Aging and symptoms of anxiety and depression: Structural invariance of the tripartite model.

Negative affect measures were evaluated in a cross-sectional community sample of adults aged 18-93 (N = 335) to examine the structure of neuroticism, anxiety, and depressive symptoms in young, middle, and older adult cohorts. Structural equation modeling was used to contrast 3 nested models: a 1-factor general distress model; a 2-factor high negative-low positive affect model; and a 3-factor "tripartite model" reflecting a higher order Negative Affect factor that is common to depression and anxiety problems and 2 lower order factors, Low Positive Affect (mostly specific to depression) and Arousal (specific to anxiety/panic). As expected, the tripartite model fit best for all age groups. Further, multigroup analyses indicated age invariance for the tripartite model, suggesting the model can be effectively applied with older populations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Motivation to volunteer by older adults: a test of competing measurement models

Four measurement models of the structure of motivation to volunteer were evaluated in 2 samples of older (minimum age = 50 years), active volunteers. Motivation to volunteer was assessed with the Volunteer Functions Inventory. Whereas no support was found for either unidimensional or bipartite models, qualified support was observed for both 6-factor and 2nd-order factor models. The best fit of the data was obtained with the 6-factor model of motivation to volunteer (career, enhancement, protective, social, understanding, and values). Contrary to the prediction derived from the 2nd-order factor model, the 6 volunteer motives were differentially related to demographic variables and number of hours spent volunteering for the organization during the past year. Implications for assessing motivation to volunteer among older adults and recruiting older adults as volunteers are discussed.     

Anomalous factor structure of the WISC—R for diabetic children.

The factor structure of the Wechsler Intelligence Scale for Children—Revised (WISC—R) was analyzed with 95 diabetic children (aged 8–16 yrs), 97 regionally and demographically matched controls, and an age- and race-matched sample from the WISC—R standardization sample (n?=?1,405). Controls exhibited a 3-factor IQ structure, consistent with the standardization sample. Diabetic Ss exhibited a 4-factor structure, with the Perceptual Organization factor splitting in two. Picture Completion (PC) and Picture Arrangement (PA) formed a visual discrimination factor, and Block Design and Object Assembly created a spatial conceptual factor. Among the diabetic Ss, the PC and PA subtests did not act as traditional measures of nonverbal intelligence, and the performance of diabetic Ss on the visual discrimination factor may reflect mild visual atypicalities. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Test of the Tripartite Model of Depression and Anxiety in Older Adult Psychiatric Outpatients.

This study examined the tripartite model of depression and anxiety in 131 psychiatric outpatients, ages 55-87. Confirmatory factor analyses revealed that a 3-factor model provided an adequate fit to the observed data, that the 3-factor model was empirically superior to 1- or 2-factor models, and that the 3-factor structure obtained in the current sample of older adult outpatients converged with that obtained on a separate, younger 'sample. Negative affect was significantly related to depression and anxiety symptoms and syndromes, and positive affect was more highly related to depression than anxiety symptoms and syndromes. Ways for taking into account possible age-associated differences in emotion in older adults and thus improving the conceptual model of anxiety and depression are briefly noted. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Model stability of the 15-item Geriatric Depression Scale across cognitive impairment and severe depression.

The 15-item Geriatric Depression Scale (GDS) is used in a wide variety of clinical and research settings. The study's purpose was to further establish the validity of the 15-item GDS by exploring the underlying factor structure in a healthy, nondemented sample of older adults and then analyzing whether this factor structure remained stable across a sample of demented individuals and a sample of individuals with a history of depression 6 months after discharge from an inpatient psychiatric setting. A 2-factor model fit the data best in the exploratory analyses. The 2 factors, Life Satisfaction and General Depressive Affect, found in the nondemented sample (r = .39) remained stable across cognitive impairment (r = .12) but merged into a 1-factor model in the psychiatric sample (r = .93). The results indicate that nondepressed older adults with poor life satisfaction may be identified as depressed on screening instruments such as the 15-item GDS. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The composition and structure of depressive symptomatology in renal disease.

