Mechanism of block by 4-aminopyridine of the transient outward current in rat ventricular cardiomyocytes

Binocular information has been shown to be important for the programming and control of reaching and grasping. But even without binocular vision, people are still able to reach out and pick up objects accurately - albeit less efficiently. As part of a continuing investigation into the role that monocular cues play in visuomotor control, we examined whether or not subjects could use retinal motion information, derived from movements of the head, to help program and control reaching and grasping movements when binocular vision is denied. Subjects reached out in the dark to an illuminated sphere presented at eye-level, under both monocular and binocular viewing conditions with their head either free to move or restrained. When subjects viewed the display monocularly, they showed fewer on-line corrections when they were allowed to move their head. No such difference in performance was seen when subjects were allowed a full binocular view. This study, combined with previous work with neurological patients, confirms that the visuomotor system "prefers" to use binocular vision but, when this information is not available, can fall back on other monocular depth cues, such as information produced by motion of the object (and the scene) on the retina, to help program and control manual prehension.     

Infants' sensitivity to relative size information for distance.

In Exp I, 40 203–231 day old infants were used to test the hypothesis that sensitivity to pictorial depth information emerges between 5 and 7 mo of age. Pairs of discs and triangles (identical except in size) were presented to Ss to test their reaching preference or lack of it under either monocular or binocular conditions. In Exp II, 20 157–270 day old and 40 140–256 day old infants were tested with the same apparatus and procedures but were moved closer to the objects. Results show that Ss in both experiments were sensitive to relative size. Under monocular viewing conditions, both 203–231 and 157–270 days old Ss showed a preference to reach for the larger object of the pair. Under binocular viewing conditions, no difference in number of reaches for the large and small objects was found in either group. The lack of reaching preference in the binocular condition suggests that the reaching preference observed in the monocular condition was due to the perceived spatial locations of the objects and not to a preference to reach for the larger object without regard to distance. Ss in the youngest age group (140–256 days old) gave no evidence of sensitivity to relative size. Findings support the hypothesis. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of ecological viewing conditions on the Ames' distorted room illusion.

Ecological theory asserts that the Ames' distorted room illusion (DRI) occurs as a result of the artificial restriction of information pickup. According to J. J. Gibson (1966, 1979), the illusion is eliminated when binocular vision and/or head movement are allowed. Exp I, with 144 undergraduates, used size-matching technique employing discs placed within an Ames' distorted room to measure the DRI. Ss viewed the distorted room or a control apparatus under 4 viewing conditions (i.e., restricted or unrestricted head movement), using monocular and binocular vision. In Exp II, 20 Ss viewed binocularly and were instructed to move freely while making judgments. Findings show that the DRI decreased with increases in viewing access, although it persisted under all viewing conditions. The persistence of the illusion is seen as contradicting Gibson's position. (12 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of pictorial illusion on prehension and perception

The present study examined the effect of a size-contrast illusion (Ebbinghaus or Titchener Circles Illusion) on visual perception and the visual control of grasping movements. Seventeen right-handed participants picked up and, on other trials, estimated the size of "poker-chip" disks, which functioned as the target circles in a three-dimensional version of the illusion. In the estimation condition, subjects indicated how big they thought the target was by separating their thumb and forefinger to match the target's size. After initial viewing, no visual feedback from the hand or the target was available. Scaling of grip aperture was found to be strongly correlated with the physical size of the disks, while manual estimations of disk size were biased in the direction of the illusion. Evidently, grip aperture is calibrated to the true size of an object, even when perception of object size is distorted by a pictorial illusion, a result that is consistent with recent suggestions that visually guided prehension and visual perception are mediated by separate visual pathways.     

The Ponzo illusion affects grip-force but not grip-aperture scaling during prehension movements.

