苯甲醛缩2-氨基嘧啶席夫碱铜配合物的合成及其与DNA相互作用

在非水溶剂中合成出一种新型席夫碱试剂(L):苯甲醛缩2-氨基嘧啶及其过渡金属铜配合物。由元素分析、络合滴定法、红外光谱、热重谱、质谱和摩尔电导值对配体和配合物的结构进行了表征,并推测出其组成为CuL2,采用荧光光谱和黏度分析方法初步研究了该配合物与小牛胸腺DNA之间的相互作用。表征结果表明:配合物为两分子配体以亚氨基和嘧啶环上的两个N原子与铜中心离子成键,配位数为4;与小牛胸腺DNA作用结果显示:配合物主要以插入方式与DNA相互作用,破坏了DNA的双螺旋结构。     

Synthesis,characterization and catalytic activity of Fe(III) complexes containing Schiff base and triphenylphosphine ligands

The oxidation of alcohols to carbonyls was investigated by an efficient catalyst system comprising of Fe(III)–Schiff base–triphenylphosphine complex. The complex chloroN-(2-mercaptophenyl)salicylideneiminebis(triphenylphosphine)iron(III) showed higher activity for oxidation of various alcohols under relatively mild conditions.     

乙酰基甲酰苯胺缩氨基脲Schif碱配合物的合成及表征

合成了乙酰基甲酰苯胺缩氨基脲Ｓｃｈｉｆ碱及其与某些过渡金属离子的配合物。对产物进行了元素分析和红外光谱的解析。对其抗菌活性作了初步的研究     

Synthesis,characterization and biomolecular interactions of Cu(II) and Ni(II) complexes of acyclic Schiff base ligand

Mononuclear copper(II) (1) and nickel(II) complexes (2) of acyclic Schiff base ligand, N,N′-bis(2-hydroxy-1-naphthyl)-1,4-bis(3-iminopropyl) piperazine (L) were synthesized and characterized. The molecular structure of the ligand was confirmed using single crystal X-ray diffraction analysis. The complexes displayed good binding abilities to bovine serum albumin protein (BSA). The binding interactions of complexes 1 and 2 with calf thymus DNA (CT-DNA) was investigated by absorption, fluorescence, circular dichroism spectral analysis and molecular docking studies. Complex 1 showed greater interaction with DNA than nickel(II) complex 2. The cleavage studies with pBR322 DNA showed efficient oxidative cleavage in the presence of 3-mercaptopropionicacid (MPA) and for hydrogen peroxide for complexes 1 and 2 respectively.     

糠醛缩邻氨基苯甲酸Schiff碱稀土配合物的合成与表征

合成了糠醛缩邻氨基苯甲酸Schiff碱及其4种稀土配合物,并通过元素分析、IR、UV、1H NMR和热失重分析对其组成和结构进行表征,结果表明,配体是以四齿的形式参与配位,配位数为8,配合物的组成为Re(L)2.2.5H2O(Re=Eu、Sm、La、Y)。     

Synthesis,crystal structures and urease inhibitory activity of copper(II) complexes with Schiff bases

Two thiocyanate-coordinated Schiff base copper(II) complexes, [CuL¹(NCS)] (1) and [Cu₂(L¹)₂(μ_1,3-NCS)₂]_n (2), where L¹ and L² are the deprotonated forms of 4-bromo-2-[(2-propylaminoethylimino)methyl]phenol (HL¹) and 2-ethoxy-6-[(2-propylaminoethylimino)methyl]phenol (HL²), respectively, have been prepared and structurally characterized. Single crystal X-ray diffraction indicates that 1 is a mononuclear copper(II) complex, while in 2, the adjacent two complex molecules are linked through two phenolate O atoms, forming a dimer. The dimers in 2 are further weakly linked through end-to-end thiocyanate bridges to form a two-dimensional sheet. The Cu atom in 1 is four-coordinate in a square planar geometry, and that in 2 is six-coordinate in an octahedral geometry. Complex 1 shows strong urease inhibitory activity, while complex 2 shows no activity.     