Renal disease is an increasingly common illness among middle-aged and older adults, and is often associated with depression. The Center for Epidemiologic Studies Depression Scale (CES–D) is a widely used self-report screening measure on which responses generally conform to a 4-factor structure, with each factor loading onto a higher-order Depression factor. The current study examines whether this structure is supported among individuals with renal disease (both predialysis and posttransplant kidney disease patients). Persons with renal disease (n = 225) and healthy control participants (n = 230) were recruited from Vancouver General Hospital and the community. Participants completed the CES–D as part of an extended assessment. Confirmatory factor analytic models were computed for the renal disease and healthy control groups. Results support a 4-factor structure for CES–D responses in persons with renal disease and healthy controls. The hierarchical structure of CES–D responses also appears invariant between groups. Factor structure was similar between groups; only for Depressive Affect was the strength of association with the second-order factor greater among the renal disease than healthy control participants. Findings support similarity of CES–D factor structures between patients with renal disease and healthy individuals. Results suggest that the CES–D's 4 factors contribute to measurement of a higher-order Depression factor in both groups; furthermore, 3 of 4 factors appear invariant between groups. As such, this measure can be used confidently to quantify depressive symptoms in individuals with renal disease. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

A confirmatory factor analysis of the Impact of Event Scale using a sample of World War II and Korean War Veterans.

This study assessed the factor structure of the Impact of Event Scale (IES), a measure of intrusion and avoidance, using a sample of World War II and Korean War veterans who had experienced combat 40–50 years earlier. A series of 3 confirmatory factor analytic models were specified and estimated using LISREL 8.3. Model 1 specified a 1-factor model. Model 2 specified a correlated 2-factor model. Model 3 specfied a 2-factor model with additional cross-factor loadings for Items 2 and 12. Model 3 was found to fit the data. In addition, this model was found to be a better explanation of the data than the other models. Also in addition, the correlations between the Intrusion and Avoidance factors and the 4 subscales of the 28-item General Health Questionnaire were examined to determine the distinctiveness of the two IES factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Factor structure of mental health measures for older adults.

This article examines the factor structure of mental health self-reports among 246 older adults, ages 60 to 80 years, who were either recently physically disabled (n?=?62), recently bereaved (n?=?61), or matched control subjects (n?=?123). Confirmatory factor analyses were carried out on the Mental Health Inventory and the Psychiatric Epidemiology Research Interview (PERI) Demoralization Composite to test whether factor structures obtained in previous studies would fit the data for this older adult sample and whether those structures would be equivalent among groups that differ in degree of life stress. The structure of these two inventories was reorganized as a result of these analyses, resulting in 9 subscales that varied somewhat from the original subscale structure. The Bradburn Positive Affect Scale was added, and a second order confirmatory factor analysis was performed on these 10 scales. Two highly correlated superordinate factors emerged: Psychological Distress and Psychological Well-Being. Although the factor structure was generally similar across groups, there were some notable exceptions that could be attributed to between-groups differences in exposure to life stress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Regenerating sciatic nerve does not utilize circulating cholesterol

Vascular endothelial growth factor (VEGF) is a major contributor to retinal neovascularization. The possible participation of VEGF and its high-affinity tyrosine kinase receptors, flk-1 and flt-1, in early background diabetic retinopathy was studied in the streptozotocin-induced diabetic rat model of experimental retinopathy using in situ hybridization, blotting techniques, and immunohistochemistry. Diabetic retinopathy was assessed by quantitative morphometry of retinal digest preparations. The number of acellular capillaries increased 2.7-fold in diabetic animals with diabetes' duration of 6 months compared with nondiabetic controls. VEGF expression was not detectable by in situ hybridization in nondiabetic rats but was highly increased in the ganglion cell layer and in the inner and outer nuclear layers of retinas from diabetic animals. VEGF protein was extractable only from diabetic retinas, and a strong immunolabeling was detected in vascular and perivascular structures. Increased flk-1 and flt-1 mRNA levels were also found in the ganglion cell and both nuclear layers of diabetic samples only. Dot blot and Western blot analyses confirmed the increase in flk-1 mRNA and protein in diabetic retinas. Also, flk-1 immunoreactivity was associated with vascular and nonvascular structures of the inner retinas from diabetic animals. These data obtained from a rodent model in which retinal neovascularization does not occur support the concept that the VEGF/VEGF receptor system is upregulated in early diabetic retinopathy.     

