COVID-19 pandemic dynamics in India,the SARS-CoV-2 Delta variant and implications for vaccination

The Delta variant is a major SARS-CoV-2 variant of concern first identified in India. To better understand COVID-19 pandemic dynamics and Delta, we use multiple datasets and model-inference to reconstruct COVID-19 pandemic dynamics in India during March 2020–June 2021. We further use the large discrepancy in one- and two-dose vaccination coverage in India (53% versus 23% by end of October 2021) to examine the impact of vaccination and whether prior non-Delta infection can boost vaccine effectiveness (VE). We estimate that Delta escaped immunity in 34.6% (95% CI: 0–64.2%) of individuals with prior wild-type infection and was 57.0% (95% CI: 37.9–75.6%) more infectious than wild-type SARS-CoV-2. Models assuming higher VE among non-Delta infection recoverees, particularly after the first dose, generated more accurate predictions than those assuming no such increases (best-performing VE setting: 90/95% versus 30/67% baseline for the first/second dose). Counterfactual modelling indicates that high vaccination coverage for first vaccine dose in India combined with the boosting of VE among recoverees averted around 60% of infections during July–mid-October 2021. These findings provide support to prioritizing first-dose vaccination in regions with high underlying infection rates, given continued vaccine shortages and new variant emergence.     

Technology Landscape for Epidemiological Prediction and Diagnosis of COVID-19

The COVID-19 outbreak initiated from the Chinese city of Wuhan and eventually affected almost every nation around the globe. From China, the disease started spreading to the rest of the world. After China, Italy became the next epicentre of the virus and witnessed a very high death toll. Soon nations like the USA became severely hit by SARS-CoV-2 virus. The World Health Organisation, on 11th March 2020, declared COVID-19 a pandemic. To combat the epidemic, the nations from every corner of the world has instituted various policies like physical distancing, isolation of infected population and researching on the potential vaccine of SARS-CoV-2. To identify the impact of various policies implemented by the affected countries on the pandemic spread, a myriad of AI-based models have been presented to analyse and predict the epidemiological trends of COVID-19. In this work, the authors present a detailed study of different artificial intelligence frameworks applied for predictive analysis of COVID-19 patient record. The forecasting models acquire information from records to detect the pandemic spreading and thus enabling an opportunity to take immediate actions to reduce the spread of the virus. This paper addresses the research issues and corresponding solutions associated with the prediction and detection of infectious diseases like COVID-19. It further focuses on the study of vaccinations to cope with the pandemic. Finally, the research challenges in terms of data availability, reliability, the accuracy of the existing prediction models and other open issues are discussed to outline the future course of this study.     

Attention-Based and Time Series Models for Short-Term Forecasting of COVID-19 Spread

The growing number of COVID-19 cases puts pressure on healthcare services and public institutions worldwide. The pandemic has brought much uncertainty to the global economy and the situation in general. Forecasting methods and modeling techniques are important tools for governments to manage critical situations caused by pandemics, which have negative impact on public health. The main purpose of this study is to obtain short-term forecasts of disease epidemiology that could be useful for policymakers and public institutions to make necessary short-term decisions. To evaluate the effectiveness of the proposed attention-based method combining certain data mining algorithms and the classical ARIMA model for short-term forecasts, data on the spread of the COVID-19 virus in Lithuania is used, the forecasts of epidemic dynamics were examined, and the results were presented in the study. Nevertheless, the approach presented might be applied to any country and other pandemic situations. The COVID-19 outbreak started at different times in different countries, hence some countries have a longer history of the disease with more historical data than others. The paper proposes a novel approach to data registration and machine learning-based analysis using data from attention-based countries for forecast validation to predict trends of the spread of COVID-19 and assess risks.     

