A prospective study of risk factors for unipolar depression.

The purpose of this study was to identify variables that are antecedents for unipolar depression. Information regarding a number of sociodemographic and psychosocial variables was collected on a community sample of adults (N?=?998), 562 of whom were interviewed and diagnosed according to Schedule for Affective Disorders and Schizophrenia-Research Diagnostic Criteria procedures and received a second assessment on most of the variables. The average time elapsed between Time 1 and Time 2 was 8.3 months. Depressive symptomatology was also assessed with the Center for Epidemiologic Studies Depression Scale CES-D. A number of variables emerged, which predicted both the development of an episode of depression and elevated CES-D scores. These include reporting an elevated level of depressive and other symptoms and having experienced an elevated level of stress. Variables that are predictive of developing an episode of depression include young age, being female, and having had a previous episode of depression. The presence of depressogenic cognitions was uniquely predictive of an elevation of depression symptoms as measured by the CES-D. Virtually no variables demonstrated a significant moderating effect on the stress–depression relation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Vulnerability to postpartum depression: A prospective multivariate study.

A sample of 115 primiparous women was assessed during pregnancy and the postpartum to identify the predictors and correlates of postpartum depression. The variables considered were marital adjustment, attributional style, life stress, maternal expectations for and perceptions of infant behavior, and blues symptoms. The data obtained at each assessment were submitted to principal-components analyses to identify variable clusters or constructs, which were used to predict both depressive symptom levels and a diagnosis of depression. Concurrently, symptoms and diagnosis were related to mothers' perceptions of their infants as temperamentally difficult. Prospectively, depressive symptomatology was predicted by low marital adjustment and depressed mood during pregnancy, optimistic expectations for infants, prepartum life stress, and early postpartum symptoms of anxiety and cognitive impairment. Although diagnostic status was related to a subset of these variables, results indicate that depressive symptom levels and diagnosis are not synonymous measures of the construct "postpartum depression." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A prospective study of stress autonomy versus stress sensitization in adolescents at varied risk for depression.

This longitudinal study investigated the stress autonomy, stress sensitization, and depression vulnerability hypotheses in adolescents across 6 years (i.e., Grades 6 through 12). Participants were 240 children (Time 1 mean age = 11.86, SD = 0.57) who varied in risk for depression on the basis of their mother's history of mood disorders. All analyses were conducted as multilevel models to account for nesting in the data. Results were consistent with the stress sensitization hypothesis. The within-subject relation of stress levels to depressive symptoms strengthened with increasing numbers of prior depressive episodes. In addition, evidence consistent with the vulnerability hypothesis was found. The relation of stress levels to depressive symptoms was stronger for adolescents who were at risk for depression on the basis of maternal depression history and for those who had experienced more depressive episodes through Grade 12. These findings suggest that onsets of depression in adolescents may be predicted by both relatively stable and dynamic transactions between stressful life events and vulnerabilities such as maternal depression and youths' own history of depressive episodes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-schemas and gender.

Examined the information processing consequences of self-schemas about gender in 2 studies (467 undergraduates). Systematic differences in cognitive performance were observed among Ss identified as masculine schematics, feminine schematics, low androgynous, and high androgynous (Bem Sex-Role Inventory). Feminine schematics remembered more feminine than masculine attributes, endorsed more feminine qualities, required shorter processing times for "me" judgments to these attributes, were more confident of their judgments, and were able to supply relatively more examples of past feminine than masculine behavior. A parallel pattern of results was found for masculine stimuli in masculine schematics. Androgynous Ss recalled as many masculine as feminine attributes and did not differentiate between masculine and feminine attributes with respect to latency or confidence. Comparison of the 2 groups of androgynous Ss shows that only low androgynous Ss should be considered aschematic with respect to gender. (14 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stability of cognitive vulnerabilities to depression: A short-term prospective multiwave study.

The stability of 3 cognitive vulnerabilities--a negative cognitive style, dysfunctional attitudes, and rumination--as well as depressive symptoms as a benchmark were examined to investigate whether cognitive vulnerabilities are stable, enduring risks for depression. A sample of adolescents (6th-10th graders) completed measures of these 3 cognitive vulnerabilities and depressive symptoms every 5 weeks for 4 waves of data across 5 months. Mean-level and differential stability were examined for the sample overall and by age subgroups. A negative cognitive style exhibited mean-level stability, whereas rumination and dysfunctional attitudes showed some mean-level change. Absolute magnitudes of test-retest reliabilities were strong for depressive symptoms (mean r = .70), moderately high for a negative cognitive style (mean r = .52), and more modest for rumination (mean r = .28) and dysfunctional attitudes (mean r = .26). Structural equation modeling showed that primarily enduring processes, but not contextual forces, contributed to the patterning of these test-retest reliabilities over time for a negative cognitive style and dysfunctional attitudes, whereas both enduring and contextual dynamics appeared to underlie the stability for rumination. Theoretical and clinical implications of these findings are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predicting prospective episodes of depression in patients with panic disorder: A longitudinal study.

