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Brian DALY Jue LING A. Prasanna de SILVA 《Frontiers of Chemical Science and Engineering》2014,8(2):240-251
Molecular information gathering and processing — a young field of applied chemistry — is undergoing good growth. The progress is occurring both in terms of conceptual development and in terms of the strengthening of older concepts with new examples. This review critically surveys these two broad avenues. We consider some cases where molecules emulate one of the building blocks of electronic logic gates. We then examine molecular emulation of various Boolean logic gates carrying one, two or three inputs. Some single-input gates are popular information gathering devices. Special systems, such as ‘lab-on-a-molecule’ and molecular keypad locks, also receive attention. A situation deviating from the Boolean blueprint is also discussed. Some pointers are offered for maintaining the upward curve of the field. 相似文献
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利用分子模拟技术对加拿大Athabasca油砂沥青超临界萃取分馏残渣组分的化学分子结构进行了研究,首先选用长度不同的桥链构建了其三维平均结构,然后采用分子力学(MM)和分子动力学(MD)方法得到能量最低也即最稳定的构象.研究发现,即使分子的二维结构相同,其三维结构差别也很大,由此可见仅用二维模型来表征重质油大分子的结构和物理化学性质远远不够.另外,分子模拟还可以预测沥青质残渣中最有可能存在的桥链长度.Athabasca沥青残渣组分中长度为C5到C7的桥链存在的可能性最大,而C1和C2桥链则由于其总能量相对较高,存在的可能性较小. 相似文献
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分子钳化学是当今化学学科研究的热点之一.介绍了分子钳化合物的结构、应用及新进展,重点综述了分子钳化合物的合成、分子钳对手性分子及阴离子的识别作用、分子钳对中性分子的识别作用,并对其应用前景进行了展望,期望能在医药学、生命科学、材料科学、环境科学、分子器件、生物传感器、仿生催化及分析分离科学中得到更广泛的应用. 相似文献
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Hye Ree Yoon Chong Chul Chai Cheol Hee Kim Nam Sook Kang 《International journal of molecular sciences》2022,23(6)
The intrinsic inductive properties of atoms or functional groups depend on the chemical properties of either electron-withdrawing groups (EWGs) or electron-donating groups (EDGs). This study aimed to evaluate in silico methods to determine whether changes in chemical properties of the compound by single atomic substitution affect the biological activity of target proteins and whether the results depend on the properties of the functional groups. We found an imidazo[4,5-b]pyridine-based PAK4 inhibitor, compound 1, as an initial hit compound with the well-defined binding mode for PAK4. In this study, we used both experimental and in silico methods to investigate the effect of atomic substitution on biological activity to optimize the initial hit compound. In biological assays, in the case of EWG, as the size of the halogen atom became smaller and the electronegativity increased, the biological activity IC50 value ranged from 5150 nM to inactive; in the case of EDG, biological activity was inactive. Furthermore, we analyzed the interactions of PAK4 with compounds, focusing on the hinge region residues, L398 and E399, and gatekeeper residues, M395 and K350, of the PAK4 protein using molecular docking studies and fragment molecular orbital (FMO) methods to determine the differences between the effect of EWG and EDG on the activity of target proteins. These results of the docking score and binding energy did not explain the differences in biological activity. However, the pair-interaction energy obtained from the results of the FMO method indicated that there was a difference in the interaction energy between the EWG and EDG in the hinge region residues, L398 and E399, as well as in M395 and K350. The two groups with different properties exhibited opposite electrostatic energy and charge transfer energy between L398 and E399. Additionally, we investigated the electron distribution of the parts interacting with the hinge region by visualizing the molecular electrostatic potential (MEP) surface of the compounds. In conclusion, we described the properties of functional groups that affect biological activity using an in silico method, FMO. 相似文献
