Adaptive optics and vision

It has long been recognised that the optical quality of the human eye is far from diffraction limited. This affects our visual acuity and severely limits the resolution at which images of the living retina can be obtained. Adaptive optics is a technique that can correct for the eye's aberrations and provide diffraction limited resolution. The origins of the technique lie in astronomy, but it was successfully adapted to the human eye just over 10 years ago. Since then there have been rapid developments in the field of adaptive optics and vision science. In vivo images of the retina can now be routinely achieved with unprecedented resolution. Sophisticated experiments can be performed to gain a deeper knowledge of the interaction of neural retinal architecture and visual perception. This article presents the theory behind adaptive optics for the human eye and reviews the developments in this field to date.     

High-resolution retinal imaging with micro adaptive optics system

Based on the dynamic characteristics of human eye aberration, a microadaptive optics retina imaging system set is established for real-time wavefront measurement and correction. This paper analyzes the working principles of a 127-unit Hartmann-Shack wavefront sensor and a 37-channel micromachine membrane deformable mirror adopted in the system. The proposed system achieves wavefront reconstruction through the adaptive centroid detection method and the mode reconstruction algorithm of Zernike polynomials, so that human eye aberration can be measured accurately. Meanwhile, according to the adaptive optics aberration correction control model, a closed-loop iterative aberration correction algorithm based on Smith control is presented to realize efficient and real-time correction of human eye aberration with different characteristics, and characteristics of the time domain of the system are also optimized. According to the experiment results tested on a USAF 1951 standard resolution target and a living human retina (subject ZHY), the resolution of the system can reach 3.6?LP/mm, and the human eye wavefront aberration of 0.728λ (λ=785?nm) can be corrected to 0.081λ in root mean square (RMS) so as to achieve the diffraction limit (Strehl ratio is 0.866), then high-resolution retina images are obtained.     

Adaptive optics for peripheral vision

Understanding peripheral optical errors and their impact on vision is important for various applications, e.g. research on myopia development and optical correction of patients with central visual field loss. In this study, we investigated whether correction of higher order aberrations with adaptive optics (AO) improve resolution beyond what is achieved with best peripheral refractive correction. A laboratory AO system was constructed for correcting peripheral aberrations. The peripheral low contrast grating resolution acuity in the 20° nasal visual field of the right eye was evaluated for 12 subjects using three types of correction: refractive correction of sphere and cylinder, static closed loop AO correction and continuous closed loop AO correction. Running AO in continuous closed loop improved acuity compared to refractive correction for most subjects (maximum benefit 0.15?logMAR). The visual improvement from aberration correction was highly correlated with the subject's initial amount of higher order aberrations (p?=?0.001, R ^2?=?0.72). There was, however, no acuity improvement from static AO correction. In conclusion, correction of peripheral higher order aberrations can improve low contrast resolution, provided refractive errors are corrected and the system runs in continuous closed loop.     

Spherical aberration gauge for human vision

Spherical aberration affects vision in varying degrees depending on pupil size, accommodation, individual eye characteristics, and interpretations by the brain. We developed a spherical aberration gauge to help evaluate the correction potential of spherical aberration in human vision. Variable aberration levels are achieved with laterally shifted polynomial plates from which a user selects a setting that provides the best vision. The aberration is mapped into the pupil of the eye using a simple telescope. Calibration data are given.     

Statistical variation of aberration structure and image quality in a normal population of healthy eyes

