be approximately 95.5 percent while statistical parameters like sensitivity and specificity for training is 98.03 percent and 98.20 percent respectively, and for validation 94.38 percent and 97.06 percent respectively. The suggested Deep Learning-based CNN model unleashed here opts for a comparable performance with medical experts and it is helpful to enhance the working productivity of radiologists. It could take the curve down with the downright contribution of radiologists, rapid detection of COVID-19, and to overcome this current pandemic with the proven efficacy.     

Intelligent Firefly Algorithm Deep Transfer Learning Based COVID-19 Monitoring System

With the increasing and rapid growth rate of COVID-19 cases, the healthcare scheme of several developed countries have reached the point of collapse. An important and critical steps in fighting against COVID-19 is powerful screening of diseased patients, in such a way that positive patient can be treated and isolated. A chest radiology image-based diagnosis scheme might have several benefits over traditional approach. The accomplishment of artificial intelligence (AI) based techniques in automated diagnoses in the healthcare sector and rapid increase in COVID-19 cases have demanded the requirement of AI based automated diagnosis and recognition systems. This study develops an Intelligent Firefly Algorithm Deep Transfer Learning Based COVID-19 Monitoring System (IFFA-DTLMS). The proposed IFFA-DTLMS model majorly aims at identifying and categorizing the occurrence of COVID19 on chest radiographs. To attain this, the presented IFFA-DTLMS model primarily applies densely connected networks (DenseNet121) model to generate a collection of feature vectors. In addition, the firefly algorithm (FFA) is applied for the hyper parameter optimization of DenseNet121 model. Moreover, autoencoder-long short term memory (AE-LSTM) model is exploited for the classification and identification of COVID19. For ensuring the enhanced performance of the IFFA-DTLMS model, a wide-ranging experiments were performed and the results are reviewed under distinctive aspects. The experimental value reports the betterment of IFFA-DTLMS model over recent approaches.     

Aerial Bots in the Supply Chain: A New Ally to Combat COVID-19

The rapid global spread of COVID-19 has caused disruptions in various supply chains and people's lives. At the same time, it has paved the way for drone technology (Aerial bots). With the countries gone into lockdown for an unspecified time, it is self-evident that people will run out of food, medicine, and other essentials because of the middleman's unavailability to move products from supply to demand point. Lack of medical infrastructure and distant testing laboratories is another challenge faced by the countries, which result in a delayed testing report leading to delay in medical treatment—such critical problems arising in the fight against COVID-19 highlight the need for improving the efficiency of supply chains. Recently used for commercial purposes, drone technology has already proved its utility in inventory and logistics management. Therefore, we argue that drones could be a viable option to improve the efficiency and effectiveness of the supply chains working for humanitarian aid to combat COVID-19. Specifically, the focus is on food, administrative, and healthcare supply chains that are the core to combat the pandemic. Moreover, in this article, we highlight various present and future application areas for drone technology, which could pave the way for future research and industry applications.     

A multi-layer model for the early detection of COVID-19

Current COVID-19 screening efforts mainly rely on reported symptoms and the potential exposure to infected individuals. Here, we developed a machine-learning model for COVID-19 detection that uses four layers of information: (i) sociodemographic characteristics of the individual, (ii) spatio-temporal patterns of the disease, (iii) medical condition and general health consumption of the individual and (iv) information reported by the individual during the testing episode. We evaluated our model on 140 682 members of Maccabi Health Services who were tested for COVID-19 at least once between February and October 2020. These individuals underwent, in total, 264 516 COVID-19 PCR tests, out of which 16 512 were positive. Our multi-layer model obtained an area under the curve (AUC) of 81.6% when evaluated over all the individuals in the dataset, and an AUC of 72.8% when only individuals who did not report any symptom were included. Furthermore, considering only information collected before the testing episode—i.e. before the individual had the chance to report on any symptom—our model could reach a considerably high AUC of 79.5%. Our ability to predict early on the outcomes of COVID-19 tests is pivotal for breaking transmission chains, and can be used for a more efficient testing policy.     