Assessment of psychopathy in a population of incarcerated adolescent offenders.

The reliability, validity, and factor structure of a modified version of the Psychopathy Checklist—Revised (PCL—R) for adolescents was investigated, completed using file information only, in a sample of incarcerated Black and White male adolescents. Interrater reliability and internal consistency were high, and confirmatory factor analyses and coefficients of congruence showed that the factor structure in this sample resembled the 2-factor solution found in adults. No significant racial differences were found for reliability or mean PCL—R scores. In addition, relationships between PCL—R scores and psychometric measures and behavioral indicators of maladjustment were similar to those previously found in adult populations. The construct of psychopathy, as defined by the PCL—R modified for use with adolescents, appears applicable to both Black and White adolescent male offenders. The study gives evidence for the structural and substantive validity of the modified PCL—R in this population. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exploring the structure of a neuropsychological battery across healthy elders and those with questionable dementia and Alzheimer's disease.

An exploratory factor analysis (EFA) and a series of confirmatory factor analyses were conducted on 17 variables designed to assess different cognitive abilities in a sample of healthy older adults. In the EFA, 4 factors emerged corresponding to language, memory, processing speed, and fluid ability constructs. The results of the confirmatory factor analyses suggested that a 5-factor model with an additional Attention factor improved the fit. The invariance of the 5-factor model was examined across 3 groups: a group of cognitively healthy older adults, a group of patients diagnosed with questionable dementia (QD), and a group of patients diagnosed with probable Alzheimer's disease (AD). Results of the invariance analysis suggest that the model may have configural invariance across the 3 groups but not metric invariance. Specifically, preliminary analyses suggest that the memory construct may represent something different in the QD and AD groups as compared to the healthy older adult group, consistent with the underlying pathology in early AD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The factor structure and factorial invariance of the 12-item General Health Questionnaire (GHQ-12) across time: Evidence from two community-based samples.

This study provides new knowledge about the factor structure of the 12-item General Health Questionnaire (GHQ-12; D. Goldberg, 1972) through the application of confirmatory factor analysis to longitudinal data, thereby enabling investigation of the factor structure, its invariance across time, and the rank-order stability of the factors. Two community-based longitudinal adult samples with 1-year (n = 640) and 6-year (n = 330) follow-up times were studied. As a result, the correlated 3-factor model (i.e., Anxiety/Depression, Social Dysfunction, and Loss of Confidence) showed a better fit with both samples than the alternative models. The correlated 3-factor structure was also relatively invariant across time in both samples, indicating that the scale has good construct validity. The rank-order stabilities of the factors were low across time, which suggests that the GHQ-12 measures temporal mental state. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The blood contribution to early myocardial reperfusion injury is amplified in diabetes