Impact Assessment of COVID-19 Pandemic Through Machine Learning Models

Ever since its outbreak in the Wuhan city of China, COVID-19 pandemic has engulfed more than 211 countries in the world, leaving a trail of unprecedented fatalities. Even more debilitating than the infection itself, were the restrictions like lockdowns and quarantine measures taken to contain the spread of Coronavirus. Such enforced alienation affected both the mental and social condition of people significantly. Social interactions and congregations are not only integral part of work life but also form the basis of human evolvement. However, COVID-19 brought all such communication to a grinding halt. Digital interactions have failed to enthuse the fervor that one enjoys in face-to-face meets. The pandemic has shoved the entire planet into an unstable state. The main focus and aim of the proposed study is to assess the impact of the pandemic on different aspects of the society in Saudi Arabia. To achieve this objective, the study analyzes two perspectives: the early approach, and the late approach of COVID-19 and the consequent effects on different aspects of the society. We used a Machine Learning based framework for the prediction of the impact of COVID-19 on the key aspects of society. Findings of this research study indicate that financial resources were the worst affected. Several countries are facing economic upheavals due to the pandemic and COVID-19 has had a considerable impact on the lives as well as the livelihoods of people. Yet the damage is not irretrievable and the world’s societies can emerge out of this setback through concerted efforts in all facets of life.     

Integrated vaccination and non-pharmaceutical interventions based strategies in Ontario,Canada, as a case study: a mathematical modelling study

Recently, two coronavirus disease 2019 (COVID-19) vaccine products have been authorized in Canada. It is of crucial importance to model an integrated/combined package of non-pharmaceutical (physical/social distancing) and pharmaceutical (immunization) public health control measures. A modified epidemiological, compartmental SIR model was used and fit to the cumulative COVID-19 case data for the province of Ontario, Canada, from 8 September 2020 to 8 December 2020. Different vaccine roll-out strategies were simulated until 75% of the population was vaccinated, including a no-vaccination scenario. We compete these vaccination strategies with relaxation of non-pharmaceutical interventions. Non-pharmaceutical interventions were supposed to remain enforced and began to be relaxed on 31 January, 31 March or 1 May 2021. Based on projections from the data and long-term extrapolation of scenarios, relaxing the public health measures implemented by re-opening too early would cause any benefits of vaccination to be lost by increasing case numbers, increasing the effective reproduction number above 1 and thus increasing the risk of localized outbreaks. If relaxation is, instead, delayed and 75% of the Ontarian population gets vaccinated by the end of the year, re-opening can occur with very little risk. Relaxing non-pharmaceutical interventions by re-opening and vaccine deployment is a careful balancing act. Our combination of model projections from data and simulation of different strategies and scenarios, can equip local public health decision- and policy-makers with projections concerning the COVID-19 epidemiological trend, helping them in the decision-making process.     

Pandemic Analysis and Prediction of COVID-19 Using Gaussian Doubling Times

COVID-19 has become a pandemic, with cases all over the world, with widespread disruption in some countries, such as Italy, US, India, South Korea, and Japan. Early and reliable detection of COVID-19 is mandatory to control the spread of infection. Moreover, prediction of COVID-19 spread in near future is also crucial to better plan for the disease control. For this purpose, we proposed a robust framework for the analysis, prediction, and detection of COVID-19. We make reliable estimates on key pandemic parameters and make predictions on the point of inflection and possible washout time for various countries around the world. The estimates, analysis and predictions are based on the data gathered from Johns Hopkins Center during the time span of April 21 to June 27, 2020. We use the normal distribution for simple and quick predictions of the coronavirus pandemic model and estimate the parameters of Gaussian curves using the least square parameter curve fitting for several countries in different continents. The predictions rely on the possible outcomes of Gaussian time evolution with the central limit theorem of statistics the predictions to be well justified. The parameters of Gaussian distribution, i.e., maximum time and width, are determined through a statistical χ2-fit for the purpose of doubling times after April 21, 2020. For COVID-19 detection, we proposed a novel method based on the Histogram of Oriented Gradients (HOG) and CNN in multi-class classification scenario i.e., Normal, COVID-19, viral pneumonia etc. Experimental results show the effectiveness of our framework for reliable prediction and detection of COVID-19.     