This study used a naturalistic, longitudinal study to examine predictors of the emergence of major depression among 90 nondepressed patients with panic disorder who were followed for a 2-yr period. 24% of the sample experienced a major depressive episode during the study period. Adequacy and type of medication treatment were not associated with decreased risk. Past history of major depression was associated with a greater risk for a prospective episode. The degree of assertiveness, presence of comorbid generalized anxiety disorder, and severity of agoraphobia were each significant predictors of the occurrence of depression when considered alone and when the influence of past history of depression was statistically controlled. The implications of these findings for the clinical management of patients with panic disorder are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fasting increases risk for onset of binge eating and bulimic pathology: A 5-year prospective study.

Although adolescent girls with elevated dietary restraint scores are at increased risk for future binge eating and bulimic pathology, they do not eat less than those with lower restraint scores. The fact that only a small proportion of individuals with elevated dietary restraint scores develop bulimic pathology suggests that some extreme but rare form of dietary restriction may increase risk for this disturbance. The authors tested the hypothesis that fasting (going without eating for 24 hr for weight control) would be a more potent predictor of binge eating and bulimic pathology onset than dietary restraint scores using data from 496 adolescent girls followed over 5 years. Results confirmed that only 23% of participants with elevated dietary restraint scores reported fasting. Furthermore, fasting generally showed stronger and more consistent predictive relations to future onset of recurrent binge eating and threshold/subthreshold bulimia nervosa over 1- to 5-year follow-up relative to dietary restraint, though the former effects were only significantly stronger than the latter for some comparisons. Results provide preliminary support for the hypothesis that fasting is a stronger risk factor for bulimic pathology than is self-reported dieting. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hardiness and health: A prospective study.

Hypothesized that hardiness—commitment, control, and challenge—functions to decrease the effect of stressful life events to producing illness symptoms. 259 upper- and middle-level male managers (mean age 48 yrs) were administered a battery of tests (including Rotter's Internal–External Locus of Control Scale, the Schedule of Life Events, and the Seriousness of Illness Survey) covering a 5-yr period. Results support the hypothesis by showing main effects on illness for both stressful life events and hardiness and an interaction effect for these independent variables. (37 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dieting and depression: A methodological study.

Examined the effects of 3 variables on reports of psychological functioning in 28 obese women (mean age 42.1 yrs) who lost an average of 19.2 kg in 6 mo. Analysis of the 1st variable, frequency of assessment, showed that although Ss experienced improvements in mood from pre- to posttreatment, more than 50% showed worsening in mood during 1 or more wks. Analysis of the 2nd variable, time of assessment, revealed that retrospective reports of depression and anxiety were greater than were concurrent reports. Analysis of the 3rd variable, method of assessment, showed that Ss reported several symptoms in response to an open-ended interview that were not measured by objective tests. Data indicate that the method of mood assessment determines the answer to the question of whether dieting is associated with adverse psychological consequences. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A prospective test of an integrative interpersonal theory of depression: A naturalistic study of college roommates.

This study tested an integrated interpersonal theory of depression, which combines J. C. Coyne's (1976) interpersonal theory of depression with work on the interplay between self-enhancement and self-consistency theory. Students' (targets') and their same-gender roommates' appraisals of each other, depression and anxiety levels, reassurance seeking, and negative feedback seeking were assessed at Time 1 (T1), and again at Time 2 (T2), 3 wks later. Consistent with the theoretical integration (1) depressed targets reported engaging in more negative feedback seeking than nondepressed targets, and tended to report seeking more reassurance than nondepressed targets at T1; (2) for male (but not female) targets, the combination of negative feedback seeking, high reassurance seeking, and depression at T1 predicted T1 to T2 increases in rejection by roommates; and (3) rejection effects applied to depressive symptoms, but not anxious symptoms or anhedonic mood. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-schemas, gender, and social comparison: A clarification of the related attributes hypothesis.

