含锶纳米羟基磷灰石的制备及性能研究

采用化学沉淀法制备了纳米掺锶羟基磷灰石（Sr-CaHAP）,通过XRD、FT-IR、TEM等手段,对纳米掺锶羟基磷灰石进行了结构分析。以牛血清白蛋白（BSA）为吸附目标,研究了纳米掺锶羟基磷灰石的吸附性能。结果表明,实验制备的纳米掺锶羟基磷灰石分散性好,是具有一定粒径的纳米针状晶体。在吸附时间为1 h、反应温度为45 ℃、pH为7时,掺锶羟基磷灰石对牛血清白蛋白的吸附量最大;且随着牛血清白蛋白浓度的增加,对牛血清白蛋白的吸附量也随之增加。相比较,掺锶羟基磷灰石对牛血清白蛋白的吸附量较羟基磷灰石大。     

锶掺杂羟基磷灰石除氟的吸附行为及机理研究

通过共沉淀法合成锶掺杂羟基磷灰石(Sr-HAP),并将其用于水中氟离子的去除。结果表明,少量锶掺杂提高了HAP比表面积,从而暴露出更多的活性OH^-位点;Sr-HAP对氟离子的吸附符合Langmuir模型和拟二级动力学模型,通过模型拟合计算出对氟离子的q_m为20.75 mg/g;偏酸性和中性条件下,Sr-HAP对氟离子的吸附效果稳定;Sr-HAP吸附除氟的机理主要是静电吸引作用和离子交换。     

微波合成掺锶羟基磷灰石

以SrCl2、Ca(NO3)2和(NH4)2HPO4为原料,采用微波法合成了掺锶羟基磷灰石。对制备的SrHAP进行元素含量分析,采用XRD对其结构进行了表征,并测定粉体产物的粒度。研究结果表明:采用微波法可以制备出元素组成接近原料计算化学计量比的掺锶羟基磷灰石;采用微波法可以快速得到结晶性好的SrHAP;掺锶量对微波合成的SrHAP的结构有显著影响;微波法比常规方法制备出的SrHAP粉体的粒度小。     

纳米掺锶羟基磷灰石的制备及其吸附性能研究

采用溶胶-凝胶-超临界流体干燥法制备了粒径在100 nm以下的纳米掺锶羟基磷灰石(SrHAP),以牛血清白蛋白(BSA)为吸附目标,研究了纳米SrHAP的吸附性能.结果发现在偏酸性条件下,纳米SrHAP比纳米HAP对BSA的吸附量大,表明掺锶后吸附性能提高;但在碱性条件下,纳米SrHAP对BSA的吸附量减小.纳米SrHAP对BSA的吸附是个快速吸附过程,增加Sr/[Ca Sr]原子比XSr和BSA的起始浓度有利于吸附,升高温度不利于吸附.     

纳米掺锶羟基磷灰石及其在牙膏中的应用研究

采用化学沉淀法以金属锶元素取代纳米羟基磷灰石中的部分钙元素。可制得纳米掺锶羟基磷灰石；通过XRD、FTIR、TEM等手段，对纳米掺锶羟基磷灰石进行了结构分析；掺锶后提高了纳米掺锶羟基磷灰石的生物性能和使用性能，将其应用于牙膏，可以提高牙膏的使用功效作用，具有广阔的应用前景。     

硅掺杂羟基磷灰石包覆镁合金的微波制备

以Ca(NO_3)_2·4H-_2O为钙源、Na_2HPO_4·12H_2O为磷源、Na_2SiO_3为硅源,采用微波液相化学法在镁合金表面制备了硅掺杂羟基磷灰石双层涂层。涂层表层为絮状晶体,底层为长片状晶体,涂层的厚度约为9.9μm。研究了微波溶液中Na_2SiO_3添加量和微波溶液的pH值对硅掺杂羟基磷灰石涂层的结构和性能的影响。结果表明,与羟基磷灰石相比,硅掺杂羟基磷灰石涂层提高了对镁合金的保护作用,促进了成骨细胞的增殖和分化。     

离子掺杂羟基磷灰石的抗菌性能研究进展

羟基磷灰石(HA)由于其在人体牙齿和骨骼中具有十分出色的生物相容性和生物活性,在生物医学材料领域引起了广泛关注.为了解决植入物的细菌感染问题,人们已经尝试在纯相HA晶体结构内掺杂具有一定抗菌效果的离子,并且已经证明,对纯相HA进行单掺杂或共掺杂能够进一步改善HA的理化和生物学特性,并赋予其出色的抗菌性能.离子掺杂抗菌羟...     

