A prototype of very high resolution small animal PET scanner using silicon pad detectors

A very high-resolution small animal positron emission tomograph (PET), which can achieve sub-millimeter spatial resolution, is being developed using silicon pad detectors. The prototype PET for a single slice instrument consists of two 1 mm thick silicon pad detectors, each containing a 32×16 array of 1.4×1.4 mm pads readout with four VATAGP3 chips which have 128 channels low-noise self-triggering ASIC in each chip, coincidence units, a source turntable and tungsten slice collimator. The silicon detectors were located edgewise on opposite sides of a 4 cm field-of-view to maximize efficiency. Energy resolution is dominated by electronic noise, which is 0.98% (1.38 keV) FWHM at 140.5 keV. Coincidence timing resolution is 82.1 ns FWHM and coincidence efficiency was measured to be 1.04×10⁻³% from two silicon detectors with annihilation photons of ¹⁸F source. Image data were acquired and reconstructed using conventional 2-D filtered-back projection (FBP) and a maximum likelihood expectation maximization (ML-EM) method. Image resolution of approximately 1.45 mm FWHM is obtained from 1-D profile of 1.1 mm diameter ¹⁸F line source image. Even better resolution can be obtained with smaller detector element sizes. While many challenges remain in scaling up the instrument to useful efficiency including densely packed detectors and significantly improved timing resolution, performance of the test setup in terms of easily achieving sub-millimeter resolution is compelling.     

Ultra-high Resolution Alpha Particle Spectrometry with Transition-Edge Sensor Microcalorimeters

Alpha particle spectrometry is a powerful analytical tool for nuclear forensics and environmental monitoring. Microcalorimeter detectors have been shown to yield nearly an order of magnitude better energy resolution (1.06?keV FWHM at 5.3?MeV) than current state-of-the-art silicon detectors (8–10?keV FWHM at 5.3?MeV). This superior resolution allows isotopic analysis with a single non-consumptive measurement of samples that contain multiple radioisotopes with overlapping alpha energies. Measurement of such a sample with a silicon detector would require expensive and time-consuming radiochemical separations. We are developing two alpha spectrometer systems with superconducting transition-edge sensor microcalorimeters. The first system has eight independent detector channels that measure eight different alpha sources, and is optimized for detector development experiments. The second system incorporates a prototype cryogenic load lock that allows for rapid exchange of alpha samples. This paper will present results from these two systems.     

Development and characterization of a modular acquisition system for a 4D PET block detector

Next generation PET scanners should fulfill very high requirements in terms of spatial, energy and timing resolution. Modern scanner performances are inherently limited by the use of standard photomultiplier tubes. The use of Silicon Photomultiplier (SiPM) matrices is proposed for the construction of a 4D PET module based on LSO continuous crystals, which is envisaged to replace the standard PET block detector. The expected spatial resolution of the module for the photon hit position is below 1 mm, and it will perform at the same time, the Depth Of Interaction (DOI) calculation and the Time Of Flight (TOF) measurement. The use of large area multi-pixel Silicon Photomultiplier (SiPM) detectors requires the development of a multichannel Digital Acquisition system (DAQ) as well as of a dedicated front-end in order not to degrade the intrinsic detector performances. We have developed a flexible and modular DAQ system for the read-out of two modules in time coincidence for Positron Emission Tomography (PET) applications. The DAQ system is based on a previously developed custom front-end ASIC chip (BASIC) which allows to read-out SiPM matrices preserving their spectroscopy and timing capabilities. Here we describe the acquisition system architecture and its characterization measurements.     

Damage observed in silicon diodes after low energy pion irradiation

We present results of irradiation tests performed in the pion beam of the Paul Scherrer Institute. Our results confirm the prediction, that the Δ-resonance is reflected as an enhancement of the damage caused by low energy pions. At the peak of the Δ-resonance we measure a damage constant 1.5 times higher than generally adopted for neutrons and high energy protons. This result means that the lifetime of silicon detectors close to the vertex at LHC experiments will be limited by the pion background. We predict type inversion of high resistivity detectors to occur after two months of full luminosity and the depletion voltage to reach 200 V within the first four years, even if the detectors are operated at 0°C.     