Contextual cues such as linear perspective and relative size can exert a powerful effect on the perception of objects. This fact is demonstrated by the illusory effects that can be induced by such cues (e.g., the Ponzo railway track and Titchener circles illusions). Several recent studies have reported, however, that visual illusions based on such cues have little or no influence on the visuomotor mechanisms used to guide hand action. Furthermore, evidence of this sort has been cited in support of a distinction between visual perception and the visual control of action. In the current study, the authors investigated the effect of the Ponzo visual illusion on the control of hand action, specifically, the scaling of grip force and grip aperture during prehension movements. The results demonstrate that grip force scaling is significantly influenced by the Ponzo visual illusion, whereas the scaling of grip aperture is unaffected by the illusion. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Accommodative-convergence in young infants: Development of a synergistic sensory-motor system.

Measured binocular eye alignment in 20 2–6 mo old infants under both binocular and monocular viewing conditions. Corneal photography was used to assess whether Ss converged to a target presented at a 15-cm viewing distance. Ss at all ages showed reliable convergence under both binocular and monocular viewing conditions. The presence of convergence during monocular viewing indicates that an accommodative-convergence link is present at an early age. The implications of this early synergistic relationship between accommodation and convergence are discussed both with respect to the influence of early visuomotor experience on the developing visual system and the onset of various ocular anomalies during infancy. (French abstract) (23 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Accuracy of estimating time to collision using binocular and monocular information

We measured both the just-noticeable difference in time to collision (TTC) with an approaching object, and the absolute accuracy in estimating TTC in the following cases: only binocular information available; only monocular information available; both binocular and monocular information available as in the everyday situation. Observers could discriminate trial-to-trial variations in TTC on the basis of binocular information alone: the just-noticeable difference in TTC (5.1-9.8%) was the same for a small (0.03 deg) target and for a large (0.7 deg) target. In line with previous reports, when only monocular information was available, the just-noticeable difference in TTC was 5.8-12% for the large target. However, observers could not reliably discriminate trial-to-trial variations in TTC with the small target when only monocular information was available. When both binocular and monocular information was available, the just-noticeable difference in TTC for the large target was not significantly different from when only binocular or only monocular information was available. Observers could make reliable estimates of absolute TTC using binocular information only. Errors ranged from 2.5 to 10% for the large target, and 2.6 to 3.0% for the small target, all being overestimates. Errors for the small target were the same or lower than errors for the large target. Observers could make reliable estimates of TTC with the large target using monocular information only. Errors ranged from 2.0 to 12%, all being underestimates. Since monocular information did not provide a basis for reliable estimates of absolute TTC with the small target we conclude that, in everyday conditions, accurate estimates of TTC with small targets are based on binocular information when the object is small and is no more than a few metres away. Errors in estimating absolute TTC were lower in the case where both binocular and monocular information were available (as in the everyday situation) than when only binocular information or only monocular information was available. Errors ranged from 1.3 to 2.7%. An error of 1.3% approaches the accuracy required to explain the +/- 2.0-2.5 msec accuracy with which top sports players can estimate the instant of impact between bat and ball.     

Bilaterally projecting neurons in the two visual pathways of chicks

The influence of stereoscopic vision on the perception of optic flow fields was investigated in experiments based on a recently described illusion. In this illusion, subjects perceive a shift of the center of an expanding optic flow field when it is transparently superimposed by a unidirectional motion pattern. This illusory shift can be explained by the visual system taking the presented flow pattern as a certain self-motion flow field. Here we examined the dependence of the illusory transformation on differences in depth between the two superimposed motion patterns. Presenting them with different relative binocular disparities, we found a strong variation in the magnitude of the illusory shift. Especially when translation was in front of expansion, a highly significant decrease of the illusory shift occurred, down to 25% of its magnitude at zero disparity. These findings confirm the assumption that the motion pattern is interpreted as a self-motion flow field. In a further experiment we presented monocular depth cues by changing dot size and dot density. This caused a reduction of the illusory shift which is distinctly smaller than under stereoscopic presentation. We conclude that the illusory optic flow transformation is modified by depth information, especially by binocular disparity. The findings are linked to the phenomenon of induced motion and are related to neurophysiology.     