溶胶-凝胶结合超临界流体干燥法制备纳米掺锶羟基磷灰石的研究

以硝酸钙、氯化锶、磷酸氢二氨等无机盐为原料,采用溶胶-凝胶结合超临界流体干燥法,制备了羟基磷灰石(HAP)纳米微粒、钙被半取代的掺锶羟基磷灰石(SrCaHAP)纳米微粒以及钙被全取代的掺锶羟基磷灰石(SrHAP)纳米微粒.通过元素含量分析、TEM、XRD、FT-IR等手段,对这些纳米微粒的结构进行了分析;探讨了锶的掺入对羟基磷灰石(HAP)的结构、晶形以及结晶度的影响.结果表明:采用溶胶-凝胶结合超临界CO2干燥法,在给定的反应条件下按Sr/[Sr Ca]原子比为0、0.5、1,锶可以按化学计量比掺入到HAP的分子结构中,可分别制备纯度较高、晶型结构较好的HAP、SrCaHAP和SrHAP纳米微粒.HAP掺入锶元素后,不仅降低SrCaHAP和SrHAP 中OH(,PO3(主要官能团的红外光谱吸收峰的振动频率,还改变了纳米微粒的晶形,从短棒状的HAP改变为针状的SrCaHAP,再改变为短棒状的SrHAP.HAP中钙被锶半取代后形成SrCaHAP,微粒结晶度降低,生物学性能改善;当钙被锶完全取代后形成不含钙的SrHAP,微粒结晶度增加,生物学性能变差.     

聚乙烯醇改性纳米羟基磷灰石的制备

本文以四水硝酸钙和磷酸氢二铵为原料,通过化学沉淀法合成了纳米羟基磷灰石(HA)粉,并引入聚乙烯醇(PVA)做HA的有机改性剂,制备了有机改性的羟基磷灰石纳米粉。用X射线衍射(XRD)、红外光谱(FTIR)和透射电镜(TEM)对HA粉体进行了分析表征。结果表明,引入聚乙烯醇做有机添加剂后,羟基磷灰石粉在700℃煅烧后的粒度在80nm左右。     

锶羟基磷灰石的荧光性能及药物缓释性能

为探索具有荧光性能的锶羟基磷灰石作为骨疾病治疗用药物载体材料的应用前景,以Ca(NO3)2.4H2O)、Sr(NO3)2、(NH4)2HPO4、柠檬酸三钠、十六烷基三甲基溴化铵为原料,在180℃水热处理24h,制得了不同掺锶量的羟基磷灰石。表征了锶羟基磷灰石微球的晶相、形貌、组成、比表面积和荧光性能;研究了以锶羟基磷灰石作为载体,溶菌酶为模型药物的缓释效果。结果表明:合成的产物为花束状羟基磷灰石微球,随着掺锶量的增大,锶羟基磷灰石单球形貌由短棒状变为片状再变为长棒状,而比表面积和荧光强度则先增大后减小。此外,锶羟基磷灰石作为药物载体的缓释速率和释放量,随着锶含量的增大,呈现先减小后增大的趋势。     

Strontium and ciprofloxacin modified hydroxyapatites as functional grafts for bone prostheses

Both strontium and ciprofloxacin are known to be functional materials for the treatment of bone diseases associated to the loss of bone substance. In this work we prepared the strontium (Sr) modified hydroxyapatite (SrHA) and ciprofloxacin (Cip) modified SrHA bone substitutes by one pot facile chemical precipitation route. The calcium release is improved more for SrHA compared with stoichiometric HA owing to the higher solubility of the Sr. Drug release profile exhibited the sustained and prolonged release of Cip up to 45 days. The in-vitro cell responses showed that the Sr addition improved the ALP activity of the osteoblast like MG-63 cells which confirms the enhanced cell viability and functionality of the strontium modified hydroxyapatite ceramics.     

Strontium substituted hydroxyapatite promotes direct primary human osteoblast maturation

Strontium-substituted hydroxyapatite (SrHAp) materials are known to actively promote bone formation. However, the optimum level of Sr inclusion needed to elicit a physiologically relevant response from bone cells is unclear and can vary dependent on the fabrication process employed. In this work hydroxyapatite (HAp), SrHAp powders (2, 5 and 10 wt% (i.e., 1, 2 and 5 at%) with respect to [Sr/(Sr + Ca) ?100]), were synthesized with the purity and Sr-substitution was confined in the range of 1–8 wt% (1–4 at%). All SrHAp samples contained rod-like crystals (<106 nm in length), which decreased in length with increasing Sr content, and exhibited larger flatter crystals (>300 nm in length). TEM-EDX confirmed the presence of Sr and maintenance of the HAp lattice structure for both types of crystals. Qualitative in vitro evaluation using primary human ostesoblast cells (HOBC) cultured in contact with the SrHAp over 28 days showed that the presence of Sr (in particular with the highest Sr content) directly promotes the maturation of osteoblasts into osteocytes as compared to the response observed for HAp. As these materials contain no additives other than Sr, the effects observed here can only be attributed to the physiologically important levels of Sr in the samples.     

