A prototype of very high resolution small animal PET scanner using silicon pad detectors

A very high-resolution small animal positron emission tomograph (PET), which can achieve sub-millimeter spatial resolution, is being developed using silicon pad detectors. The prototype PET for a single slice instrument consists of two 1 mm thick silicon pad detectors, each containing a 32×16 array of 1.4×1.4 mm pads readout with four VATAGP3 chips which have 128 channels low-noise self-triggering ASIC in each chip, coincidence units, a source turntable and tungsten slice collimator. The silicon detectors were located edgewise on opposite sides of a 4 cm field-of-view to maximize efficiency. Energy resolution is dominated by electronic noise, which is 0.98% (1.38 keV) FWHM at 140.5 keV. Coincidence timing resolution is 82.1 ns FWHM and coincidence efficiency was measured to be 1.04×10⁻³% from two silicon detectors with annihilation photons of ¹⁸F source. Image data were acquired and reconstructed using conventional 2-D filtered-back projection (FBP) and a maximum likelihood expectation maximization (ML-EM) method. Image resolution of approximately 1.45 mm FWHM is obtained from 1-D profile of 1.1 mm diameter ¹⁸F line source image. Even better resolution can be obtained with smaller detector element sizes. While many challenges remain in scaling up the instrument to useful efficiency including densely packed detectors and significantly improved timing resolution, performance of the test setup in terms of easily achieving sub-millimeter resolution is compelling.     

High precision axial coordinate readout for an axial 3-D PET detector module using a wave length shifter strip matrix

We describe a novel method to extract the axial coordinate from a matrix of long axially oriented crystals, which is based on wavelength shifting (WLS) plastic strips. The method allows building compact 3-D axial gamma detector modules for PET scanners with excellent 3-D spatial, timing and energy resolution while keeping the number of readout channels reasonably low. A voxel resolution of about 10 mm³ is expected. We assess the performance of the method in two independent ways, using classical PMTs and G-APDs to read out the LYSO (LSO) scintillation crystals and the WLS strips. We observe yields in excess of 35 photoelectrons from the strips for a 511 keV gamma and reconstruct the axial coordinate with a precision of about 2.5 mm (FWHM).     

Analysis and characterization of switched reluctance motors: Part I /sub y/namic, static, and frequency spectrum analyses

This paper consists of three parts. Section I explores two software applications for modeling and simulating the dynamic characteristics of switched reluctance motors (SRMs). The software applications are the electromechanical structure system (EMSS), which is a tool within the proprietary Maxwell SPICE environment, and power system computer-aided design (PSCAD). The major parameter of an SRM, the nonlinear winding inductance, which determines the dynamic torque, is individually modeled for use with these applications. Simulation of the dynamic torque and the speed for any load is discussed. Section II presents a new stator geometry for SRMs that improves the torque profile. In the new geometry, pole shoes are affixed to the stator poles. The paper discusses a sensitivity study of the torque profile using a two-dimensional finite-element field simulation. Section III presents a frequency spectrum analysis of torque profile using the fast Fourier transform (FFT) capability of MATLAB. Salient features of this analysis for torque profile of SRM and the results of simulation are presented. Section IV concludes the paper.     

A method to modify coordinates of detectors in positron emission tomography systems

A new method to modify coordinates of detectors in any positron emission tomography (PET) system using a radioactive point source is developed. This method is based on selecting a centered detector in each detector block of PET and measuring coincidence counts between the two centered detectors in opposite detector blocks to find the coordinates of their LOR (Line of Response). Due to slight misalignment of detector positions, measured LORs may not intersect at a single point. Based on the proposed method, the coordinates of detectors can be measured with very high accuracy and the coordinate of the center of the gantry (which is normally the same as the center of field of view) can be defined correctly. The results of the application of our method to a small animal PET system (FinePET), which was recently developed at Tohoku University, Japan, are shown here. The method is expected to contribute to the design and development of PET systems which can realize a very high spatial resolution of less than 1 mm FWHM.     