IoT & AI Enabled Three-Phase Secure and Non-Invasive COVID 19 Diagnosis System

Corona is a viral disease that has taken the form of an epidemic and is causing havoc worldwide after its first appearance in the Wuhan state of China in December 2019. Due to the similarity in initial symptoms with viral fever, it is challenging to identify this virus initially. Non-detection of this virus at the early stage results in the death of the patient. Developing and densely populated countries face a scarcity of resources like hospitals, ventilators, oxygen, and healthcare workers. Technologies like the Internet of Things (IoT) and artificial intelligence can play a vital role in diagnosing the COVID-19 virus at an early stage. To minimize the spread of the pandemic, IoT-enabled devices can be used to collect patient’s data remotely in a secure manner. Collected data can be analyzed through a deep learning model to detect the presence of the COVID-19 virus. In this work, the authors have proposed a three-phase model to diagnose covid-19 by incorporating a chatbot, IoT, and deep learning technology. In phase one, an artificially assisted chatbot can guide an individual by asking about some common symptoms. In case of detection of even a single sign, the second phase of diagnosis can be considered, consisting of using a thermal scanner and pulse oximeter. In case of high temperature and low oxygen saturation levels, the third phase of diagnosis will be recommended, where chest radiography images can be analyzed through an AI-based model to diagnose the presence of the COVID-19 virus in the human body. The proposed model reduces human intervention through chatbot-based initial screening, sensor-based IoT devices, and deep learning-based X-ray analysis. It also helps in reducing the mortality rate by detecting the presence of the COVID-19 virus at an early stage.     

Assessing the Effect of Global Travel and Contact Restrictions on Mitigating the COVID-19 Pandemic

Travel restrictions and physical distancing have been implemented across the world to mitigate the coronavirus disease 2019 (COVID-19) pandemic, but studies are needed to understand their effectiveness across regions and time. Based on the population mobility metrics derived from mobile phone geolocation data across 135 countries or territories during the first wave of the pandemic in 2020, we built a metapopulation epidemiological model to measure the effect of travel and contact restrictions on containing COVID-19 outbreaks across regions. We found that if these interventions had not been deployed, the cumulative number of cases could have shown a 97-fold (interquartile range 79–116) increase, as of May 31, 2020. However, their effectiveness depended upon the timing, duration, and intensity of the interventions, with variations in case severity seen across populations, regions, and seasons. Additionally, before effective vaccines are widely available and herd immunity is achieved, our results emphasize that a certain degree of physical distancing at the relaxation of the intervention stage will likely be needed to avoid rapid resurgences and subsequent lockdowns.     

Tele-COVID: A Telemedicine SOA-Based Architectural Design for COVID-19 Patients

In Wuhan, China, a novel Corona Virus (COVID-19) was detected in December 2019; it has changed the entire world and to date, the number of diagnosed cases is 38,756,289¹ and 1,095,216¹ people have died. This happened because a large number of people got affected and there is a lack of hospitals for COVID-19 patients. One of the precautionary measures for COVID-19 patients is isolation. To support this, there is an urgent need for a platform that makes treatment possible from a distance. Telemedicine systems have been drastically increasing in number and size over recent years. This increasing number intensifies the extensive need for telemedicine for the national healthcare system. In this paper, we present Tele-COVID which is a telemedicine application to treat COVID-19 patients from a distance. Tele-COVID is uniquely designed and implemented in Service-Oriented Architecture (SOA) to avoid the problem of interoperability, vendor lock-in, and data interchange. With the help of Tele-COVID, the treatment of patients at a distance is possible without the need for them to visit hospitals; in case of emergency, necessary services can also be provided.     

A Hybrid Virtual Cloud Learning Model during the COVID-19 Pandemic

The COVID-19 pandemic has affected the educational systems worldwide, leading to the near-total closures of schools, universities, and colleges. Universities need to adapt to changes to face this crisis without negatively affecting students’ performance. Accordingly, the purpose of this study is to identify and help solve to critical challenges and factors that influence the e-learning system for Computer Maintenance courses during the COVID-19 pandemic. The paper examines the effect of a hybrid modeling approach that uses Cloud Computing Services (CCS) and Virtual Reality (VR) in a Virtual Cloud Learning Environment (VCLE) system. The VCLE system provides students with various utilities and educational services such as presentation slides/text, data sharing, assignments, quizzes/tests, and chatrooms. In addition, learning through VR enables the students to simulate physical presence, and they respond well to VR environments that are closer to reality as they feel that they are an integral part of the environment. Also, the research presents a rubric assessment that the students can use to reflect on the skills they used during the course. The research findings offer useful suggestions for enabling students to become acquainted with the proposed system’s usage, especially during the COVID-19 pandemic, and for improving student achievement more than the traditional methods of learning.     

