原子吸收光谱在分析中药微量元素中的应用

本文对近年来原子吸收光谱在分析中药微量元素中的应用现状做一概述。为我国中草药的种植与开发利用提供参考。     

膜分离在中药制药中的应用进展

对膜分离技术在中药生产过程中的应用领域以及常用的微滤、超滤、纳滤、反渗透、分子印迹膜、膜蒸馏和膜集成联用技术等的应用现状进行了综述,并对膜分离技术的应用前景进行了展望.     

近代以来中医命运的三个历史必然性

论证了近代以来在工业文明的影响下中医衰落的必然性和中医大难不死的必然性,以及随着新文明转型的到来中医复兴的必然性,进而分析了中医复兴的曲折性。     

色谱—质谱联用技术在中药研究中的应用

本文从GC—MS、HPLC—MS、CE—MS三方面阐述了色谱联用技术在中药研究中的应用。     

Advanced treatment of wastewater generated by traditional Chinese medicine by coagulating sedimentation after oxidation with potassium ferrate

The objectives of the study were to test the effects of coagulation sedimentation after oxidation with potassium ferrate (CSOPF) in advanced treatment of wastewater from traditional Chinese medicine (TCMW) and to research kinetics of chemical oxygen demand (CODcr) and color removal by means of potassium ferrate oxidation. It was hoped to develop a feasible technology and provide technical support for TCMW factories. This study confirmed that implementing coagulating sedimentation after oxidation with potassium ferrate was very efficient for the advanced treatment of the secondary treatment effluent of TCMW. In this optimal situation, the performance of the CSOPF was stable, and the CODcr and the color in the effluent were always under 45and 25?mg?L^?1 respectively, which meet the strictest discharge standards of the discharge standard of water pollutes for pharmaceutical industry Chinese traditional medicine category (GB21906-2008)(DSWPPICTMC). Moreover, the experiment proved that the economic benefits of CSOPF implementation were striking because its operation cost is only 0.08380 US$ per m³. Compared with the total cost of the existing wastewater treatment system in the sampled factory, the total saving of CSOPF implementation was 0.15845 US$ per m³. Finally, the experiment confirmed that in potassium ferrate oxidation, the removal rate for COD can be described by C/C₀ = exp(?0.0421t) and the removal rate for color can be described by C/C₀ = exp(?0.0434t).     

现代包装设计与中国传统文化的关系

通过对中国传统文化重要思想和现代包装设计理念的剖析,力图寻找两者之间的契合点,从而阐述现代包装设计和传统文化的关系.     

中药大健康产业发展机遇与战略思考

随着经济社会发展,人们对健康服务的需求快速增长。中医药是我国独具特色的健康资源,也是潜力巨大的经济资源。中医药健康服务主要包括养生、保健、医疗、康复等,但核心是以中药相关产品为主体的健康服务供给。随着中药现代化进程的推进,也促进了中药大健康产业的悄然形成,形成了涉及中药种植,产品研发、生产、流通、销售在内的跨行业、跨区域的产业链,并具有调整产业结构、增加就业、农民增收、服务医改、惠及民生及保护生态等综合优势。本文介绍了中药大健康产业发展的现状,分析存在的问题和不足,提出了一个战略中心(以服务健康需求为中心),两个战略重点(规划监管、提质增效),四个发展方向(规范种植、新品研发、商贸物流、国际发展)和六项重点任务。     

陶瓷膜澄清生地黄提取液的膜污染和清洗研究

采用陶瓷膜澄清生地黄提取液,通过阻力分析法,比较了Al2O3和ZrO2膜的抗污染性能;采用红外光谱仪(IR)、等离子发射光谱(ICP)、电镜(SEM)和能谱(EDX)等检测仪器分析了污染物位置和成分,探讨了膜污染的机理;考察了不同清洗剂的清洗效果,确定了合适的清洗方法,为陶瓷膜在中药提取液澄清过程的应用提供指导．     

光子学技术在祖国医学中的应用

本文简要叙述了激光针灸、激光血管内照射、超弱发光研究的概况 ,并指出了这些光子学技术在祖国医学领域应用中存在的问题 ,以及进一步研究工作的方向 .激光针灸、激光血管内照射的剂量、疗程及适应病症等问题仍处于临床摸索阶段 ;激光针灸仍不能完全取代传统针灸方法 ;血管内照射的中医治疗方案尚需生物学和临床医学的验证 ;影响生物超弱发光的因素较多 ,对实验现象的解释应审慎     