Cardiovascular disease is excessive in diabetes, and blood cell function is altered. It is not clear, however, if alterations in the blood contribute to the excessive cardiovascular complications of this disease. In this study, we compared the contribution of nondiabetic and diabetic blood to myocardial reperfusion injury. The recovery of cardiac contractile function following no-flow ischemia was studied in isolated diabetic and nondiabetic rat hearts perfused with diabetic or nondiabetic diluted whole blood. Hearts were isolated from 10- to 12-week-old diabetic (streptozotocin, 65 mg/kg, i.v.) and nondiabetic rats and perfused with a Krebs-albumin-red cell solution (K2RBC, Hct 20%). After a 30-min pre-ischemic control period, during which cardiac pump function was evaluated, diabetic and nondiabetic hearts were perfused for 5 min with diluted whole blood (DWB; Hct 20%) collected from either diabetic or nondiabetic donor animals. Coronary flow was then stopped and the hearts subjected to 30 min of no-flow ischemia. Following ischemia, the hearts were reperfused with the K2RBC perfusate. Cardiac contractile function was evaluated throughout the 60-min reperfusion period. Six groups were studied: diabetic and nondiabetic hearts perfused before ischemia with either K2RBC, nondiabetic DWB (NDDWB), or diabetic DWB (DDWB). Perfusion with DWB prior to ischemia impaired the recovery of contractile function in all cases. The impairment to recovery was greater with DDWB than with NDDWB. Although diabetic hearts perfused with K2RBC throughout recovered quite well, the effect of DDWB perfusion in the diabetic hearts was dramatic. In an effort to determine why diabetic blood impaired functional recovery, measures of blood filterability and the generation of reactive oxygen species (ROS) were made. We found that diabetic blood was less filterable than nondiabetic blood; that is, the diabetic blood cells tended to plug the 5-microm filter pores more readily than the nondiabetic blood cells. Also, we found that the diabetic blood was capable of generating significantly greater ROS (oxygen free radicals) than nondiabetic blood (P < 0.05). These findings suggest that the blood contribution to myocardial reperfusion injury is amplified in diabetes. A tendency for diabetic blood cells to plug capillary-sized pores and show enhanced oxygen free radical production may account for the excessive contribution of diabetic blood to reperfusion injury in the heart.     

Factorial validity of the Texas Revised Inventory of Grief—Present scale among bereaved older adults.

The Texas Revised Inventory of Grief—Present scale (TRIG–Present) is one of the most widely used grief measures; however, researchers have only empirically examined the validity and underlying factor structure of TRIG–Present scores in a few studies. Hence, in the present investigation, we sought to examine the factorial validity of the TRIG–Present (those scores that index current grief) among 2 samples of bereaved older adults—a community-dwelling sample of 162 individuals who experienced a diverse set of losses in terms of relationship to the deceased and time since loss, and a recently widowed sample of 212 individuals who were assessed at 2-months and 12-months postloss. Across both samples, we found support for a 3-factor model, composed of clusters of items representing Emotional Response, Thoughts, and Nonacceptance regarding a loss. Additionally, this 3-factor model exhibited significant invariance from 2-months to 12-months postloss in the recently widowed sample. Analyses examining the convergent validity of these 3 factors also suggest that this conceptualization of the TRIG–Present could have practical advantages and potentially influence the way in which clinicians and/or researchers assess grief and evaluate bereavement interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Purpose in life as a mediator of adjustment after spinal cord injury.

Objective: Determine how purpose in life influences adjustment after spinal cord injury (SCI). Study Design: Cross-sectional survey with mediation analysis. Subjects: 1,391 adults with traumatic SCI 1 or more years prior. Main Outcome Measure: Ladder of Adjustment (N. M. Crewe & J. S. Krause, 1990). The Purpose in Life scale (PIL: .J. C. Crumbaugh, 1968), the Zuckerman-Kuhlman Personality Questionnaire (M. Zuckerman, D. M. Kuhlman, J. Joireman, P. Teta, & M. Kraft, 1993), and the Multidimensional Health Locus of Control scale (K. A. Wallston, B. S. Wallston, & R. DeVellis, 1978) were assessed. Results: PIL mediated between most measures and adjustment. Conclusions: Logotherapy is effective in strengthening purpose in life. Its use with persons with SCI may improve their adjustment and quality of life. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differentiating anxiety and depression in older adults with generalized anxiety disorder.

To examine affect and cognition in differentiating anxiety and depression, 83 older participants with generalized anxiety disorder completed the Cognitive Checklist (CCL) and the Positive and Negative Affect Schedule (PANAS). A 3-factor solution was found for the PANAS: positive affect (PA), anxiety and anger (Negative Affect 1 [NA-1]), and guilt and shame (Negative Affect 2 [NA-2]). A 2-factor structure was noted for the CCL. Correlations with anxiety and depression measures suggested that the CCL Depression (CCL-D) subscale showed stronger correlations with depression, whereas the CCL Anxiety subscale did not uniquely correlate with anxiety. The NA-1 subscale correlated positively with measures of depression and anxiety, whereas the PA subscale showed negative correlations. Hierarchical regression suggested that the CCL-D subscale was a significant predictor of self-reported depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Health locus of control in late life: A study of genetic and environmental influences in twins aged 80 years and older.