Optimization Model for Selecting Temporary Hospital Locations During COVID-19 Pandemic

The two main approaches that countries are using to ease the strain on healthcare infrastructure is building temporary hospitals that are specialized in treating COVID-19 patients and promoting preventive measures. As such, the selection of the optimal location for a temporary hospital and the calculation of the prioritization of preventive measures are two of the most critical decisions during the pandemic, especially in densely populated areas where the risk of transmission of the virus is highest. If the location selection process or the prioritization of measures is poor, healthcare workers and patients can be harmed, and unnecessary costs may come into play. In this study, a decision support framework using a fuzzy analytic hierarchy process (FAHP) and a weighted aggregated sum product assessment model are proposed for selecting the location of a temporary hospital, and a FAHP model is proposed for calculating the prioritization of preventive measures against COVID-19. A case study is performed for Ho Chi Minh City using the proposed decision-making framework. The contribution of this work is to propose a multiple criteria decision-making model in a fuzzy environment for ranking potential locations for building temporary hospitals during the COVID-19 pandemic. The results of the study can be used to assist decision-makers, such as government authorities and infectious disease experts, in dealing with the current pandemic as well as other diseases in the future. With the entire world facing the global pandemic of COVID-19, many scientists have applied research achievements in practice to help decision-makers make accurate decisions to prevent the pandemic. As the number of cases increases exponentially, it is crucial that government authorities and infectious disease experts make optimal decisions while considering multiple quantitative and qualitative criteria. As such, the proposed approach can also be applied to support complex decision-making processes in a fuzzy environment in different countries.     

Geospatial Analytics for COVID-19 Active Case Detection

Ever since the COVID-19 pandemic started in Wuhan, China, much research work has been focusing on the clinical aspect of SARS-CoV-2. Researchers have been leveraging on various Artificial Intelligence techniques as an alternative to medical approach in understanding the virus. Limited studies have, however, reported on COVID-19 transmission pattern analysis, and using geography features for prediction of potential outbreak sites. Predicting the next most probable outbreak site is crucial, particularly for optimizing the planning of medical personnel and supply resources. To tackle the challenge, this work proposed distance-based similarity measures to predict the next most probable outbreak site together with its magnitude, when would the outbreak likely to happen and the duration of the outbreak. The work began with preprocessing of 1365 patient records from six districts in the most populated state named Selangor in Malaysia. The dataset was then aggregated with population density information and human elicited geography features that might promote the transmission of COVID-19. Empirical findings indicated that the proposed unified decision-making approach outperformed individual distance metric in predicting the total cases, next outbreak location, and the time interval between start dates of two similar sites. Such findings provided valuable insights for policymakers to perform Active Case Detection.     

COVID-19 Infected Lung Computed Tomography Segmentation and Supervised Classification Approach

The purpose of this research is the segmentation of lungs computed tomography (CT) scan for the diagnosis of COVID-19 by using machine learning methods. Our dataset contains data from patients who are prone to the epidemic. It contains three types of lungs CT images (Normal, Pneumonia, and COVID-19) collected from two different sources; the first one is the Radiology Department of Nishtar Hospital Multan and Civil Hospital Bahawalpur, Pakistan, and the second one is a publicly free available medical imaging database known as Radiopaedia. For the preprocessing, a novel fuzzy c-mean automated region-growing segmentation approach is deployed to take an automated region of interest (ROIs) and acquire 52 hybrid statistical features for each ROIs. Also, 12 optimized statistical features are selected via the chi-square feature reduction technique. For the classification, five machine learning classifiers named as deep learning J4, multilayer perceptron, support vector machine, random forest, and naive Bayes are deployed to optimize the hybrid statistical features dataset. It is observed that the deep learning J4 has promising results (sensitivity and specificity: 0.987; accuracy: 98.67%) among all the deployed classifiers. As a complementary study, a statistical work is devoted to the use of a new statistical model to fit the main datasets of COVID-19 collected in Pakistan.     