A semi-parametric,state-space compartmental model with time-dependent parameters for forecasting COVID-19 cases,hospitalizations and deaths

Short-term forecasts of the dynamics of coronavirus disease 2019 (COVID-19) in the period up to its decline following mass vaccination was a task that received much attention but proved difficult to do with high accuracy. However, the availability of standardized forecasts and versioned datasets from this period allows for continued work in this area. Here, we introduce the Gaussian infection state space with time dependence (GISST) forecasting model. We evaluate its performance in one to four weeks ahead forecasts of COVID-19 cases, hospital admissions and deaths in the state of California made with official reports of COVID-19, Google’s mobility reports and vaccination data available each week. Evaluation of these forecasts with a weighted interval score shows them to consistently outperform a naive baseline forecast and often score closer to or better than a high-performing ensemble forecaster. The GISST model also provides parameter estimates for a compartmental model of COVID-19 dynamics, includes a regression submodel for the transmission rate and allows for parameters to vary over time according to a random walk. GISST provides a novel, balanced combination of computational efficiency, model interpretability and applicability to large multivariate datasets that may prove useful in improving the accuracy of infectious disease forecasts.     

A data driven agent-based model that recommends non-pharmaceutical interventions to suppress Coronavirus disease 2019 resurgence in megacities

Before herd immunity against Coronavirus disease 2019 (COVID-19) is achieved by mass vaccination, science-based guidelines for non-pharmaceutical interventions are urgently needed to reopen megacities. This study integrated massive mobile phone tracking records, census data and building characteristics into a spatially explicit agent-based model to simulate COVID-19 spread among 11.2 million individuals living in Shenzhen City, China. After validation by local epidemiological observations, the model was used to assess the probability of COVID-19 resurgence if sporadic cases occurred in a fully reopened city. Combined scenarios of three critical non-pharmaceutical interventions (contact tracing, mask wearing and prompt testing) were assessed at various levels of public compliance. Our results show a greater than 50% chance of disease resurgence if the city reopened without contact tracing. However, tracing household contacts, in combination with mandatory mask use and prompt testing, could suppress the probability of resurgence under 5% within four weeks. If household contact tracing could be expanded to work/class group members, the COVID resurgence could be avoided if 80% of the population wear facemasks and 40% comply with prompt testing. Our assessment, including modelling for different scenarios, helps public health practitioners tailor interventions within Shenzhen City and other world megacities under a variety of suppression timelines, risk tolerance, healthcare capacity and public compliance.     

Further research on accident rates in developing countries

Earlier studies have shown that by using cross-sectional data for a group of developing countries, a significant relationship can be established between fatality rates and vehicle ownership levels. This paper updates relationships established in earlier years and identifies whether or not the slope of the regression line has continued to increase (and suggests that for the group of countries as a whole, there is a worsening in the safety situation). Similar relationships are also established for casualty rates. A detailed analysis is made of the relationship between fatality rates and parameters which describe, in part, the social, physical and economic characteristics of the developing countries. These include vehicle ownership, gross national product per capita, road density, vehicle density (per kilometre of road), population per physician and population per hospital bed. Again, comparisons are made with results obtained on earlier studies.     

Civil liability, criminal law, and other policies and alcohol-related motor vehicle fatalities in the United States: 1984-1995

This study examines the associations between alcohol policies and motor vehicle fatality rates from 1984 to 1995 in the United States. State policies and state characteristics variables were merged with motor vehicle fatality rates over an 11 year period and analyzed using minimum logit chi-square method and fixed effects to create a quasi time-series analysis. Laws allowing individuals to sue bars for the drunken behavior of their patrons were the policies most strongly associated with lower minor and adult fatality rates. The mandatory first offense fine was associated with lower minor fatality rates but not adult fatality rates, while minor and adult rates fell after administrative per se license suspension and anti-consumption laws for all vehicle occupants. Many other public policies evaluated were not associated with lower fatality rates.     

analysis of pedestrian accident costs in Sudan using the willingness-to-pay method