G. Goethals and J. Darley (1977) proposed that people evaluate their abilities by comparing with someone who is similar to themselves on nonability attributes that influence performance. However, research on this related-attributes hypothesis shows that people compare with same-sex others regardless of the relationship between sex and performance. The present experiment was conducted to determine if self-schemas with respect to gender (defined as organizations of self-related information about masculinity and/or femininity) could explain this finding. 184 female and 66 male undergraduates who previously had completed a self-schema measure took an ability test on which males, females, or neither sex supposedly excelled. Ss then chose which of several group norms they wanted to see to evaluate their performance. As predicted, results show that schematic Ss made same-sex comparisons regardless of the relationship of sex to performance. In contrast, the comparison choices of aschematic Ss were consistent with the related-attributes hypothesis. Thus, self-schema theory can explain why self-evaluators sometimes ignore an attribute's relevance to performance in choosing comparison others. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Leisure-time physical activity and marital status in relation to depression between men and women: A prospective study.

Background: Previous studies have identified the preventive effect of leisure-time physical activity (LTPA) on depression. Women and men have different emotional vulnerabilities. The impact of LTPA on depression varies by gender. Little is known about the impact of LTPA on depression for people with different marital status. Objectives: The objective of this study was to assess the long-term effects of LTPA, changes in LTPA, and marital status on the risk of developing depression for general Canadians. Methods: Data from the biennial National Population Health Survey (NPHS) cycles conducted between 1994/95 and 2004/05 were analyzed in 2008. After excluding individuals with preexisting depression at baseline, respondents were classified as physically active or inactive and then followed up in subsequent cycles of the NPHS to look at risk of developing depression. Individuals who changed their activity level were also examined. Subgroup analyses by different marital status were performed to identify high-risk populations. Results: In 1994/1995, 17,276 participants were included in the NPHS longitudinal panel. Respondents who were inactive were more likely to be older, female, obese, widowed/separated/divorced, not working, low income, and lacking social support. After controlling for potential confounding factors, it was found that LTPA reduced the risk of developing depression for women. The modest risk reduction observed for men was not statistically significant. Women who were active at baseline and two years of follow-up were significantly less likely to report depression at four years of follow-up compared to women who were inactive at baseline and at two years of follow-up. A 51% greater probability of developing depression was observed after two years for women who changed their LTPA from active to inactive compared to women who remained active. No significant results were found for men. Divorced/separated/widowed women who stopped LTPA had 4.2 times the risk of developing depression after two years compared to those who remained active. The risk of developing depression after stopping activity did not vary according to marital status among men. Conclusions: LTPA has preventive effects on depression for women. Reduction in LTPA level is associated with subsequent depression for women. Divorced/separated/widowed women are at particularly high risk of developing depression if LTPA is stopped. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Modification of depression risk factors: A solution-focused approach.

M. Seligman (1990) postulated that 3 meaning frames determine whether temporary sad feelings persist and eventually evolve into clinical depression: the permanence, pervasiveness, and personal causation of negative or stressful events. Successful treatment is thought to consist of interventions that modify these 3 meaning frames that contribute to depression. The authors combine Seligman's observations with 3 types of intervention questions used by therapists in solution-focused psychotherapy: exception, outcome, and coping and/or externalization questions. It is suggested that use of certain classes of intervention from solution-focused psychotherapy may shorten and potentiate treatment of depression. Solution-focused psychotherapy techniques are illustrated using a case study of a 69-yr-old man treated for depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Chrysotherapy. A prospective study

A 4-year prospective clinical study of chrysotherapy was designed to reexamine old beliefs and traditions, and to test potentially new approaches to chrysotherapy. The standard weekly dosage of 50 mg was compared to that based on 1 mg/kg body weight; no significant differences were found. The rapidly absorbed aqueous thiomalate was compared to the slowly absorbed oil repository thioglucose; the latter produced significantly less side effects and an appreciably higher percentage of improvement. Almost half (43%) of nonresponders on standard regimen had a satisfactory clinical response at higher dosage levels without increase in toxicity. Some of these findings vary so much with traditional beliefs and practices that the authors urge caution in their interpretation. But generally speaking these problems are technical and do not detract from the conviction that chrysotherapy is valuable and comparatively safe in the management of rheumatoid arthritis and that it deserves more widespread application in clinical practice.     

Adolescent psychopathology: II. Psychosocial risk factors for depression.