扁鹊传统的古今对话与反思

在采用描述性流行性学解读《史记·扁鹊传》的基础上,从宏观与微观两个方面探讨了《史记》背景资料的真伪和鼠疫流行的可能性。结合鼠疫恶寒发热、消化道与中枢神经系统等症状对中医外感热病学说、脾胃内伤学说与温疫温病等学说的影响,围绕伤寒热病与鼠疫病程的一致性,以及由此抽象而来的六经学说,从疾病流行、象数、复杂性思维路径依赖和知识考古,揭示了疫病流行对早期医学理论、原始宗教与思想文化的影响,提出医源于疫的假说,并就疫病流行与中医教育、中西医结合等问题阐述了看法。     

A chitosan lactate/poloxamer 407-based matrix containing Eudragit RS microparticles for vaginal delivery of econazole: design and in vitro evaluation

A matrix based on chitosan lactate and poloxamer 407 was evaluated as a delivery system for the vaginal administration of the antifungal drug econazole. The matrix was investigated both containing the pure drug and after introducing microparticles of Eudragit RS 100 containing econazole. Eudragit RS 100 microparticles were prepared using an emulsion-extraction method and dispersed in a solution containing chitosan lactate (2% w/w) and poloxamer 407 (1.7% w/w). The microparticles, obtained with a yield of 64% w/w and an encapsulation efficiency of 42% w/w, had a diameter of less than 2 μm and a drug loading of 13% w/w. The compressed matrices, characterized by DSC, swelling, erosion, release and mucoadhesion studies, had behaviours dependent on the relative amounts of the contained microparticles. The matrix without microparticles (MECN) showed zero-order release kinetics, with a maximum drug-release of 60% w/w, while those containing 50 or 75% w/w microparticles showed a diffusion controlled release up to 8 and 16 h, respectively, and a linear trend after those time intervals, caused by the erosion process, which allowed reaching a drug-release of approximately 100% w/w at 22 h. In in vitro experiments, the matrices were mucoadhesive and active in inhibiting the growth of Candida albicans 796.     

Microemulsion loaded hydrogel as a promising vehicle for dermal delivery of the antifungal sertaconazole: design,optimization and ex vivo evaluation

The purpose of the present study was to develop and optimize sertaconazole microemulsion-loaded hydrogel (STZ ME G) to enhance the dermal delivery and skin retention of the drug. Following screening of various oils for maximum drug solubility, 12 pseudoternary phase diagrams were constructed using oils (Peceol^®, Capryol^® 90), surfactants (Tween^® 80, Cremophor^® EL), a cosurfactant (Transcutol^® P) and water. A 2¹ × 3¹ × 2¹ × 3¹ full factorial design was employed to optimize a ME of desirable characteristics. The MEs were formulated by varying the oil type, oil concentration, surfactant type and surfactant: cosurfactant ratio. Optimized ME formulae F22 [5% Peceol^®, 55% Tween^® 80: Transcutol^® (1:2), 40% water] and F31 [5% Peceol^®, 55% Cremophor^® EL: Transcutol^® (1:2), 40% water] acquired mean droplet size of 75.21 and 8.68?nm, and zeta potential of 34.65 and 24.05?mV, respectively. Since F22 showed higher STZ skin retention during ex vivo studies (686.47?μg/cm²) than F31 (338.11?μg/cm²); hence it was incorporated in 0.5% Carbopol 934 gel to augment STZ skin retention capability. STZ ME G exhibited higher STZ skin retention (1086.1?μg/cm²) than the marketed product “Dermofix^® cream” (270.3?μg/cm²). The antimycotic activity against C.albicans revealed increased zones of inhibition for F22 and STZ ME G (35.75 and 30.5?mm, respectively) compared to Dermofix^® cream (26?mm). No histopathological changes were observed following topical application of STZ ME G on rats’ skin (n?=?9). Overall, the obtained results confirmed that the fabricated formulation could be a promising vehicle for the dermal delivery of STZ.