姜黄素苯胺希夫碱稀土配合物的抑菌性研究

以稀土Ce、La、Nd金属(Ⅲ)硝酸盐和姜黄素缩二苯胺Schiff碱和姜黄素缩二(4-甲基苯胺)Schiff碱为配体,合成了6种配合物。通过红外光谱、热重-差热、摩尔电导和元素分析方法对其进行了表征,确定了配合物的结构。同时研究了合成的6种配合物的抑菌性能。试验表明配合物比姜黄素、姜黄素Schiff碱和稀土离子具有更好的抑菌性质。     

水杨醛缩对羟基苯甲酰肼及其配合物的荧光研究

将Schiff碱与金属盐在一定的条件下反应,生成了具有稳定的结构和生物活性的配合物.该类配合物被广泛应用于药学、催化和分析化学等领域.本实验设计合成了水杨醛缩对羟基苯甲酰肼Schiff碱配体(H2L)及其10种金属配合物.采用红外光谱、元素分析、热重-差热分析对Schiff碱配体及其配合物进行了表征.并对目标化合物的荧光活性进行了初步测定.     

1-羟基-2-萘醛缩对溴苯胺Schiff碱过渡金属配合物的合成及表征

1-羟基-2-萘醛和对溴苯胺在乙醇溶剂中加热回流制得1-羟基-2-萘醛缩对溴苯胺Schiff碱,该Schiff碱分别与铜(Ⅱ),钴(Ⅱ),镍(Ⅱ),锌(Ⅱ)的醋酸盐反应生成相应的4种过渡金属Schiff碱配合物;采用元素分析、电导测定、紫外光谱、红外光谱等手段对上述配体及其配合物进行分析和表征。     

邻苯二甲醛双缩氨基硫脲Schiff碱及其银配合物的合成与表征

Schiff碱及其配合物具有特殊的结构和性质.文章以邻苯二甲醛(OPA)和氨基硫脲为原料,在不同反应条件下合成出一种对称的邻苯二甲醛双缩氨基硫脲Schiff碱配体,并制备出其银配合物.通过红外光谱、紫外光谱、元素分析等手段对配体及配合物的结构进行了初步表征.测定了银配合物的电导性能.抑菌试验结果表明,配体和银配合物对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌均有不同程度的抑菌效果.     

5-氯水杨醛缩甘氨酸与过渡金属离子配合物的合成及性质研究

合成了5-氯水杨醛缩甘氨酸Schiff碱配体及其三种金属离子(Ni2+、Cu2+、Co2+)的Schif碱配合物.用熔点、红外光谱、紫外-可见光谱、电导率等方法对配体及配合物的组成、结构、性质进行了研究,并检测了其抑菌活性.     

皮考林酰腙乙酰二茂铁Schiff碱Co(Ⅱ)配合物的合成与表征

用皮考林酰肼与乙酰二茂铁反应合成皮考林酰腙缩乙酰二茂铁Schiff碱。将其与无水乙酸钴反应合成皮考林酰腙缩乙酰二茂铁Schiff碱Co(Ⅱ)配合物。通过元素分析、飞行时间串联质谱、核磁共振氢谱等手段对其进行了表征,发现配合物Schiff碱配体中的亚氨基氮原子及羰基中的氧原子与Co(Ⅱ)配位,同时配合物分子中有水分子存在使配合物形成六配位的八面体结构。     

苯乙酮双缩硫代对称二氨基脲与ZnCl_2、NiAc_2、CoAc_2配合物及其抗癌活性研究

合成了苯乙酮双缩硫代对称二氨基脲 ( HL)及其与 Zn Cl2 、Ni Ac2 、Co Ac2 的配合物 ,通过元素分析、红外光谱、紫外光谱、磁化率、摩尔电导等对配体和配合物进行了表征。测试了配体和配合物的抗癌活性。     

邻苯二甲醛双缩氨基硫脲Schiff碱及其银配合物的合成与表征

Schiff碱及其配合物具有特殊的结构和性质。文章以邻苯二甲醛（OPA）和氨基硫脲为原料,在不同反应条件下合成出一种对称的邻苯二甲醛双缩氨基硫脲Schiff碱配体,并制备出其银配合物。通过红外光谱、紫外光谱、元素分析等手段对配体及配合物的结构进行了初步表征。测定了银配合物的电导性能。抑菌试验结果表明,配体和银配合物对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌均有不同程度的抑菌效果。     