Measurements of trapped protons and cosmic rays from recent Shuttle flights

Two new charged particle detectors have been flown in five recent Shuttle flights. The tissue-equivalent proportional counter measures the lineal energy spectrum of space radiation in the 0.26-300 keV micrometer-1 range. The charged particle spectrometer is a double dE/dx x E and dE/dx x Chrenekov detector system which provides a measurement of the differential energy spectrum of protons from 13 to 350 MeV and dose rate in silicon. In this paper the dose rate, equivalent dose rate, and radiation, quality factor for trapped protons and cosmic radiation are reported on separately. A comparison of the integral LET spectra with recent transport code calculations shows significant disagreement. Using the calculated dose rate from the omnidirectional AP8MAX model with IGRF reference magnetic field epoch 1970, and observed dose rate as a function of geographic latitude and longitude, the westward drift of the south Atlantic anomaly has been determined. The east-west effect has also been studied and a 'second' radiation belt observed. A comparison of the galactic cosmic radiation (GCR) lineal energy transfer spectra with model calculations shows disagreement comparable with those of the trapped protons.     

Low energy protons as a tool for high energy vertex detector calibration

This paper describes a method developed for the calibration of silicon detectors used to measure high multiplicity of charged particles in high energy experiments; its peculiarity is the use of low energy protons from a cyclotron. This method guarantees an useful improvement in calibration accuracy.     

Silicon detectors in electromagnetic and hadronic calorimetry

A review of investigations performed by SICAPO collaboration at CERN and Si/W and Si/U sandwich calorimeters employing silicon detectors as active medium is presented. Experimental results, such as the response of sensed energy versus incoming electron energy and depleted layer width, of the longitudinal and lateral development of electromagnetic showers and of the energy resolution, are described. Mosaic modules of silicon detectors, which enable the construction of silicon sampling hadronic calorimeters, are also given. A comparison of results from SICAPO, Hamburg (Si/Pb) and from Tokyo (Si/Pb and Si/W) calorimeters is shown.     

Silicon detectors

The status and recent progress of silicon detectors for high energy physics is reviewed. Emphasis is put on detectors with high spatial resolution and the use of silicon detectors in calorimeters.     

Mass resolution of recoil fragment detector telescopes for 0.05–0.5 A MeV heavy recoiling fragments

The factors governing the mass resolution for 0.05–0.5 A MeV recoil nuclei have been investigated for detector telescopes in which carbon-foil time zero detectors and ion-implanted silicon detectors are used to determine the time of flight and energy respectively. Experimentally determined second moments of the mass distribution have been compared with theoretical estimates based on literature data. The experimental mass resolution is in reasonably good absolute agreement with theoretical estimates. For low energy (< 0.3 A MeV) particles the mass resolution is dominated by the contribution from the silicon detector and thus largely independent of timed flight length. In fact for detection of very low energy (0.1 A MeV) recoil nuclei timed flight lengths of less than 0.22 m are sufficient.     

Compton imager using room temperature silicon detectors

We have been developing a multi-layer Compton Gamma Ray Imager using position-sensitive, intrinsic silicon detectors. Advantages of this approach include room temperature operation, reduced Doppler broadening, and use of conventional silicon fabrication technologies. We have obtained results on the imaging performance of a multi-layer instrument where each layer consists of a 2×2 array of double-sided strip detectors. Each detector is 63 mm×63 mm×2 mm thick and has 64 strips providing a strip pitch of approximately 0.9 mm. The detectors were fabricated by SINTEF ICT (Oslo Norway) from 100 mm diameter wafers. The use of large arrays of silicon detectors appears especially advantageous for applications that require excellent sensitivity, spectral resolution and imaging such as gamma ray astrophysics, detection of special nuclear materials, and medical imaging. The multiple Compton interactions (three or more) in the low-Z silicon enable the energy and direction of the incident gamma ray to be determined without full deposition of the incident gamma-ray energy in the detector. The performance of large volume instruments for various applications are presented, including an instrument under consideration for NASA's Advanced Compton Telescope (ACT) mission and applications to Homeland Security. Technology developments that could further extend the sensitivity and performance of silicon Compton Imagers are presented, including the use of low-energy (few hundred keV) electron tracking within novel silicon detectors and the potential for a wafer-bonding approach to produce thicker, position-sensitive silicon detectors with an associated reduction of required electronics and instrument cost.     