COVID-19 Vaccine Allocation: Modeling Health Outcomes and Equity Implications of Alternative Strategies

Given the scarcity of safe and effective COVID-19 vaccines, a chief policy question is how to allocate them among different sociodemographic groups. This paper evaluates COVID-19 vaccine prioritization strategies proposed to date, focusing on their stated goals; the mechanisms through which the selected allocations affect the course and burden of the pandemic; and the main epidemiological, economic, logistical, and political issues that arise when setting the prioritization strategy. The paper uses a simple, age-stratified susceptible–exposed–infectious–recovered model applied to the United States to quantitatively assess the performance of alternative prioritization strategies with respect to avoided deaths, avoided infections, and life-years gained. We demonstrate that prioritizing essential workers is a viable strategy for reducing the number of cases and years of life lost, while the largest reduction in deaths is achieved by prioritizing older adults in most scenarios, even if the vaccine is effective at blocking viral transmission. Uncertainty regarding this property and potential delays in dose delivery reinforce the call for prioritizing older adults. Additionally, we investigate the strength of the equity motive that would support an allocation strategy attaching absolute priority to essential workers for a vaccine that reduces infection-fatality risk.     

An Application Review of Artificial Intelligence in Prevention and Cure of COVID-19 Pandemic

Coronaviruses are a well-known family of viruses that can infect humans or animals. Recently, the new coronavirus (COVID-19) has spread worldwide. All countries in the world are working hard to control the coronavirus disease. However, many countries are faced with a lack of medical equipment and an insufficient number of medical personnel because of the limitations of the medical system, which leads to the mass spread of diseases. As a powerful tool, artificial intelligence (AI) has been successfully applied to solve various complex problems ranging from big data analysis to computer vision. In the process of epidemic control, many algorithms are proposed to solve problems in various fields of medical treatment, which is able to reduce the workload of the medical system. Due to excellent learning ability, AI has played an important role in drug development, epidemic forecast, and clinical diagnosis. This research provides a comprehensive overview of relevant research on AI during the outbreak and helps to develop new and more powerful methods to deal with the current pandemic.     

Three-dimensional printing in the fight against novel virus COVID-19: Technology helping society during an infectious disease pandemic

Indeed, the scientific milestones set by the ever-emerging three-dimensional printing (3DP) technologies are tremendous. Till now, the innovative 3DP technologies have benefitted the aerospace, automobile, textile, pharmaceutical, and biomedical sectors by developing pre-requisite designed and customized performance standards of the end-user products. As the scientific world, at this moment, is expediting efforts to fight against the highly damaging novel coronavirus (COVID-19) pandemic, the 3DP technologies are facilitating creative solutions in terms of personal protective equipment (PPE), medical equipment (such as ventilators and other respiratory devices), and other health and welfare tools to aid the personal hygiene as well as safe environment for humans by restricting the communication of risks. Various sources (including journal articles, news articles, white papers of the government and other non-profit organizations, commercial enterprises, as well as academic institutions have been reviewed for the collection of the information relevant to COVID-19 and 3DP. This communication presents the recent applications of the 3DP technologies aiding in developing innovative products designed to save the lives of millions of people around the world. Moreover, the potential of 3DP technologies in developing test swabs and controlled medicines has been highlighted. The literature reviewed in the present study indicated that the fused filament fabrication (FFF) is one of the most preferred technologies and contribute about 62% in the overall production of the protective gears developed through overall class of 3DP.     

Design of Intelligent Mosquito Nets Based on Deep Learning Algorithms

An intelligent mosquito net employing deep learning has been one of the hotspots in the field of Internet of Things as it can reduce significantly the spread of pathogens carried by mosquitoes, and help people live well in mosquito-infested areas. In this study, we propose an intelligent mosquito net that can produce and transmit data through the Internet of Medical Things. In our method, decision-making is controlled by a deep learning model, and the proposed method uses infrared sensors and an array of pressure sensors to collect data. Moreover the ZigBee protocol is used to transmit the pressure map which is formed by pressure sensors with the deep learning perception model, determining automatically the intention of the user to open or close the mosquito net. We used optical flow to extract pressure map features, and they were fed to a 3-dimensional convolutional neural network (3D-CNN) classification model subsequently. We achieved the expected results using a nested cross-validation method to evaluate our model. Deep learning has better adaptability than the traditional methods and also has better anti-interference by the different bodies of users. This research has the potential to be used in intelligent medical protection and large-scale sensor array perception of the environment.     