In a prospective study of adolescent depression, adolescents (N?=?1,508) were assessed at Time 1 and after 1 yr (Time 2) on psychosocial variables hypothesized to be associated with depression. Most psychosocial variables were associated with current (n?=?45) depression. Formerly depressed adolescents (n?=?217) continued to differ from never depressed controls on many of the psychosocial variables. Many of the depression-related measures also acted as risk factors for future depression (n?=?112), especially past depression, current other mental disorders, past suicide attempt, internalizing behavior problems, and physical symptoms. Young women were more likely to be, to become, and to have been depressed. Controlling for the psychosocial variables eliminated the gender difference for current and future but not for past depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-schemas, possible selves, and competent performance.

College students were classified as either schematic for being a good problem solver (i.e., they believed they were very good in this area, and this ability was very important to their self-evaluation) or aschematic for this ability (i.e., they believed they had moderate ability in this area, and this ability was of moderate to low importance to their self-evaluation). In Study 1, schematic and aschematic Ss performed equally well in an initial problem-solving test; however, aschematic Ss did not enjoy the task and had negative possible selves related to logical ability active in working memory. In Study 2, aschematic Ss maintained competent performance on a problem-solving test only when given failure feedback on an earlier test. The results point to the importance of the self-concept in the development and maintenance of competence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Personality and substance use disorders: A prospective study.

The personality systems of Cloninger (as measured by the Tridimensional Personality Questionnaire [TPQ]) and Eysenck (as measured by the Eysenck Personality Questionnaire [EPQ]) both have been linked to substance use and abuse. The current study examined the predictive utility of both systems for substance use disorder (SUD) diagnoses, both cross-sectionally and prospectively. Participants (N?=?489 at baseline) completed the EPQ and TPQ and were assessed via structured diagnostic interview at baseline and 6 years later (N?=?457 at follow-up). Both the EPQ and TPQ scales demonstrated bivariate cross-sectional and prospective associations with SUDs. Within each system, those dimensions marking a broad impulsive sensation-seeking or behavioral disinhibition trait were the best predictors prospectively, although the 2 systems were differentially sensitive to specific diagnoses. These relations remained significant even with autoregressivity, other concurrent SUD diagnoses, and multiple personality dimensions statistically controlled. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Screening for depression prevention: Identifying adolescent girls at high risk for future depression.

This study investigated a broad array of putative risk factors for the onset of major depression and examined their screening properties in a longitudinal study of 479 adolescent girls. Results indicated that the most potent predictors of major depression onset included subthreshold depressive symptoms, poor school and family functioning, low parental support, bulimic symptoms, and delinquency. Classification tree analysis revealed interactions between 4 of these predictors, suggesting qualitatively different pathways to major depression. Girls with the combination of elevated depressive symptoms and poor school functioning represented the highest risk group, with a 40% incidence of major depression during the ensuing 4-year period. Results suggest that selected and indicated prevention programs should target these high-risk populations and seek to reduce these risk factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pregnancy and risk of non-Hodgkin''s lymphoma: a prospective study

Glucose 6 phosphate dehydrogenase (G6PD) was estimated in the leucocytes of 35 patients with acute non-lymphocytic leukemia (ANLL) and 10 patients with chronic myeloid leukemia (CML). G6PD levels were found to be significantly decreased in majority of the patients with ANLL while it was increased in all CML patients. Variation in G6PD was found to be dependent on the percentage of myelocytes inANLL. Cytogenetic analysis was also carried out in these patients. Correlation analysis of leucocyte G6PD activity and karyotype with prognostic assessment clearly indicated the association of (s) high percentage of chromosomal abnormalities especially translocations, (b) low survival and remission rates, with patients having decreased G6PD activity when compared to patients with normal activity in ANLL. The studies indicate that leucocyte G6PD may be useful as a diagnostic and prognostic tool.     

Stimulation seeking and intelligence: A prospective longitudinal study.

The prediction that high stimulation seeking 3-yr-olds would have higher IQs by 11 yrs old was tested in 1,795 children on whom behavioral measures of stimulation seeking were taken at 3 yrs, together with cognitive ability at 11 yrs. High 3-yr-old stimulation seekers scored 12 points higher on total IQ at age 11 compared with low stimulation seekers and also had superior scholastic and reading ability. Results replicated across independent samples and were found for all gender and ethnic groups. Effect sizes for the relationship between age 3 stimulation seeking and age 11 IQ ranged from 0.52 to 0.87. Findings appear to be the first to show a prospective link between stimulation seeking and intelligence. It is hypothesized that young stimulation seekers create for themselves an enriched environment that stimulates cognitive development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)