A Shack-Hartmann aberrometer was used to measure the monochromatic aberration structure along the primary line of sight of 200 cyclopleged, normal, healthy eyes from 100 individuals. Sphero-cylindrical refractive errors were corrected with ophthalmic spectacle lenses based on the results of a subjective refraction performed immediately prior to experimentation. Zernike expansions of the experimental wave-front aberration functions were used to determine aberration coefficients for a series of pupil diameters. The residual Zernike coefficients for defocus were not zero but varied systematically with pupil diameter and with the Zernike coefficient for spherical aberration in a way that maximizes visual acuity. We infer from these results that subjective best focus occurs when the area of the central, aberration-free region of the pupil is maximized. We found that the population averages of Zernike coefficients were nearly zero for all of the higher-order modes except spherical aberration. This result indicates that a hypothetical average eye representing the central tendency of the population is nearly free of aberrations, suggesting the possible influence of an emmetropization process or evolutionary pressure. However, for any individual eye the aberration coefficients were rarely zero for any Zernike mode. To first approximation, wave-front error fell exponentially with Zernike order and increased linearly with pupil area. On average, the total wave-front variance produced by higher-order aberrations was less than the wave-front variance of residual defocus and astigmatism. For example, the average amount of higher-order aberrations present for a 7.5-mm pupil was equivalent to the wave-front error produced by less than 1/4 diopter (D) of defocus. The largest pupil for which an eye may be considered diffraction-limited was 1.22 mm on average. Correlation of aberrations from the left and right eyes indicated the presence of significant bilateral symmetry. No evidence was found of a universal anatomical feature responsible for third-order optical aberrations. Using the Marechal criterion, we conclude that correction of the 12 largest principal components, or 14 largest Zernike modes, would be required to achieve diffraction-limited performance on average for a 6-mm pupil. Different methods of computing population averages provided upper and lower limits to the mean optical transfer function and mean point-spread function for our population of eyes.     

Design and fabrication of a freeform phase plate for high-order ocular aberration correction

In recent years it has become possible to measure and in some instances to correct the high-order aberrations of human eyes. We have investigated the correction of wavefront error of human eyes by using phase plates designed to compensate for that error. The wavefront aberrations of the four eyes of two subjects were experimentally determined, and compensating phase plates were machined with an ultraprecision diamond-turning machine equipped with four independent axes. A slow-tool servo freeform trajectory was developed for the machine tool path. The machined phase-correction plates were measured and compared with the original design values to validate the process. The position of the phase-plate relative to the pupil is discussed. The practical utility of this mode of aberration correction was investigated with visual acuity testing. The results are consistent with the potential benefit of aberration correction but also underscore the critical positioning requirements of this mode of aberration correction. This process is described in detail from optical measurements, through machining process design and development, to final results.     

Apodization by the Stiles-Crawford effect moderates the visual impact of retinal image defocus

Previous optical modeling of the human eye with large pupils has predicted a larger impact of defocus on the human contrast sensitivity function and modulation transfer function than is observed experimentally. Theory predicts that aberrations and the Stiles-Crawford effect (SCE) should both lead to increased depth of focus, resulting in higher contrast sensitivities and veridical (not phase-reversed) perception over a larger range of spatial frequencies in defocused retinal images. Using a wave optics model, we examine these predictions quantitatively and compare them with psychophysical experiments that measure the effect of defocus on contrast sensitivity and perceived phase reversals. We find that SCE apodization has its biggest effect on defocused image quality when defocus and spherical aberration have the same sign. A model including typical amounts of spherical aberration and pupil apodization provides a dramatically improved prediction of the effects of defocus on contrast sensitivity with large pupils. The SCE can significantly improve defocused image quality and defocused vision, particularly for tasks that require veridical phase perception.     

Analysis of the optical field on the human retina from wavefront aberration data

Wave aberrations in the human eye are usually known with respect to the ideal spherical wavefront in the exit pupil. Using Kirchhoff's diffraction theory, we have derived a diffraction integral to compute the optical field on the retina from the wave aberration data. We have proposed a numerical algorithm based on the Stamnes-Spjelkavik-Pedersen (SSP) method to solve that integral. We have shown which approximations are admissible to reduce the complexity of the diffraction integral. In addition, we have compared our results with those of the conventional procedure used to compute intensities on the retina. We have found significant differences between our results and the conventional ones.     

Wide-angle chromatic aberration corrector for the human eye

The human eye is affected by large chromatic aberration. This may limit vision and makes it difficult to see fine retinal details in ophthalmoscopy. We designed and built a two-triplet system for correcting the average longitudinal chromatic aberration of the eye while keeping a reasonably wide field of view. Measurements in real eyes were conducted to examine the level and optical quality of the correction. We also performed some tests to evaluate the effect of the corrector on visual performance.     