Image quality phantom and parameters for high spatial resolution small-animal SPECT

At present, generally accepted standards to characterize small-animal single photon emission tomographs (SPECT) do not exist. Whereas for small-animal positron emission tomography (PET), the NEMA NU 4-2008 guidelines are available, such standards are still lacking for small-animal SPECT. More specifically, a dedicated image quality (IQ) phantom and corresponding IQ parameters are absent. The structures of the existing PET IQ phantom are too large to fully characterize the sub-millimeter spatial resolution of modern multi-pinhole SPECT scanners, and its diameter will not fit into all scanners when operating in high spatial resolution mode. We therefore designed and constructed an adapted IQ phantom with smaller internal structures and external diameter, and a facility to guarantee complete filling of the smallest rods. The associated IQ parameters were adapted from NEMA NU 4. An additional parameter, effective whole-body sensitivity, was defined since this was considered relevant in view of the variable size of the field of view and the use of multiple bed positions as encountered in modern small-animal SPECT scanners. The usefulness of the phantom was demonstrated for ^99mTc in a USPECT-II scanner operated in whole-body scanning mode using a multi-pinhole mouse collimator with 0.6 mm pinhole diameter.     

Determination of polycyclic aromatic hydrocarbons with molecular weight 300 and 302 in environmental-matrix standard reference materials by gas chromatography/mass spectrometry

An analytical approach based on gas chromatography/ mass spectrometry (GC/MS) is presented for the measurement of polycyclic aromatic hydrocarbons with molecular weight (MW) 300 and 302 in environmental samples. Three different GC stationary phases [5% and 50% phenyl methylpolysiloxane and dimethyl (50% liquid crystalline) polysiloxane] were compared, and retention indexes (RI) are given for 23 individual MW 302 isomers. Identification of MW 300 and 302 isomers in four environmental-matrix Standard Reference Materials (SRMs) (SRM 1597, coal tar extract; SRM 1648 and SRM 1649a, air particulate matter; and SRM 1941, marine sediment) was based on the comparison of RI data and mass spectra from authentic standards. Dibenzo[a,l]pyrene, which is of considerable interest because of its high carcinogenicity, was identified and quantified in the four environmental-matrix SRMs. A total of 23 isomers of MW 302 and four isomers of MW 300 were quantified in four different environmental-matrix SRMs, and the results are compared to previously reported results based on liquid chromatography with fluorescence detection.     

A Monte Carlo model for studying the microheterogeneity of trace elements in reference materials by means of synchrotron microscopic X-ray fluorescence

Synchrotron micro-XRF, a trace-level microanalytical method, allows quantitative study of the nature and degree of heterogeneity of inorganic trace constituents in solid materials with a homogeneous matrix. In this work, the standard reference materials NIST SRM 613, Trace Elements in 1 mm Glass Wafers, and NIST SRM 1577a, Trace Elements in Bovine Liver, are examined at the 10100-ng mass level using X-ray beams of 5-150 microm in diameter. A procedure based on a large number of repeated analyses of small absolute amounts of the SRMs allows calculation of the minimal representative mass of the standard. The microheterogeneity of both NIST SRM 613 and NIST SRM 1577a was investigated with the aim of evaluating their suitability as reference materials for trace-level microanalytical techniques. A Monte Carlo simulation model was constructed for both homogeneous and heterogeneous materials to elucidate the dependence of the calculated minimal representative mass on the total analyzed mass in the case of materials that showstrongly heterogeneous features at the microscopic level.     

Development and characterization of a modular acquisition system for a 4D PET block detector

Next generation PET scanners should fulfill very high requirements in terms of spatial, energy and timing resolution. Modern scanner performances are inherently limited by the use of standard photomultiplier tubes. The use of Silicon Photomultiplier (SiPM) matrices is proposed for the construction of a 4D PET module based on LSO continuous crystals, which is envisaged to replace the standard PET block detector. The expected spatial resolution of the module for the photon hit position is below 1 mm, and it will perform at the same time, the Depth Of Interaction (DOI) calculation and the Time Of Flight (TOF) measurement. The use of large area multi-pixel Silicon Photomultiplier (SiPM) detectors requires the development of a multichannel Digital Acquisition system (DAQ) as well as of a dedicated front-end in order not to degrade the intrinsic detector performances. We have developed a flexible and modular DAQ system for the read-out of two modules in time coincidence for Positron Emission Tomography (PET) applications. The DAQ system is based on a previously developed custom front-end ASIC chip (BASIC) which allows to read-out SiPM matrices preserving their spectroscopy and timing capabilities. Here we describe the acquisition system architecture and its characterization measurements.     