Strontium incorporated hydroxyapatite/hydrothermally reduced graphene oxide nanocomposite as a cytocompatible material

Hydroxyapatite (HA)/reduced graphene oxide (rGO) composites with different mol% of strontium and 1?wt% of GO were fabricated through a green hydrothermal reduction method and this combination has been reported for the first time. All the synthesized composites had strontium incorporated onto the crystal structure of HA as can be substantiated from XRD and FTIR. This paper also discusses a possible role of surface and pore characteristics on the in vitro cytocompatibility and the contribution of graphene oxide in directing the nucleation points resulting in dispersed strontium incorporated hydroxyapatite (SHA) based on P-31 NMR and TEM studies. In addition, a reasonable speculation also has been made to correlate the cytocompatibility with the selective occupancy of strontium ions in the apatite lattice. The in vitro cytocompatibility of SHA/rGO composites (SHAG) has been evaluated using cell proliferation tests with MG-63 cells, under a wider range of concentrations (1000–7.8?µg/ml) and by varying Sr/(Ca+Sr) molar ratio. SHAG with strontium substitution of 10?mol% exhibited the maximum viability among the samples tested. These results suggest that the SHAG composites will be a promising material for biomedical application.     

铌酸锶钡的结构和制备工艺研究进展

铌酸锶钡(Sr1-xBaxNb2O6,简称SBN)是一种重要的滤波压电陶瓷,具有重要的实际应用价值。本文综述了铌酸锶钡的结构,从烧结温度、制备方法、掺杂等方面分析了铌酸锶钡的研究进展,评述了制备工艺和掺杂等对铌酸锶钡的结构和性能的影响,并指出了铌酸锶钡研究领域内尚待解决的问题。     

纳米钛酸锶粉体的溶胶—凝胶法制备与研究

以硝酸锶和钛酸丁酯为原料,柠檬酸为络合剂,乙二醇为稳定剂,在液相中发生络合反应制备前驱物,再将前驱物干燥,烧结得到钛酸锶粉体,并对粉体进行XRD分析。经多组对比试验表明,pH值、用水量、柠檬酸用量对粉体的性质有比较明显的影响。     

液相法制备钛酸锶铅粉的研究

研究了反应温度、酸碱度、放置时间和煅烧温度对化学共沉淀法制得的钛酸锶铅粉末的影响,探讨了其热分解过程,用XRD、SEM、DTA和EPMA对粉体进行了综合分析,得到了纯度较高的钛酸锶铅粉末.     

Strontium and zinc co-substituted nanophase hydroxyapatite

It is well documented that biological hydroxyapatite (HA) differs from pure and synthetically produced HA, and contains of a mixture of calcium phosphate (CaP) phases in addition to a range of impurity ions, such as strontium (Sr²⁺), zinc (Zn²⁺), magnesium (Mg²⁺), fluoride (F^-) and carbonate(CO₃^2-), but to name a few. Further to this, biological apatite is generally in the form of rod (or needle-like) crystals in the nanometre (nm) size range, typically 60 nm in length by 5–20 nm wide. In this study, a range of nano-hydroxyapatite (nHA), substituted nHA materials and co-substituted nHA (based on Sr²⁺ and Zn²⁺) were manufactured using an aqueous precipitation method. Sr²⁺ and Zn²⁺ were chosen due to the significant performance enhancements that these substitutions can deliver. The materials were then characterised using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy (XPS) and Transmission Electron Microscopy (TEM) techniques. The TEM results show that all of the samples produced were nano-sized, with Zn-substituted nHA being the smallest crystals around 27 nm long and 8 nm wide. The FTIR, XRD and XPS results all confirm that the materials had undergone substitution with either Sr²⁺ and Zn²⁺, for Ca²⁺ within the HA lattice (or both in the case of the co-substituted materials). The FTIR results confirmed that all of the samples were carbonated, with a significant loss of hydroxylation as a consequence of the incorporation of Sr²⁺ and Zn²⁺ into the HA lattice. None of the materials synthesised here in this study contained any other impurity CaP phases. Therefore this study has shown that substituted and co-substituted nanoscale apatites can be prepared, and that the degree of substitution (and the substituting ion) can have a profound effect of the attendant materials’ properties.     

掺杂改性LiFePO_4正极材料制备及表征

采用微波热合法制备了掺杂LiFePO4锂电池用正极材料。通过XRD、SEM表征了材料的晶体结构和形貌,采用恒电流充放电法研究了材料的电化学性能。XRD结果表明,掺杂后的材料晶相为橄榄石型磷酸铁锂;SEM测试结果表明,加热时间延长促使材料颗粒团聚长大,且结晶完整,颗粒分布均匀。对电池的电化学测试表明,制备的掺杂LiFePO4材料表现出优良倍率性能和循环稳定性,充放电比容量分别为131.7 mAh/g和123.8 mAh/g,10次循环后比容量没有明显衰减。     

微乳液法制备Fe3+掺杂纳米TiO2

以四氯化钛和硝酸铁为原料,通过微乳液法制备纳米TiO2和Fe3 掺杂纳米TiO2;运用热重/差热(TG/DTA)、红外光谱分析(IR)、X-射线衍射(X-RD)等方法对产物的晶体结构、晶粒大小进行了表征;X-RD分析结果表明,所制备的TiO2主要为锐钛矿型,粒子平均粒径约为12 nm,在Fe3 掺杂下,TiO2的晶型转变温度发生了改变,平均粒径减小;红外光谱测试结果表明,随着微乳体系油水比的增大,Ti-O-Ti键的吸收频率产生蓝移,TiO2粒径减小。