The Computation of Diffraction Patterns in the Presence of Aberrations

The diffraction integral for the disturbance produced in the image plane normal to the optical axis by an extra-axial pencil has been shown to lead to a Fourier transform provided the exit pupil surface is taken to be that of the reference sphere. It has been shown also that, except for small aperture and field sizes, the effect on the wave-front aberration of a shift of the image plane is not represented with sufficient accuracy merely by a term proportional to the aperture squared. Both of these results have been respected in formulating a numerical technique for the calculation of point spread functions. The diffraction integral is evaluated in polar coordinates, and is such that no error is made in approximating the domain of the exit pupil in cases where this may be represented by an ellipse. A study of the accuracy obtained has shown that, if each quadrant of the pupil is divided into a 20 × 20 mesh of elementary areas, the error in the intensity is not expected to exceed 0·8 per cent of the intensity at the focus of a diffraction limited system. The method takes account of the first derivatives of the wave aberration at each mesh point, and the results are therefore expected to be more accurate than those obtained by merely replacing the integral by a simple sum. Results are given for a case of primary and secondary coma, and of a study of the influence of secondary spectrum and spherical aberration on the images formed by 2 mm achromatic microscope objectives of numerical aperture equal to 1·40.     

Influences of reference plane and direction of measurement on eye aberration measurement

We explored effects of measurement conditions on wave aberration estimates for uncorrected, axially myopic model eyes. Wave aberrations were initially referenced to either the anterior corneal pole or the natural entrance pupil of symmetrical eye models, with rays traced into the eye from infinity (into the eye) to simulate normal vision, into the eye from infinity and then back out of the eye from the retinal intercepts (into/out of the eye), or out of the eye from the retinal fovea (out of the eye). The into-the-eye and out-of-the-eye ray traces gave increases in spherical aberration as myopia increased, but the into/out-of-the-eye ray trace showed little variation in spherical aberration. Reference plane choice also affected spherical aberration. Corresponding residual aberrations were calculated after the models had been optically corrected, either by placing the object or image plane at the paraxial far point or by modifying corneas to simulate laser ablation corrections. Correcting aberrations by ablation was more complete if the original aberrations were referenced to the cornea rather than to the entrance pupil. For eyes corrected by spectacle lenses, failure to allow for effects of pupil magnification on apparent entrance pupil diameter produced larger changes in measured aberrations. The general findings regarding choice of reference plane and direction of measurement were found to be equally applicable to eyes that lacked rotational symmetry.     

不同年龄段对比敏感度函数研究及模型建立

目的为了探讨不同年龄段人眼的对比度敏感视觉特性,以获取对比度敏感函数模型。方法基于LCH颜色空间,利用显示器显示不同空间频率正弦波图像,测量青年(18～25岁)、中年(30～45岁)、老年(50～70岁)共30位观察者的明度、彩度、色调角对比敏感度数据。结果随着空间频率的增加,人眼对比敏感度先增加后减小,当空间频率在2～4周期/度时,人眼最为敏感;明度对比敏感度高于彩度、色调角;青年组3种对比敏感度数据均高于中老年组。结论采用指数函数对测量数据进行了拟合,构建了对比敏感度函数模型,可用于实现人眼视觉系统的建模,能够用数学公式预测人眼对彩色图像质量的感知。     

Dynamic eye model for adaptive optics testing

An artificial dynamic eye model is proposed. The prototype enabled us to introduce temporal variations in defocus and spherical aberration, resembling those typically found in the human eye. The eye model consisted of a meniscus lens together with a modal liquid crystal lens with controllable focus. A diffuser placed at a fixed distance from the lenses acted as the artificial retina. Developed software allowed the user to precisely control the dynamic generation of aberrations. In addition, different refractive errors could simultaneously be emulated by varying the distance between the components of the model. The artificial eye was first used as a dynamic generator of both spherical aberration and defocus, imitating the behavior of a real eye. The artificial eye was implemented in an adaptive optics system designed for the human eye. The system incorporated an electrostatic deformable mirror and a Hartmann-Shack wavefront sensor. Results with and without real time closed-loop aberration correction were obtained. The use of the dynamic artificial eye could be quite useful for testing and evaluating adaptive optics instruments for ophthalmic applications.     