The willingness-to-pay (WTP) with contingent valuation (CV) method has been proven to be a valid tool for the valuation of non-market goods or socio-economic costs of road traffic accidents among communities in developed and developing countries. Research on accident costing tends to estimate the value of statistical life (VOSL) for all road users by providing a principle for the evaluation of road safety interventions in cost-benefit analysis. As in many other developing countries, the economic loss of traffic accidents in Sudan is noticeable; however, analytical research to estimate the magnitude and impact of that loss is lacking. Reports have shown that pedestrians account for more than 40% of the total number of fatalities. In this study, the WTP-CV approach was used to determine the amount of money that pedestrians in Sudan are willing to pay to reduce the risk of their own death. The impact of the socioeconomic factors, risk levels, and walking behaviors of pedestrians on their WTP for fatality risk reduction was also evaluated. Data were collected from two cities—Khartoum and Nyala—using a survey questionnaire that included 1400 respondents. The WTP-CV Payment Card Questionnaire was designed to ensure that Sudan pedestrians can easily determine the amount of money that would be required to reduce the fatality risk from a pedestrian-related accident. The analysis results show that the estimated VOSL for Sudanese pedestrians ranges from US$0.019 to US$0.101 million. In addition, the willingness-to-pay by Sudanese pedestrians to reduce their fatality risk tends to increase with age, household income, educational level, safety perception, and average time spent on social activities with family and community.     

Compulsory seatbelt use: Further inferences

On 1 June 1972, the wearing of available seatbelts by front seat occupants (drivers and front seat passengers) became compulsory in New Zealand. A comparison of fatality rates for front seat occupants during the two years preceding and following the law has been made by Toomath and Laurenson (1976). The fatality rate per million gallons of taxable petrol consumption shows a drop of about 7% for such occupants, accompanied by a surveyed usage rate increase from 25% to 67%. Considering the well established value of seatbelts in reducing road trauma, the size of the fatality reduction is rather disappointing For clarification, fatality rates crudely adjusted for exposure were separately calculated for belted and unbelted front seat occupants. Comparative rates before and after the law were somewhat surprising, so a model was constructed in which the after-law use rate could be treated as an unknown. Principal findings were: Based on surveyed use data, the fatality rate for belted front seat occupants increased after the law; likewise so did the fatality rate for unbelted front seat occupants. Since the fatality rate for all front seat occupants (aggregate of belted and unbelted) decreased, there is an apparent paradox that can be resolved by assuming a qualitative shift in the user population. Inferential analysis suggests that belt use reduced the probability of fatal injury, in a given crash, by about 40%. Similar analysis suggests that the effects of the law, when added to those of voluntary use, were to save only about 40% as many lives as could have been saved by universal belt usage among front seat occupants. Apparently those still unbelted after the law represent a particularly high-risk group, by whom increased belt use would result in disproportionate savings.     

Optimal Machine Learning Driven Sentiment Analysis on COVID-19 Twitter Data

The outbreak of the pandemic, caused by Coronavirus Disease 2019 (COVID-19), has affected the daily activities of people across the globe. During COVID-19 outbreak and the successive lockdowns, Twitter was heavily used and the number of tweets regarding COVID-19 increased tremendously. Several studies used Sentiment Analysis (SA) to analyze the emotions expressed through tweets upon COVID-19. Therefore, in current study, a new Artificial Bee Colony (ABC) with Machine Learning-driven SA (ABCML-SA) model is developed for conducting Sentiment Analysis of COVID-19 Twitter data. The prime focus of the presented ABCML-SA model is to recognize the sentiments expressed in tweets made upon COVID-19. It involves data pre-processing at the initial stage followed by n-gram based feature extraction to derive the feature vectors. For identification and classification of the sentiments, the Support Vector Machine (SVM) model is exploited. At last, the ABC algorithm is applied to fine tune the parameters involved in SVM. To demonstrate the improved performance of the proposed ABCML-SA model, a sequence of simulations was conducted. The comparative assessment results confirmed the effectual performance of the proposed ABCML-SA model over other approaches.     