Fuzzy Based Decision Making Approach for Evaluating the Severity of COVID-19 Pandemic in Cities of Kingdom of Saudi Arabia

The World Health Organization declared COVID-19 a pandemic on March 11, 2020 stating that it is a worldwide danger and requires imminent preventive strategies to minimise the loss of lives. COVID-19 has now affected millions across 211 countries in the world and the numbers continue to rise. The information discharged by the WHO till June 15, 2020 reports 8,063,990 cases of COVID-19. As the world thinks about the lethal malady for which there is yet no immunization or a predefined course of drug, the nations are relentlessly working at the most ideal preventive systems to contain the infection. The Kingdom of Saudi Arabia (KSA) is additionally combating with the COVID-19 danger as the cases announced till June 15, 2020 reached the count of 132,048 with 1,011 deaths. According to the report released by the KSA on June 14, 2020, more than 4,000 cases of COVID-19 pandemic had been registered in the country. Tending to the impending requirement for successful preventive instruments to stem the fatalities caused by the disease, our examination expects to assess the severity of COVID-19 pandemic in cities of KSA. In addition, computational model for evaluating the severity of COVID-19 with the perspective of social influence factor is necessary for controlling the disease. Furthermore, a quantitative evaluation of severity associated with specific regions and cities of KSA would be a more effective reference for the healthcare sector in Saudi Arabia. Further, this paper has taken the Fuzzy Analytic Hierarchy Process (AHP) technique for quantitatively assessing the severity of COVID-19 pandemic in cities of KSA. The discoveries and the proposed structure would be a practical, expeditious and exceptionally precise evaluation system for assessing the severity of the pandemic in the cities of KSA. Hence these urban zones clearly emerge as the COVID-19 hotspots. The cities require suggestive measures of health organizations that must be introduced on a war footing basis to counter the pandemic. The analysis tabulated in our study will assist in mapping the rules and building a systematic structure that is immediate need in the cities with high severity levels due to the pandemic.     

Developing a Recognition System for Classifying COVID-19 Using a Convolutional Neural Network Algorithm

The COVID-19 pandemic poses an additional serious public health threat due to little or no pre-existing human immunity, and developing a system to identify COVID-19 in its early stages will save millions of lives. This study applied support vector machine (SVM), k-nearest neighbor (K-NN) and deep learning convolutional neural network (CNN) algorithms to classify and detect COVID-19 using chest X-ray radiographs. To test the proposed system, chest X-ray radiographs and CT images were collected from different standard databases, which contained 95 normal images, 140 COVID-19 images and 10 SARS images. Two scenarios were considered to develop a system for predicting COVID-19. In the first scenario, the Gaussian filter was applied to remove noise from the chest X-ray radiograph images, and then the adaptive region growing technique was used to segment the region of interest from the chest X-ray radiographs. After segmentation, a hybrid feature extraction composed of 2D-DWT and gray level co-occurrence matrix was utilized to extract the features significant for detecting COVID-19. These features were processed using SVM and K-NN. In the second scenario, a CNN transfer model (ResNet 50) was used to detect COVID-19. The system was examined and evaluated through multiclass statistical analysis, and the empirical results of the analysis found significant values of 97.14%, 99.34%, 99.26%, 99.26% and 99.40% for accuracy, specificity, sensitivity, recall and AUC, respectively. Thus, the CNN model showed significant success; it achieved optimal accuracy, effectiveness and robustness for detecting COVID-19.     

Impact Assessment of COVID-19 Pandemic Through Machine Learning Models

Ever since its outbreak in the Wuhan city of China, COVID-19 pandemic has engulfed more than 211 countries in the world, leaving a trail of unprecedented fatalities. Even more debilitating than the infection itself, were the restrictions like lockdowns and quarantine measures taken to contain the spread of Coronavirus. Such enforced alienation affected both the mental and social condition of people significantly. Social interactions and congregations are not only integral part of work life but also form the basis of human evolvement. However, COVID-19 brought all such communication to a grinding halt. Digital interactions have failed to enthuse the fervor that one enjoys in face-to-face meets. The pandemic has shoved the entire planet into an unstable state. The main focus and aim of the proposed study is to assess the impact of the pandemic on different aspects of the society in Saudi Arabia. To achieve this objective, the study analyzes two perspectives: the early approach, and the late approach of COVID-19 and the consequent effects on different aspects of the society. We used a Machine Learning based framework for the prediction of the impact of COVID-19 on the key aspects of society. Findings of this research study indicate that financial resources were the worst affected. Several countries are facing economic upheavals due to the pandemic and COVID-19 has had a considerable impact on the lives as well as the livelihoods of people. Yet the damage is not irretrievable and the world’s societies can emerge out of this setback through concerted efforts in all facets of life.