水杨醛双Schiff碱仲胺配合物的合成及抗菌活性

本文采用分步法,首先合成了新的多齿Schiff碱仲胺配体N,N’-双(2－羟基苯甲醛仲胺基乙基)-2,6-吡啶二甲酰胺（L）,进一步合成了5个新的过渡金属配合物,再通过元素分析、红外光谱、紫外光谱及核磁共振等测试手段对配体及配合物进行了表征和合理的结构推测;并采取微量稀释法研究了它们对大肠杆菌的抑菌活性。结果表明：当配体与Co和Zn离子配位后,对大肠杆菌抑菌效果明显增强。     

2-羟基-1-萘醛缩乙二胺Schiff碱及其稀土金属配合物的合成和表征

以2-羟基-1-萘醛和乙二胺为原料,乙醇为溶剂,加热回流制备2-羟基-1-萘醛缩乙二胺Schiff碱配体,然后分别与铟（Ⅲ）、钍（Ⅳ）的盐反应,生成相应的配合物,并对2-羟基-1-萘醛缩乙二胺Schiff碱及其金属配合物的抗菌活性进行探究。结果表明,配合物对枯草杆菌、大肠杆菌、绿脓杆菌和金黄色葡萄球菌的抑制作用较配体更强。     

新型氨基硫脲类Schiff碱配体的合成及结构表征

用 0 .0 5mol烯丙基异硫氰酸酯和 9.5mL质量分数为 5 0 %的水合肼溶液反应 ,制得 6 3g新的烃基取代的氨基硫脲类化合物——— 4 烯丙基氨基硫脲 (Ⅰ)白色晶体。首先用 0 0 1mol联乙酰分别与 0 0 2mol化合物Ⅰ及 0 0 2mol氨基硫脲缩合 ,合成了收率为 71%的联乙酰双缩 ( 4 烯丙基氨基硫脲 ) (Ⅱ)和收率为 70 %的联乙酰双缩氨基硫脲 (Ⅲ)两种新的含硫脲基Schiff碱。其次用 10mmol环己酮与 10mmol化合物Ⅰ在 30mL无水乙醇中 ,电磁搅拌 ,回流反应 2h ,合成出 1 8g环己酮缩烯丙基氨基硫脲 (Ⅳ )淡黄色晶体。最后将 0 0 1mol化合物Ⅰ分别与 0 0 0 5mol水合茚三酮及 1 0g乙二醛缩合 ,合成了两种新的含硫脲基的双Schiff碱型配体——— 1 6g茚三酮二缩 ( 4 烯丙基氨基硫脲 ) (Ⅴ)桔红色晶体和 1 2g乙二醛二缩 ( 4 烯丙基氨基硫脲 ) (Ⅵ )浅黄色粉末。对所合成的 5种新的含硫脲基Schiff碱配体 ,通过元素分析 ,IR ,1HNMR和MS表征了它们的结构。初步测试了它们对部分金属离子的配位性能。该合成方法具有操作简便、反应条件温和、产率高等优点     

新型dmit金属配合物的合成及其电化学性质的研究

以4,5- 二氰乙硫基-1,3- 二硫杂环戊烯-2-硫酮为原料,经醇钠消去保护基团,再与二价金属离子配位,合成了8种双(1,3-二硫杂环戊烯-2-硫酮-4,5-二硫)金属配合物,为dmit型配合物合成提出了一种新方法.研究表明这类配合物有特殊的电化学性质和很强的紫外吸收,并对其形成中性产物的主要原因和室温电导率进行了讨论.     