Systematic studies of scintillation detector with timing resolution of 10 ps for heavy ion beam

We have tested Time-Of-Flight detectors consisting of several combinations of scintillators and photomultiplier tubes for the identification of produced heavy ion beam. Timing resolution of 6.8 ps (RMS) is achieved with energy deposited of 150–160 MeV in the plastic scintillator, where ⁴⁰Ar beam is used as a primary beam at the total energies of 3.8 GeV. Our systematic studies suggest the importance of maximizing the number of photoelectrons, where the timing resolution seems to be scaled by the pulse height according to the characteristic function of the photomultiplier tube. In addition, scintillator with faster timing property seems to be also essential for better timing resolution.     

Energy and Timing Measurement with Time-Based Detector Readout for PET Applications: Principle and Validation with Discrete Circuit Components

A new signal processing method for PET application has been developed, with discrete circuit components to measure energy and timing of a gamma interaction based solely on digital timing processing without using an amplitude-to-digital convertor (ADC) or a constant fraction discriminator (CFD). A single channel discrete component time-based readout (TBR) circuit was implemented in a PC board. Initial circuit functionality and performance evaluations have been conducted. Accuracy and linearity of signal amplitude measurement were excellent, as measured with test pulses. The measured timing accuracy from test pulses reached to less than 300 ps, a value limited mainly by the timing jitter of the prototype electronics circuit. Both suitable energy and coincidence timing resolutions (~18% and ~1.0 ns) have been achieved with 3 × 3 × 20 mm(3) LYSO scintillator and photomultiplier tube-based detectors. With its relatively simple circuit and low cost, TBR is expected to be a suitable front-end signal readout electronics for compact PET or other radiation detectors requiring the reading of a large number of detector channels and demanding high performance for energy and timing measurement.     

Angular resolution of the Ohya air shower detector

Accurate measurements of the total number of muons in an air shower are important for the discrimination of showers produced by astronomical gamma rays from those produced by protons. In order to perform this discrimination, muon detectors with a total area of about 400 m² have been constructed in the Ohya stone mine. At ground level, scintillation detectors have been distributed for determining the total number of electrons in the air shower. The arrival direction of the air shower determined by usual timing information was examined using independent data on the arrival direction determined by muons in the shower. The angular resolution thus obtained at the shower maximum is 1.7° in the south-north plane and 2° in the east-west plane. The difference of the resolution is due to the asymmetric arrangement of scintillation detectors.     

A multiwire chamber system for measurements of charged particle spectra

A large solid angle, high counting rate detection system for p, d t identification and energy measurement in the range of 15 to 65 MeV has been developed. The detector consists of two position-sensitive delay-line multiwire chambers, a thin plastic scintillator ΔE, and two large area NaI E detectors. Measurements of energy spectra of protons from ¹²C(n, p) are presented.     

Response studies on silicon surface barrier detectors for low energy ion spectrometry in space

Accurate measurements of the three-dimensional directional distribution of low energy ions in space require a careful calibration of the silicon surface barrier detectors mostly employed. This paper describes a systematic search for the pulse-height defects in the detector response to protons in the 25–150 keV energy range. The results ensured a proper pre-flight calibration of the ISEE-3 proton spectrometer and also allow some conclusions on the ratio of the average energies ?_p and ?_e? expended for electron-hole pair generation in silicon.     