The tilt-consistency theory of visual illusions.

The authors argue that changes in the perception of vertical and horizontal caused by local visual cues can account for many classical visual illusions. Because the perception of orientation is influenced more by visual cues than gravity-based cues when the observer is tilted (e.g., S. E. Asch and H. A. Witkin, 1948), the authors predicted that the strength of many visual illusions would increase when observers were tilted 30°. The magnitude of Z?llner, Poggendorff, and Ponzo illusions and the tilt-induction effect substantially increased when observers were tilted. In contrast, the Müller-Lyer illusion and a size constancy illusion, which are not related to orientation perception, were not affected by body orientation. Other theoretical approaches do not predict the obtained pattern of results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The visual control of reaching and grasping: Binocular disparity and motion parallax.

The primary visual sources of depth and size information are binocular cues and motion parallax. Here, the authors determine the efficacy of these cues to control prehension by presenting them in isolation from other visual cues. When only binocular cues were available, reaches showed normal scaling of the transport and grasp components with object distance and size. However, when only motion parallax was available, only the transpont component scaled reliably. No additional increase in scaling was found when both cues were available simultaneously. Therefore, although equivalent information is available from binocular and motion parallax information, the latter may be of relatively limited use for the control of the grasp. Binocular disparity appears selectively important for the control of the grasp. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A motor signal and "visual" size perception

Recent models of the visual system in primates suggest that the mechanisms underlying visual perception and visuomotor control are implemented in separate functional streams in the cerebral cortex. However, a little-studied perceptual illusion demonstrates that a motor-related signal representing arm position can contribute to the visual perception of size. The illusion consists of an illusory size change in an afterimage of the hand when the hand is moved towards or away from the subject. The motor signal necessary for the illusion could be specified by feedforward and/or feedback sources (i.e. efference copy and/or proprioception/kinesthesis). We investigated the nature of this signal by measuring the illusion's magnitude when subjects moved their own arm (active condition, feedforward and feedback information available), and when arm movement was under the control of the experimenter (passive condition, feedback information available). Active and passive movements produced equivalent illusory size changes in the afterimages. However, the illusion was not obtained when an after-image of subject's hand was obtained prior to movement of the other hand from a very similar location in space. This evidence shows that proprioceptive/kinesthetic feedback was sufficient to drive the illusion and suggests that a specific three-dimensional registration of proprioceptive input and the initial afterimage is necessary for the illusion to occur.     

Binocular vision and spatial perception on 4- and 5-month-old infants.

Conducted 4 experiments investigating the relation between the development of binocular vision and infant spatial perception. Exps I and II compared monocular depth perception in 39 4- and 5-mo-old infants. Results show that Ss in both age groups reached more consistently for the nearer of 2 objects under binocular viewing conditions than under monocular viewing conditions. Exps III and IV investigated whether the superiority of binocular depth perception in 89 4-mo-olds is related to the development of sensitivity to binocular disparity. In Exps I–II, under binocular viewing conditions, Ss who were identified as disparity-sensitive reached more consistently for the nearer object than did Ss who were identified as disparity-insensitive. The 2 group's performances did not differ under monocular viewing conditions. Results suggest that, binocularly, the disparity-sensitive Ss perceived the objects' distances more accurately than did the disparity-insensistive Ss. In Exps II–IV when Ss were habituated to an object, then presented with the same object and a novel object that differed only in size, disparity-sensitive Ss showed size constancy by recovering from habituation when viewing the novel object. Disparity-insensitive Ss did not show clear evidence of size constancy. Findings suggest that the development of sensitivity to binocular disparity is accompanied by a substantial increase in the accuracy of infant spatial perception. (64 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Accuracy demands, environmental structure and viewing conditions in interception tasks

30 subjects performed an interception task in which the accuracy demands were varied under binocular vs monocular viewing conditions and under different conditions of environmental structure. The pattern of results suggests that the advantage of binocular viewing is due to the concordance of information detected by both eyes rather than to binocular vision per se. The presence of static environmental structure enhances performance because it provides a stable external basis against which optical changes can be evaluated.     

Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway.

This study frames anomalous functional brain organization in schizophrenia (SCZ) within an evolutionary model of brain development, the dual trends theory (DTT). The DTT argues that neural architecture develops along 2 separate pathways: the dorsal archicortical trend and the ventral paleocortical trend. The DTT dovetails with visual system organization, which is also composed of 2 independent pathways: a dorsal stream dedicated to visuomotor action and a ventral stream dedicated to perceptual processing. The present study examined the integrity of these pathways using a size-contrast visual illusion. Prior research has shown that, normally, perceptual estimations of object size are susceptible to visual illusions, whereas goal-directed actions are resistant. The authors hypothesized that, unlike control participants, SCZ patients' actions would be susceptible to the illusion, reflecting dorsal stream dysfunction. Here, 42 SCZ patients and 42 healthy controls grasped and estimated the size of target blocks in control and illusion conditions. During estimation, both groups were equally perturbed by the illusion; however, grasping movements of patients alone were influenced by the illusion. These results suggest disrupted dorsal brain circuitry in SCZ but relatively intact ventral circuitry. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cellular kinetic differences between Hodgkin''s and anaplastic large cell lymphomas: relation to the expression of p34cdc2 and cyclin B-1

Normal human subjects were tested for their ability to discriminate the orientation of a square plaque tilted in depth, using two different tasks: a grasping task and a perceptual matching task. Both tasks were given under separate monocular and binocular conditions. Accuracy of performance was measured by use of an opto-electronic motion analysis system, which computed the hand orientation (specifically, a line joining the tips of the thumb and index finger) as the hand either approached the target during grasping or was used to match the target. In all cases there was a very strong statistical coupling between hand orientation and target orientation, irrespective of viewing conditions. However, the matching data differed from the grasping data in showing a consistent curvature in the hand-target relationship, whereby the rate of change of hand orientation as a function of object orientation was smaller for oblique orientations than for those near the horizontal or vertical. The results are interpreted as reflecting the operation of two different mechanisms for analysing orientation in depth: a visuomotor system (assumed to be located primarily in the dorsal cortical visual stream) and a perceptual system (assumed to be located in the ventral stream). It may be that the requirements of visuomotor control dictate a primary need for absolute orientation coding, whereas those of perception dictate a need for more categorical coding.     

Horses are sensitive to pictorial depth cues

In an attempt to demonstrate whether horses could make use of pictorial cues to depth, two were trained initially to make a relative-line-length discrimination between two lines placed one above the other. Psychophysical measurement of their discrimination thresholds showed that from a viewing distance of approximately 160 cm they could reliably distinguish a lower line of 10 cm from an upper one of 14 cm. In the second phase of the experiment, two lines of equal length were superimposed on a photograph of a set of railway tracks with many pictorial cues to depth, or a photograph of a pastoral scene with fewer obvious depth cues. To humans, the railway tracks created a Ponzo illusion, making the upper line-appear longer. When the horses were allowed to choose between the photographs, they overwhelmingly chose the display containing the converging railway tracks. Control experiments ruled out alternative explanations, leading to the conclusion that horses are susceptible to a Ponzo illusion created by depth cues in photographs.     

Dissociation between location and shape in visual space.

There are often large perceptual distortions of shapes lying on the ground plane, even in well-lit environments. These distortions occur under conditions for which the perception of location is accurate. Four hypotheses are considered for reconciling these seemingly paradoxical results, after which 2 experiments are reported that lend further support to 1 of them-that perception of shape and perception of location are sometimes dissociable. The 2 experiments show that whereas perception of location does not depend on whether viewing is monocular or binocular (when other distance cues are abundant), perception of shape becomes more veridical when viewing is binocular. This means that perception of shape is not fully constrained by the perceived locations of the vertices that define the shape. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparing depth from motion with depth from binocular disparity.