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Ebru Çubuk Demiralay Muge Andac Rıdvan Say Guleren Alsancak Adil Denizli 《应用聚合物科学杂志》2010,117(6):3704-3714
Ni2+‐imprinted monolithic column was prepared for the removal of nickel ions from aqueous solutions. N‐Methacryloyl‐L ‐histidine was used as a complexing monomer for Ni2+ ions in the preparation of the Ni2+‐imprinted monolithic column. The Ni2+‐imprinted poly(hydroxyethyl methacrylate‐N‐methacryloyl‐L ‐histidine) (PHEMAH) monolithic column was synthesized by bulk polymerization. The template ion (Ni2+) was removed with a 4‐(2‐pyridylazo) resorcinol (PAR):NH3? NH4Cl solution. The water‐uptake ratio of the PHEMAH–Ni2+ monolith increased compared with PHEMAH because of the formation of nickel‐ion cavities in the polymer structure. The adsorption of Ni2+ ions on both the PHEMAH–Ni2+ and PHEMAH monoliths were studied. The maximum adsorption capacity was 0.211 mg/g for the PHEMAH–Ni2+ monolith. Fe3+, Cu2+, and Zn2+ ions were used as competitive species in the selectivity experiments. The PHEMAH–Ni2+ monolithic column was 268.8, 25.5, and 10.4 times more selective than the PHEMAH monolithic column for the Zn2+, Cu2+, and Fe3+ ions, respectively. The PHEMAH–Ni2+ monolithic column could be used repeatedly without a decrease in the Ni2+ adsorption capacity. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 相似文献
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Molecular imprinting is a method for making artificial receptor sites in a polymer. This article reports the direct nanolayer immobilization of molecularly imprinted polymers (MIPs) on hydroxyl-functionalized multiwalled carbon nanotubes (MWCNTs) without any binder to improve their characteristics. MIPs were formed for hydrochlorothiazide (HCT) as a template on the surface of the MWCNTs with methacrylic acid (functional monomer) and ethylene glycol dimethacrylate (crosslinking agent) with a thermal polymerization technique. The morphology and stability of the immobilized molecularly imprinted polymers on the surface of multiwalled carbon nanotubes (MIPCNTs) was characterized with scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The resulting MIPCNTs demonstrated favorable selectivity, good stability, and a higher adsorption capacity for the template molecule (93.0 μg/mg) compared to products created by bulk polymerization. The adsorption kinetics of HCT at the surface of the MIPCNTs was in agreement with the second-order rate equation. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献
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综述了近年来高分子溶液领域的分子模拟研究进展。介绍了国内外研究者基于分子动力学法(MD)和蒙特卡洛(MC)法对高分子溶液的相形为,溶解动力学性质以及流变性质的模拟。同时还介绍了利用分子模拟技术对高分子溶液进行的一些新的研究方向。 相似文献
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气体在水中的分子动力学模拟 总被引:4,自引:0,他引:4
采用分子动力学(MD)模拟的方法在常温及工业应用背景条件下对CH4、NH3、CO2、O2这些气体在水中的结构及扩散情形进行了研究。MD模拟可以为这些涉及到气体在水中的工业应用情形的机理提供分子水平的解释,同时MD模拟还可为一些不易实验测定扩散性质的体系提供工程初步设计和过程开发所需的数据。 相似文献
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Hye Ryoung Park Soon Do Yoon Eui Yong Bang Kim R. Rogers Sung Hyo Chough 《应用聚合物科学杂志》2005,96(3):650-654
Molecular imprinting polymers (MIPs) were prepared with styrene, 4‐vinyl pyridine, and divinylbenzene for the separation of toluic acid isomers. The uptake and selectivity were investigated, with respect to how they were governed by the swelling degree of a soft MIP that contained a small amount of crosslinker. The optimum swelling range led to high uptake and the easy removal of the template without sacrificing the selectivity, which was controlled by the shape and size of the imprinting cavity under the same functional monomer, to the guest molecule. The original imprinting cavities were reversibly maintained within the range of 200% swelling and shrinking of MIPs throughout the template extraction. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 650–654, 2005 相似文献