几种新型吡啶腙类Schiff碱配体的合成

分别以6-溴吡啶-2-甲酸和3-腈基-4-甲基-2,6-二氯吡啶为原料,经过酰胺化、肼取代、缩合等反应合成4种新型吡啶腙类Schiff碱有机配体:N-苯基-2-甲酰胺-6-肼吡啶缩水杨醛;N-苯基-2-甲酰胺-6-肼吡啶缩香草醛;N-苯基-2-甲酰胺-6-肼吡啶缩对羟基苯甲醛;3-腈基-4-甲基-2,6-二肼吡啶二缩水杨醛。通过红外光谱、核磁共振谱对其结构进行了表征。     

In situ synthesis and dielectric properties of copper(II) and nickel(II) chiral Schiff base complexes

Two chiral Schiff base-containing complexes, [Cu(L¹)](ClO₄)₂·H₂O (1, L¹ = (S,S)-N1,N2-bis((1H-imidazol-4-yl)methylene)cyclohexane-1,2-diamine) and [Ni(L²)₂](ClO₄)₂ (2, L² = (S,S)-N1-((1H-imidazol-4-yl)methylene)cyclohexane-1,2-diamine) were synthesized from the reaction mixture of 1H-imidazole-4-carbaldehyde, (S,S)-1,2-diaminocyclohexane and Cu(ClO₄)₂·6H₂O or Ni(ClO₄)₂·6H₂O in methanol. Single-crystal X-ray diffraction analyses reveal that the in situ generated chiral Schiff base ligands L¹ and L² are bisubstituted and monosubstituted, respectively, corresponding to the different metal ions Cu^II and Ni^II. Variable-frequency and -temperature dielectric properties of 1 and 2 have been studied.     

Synthesis, characterization, DNA interaction and antibacterial activities of two tetranuclear cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone

Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H₂L), and its novel tetranuclear cobalt(II), nickel(II) complexes have been synthesized and characterized. The crystal structure of (NiL)₂·[NiL(H₂O)(DMF)]₂·H₂O·DMF obtained from DMF solutions of compound 2 was determined by X-ray diffraction analysis. The DNA-binding investigation suggests that the two complexes bind to DNA via groove binding mode. The in vitro antibacterial activity of complexes against Escherichia coli, Staphylococcus aureus, Bacillus subtilis was screened and compared to the activity of the free ligand, the antibacterial activity of complex 1 is active than complex 2 which is in consistent with their DNA-binding behaviors.     

2-取代苯并咪唑与铜（II）配合物的微波合成与表征

采用2-取代基苯并咪唑化合物、氯化铜为原料、丙酮或2-丁酮为溶剂,在微波辐射下合成了2-苄基苯并咪唑(BIm_a)和1-(对甲氧基苄基)-2-(对甲氧基苯基)苯并咪唑(BIm_b)的铜配合物,收率分别为80%和75%.测得BIm_a和BIm_b铜配合物熔点分别为144.7～145.8 ℃和224.5～226.0℃.应用摩尔电导率、XRD、紫外光谱、SEM和热分析测试对目标配合物进行表征,摩尔电导率、紫外和红外光谱解析表明,2-取代苯并咪唑配体与Cu(Ⅱ) 发生了配合反应;XRD和SEM表征证明晶型为单斜晶系;热分析得出BIm_a、BIm_b和氯化铜的配位数分别为1和1/2.     

水杨醛缩丙氨酸Schiff碱氧钒-多吡啶三元混配配合物的合成及表征

本文合成了三个水杨醛缩丙氨酸Schiff碱氧钒-多吡啶二三元混配配合物,通过EA、IR、UV、EPR、熔点等技术对其进行了分析和表征,并推测其可能的结构式。     

Syntheses,characterizations, antitumor activities and cell apoptosis induction of Cu(II), Zn(II) and Cd(II) complexes with hydrazone Schiff base derived from isonicotinohydrazide

Three novel complexes, [Cu₄(L)₄Cl₄]·H₂O (1), Zn(L)₂ (2) and Cd(L)₂ (3), based on HL (where HL = 2-acetylpyridine isonicotinohydrazone) were synthesized and characterized by X-ray diffraction analyses. In the tetranuclear complex 1, each copper(II) ion with a distorted square-planar coordination geometry is five-coordinated by one chloride anion, one ON₂ donor set and one 4-pyridine nitrogen atom from another adjacent actylhydrazone ligand. However, the central ions in complexes 2 and 3 possess distorted octahedral coordination geometry, surrounded by two ON₂ donor sets. In addition, all the complexes have excellent antitumor activity towards human lung cancer (A549) and human gastric cancer (SGC7901 and BGC823) cell lines. Furthermore, cell apoptosis induced by complex 1 was detected through TUNEL and Annexin V/PI staining with flow cytometric analysis and western blotting analysis.     