The factor structure of health locus of control (Form A; K. A. Wallston, B. S. Wallston, & R. DeVellis, 1978) was examined in 420 octogenarians (M age?=?83.2 years), and the contributions of genetic and environmental factors to health-control beliefs in 141 octogenarian twin pairs (71 identical, 70 same-sex fraternal) were estimated. Factor analyses reproduced previously proposed factors (Internal, Chance, and Powerful Others). Associations between health-control beliefs and life satisfaction, depression, and other health-related measures (e.g., self-rated health, outpatient contacts, and hospitalization), were modest. Quantitative genetic analyses revealed significant shared environmental influence on the Chance subscale, and significant familiarity (attributable to a combination of genetic and shared environmental influences) on the Powerful Others subscale; there was no evidence of familiarity on the Internal subscale. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rotter's internal-external scale: Confirmatory factor analysis and correlation with social desirability for alternative scale formats.

536 undergraduates completed alternative versions of Rotter's Internal–External Locus of Control Scale and the Marlowe-Crowne Social Desirability Scale. 178 Ss completed the scales in their original formats (forced-choice and true/false, respectively), and 358 Ss completed a Likert instrument that incorporated both measures. It was hypothesized (a) that J. F. Watson's (see record 1982-29470-001) 2-factor structure for the forced-choice scale and B. E. Collins's (see record 1974-25219-001) 4-factor structure for the Likert version would be confirmed and (b) that both scales would exhibit significant social desirability correlation. A restricted factor analysis of the data confirmed the reported factorial structures, but the variance explained by the factors was small, and there was evidence that the scale may be tapping a unitary construct. Correlation with social desirability was found for the Likert data but not for the forced-choice results. However, data indicate that there may be problems with the interpretation of results that were based on use of the Marlowe-Crowne scale. (54 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A reexamination of the factor structure of the Center for Epidemiologic Studies Depression Scale: Is a one-factor model plausible?

The Center for Epidemiologic Studies Depression Scale (CES–D) is one of the most widely used measures of depressive symptoms in research today. The original psychometric work in support of the CES–D (Radloff, 1977) described a 4-factor model underlying the 20 items on the scale. Despite a long history of evidence supporting this structure, researchers routinely report single-number summaries from the CES–D. The research described in this article examines the plausibility of 1-factor model using an initial sample of 595 subjects and a cross-validation sample of 661. After comparing a series of models found in the literature or suggested by analyses, we determined that the good fit of the 4-factor model is mostly due to its ability to model excess covariance associated with the 4 reverse-scored items. A 2-factor model that included a general depression factor and a positive wording method factor loading only on those 4 items had fit that was nearly as good as the original 4-factor model. We conclude that although a 1-factor model may not be the best model for the full 20-item CES–D, it is at least plausible. If a unidimensional set of items is required (e.g., for a unidimensional item response theory analysis), by dropping 5 items, we were able to find a 1-factor model that had very similar fit to the 4-factor model with the original 20 items. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Distress and self-restraint as measures of adjustment across the life span: Confirmatory factor analyses in clinical and nonclinical samples.

The Weinberger Adjustment Inventory (WAI; D. Weinberger & G. Schwartz, 1990) was designed as a hierarchical self-report measure of general social-emotional adjustment in older children and adults. The superordinate constructs of distress (i.e., anxiety, depression, low self-esteem, and low well-being) and self-restraint (i.e., impulse control, suppression of aggression, consideration of others, and responsibility) are each operationalized as a composite of 4 subscales. Confirmatory factor analyses were conducted using 6 samples (n?=?153–392; N?=?1,486). The factor structure was highly comparable with a mean comparative fit index (CFI) of .968 for youth (ages 10–17), young adults (ages 18–30), and adults (ages 31–65) within both clinical outpatient and nonclinical populations. The results suggest that there may be little justification for the routine practice of using different measures of general adjustment when investigating older children vs adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)