The accuracy of depth judgments that are based on binocular disparity or structure from motion (motion parallax and object rotation) was studied in 3 experiments. In Experiment 1, depth judgments were recorded for computer simulations of cones specified by binocular disparity, motion parallax, or stereokinesis. In Experiment 2, judgments were recorded for real cones in a structured environment, with depth information from binocular disparity, motion parallax, or object rotation about the y-axis. In both of these experiments, judgments from binocular disparity information were quite accurate, but judgments on the basis of geometrically equivalent or more robust motion information reflected poor recovery of quantitative depth information. A 3rd experiment demonstrated stereoscopic depth constancy for distances of 1 to 3 m using real objects in a well-illuminated, structured viewing environment in which monocular depth cues (e.g., shading) were minimized. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Human oculomotor system accounts for 3-D eye orientation in the visual-motor transformation for saccades

A recent theoretical investigation has demonstrated that three-dimensional (3-D) eye position dependencies in the geometry of retinal stimulation must be accounted for neurally (i.e., in a visuomotor reference frame transformation) if saccades are to be both accurate and obey Listing's law from all initial eye positions. Our goal was to determine whether the human saccade generator correctly implements this eye-to-head reference frame transformation (RFT), or if it approximates this function with a visuomotor look-up table (LT). Six head-fixed subjects participated in three experiments in complete darkness. We recorded 60 degrees horizontal saccades between five parallel pairs of lights, over a vertical range of +/-40 degrees (experiment 1), and 30 degrees radial saccades from a central target, with the head upright or tilted 45 degrees clockwise/counterclockwise to induce torsional ocular counterroll, under both binocular and monocular viewing conditions (experiments 2 and 3). 3-D eye orientation and oculocentric target direction (i.e., retinal error) were computed from search coil signals in the right eye. Experiment 1: as predicted, retinal error was a nontrivial function of both target displacement in space and 3-D eye orientation (e.g., horizontally displaced targets could induce horizontal or oblique retinal errors, depending on eye position). These data were input to a 3-D visuomotor LT model, which implemented Listing's law, but predicted position-dependent errors in final gaze direction of up to 19.8 degrees. Actual saccades obeyed Listing's law but did not show the predicted pattern of inaccuracies in final gaze direction, i.e., the slope of actual error, as a function of predicted error, was only -0. 01 +/- 0.14 (compared with 0 for RFT model and 1.0 for LT model), suggesting near-perfect compensation for eye position. Experiments 2 and 3: actual directional errors from initial torsional eye positions were only a fraction of those predicted by the LT model (e. g., 32% for clockwise and 33% for counterclockwise counterroll during binocular viewing). Furthermore, any residual errors were immediately reduced when visual feedback was provided during saccades. Thus, other than sporadic miscalibrations for torsion, saccades were accurate from all 3-D eye positions. We conclude that 1) the hypothesis of a visuomotor look-up table for saccades fails to account even for saccades made directly toward visual targets, but rather, 2) the oculomotor system takes 3-D eye orientation into account in a visuomotor reference frame transformation. This transformation is probably implemented physiologically between retinotopically organized saccade centers (in cortex and superior colliculus) and the brain stem burst generator.     

Imprinting: Monocular and binocular cues in object discrimination.

Conducted 2 experiments with a total of 200 Peking ducklings (Anas platyrhyncos) which predicted that under monocular conditions an imprinted preference for a 3-dimensional object should be eliminated or reduced. Results show that binocular viewing was not essential for the establishment of imprinted preferences, contrary to expectations raised by the failure to imprint the Ss to 2-dimensional images. It is suggested that ducklings rely on a hierarchy of cues when making discriminations and that the order within the hierarchy may vary from one situation to the next. (PsycINFO Database Record (c) 2010 APA, all rights reserved)