双二茂铁基Schiff碱的合成和表征

通过二茂铁甲醛与两种二胺在无水乙醇中缩合合成了两个新型的含有双二茂铁基的Schiff碱,并通过元素分析,核磁共振氢谱,红外光谱和紫外光谱的测定确证了其结构。     

Copper (II) and silver (II) complexes of polymer-bound porphyrins with Schiff base linkage

Two percent divinylbenzene (DVB)–crosslinked polystyrene was prepared and functionalized to obtain its aldehyde analog. Amino porphyrins were anchored on this polymer support by Schiff base condensation. The anchoring positions were adjusted so as to obtain ortho-, meta-, and para-isomeric systems. The polymer-bound free-base porphyrins were metallated to obtain the corresponding Cu(II) and Ag(II) complexes by treating them with the corresponding metal salt solutions. The products were characterized chemically and spectroscopically. Electronic and ESR spectral analysis shows the microenvironmental participation of the polymer network on the electronic levels of the porphyrin system. The extents of steric and electronic participation were evaluated and are presented. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 69: 89–93, 1998     

Synthesis, in vitro cytotoxicity, and interaction with DNA of platinum(II) complexes with N-monocycloalkyl derivatives of 1R,2R-diaminocyclohexane as carrier ligands

A series of platinum(II) complexes with N-monocyclopentyl/cyclohexyl derivatives of 1R,2R-diaminocyclohexane as carrier ligands and dicarboxylate anions as leaving groups were synthesized and characterized. All complexes were characterized by elemental analysis, IR, (1)H NMR, and (13)C NMR spectroscopy, as well as ESIMS. The in vitro antiproliferative activities were tested by MTT assay against four human cancer cell lines; breast carcinoma (MCF-7) and colon cancer (HCT-116) cells were particularly sensitive, especially to complexes 1f (IC(50) =9.81 and 1.49 μM) and 2f (IC(50) =4.59 and 0.36 μM). Flow cytometry indicated that representative compounds exert cytotoxicity toward MCF-7 and HCT-116 cells through induction of apoptosis and blockage of cell-cycle progression in the S phase, similar to cisplatin. The interaction between the platinum(II) complexes and pET22b plasmid DNA was observed by agarose gel electrophoresis, revealing that complex 2f has the capacity to distort plasmid DNA in a manner distinct from that of oxaliplatin.     

Synthesis and characterization of copper(I) complexes from triphenylphosphine and isatin Schiff bases of semi- and thiosemicarbazide

The reaction of isatin-3-thiosemicarbazone (ITC, 1) or isatin-3-semicarbazone (ISC, 2) with nitrato bis(triphenylphosphine)copper(I) gave the four coordinate copper(I) complexes [Cu(PPh₃)₂(ITC)]NO₃ (3) and [Cu(PPh₃)₂(ISC)]NO₃ (4). The synthesized complexes were characterized by FT-IR, UV–VIS, Raman and elemental analysis. The crystal structure of 3 was investigated by single crystal X-ray diffraction. The ITC coordinates to the copper(I) ion in a bidentate fashion via the N(imine) and S atoms which along with two triphenylphosphine ligands form a tetracoordinate complex. The complex has a distorted tetrahedral coordination environment. Crystal data at 150.0 K: space group P2₁/c with a=12.5777(4), b=15.2062(5), c=21.9057(7) Å, β=95.628(3)^o, Z=4, R ₁=0.049.

     

席夫碱稀土铈配合物的合成、表征及抗菌活性

利用四乙酰丙酮铈配合物[Ce（acac）4]和Salphen型水杨醛缩邻苯二胺（Schiff碱）合成了双齿Salphen型席夫碱铈金属配合物（SB-Ce）,用红外光谱（FTIR）、紫外-可见光谱（UV-Vis）和差热-热重（TG-DTA）分析进行结构表征,将SB-Ce配合物用于抑菌活性实验。结果表明,SB-Ce对大肠杆菌、枯草杆菌、金黄色葡萄球菌和酵母菌都有一定的抑菌活性,其中对金黄色葡萄球菌的抑菌性最好。     

Synthesis of several salicylaldehyde derivatives and preparation of two novel dltovic ligands derived from Schiff base

报道了5-甲基-3-亚甲基哌啶水杨醛及5-溴-3-亚甲基哌啶水杨醛和5-溴-3-亚甲基吗啡林水杨醛的合成;同时报道了含二级胺桥联的Salen-类Schiff碱及其还原产物的合成.初步研究分析了双位配体Schiff碱的金属盐配合物的稳定性及其水解产物.并通过核磁共振、红外、质谱等手段对相关化合物结构进行了表征.     

几种水杨醛衍生物的合成以及Schiff-碱双位配体与其还原产物的制备

报道了5-甲基-3-亚甲基哌啶水杨醛及5-溴-3-亚甲基哌啶水杨醛和5-溴-3-亚甲基吗啡林水杨醛的合成;同时报道了含二级胺桥联的Salen-类Schiff碱及其还原产物的合成。初步研究分析了双位配体Schiff碱的金属盐配合物的稳定性及其水解产物。并通过核磁共振、红外、质谱等手段对相关化合物结构进行了表征。