Large microcalorimeter arrays for high-resolution X- and gamma-rayspectroscopy

Microcalorimeter detectors provide unprecedented energy resolution for the measurement of X-rays and soft gamma-rays. Energy resolution in the 100 keV region can be up to an order of magnitude better than planar high-purity germanium (HPGe) detectors. The technology is well-suited to analysis of materials with complex spectra presenting closely spaced photopeaks. One application area is the measurement and assay of nuclear materials for safeguards and fuel cycle applications. In this paper, we discuss the operation and performance of a 256-pixel array, and present results of a head-to-head comparison of isotopic determination measurements with high-purity germanium using a plutonium standard. We show that the uncertainty of a single measurement is smaller for the microcalorimeter data compared to the HPGe data when photopeak areas are equal. We identify several key areas where analysis codes can be optimized that will likely lead to improvement in the microcalorimeter performance.     

Transition-Edge Sensors for Particle Induced X-ray Emission Measurements

In this paper we present a new measurement setup, where a transition-edge sensor detector array is used to detect X-rays in particle induced X-ray emission (PIXE) measurements with a 2 MeV proton beam. Transition-edge sensors offer orders of magnitude improvement in energy resolution compared to conventional silicon or germanium detectors, making it possible to recognize spectral lines in materials analysis that have previously been impossible to resolve, and to get chemical information from the elements. Our sensors are cooled to the operation temperature ( \(\sim \) 65 mK) with a cryogen-free adiabatic demagnetization refrigerator, which houses a specially designed X-ray snout that has a vacuum tight window to couple in the radiation. For the best pixel, the measured instrumental energy resolution was 3.06 eV full width at half maximum at 5.9 keV. We discuss the current status of the project, benefits of transition-edge sensors when used in PIXE spectroscopy, and the results from the first measurements.     

A silicon counter array for 2He detection

A multicounter array consisting of four Si detector telescopes was developed for the coincidence measurement of two protons with small relative energy (²He). Silicon detectors were designed and fabricated so that they have large solid angles when they are assembled to form a counter array. A total effective solid angle of 5–7 msr was achieved for the detection of 20–50 MeV ²He with relative energy lower than 1 MeV. A compact amplifier system was developed using low-noise hybrid ICs to treat many signals from the counter array.     

Development of cryogenic alpha spectrometers using metallic magnetic calorimeters

Cryogenic particle detectors have recently been adopted in radiation detection and measurement because of their high energy resolution. Many of these detectors have demonstrated energy resolutions better than the theoretical limit of semiconductor detectors. We report the development of a micro-fabricated magnetic calorimeter coupled to a large-area particle absorber. It is based on a planar, 1 mm² large paramagnetic temperature sensor made of sputtered Au:Er, which covers a superconducting meander-shaped pickup coil coupled to a low-noise dc-SQUID to monitor the magnetization of the sensor. A piece of gold foil of 2.5×2.5×0.07 mm³ was glued to the Au:Er film to serve as an absorber for incident alpha particles. The detector performance was investigated with an ²⁴¹Am source. The signal size comparison for alpha and gamma peaks with a large difference in energy demonstrated that the detector had good linear behavior. An energy resolution of 2.83±0.05 keV in FWHM was obtained for 5.5 MeV alpha particles.     

Response of silicon-based linear energy transfer spectrometers: implication for radiation risk assessment in space flights

There is considerable interest in developing silicon-based telescopes because of their compactness and low power requirements. Three such telescopes have been flown on board the Space Shuttle to measure the linear energy transfer spectra of trapped, galactic cosmic ray, and solar energetic particles. Dosimeters based on single silicon detectors have also been flown on the Mir orbital station. A comparison of the absorbed dose and radiation quality factors calculated from these telescopes with that estimated from measurements made with a tissue equivalent proportional counter show differences which need to be fully understood if these telescopes are to be used for astronaut radiation risk assessments. Instrument performance is complicated by a variety of factors. A Monte Carlo-based technique was developed to model the behavior of both single element detectors in a proton beam, and the performance of a two-element, wide-angle telescope, in the trapped belt proton field inside the Space Shuttle. The technique is based on: (1) radiation transport intranuclear-evaporation model that takes into account the charge and angular distribution of target fragments, (2) Landau-Vavilov distribution of energy deposition allowing for electron escape, (3) true detector geometry of the telescope, (4) coincidence and discriminator settings, (5) spacecraft shielding geometry, and (6) the external space radiation environment, including albedo protons. The value of such detailed modeling and its implications in astronaut risk assessment is addressed.