Assessment of the flotation activity of reagents in terms of the hydrogen bond energy in molecular complexes with active sites of the coal surface

The hydrogen bond energy of molecular complexes between a flotation reagent and coal’s organic mass is calculated for the first time. The electron density distribution in molecules of 2-methyl-1,3-dioxane and 2-methyl-1,3-dioxa-2-silacyclohexane is determined. It is shown that the silicon atom in the molecule of 2-methyl-1,3-dioxa-2-silacyclohexane increases the electron density at oxygen atoms from ?0.279 to ?0.424 and ?0.432 in positions 1 and 3 of the molecule, respectively. This increases the hydrogen bond energy of the reagent in molecular complexes with water and model compounds of the coal’s organic mass. In molecular complexes of 2-methyl-1,3-dioxa-2-silacyclohexane with model compounds of the coal’s organic mass, the hydrogen bond energy is considerably higher than in corresponding complexes of 2-methyl-1,3-dioxane. As a result, the adsorption of 2-methyl-1,3-dioxa-2-silacyclohexane on the coal surface is 35–45% greater than for 2-methyl-1,3-dioxane. Consequently, the coal grains become more hydrophobic, and their flotation is improved. With the same consumption of reagents, the use of 2-methyl-1,3-dioxa-2-silacyclo-hexane rather than 2-methyl-1,3-dioxane increases the concentrate yield and reduces the losses of the coal’s organic mass with the wastes. Analogous flotation properties of coal are found for other cyclic acetals and their silicon analogs. Experimental data confirm that the hydrogen bond energy in complexes between the flotation reagent and the coal’s organic mass may be used to assess its effectiveness.     

Synthetic, biochemical, antifertility and antiinflammatory aspects of manganese and iron complexes

Manganese(II) and iron(II) macrocyclic complexes of polyamide groups have been synthesized by the template codensation of diamines (2,6 diaminopyridine, 1,2 phenylenediamine and 1,3 phenylenediame) and triamine (diethylenetriamine) with phthalic acid in 1:2:2 molar ratios. On the basis of elemental analysis, IR, electronic, magnetic moment, M?ssbauer, mass and X-ray spectral studies, octahedral structure has been assigned to [M(N4macn)Cl2] (M = Mn(II) and Fe(II), n = 1 to 4) complexes. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. An attempt has been made to correlate the structural aspects of the compounds with their antiinflammatory and antifertility activities.     

Tetrathiafulvalene. XIX. Synthese und Eigenschaften elektronenleitender Poly-Dithiolenkomplexe mit Ethylentetrathiolat und Tetrathiafulvalentetrathiolat als Brückenliganden

Tetrathiafulvalenes. XIX. Synthesis and Properties of Electron Conducting Poly-Dithiolene Complexes with Ethylene Tetrathiolat and Tetrathiafulvalene Tetrathiolat as Bridge Ligands [1,3]-Dithiolo[4,5-d]-1,3-dithiol-2,5-dione 7 and 5-(5-oxo[1,3]-dithiolo[4,5–d]1,3-dithiole-2-ylidene)[1,3]-dithiolo[4,5–d]1,3–dithiol-2-one 8 were synthesised from 1,3-dithiole-2-thione-4,5-dithiolat. The ligands react with salts of iron, cobalt, nickel, palladium, platinum and copper to give the polymer complexes 22a–g and 23a–e , respectively. Irradiation of 7 in the presence of iron penta-, dicobalt octa- or nickel tetracarbonyl gives the corresponding dithiolene complexes 21a–c . The amorphous insoluble polymer complexes from types 21, 22 , and 23 have been characterised by i.r.-spectroscopy, susceptibility and conductivity measurements. The nickel complexes have the highest electrical conductivity (σ_RT ∼ 10⁻¹Ω⁻¹cm⁻¹, pellets) with a very low activation energy (0,045 eV, 100–300 K) A high electron delocalization in the direction of the polymer chain and an easy charge transfer from chain to chain is supposed.     

Acetals and Ethers. XVI [1] Hydrolysis of 2-[2-(ω-Hydroxyalkoxy)alkyl]-substituted 1,3-Dioxolanes and 1,3-Dioxanes in Aqueous Solution of Hydrochloric Acid

The rate constants of hydrolysis of 2-[2-(ω-hydroxyalkoxy)alkyl]-substituted 1,3-dioxolanes and 1,3-dioxanes ( 1–6 ) in aqueous HCl solution were determined. For two selected acetals, the parameters of active complexes were also evaluated. The acetals studied were found to be more stable than 2-alkyl-substituted 1,3-dioxolanes and 1,3-dioxanes. The presence of ether-oxygen in β-position with respect to the acetal grouping in molecules of 2-[2-(ω-hydroxyalkoxy)alkyl]-substituted 1,3-dioxolanes and 1,3-dioxanes was the stability determining factor.     