PET image reconstruction using ANN

The aim of this study is to improve the positron emission tomography (PET) image quality for medical diagnosis. The statistical reconstructions on the maximum a posteriori (MAP) algorithm often results in a blurring effect, which fails to determine the toughness class in the reconstructed image. The development of new reconstruction algorithms for PET is an active field of research. In this article, artificial neural network (ANN) is proposed for replicating the output image, which is generated from the acquired projection data with the corresponding angles using the PET images. This article proposes the advantage of arranging the neural network to stock up the information of the continuous capacity. This reduces the storage space and recuperates as much sequence of the continuous quantity as possible. The performance of image quality parameters using ANN is better when compared with MAP, FBP‐NN (filtered back projection with nearest neighbor interpolation). Thus ANN provides 63% better peak signal to noise ratio (PSNR) when compared with FBP‐NN and 47% better when compared to MAP. Thus, ANN is better than FBP and MAP algorithm, by providing better PSNR. © 2014 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 24, 249–255, 2014     

Preparation of Reference Material 8504, Transformer Oil

A new reference material (RM), RM 8504, has been prepared for use as a diluent oil with Aroclors in transformer oil Standard Reference Materials (SRMs) 3075 to 3080 and SRM 3090 when developing and validating methods for the determination of polychlorinated biphenyls (PCBs) as Aroclors in transformer oil or similar matrices. SRMs 3075-3080 and SRM 3090 consist of individual Aroclors in the same transformer oil that was used to prepare RM 8504. A unit of RM 8504 consists of one bottle containing approximately 100 mL of transformer oil. No additional constituents have been added to the oil.     

Summarizing the effectiveness of supercritical fluid extraction of polycyclic aromatic hydrocarbons from natural matrix environmental samples

A summary of the supercritical fluid extraction (SFE) of polycyclic aromatic hydrocarbons (PAHs) from four natural matrix Standard Reference Materials (SRMs) is presented. The work involved the investigation of the effects of extraction fluid [carbon dioxide (CO(2)), chlorodifluoromethane (R22), and 1,1,1,2-tetrafluoroethane (HFC134a)], fluid modifier (dichloromethane and aniline), temperature (60, 150, and 200 °C) and added water on the SFE recoveries of PAHs compared to certified results from Soxhlet extractions. For SRM 1649a (Urban Dust/Organics), R22 yielded excellent recoveries (>90% of certified concentrations) of all PAHs measured, while results for the same SRM using HFC134a as the fluid were typically <80% of the certified concentrations for most of the PAHs measured. For SRM 1941a and 1944, both aquatic sediments with similar physical and chemical compositions, extractions of the wet materials with dichloromethane-modified CO(2) (10%, v/v) yielded quantitative recoveries of all PAHs for SRM 1944 but an obvious trend of lower recoveries for higher molecular weight PAHs (≥228 amu) for SRM 1941a. Results of SFEs of SRM 1650 (Diesel Particulate Matter) showed that this material is the most refractory of the SRMs investigated in this study, with recoveries of indeno[1,2,3-cd]pyrene and benzo[ghi]perylene at <20% of the Soxhlet results.     

Analysis and characterization of switched reluctance motors: Part II. Flow, thermal, and vibration analyses

This paper presents new approaches for certain mechanical characterizations, such as thermal and vibration analyses, of switched reluctance motors (SRMs). The paper presents, in three parts, the modeling and simulation procedure for three-dimensional (3-D) finite-element analysis (FEA)-based flow analysis, flow-analysis-based thermal analysis, and a realistic vibration analysis. Section I documents a computational fluid dynamics (CFD) flow analysis procedure for the evaluation of the air velocity distribution inside the SRM at any speed. Section II presents a prediction method for steady-state and transient thermal characteristics of an SRM, using 3-D FEA. The convection coefficient at various heat-dissipating surfaces inside SRM, which is not a material property, but a quantity that solely depends on the air velocity at the respective surfaces, is the major parameter to be evaluated for an accurate simulation of heat distribution. The results of CFD analysis are used, for the first time on SRM, for this purpose. Windage loss calculation, one of the other applications of CFD, is introduced. Vibration in electric motors is an inevitable, at the same time undesirable, property that originates from four major sources: mechanical, magnetic, applied loads and, to a smaller extent, the associated electronic devices. Section III presents: 1) a thorough numerical study of vibration analysis in SRMs, using 3-D FEA methodology, covering all the above vibration sources except the electronics; 2) a 3-D modal analysis of SRMs including stator and rotor structures, shaft, end shields, bearings, and housing; 3) an unbalanced rotor dynamics analysis; 4) associated harmonic analysis; and 5) a stress analysis under various loading conditions. The 3-D vibration analyses presented in this paper to examine the vibration in SRM as a whole are new additions to SRM vibration analysis. Section IV concludes the paper. Future work in every section is highlighted.     