Three-dimensional relationship between high-order root-mean-square wavefront error, pupil diameter, and aging

We report root-mean-square (RMS) wavefront error (WFE) for individual aberrations and cumulative high-order (HO) RMS WFE for the normal human eye as a function of age by decade and pupil diameter in 1 mm steps from 3 to 7 mm and determine the relationship among HO RMS WFE, mean age for each decade of life, and luminance for physiologic pupil diameters. Subjects included 146 healthy individuals from 20 to 80 years of age. Ocular aberration was measured on the preferred eye of each subject (for a total of 146 eyes through dilated pupils; computed for 3, 4, 5, 6, and 7 mm pupils; and described with a tenth-radial-order normalized Zernike expansion. We found that HO RMS WFE increases faster with increasing pupil diameter for any given age and pupil diameter than it does with increasing age alone. A planar function accounts for 99% of the variance in the 3-D space defined by mean log HO RMS WFE, mean age for each decade of life, and pupil diameter. When physiologic pupil diameters are used to estimate HO RMS WFE as a function of luminance and age, at low luminance (9 cd/m2) HO RMS WFE decreases with increasing age. This normative data set details (1) the 3-D relationship between HO RMS WFE and age for fixed pupil diameters and (2) the 3-D relationship among HO RMS WFE, age, and luminance for physiologic pupil diameters.     

Pupil Diameter and the Depth-of-field of the Human Eye as Measured by Laser Speckle

Results are given for the variation in the depth-of-field with entrance pupil diameter for six subjects. The method was based on observation of a laser speckle pattern at 633 nm on the surface of a slowly rotating drum. Depth-of-field falls with pupil diameters up to ～ 5 mm and then remains at an approximately constant value. The roles of diffraction, aberration, the Stiles-Crawford effect and of non-optical aspects of the visual system are discussed.     

Axial and Extra-axial Responses in Aberrated Optical Systems with Apodizers. Optimization of the Strehl Ratio

Abstract

The effect of non-uniform transmission filters on the axial and extra-axial responses of aberrated optical systems is studied. The axial Strehl ratio (SR) is increased by varying the filter transmission function and the extra-axial SR by shifting the filter position along the axis of the optical system. It is shown that a filter which optimizes the axial SR can also improve the extra-axial SR. There are some positions of the filter for which the total results are improved. These positions are explained from the lack of radial symmetry of the wave aberration. The filters which improve the SR are also studied in terms of energy transmission.     

Calculation of retinal image quality for polychromatic light

Although the retinal image is typically polychromatic, few studies have examined polychromatic image quality in the human eye. We begin with a conceptual framework including the formulation of a psychophysical linking hypothesis that underlies the utility of image quality metrics based on the polychromatic point-spread function. We then outline strategies for computing polychromatic point-spread functions of the eye when monochromatic aberrations are known for only a single wavelength. Implementation problems and solutions for this strategy are described. Polychromatic image quality is largely unaffected by wavelength-dependent diffraction and higher-order chromatic aberration. However, accuracy is found to depend critically upon spectral sampling. Using typical aberrations from the Indiana Aberration Study, we assessed through-focus image quality for model eyes with and without chromatic aberrations using a polychromatic metric called the visual Strehl ratio. In the presence of typical levels of monochromatic aberrations, the effect of longitudinal chromatic aberration is greatly reduced. The effect of typical levels of transverse chromatic aberration is virtually eliminated in the presence of longitudinal chromatic aberration and monochromatic aberrations. Clinical value and limitations of the method are discussed.     

Maréchal Intensity Criteria for Apertures with Polynomial Non-uniform Transmission. Evaluation of the Diffraction Focus and the Strehl Ratio

Abstract

General formulae for the wave aberration weighted variance are obtained for rotationally symmetric systems with a non-uniform transmission pupil expressed by polynomials. They are valid for any combination of residual aberrations and any polynomial transmission function on the pupil. Expressions to obtain the position of the diffraction focus and the Strehl ratio are given. The accuracy in the evaluation of the diffraction focus is studied for optical systems with different residual aberrations.     

Focal Images Formed by a Concave Holographic Grating. A Corroborative Investigation Using Three Different Techniques

Photographic registration, ray tracing and analytical modelling are used simultaneously for a systematic investigation of focal images generated by a spherical diffraction grating under point source illumination. Special attention is devoted to the case when a circular entrance pupil is located out of the meridional plane. Good correspondence between the three techniques is observed and the meaning of some specific aberration coefficients is clarified. The reliability of two recently proposed formulae for focal spot dimensional estimation is verified over a wide spectral interval.