Analysis and Forecasting COVID-19 Outbreak in Pakistan Using Decomposition and Ensemble Model

COVID-19 has caused severe health complications and produced a substantial adverse economic impact around the world. Forecasting the trend of COVID-19 infections could help in executing policies to effectively reduce the number of new cases. In this study, we apply the decomposition and ensemble model to forecast COVID-19 confirmed cases, deaths, and recoveries in Pakistan for the upcoming month until the end of July. For the decomposition of data, the Ensemble Empirical Mode Decomposition (EEMD) technique is applied. EEMD decomposes the data into small components, called Intrinsic Mode Functions (IMFs). For individual IMFs modelling, we use the Autoregressive Integrated Moving Average (ARIMA) model. The data used in this study is obtained from the official website of Pakistan that is publicly available and designated for COVID-19 outbreak with daily updates. Our analyses reveal that the number of recoveries, new cases, and deaths are increasing in Pakistan exponentially. Based on the selected EEMD-ARIMA model, the new confirmed cases are expected to rise from 213,470 to 311,454 by 31 July 2020, which is an increase of almost 1.46 times with a 95% prediction interval of 246,529 to 376,379. The 95% prediction interval for recovery is 162,414 to 224,579, with an increase of almost two times in total from 100802 to 193495 by 31 July 2020. On the other hand, the deaths are expected to increase from 4395 to 6751, which is almost 1.54 times, with a 95% prediction interval of 5617 to 7885. Thus, the COVID-19 forecasting results of Pakistan are alarming for the next month until 31 July 2020. They also confirm that the EEMD-ARIMA model is useful for the short-term forecasting of COVID-19, and that it is capable of keeping track of the real COVID-19 data in nearly all scenarios. The decomposition and ensemble strategy can be useful to help decision-makers in developing short-term strategies about the current number of disease occurrences until an appropriate vaccine is developed.     

Patterns of safety belt usage following introduction of a safety belt wearing law

The paper reviews the process of enacting a safety belt wearing law in Israel, and studies the impact it has had on belt usage and on casualty reductions. Safety belt legislation in Israel had several unique features in that, on the one hand, all passenger vehicles were retrofitted with safety belts, but, on the other hand, it exempted drivers and front-seat passengers of pre-1969 model vehicles from the compulsory use of belts. Also, the legislation applied only to the use of belts on interurban roads. Repeated counts of safety belt usage, before and after the implementation of the law, provided strong evidence for the efficacy of the legislative act as such. Usage rates rose from an average of 6% to upward of 70%. There was a marked carryover effect of the law on belt wearing rates on urban roads and on the use by drivers of pre-1969 model cars. However, this effect diminished with time. Results of a questionnaire survey provided further evidence for the general acceptance of the law by the public. Only a small minority of drivers completely rejected the use of safety belts. A comparison with data from other countries shows that the impact of a compulsory safety belt wearing law on safety belt usage and on casualty reduction is a universal phenomenon. This fact should encourage researchers, legislators and adminstrators in jurisdictions which are still deliberating the value of mandatory safety belt legislation. On the basis of the trends in fatalities and casualties to car drivers and passengers on urban roads during the two and one-half year period following the introduction of the seat belt law, it is estimated that a reduction of 42% in car fatalities and 44% in car passengers occurred on interurban roads during those two and one-half years. The corresponding reductions in casualties were 18% and eight percent respectively.     

An Intelligent Fine-Tuned Forecasting Technique for Covid-19 Prediction Using Neuralprophet Model

COVID-19, being the virus of fear and anxiety, is one of the most recent and emergent of various respiratory disorders. It is similar to the MERS-COV and SARS-COV, the viruses that affected a large population of different countries in the year 2012 and 2002, respectively. Various standard models have been used for COVID-19 epidemic prediction but they suffered from low accuracy due to lesser data availability and a high level of uncertainty. The proposed approach used a machine learning-based time-series Facebook NeuralProphet model for prediction of the number of death as well as confirmed cases and compared it with Poisson Distribution, and Random Forest Model. The analysis upon dataset has been performed considering the time duration from January 1^st 2020 to16^th July 2021. The model has been developed to obtain the forecast values till September 2021. This study aimed to determine the pandemic prediction of COVID-19 in the second wave of coronavirus in India using the latest Time-Series model to observe and predict the coronavirus pandemic situation across the country. In India, the cases are rapidly increasing day-by-day since mid of Feb 2021. The prediction of death rate using the proposed model has a good ability to forecast the COVID-19 dataset essentially in the second wave. To empower the prediction for future validation, the proposed model works effectively.