Test results from a precision drift chamber vertex detector prototype using dimethylether

Results of beam tests of a prototype drift chamber vertex detector developed for the D-Zero experiment at the Fermilab collider are reported. The chamber design emphasizes dual goals of high accuracy position measurement and excellent two track resolution. These requirements are met by using a slow gas, dimethyl ether, in a jet chamber geometry with a double plane of field-shaping wires near the anodes. Resolution of nearby hits is facilitated by 100 MHz flash digitization of the signal pulses. The prototype tested consisted of a full-length (97 cm) model of one azimuthal sector of the innermost layer of the detector, with 8 anode wires. Position measurement accuracy of 30–80 μm for drift distances of 2–11 mm and pulse pair resolution of 0.7 mm (for 90% of all pulses) is achieved.     

DSP-Based Automated Error-Reducing Flux-Linkage-Measurement Method for Switched Reluctance Motors

The switched reluctance motor (SRM) has received considerable attention from researchers for its many inherent advantages, and thus, it has become a popular research topic in the field of variable-speed drives as well as servo drives. Research on SRMs mainly includes their design, modeling and performance analysis, control, as well as applications. However, for verification of design, performance prediction, as well as development of a high-performance sensorless control algorithm, accurate measurement of the magnetic characteristics of the SRM is most critical. Hence, one of the most important problems in the field of SRMs is a practical and accurate instrumentation system for the measurement of the SRM magnetic characteristics. This paper first describes an accurate and fully automated digital method for the measurement of the magnetic characteristic of SRMs, which includes online offset-error removal and winding resistance estimation. In this method, a digital-signal-processor-based virtual instrumentation for measurement of flux linkage is developed. Then, the results of the measurement conducted on a four-phase SRM are presented. The accuracy of the measurement system is verified by comparing with that found via a magnetic analyzer. Finally, the various sources of errors and their contributions to the errors are discussed. The scheme can also be used, in general, for transformers or inductors.     

A modular NaI(Tl) detector for intermediate energy photons

We describe the properties of a detector array made up of 64 NaI(Tl) 406 × 63 × 63 mm³ modules, used as an intermediate energy photon spectrometer. We obtain an energy resolution of 6% FWHM at 129 MeV, a time resolution of 1 ns FWHM and a resolution of 48 mm FWHM for the location of the impact point on the front face of the detector. The modularity allows to some extent a discrimination between photons and neutrons. We also present the response of the detector to 69 MeV neutrons.     

Small-animal CT - Its Difference from, and Impact on, Clinical CT

For whole-body CT images of small rodents, a voxel resolution of at least 10(-3) mm(3) is needed for scale-equivalence to that currently achieved in clinical CT scanners (～1 mm(3)) in adult humans. These "mini-CT" images generally require minutes rather than seconds to complete a scan. The radiation exposure resulting from these mini-CT scans, while higher than clinical CT scans, is below the level resulting in acute tissue damage. Hence, these scans are useful for performing clinical-type diagnostic and monitoring scans for animal models of disease and their response to treatment. "Micro-CT", with voxel size <10(-5) mm(3), has been useful for imaging isolated, intact organs at an almost cellular level of resolution. Micro-CT has the great advantage over traditional microscopic methods in that it generates detailed 3D images in relatively large, opaque, volumes such as an intact rodent heart or kidney. The radiation exposure needed in these scans results in acute tissue damage if used in living animals.Experience with micro-CT is contributing to exploration of new applications for clinical CT imaging by providing insights into different modes of x-ray image formation as follows:Spatial resolution should be sufficient to detect an individual Basic Functional Unit (BFU, the smallest collection of diverse cells, such as hepatic lobule, that behaves like the organ), which requires voxels ～10(-3) mm(3) in volume, so that the BFUs can be counted.Contrast resolution sufficient to allow quantitation of:New microvascular growth, which manifests as increased tissue contrast due to x-ray contrast agent in those vessels' lumens during passage of injected contrast agent in blood.Impaired endothelial integrity which manifests as increased opacification and delayed washout of contrast from tissues.Discrimination of pathological accumulations of metals such as Fe and Ca, which occur in the arterial wall following hemorrhage or tissue damage.Micro-CT can also be used as a test bed for exploring the utility of several modes of x-ray image formation, such as the use of dual energy x-ray subtraction, x-ray scatter, phase delay and refraction-based imaging for increasing the contrast amongst soft tissue components. With the recent commercial availability of high speed, multi-slice CT scanners which can be operated in dual energy mode, some of these micro-CT scanner capabilities and insights are becoming implementable in those CT scanners. As a result, the potential diagnostic spectrum that can be addressed with those scanners is broadened considerably.     