4-酰代-双(1,3-二苯基-5-吡唑酮)螯合剂的合成与表征

于 90℃ ,以二氧六环为溶剂 ,Ca(OH) 2 为缩合剂 ,由 1,3 二苯基 5 吡唑酮分别与戊、己和癸二酰氯作用 (量比为 2∶1) ,合成了三种新的 β 二酮螯合剂 4 酰代 双 (1,3 二苯基 5 吡唑酮 )(各以符号P、H和D表示 ) ,收率为 6 5 .5 %、6 7.4%和 6 1.0 %。通过元素分析、红外光谱和核磁共振氢谱证实了产物的结构。测定了以它们为配体的Tb(Ⅲ )配合物的荧光光谱 ,结果表明 :这三种化合物的Tb(Ⅲ )配合物的荧光强度高于 4 酰代 双 (1 苯基 3 甲基 5 吡唑酮 )的Tb(Ⅲ )配合物 ;这三种化合物的Tb(Ⅲ )配合物荧光强度的顺序为P >H >D。     

尾式5-{对-[2-(2-甲乙基)-1,3-二噁烷]苯氧基}-10,15,20- 三苯基卟啉及其金属配合物的合成与表征

2-(2-溴-2-甲乙基)-1,3-二噁烷与存在无水K2CO3的DMF溶剂中的5-(4-羟基苯基)-10,15,20-三苯基卟啉反应,合成出了一种新型卟啉5-{对-[2-(2-甲乙基)-1,3-二噁烷]苯氧基}-10,15,20-三苯基卟啉,并据此制得了锌、钯、钌配合物.对化合物的结构分别用UV-Vis、IR、1HNMR、元素分析等手段进行了表征.     

尾式1,3-二噁烷基卟啉及其金属配合物的合成与表征

在特定的条件下以桂皮醛、二苯基壬四烯酮和氢溴酸为原料合成出了一种环状β-卤代缩醛类化合物—— 2 -( 2 -溴 -2 -苯乙基 ) -1 ,3-二烷 ,在无水碳酸钾的存在下与 5 -对羟基苯基 -1 0 ,1 5 ,2 0 -三苯基卟啉反应合成出了一种新型尾式卟啉—— 5 -{对 -[2 -( 2 -苯乙基 ) -1 ,3-二烷 ]氧基苯基 } -1 0 ,1 5 ,2 0 -三苯基卟啉 ,同时合成了其锌、钌、钯金属配合物 ,并通过电子光谱、元素分析、1 HNMR、IR等光谱手段进行了表征     

New Methods for the Preparation of Multiply Substituted Cyclopentadienes and Related Compounds

Substituents on cyclopentadienyl ligands significantly influence the reactivity and catalytic efficiency of their transition metal complexes. Therefore, development of synthetic methods for cyclopentadiene derivatives possessing different substituents has been in great demand. In this paper, we report new synthetic methods for multiply substituted cyclopentadienes recently developed in this group. In principle, three types of preparative methods are described. Firstly, zirconacyclopentadienes in the presence of Lewis acids react with aldehydes to afford multiply substituted cyclopentadienes, thus providing a one-pot procedure from two molecules of identical or different alkynes and one molecule of aldehyde; reaction of aluminacyclopentadienes with aldehydes also result in high-yield formation of multiply substituted cyclopentadienes. Secondly, 1,2,3,4-tetrasubstituted 1,4-dilithio- and 1,4-bis(magnesiobromo)-1,3-diene derivatives react with aldehydes or ketones via deoxygenation of the C=O moieties to afford cyclopentadiene derivatives. Thirdly, monolithio reagents, 1,2,3,4-tetrasubstituted 1-lithio-1,3-butadienes, and Grignard reagents, 1,2,3,4-tetrasubstituted 1-magnesiobromo-1,3-butadienes react with aldehydes or ketones to afford cyclopentadiene derivatives upon hydrolysis.