Simultaneous mass bias and fractionation corrections utilizing isotopic solid standards and laser ablation ICPMS

Homogeneous incorporation of analytes of known isotopic abundance into sol-gel-derived standards that mimic important mineral systems has the potential to contribute significantly to providing solid standard benchmarks for a range of applications. This preliminary study reports on the synthesis of solid glass standards produced via the sol-gel method and their doping with Standard Reference Material (SRM) 981 Common Lead Isotopic Standard and SRM 982 Equal-Atom Lead Isotopic Standard. Custom isotopic materials were also prepared using mixtures of the two isotopic SRMs. Particles from these solid samples were then introduced into an inductively coupled plasma mass spectrometer via laser ablation to determine whether materials of suitable homogeneity could be developed as isotopic reference materials. Preliminary results for Pb isotope ratios show that these solid isotopic reference standards are capable of correcting for instrumental mass bias and laser ablation-induced bias due to fractionation simultaneously. Correction factors generated from the quotient of the certified and measured Pb isotopic ratios in sol-gel disks spiked with SRMs 981 and 982 were successfully applied to produce accurate isotope ratios using comparative control/unknown checks. These correction factors were also used to assign Pb isotopic ratios in NIST SRM 612 Trace Elements in Glass that were in excellent agreement with published measurements, suggesting that tunable matrix sol-gel disks can serve as adequate control matrixes for evaluation of isotope ratios in glass samples.     

Standard Reference Materials (SRMs) for the Calibration and Validation of Analytical Methods for PCBs (as Aroclor Mixtures)

Six Standard Reference Materials (SRMs®) have been prepared by the National Institute of Standards and Technology (NIST) for the determination of PCBs as different Aroclor mixtures in methanol. Six additional SRMs of the same Aroclors in transformer oil have also been prepared. Specifically, solutions of Aroclors 1016, 1232, 1242, 1254, and 1260 have been gravimetrically prepared (individually) in methanol and transformer oil, mixed, and transferred to amber glass ampoules in approximately 1.2 mL aliquots. Gas chromatography with electron capture detection (GC-ECD) has been used to verify the gravimetric data for each solution and transformer oil SRM. Liquid chromatography was used for the isolation of the Aroclors from the transformer oil SRMs prior to GC-ECD analysis. Separate calibration solutions and oils were prepared with Aroclor levels similar to those in each methanol solution and transformer oil SRM and were processed alongside the samples. The GC-ECD response of each Aroclor was monitored relative to internal standards that were added to the complex mixtures for quantification. The gravimetric concentrations of Aroclors 1242 and 1254 in methanol were also examined by the same method of analysis (GC-ECD) using several different sources of Aroclors and two different capillary GC columns: a 5 % phenyl methylpolysiloxane phase and a relatively non-polar phase. The preparation of the materials, the gas chromatographic results, and the certified concentration values for each Aroclor SRM are described in this paper.     

Speciation of elements in NIST particulate matter SRMs 1648 and 1650

X-ray absorption fine structure (XAFS) spectra for S, Cl, V, Cr, Mn, Cu, Zn, As, Br, Cd and Pb and Mossbauer spectra for Fe have been obtained for two National Institute of Standards and Technology (NIST) particulate matter (PM) standard reference materials (SRMs): urban PM (SRM 1648) and diesel PM (SRM 1650). The spectral data, complemented by information on elemental concentrations from proton-induced X-ray-emission (PIXE) spectroscopy, were used to interpret the speciation of these elements in these complex materials. It appears that all the metallic elements investigated occur in oxidized forms, principally as sulfates in the diesel PM SRM and as sulfates, oxides, and possibly other forms (e.g. clays?) in the urban PM. A minor fraction of the sulfur and major fractions of the halogens, Cl and Br, occur as organosulfide (thiophene) and organohalide occurrences, respectively, that must be associated with the abundant carbonaceous matter that constitutes the major component of the two PM SRMs. Most of the sulfur, however, occurs as sulfate in the urban PM and as bisulfate in the diesel PM. In addition, elemental oxidation states have been determined directly by the spectroscopic techniques. Such information is often the key parameter in determining the toxicity and solubility of specific elements in PM, both of which are important in understanding the threat that such elements may pose to human health. For the two HAP elements, Cr and As, for which the toxicity depends greatly on oxidation state, the XAFS data showed that both elements are present in both SRMs predominantly in the less toxic oxidation states, Cr(III) and As(V). The potential of the XAFS spectra for use as source apportionment signatures is illustrated by reference to chromium, which exists in these two PM SRMs in very different forms.