聚醚醚酮表面接枝聚丙烯酸及其成骨细胞相容性

采用紫外光诱导接枝聚合技术制备表面接枝聚丙烯酸(PAA)的聚醚醚酮(PEEK)以改善其成骨细胞相容性。用X射线光电子能谱、衰减全反射红外光谱和水接触角测试对表面改性的PEEK进行表征,同时,用MC3T3-E1成骨细胞评价PEEK表面接枝PAA后的成骨细胞相容性和成骨分化活性。结果表明,采用紫外光诱导接枝聚合技术在PEEK表面成功接枝PAA;与未处理的PEEK表面相比,接枝PAA的PEEK表面能显著改善成骨细胞的黏附、铺展与增殖,但对成骨细胞的成骨分化活性并没有明显的促进作用。     

不同表面处理方式对PEEK粘接强度的影响

采用砂纸打磨、喷砂和等离子处理等方式对PEEK进行表面处理,并使用环氧胶进行粘接。通过粗糙度仪、接触角测试仪和万能材料拉伸试验机对PEEK的粗糙度、润湿性和粘接强度等特性进行表征分析。结果表明,不同的表面处理方法对PEEK粘接的性能影响不同。砂纸打磨和喷砂能够有效增加PEEK表面的粗糙度,增大PEEK与粘结剂的粘接面积,从而提高PEEK的粘结强度。而等离子处理能够有效降低PEEK表面的接触角,改善PEEK表面的润湿性,提高PEEK的粘接强度,并且等离子处理后PEEK的粘接强度比未处理、砂纸打磨和喷砂分别提高了600%、260%和110%。     

高生物活性聚醚醚酮化学改性研究进展

由于聚醚醚酮（PEEK）表面疏水及生物惰性，用作骨科材料难以与周围细胞、骨组织结合。通过化学改性在PEEK分子链中引入具有生物活性的功能化基团是提高其表面细胞黏附、增殖和成骨分化能力最有效的方式。基于功能化基团引入位置的不同，本文将PEEK化学改性分为苯环位改性、酮基位改性和共聚改性等三种，并且重点综述了这些不同化学改性方法的原理和特性及其对PEEK材料生物活性的影响。苯环位改性主要是通过强酸处理引入羧基等官能团，但会残留含硫或含硝化合物，对细胞有一定的毒害作用；酮基位改性是通过胺类、硼氢化钠等试剂与酮基反应，进一步接枝引入功能化基团，但是会破坏PEEK主链上的醚酮比，影响物理性能和热性能。通过亲电、亲核及卤代改性等共聚方式在PEEK侧链引入功能化基团，能保持聚合物主链醚酮比基本不变，同时提升材料生物活性，具有良好的应用前景。在化学改性的基础上，研究多种功能基团的协同作用，进一步引入物理改性，优化面向不同场景的综合性能，是拓宽其在医疗领域应用的发展趋势。     

RGD肽修饰PEEK表面及其与成骨细胞的相容性

采用丙烯酸等离子体处理聚醚醚酮（PEEK）表面,引入羧基（—COOH）,并利用—COOH将具有生物活性的精氨酸甘氨酸天冬氨酸（RGD）肽化学键合在PEEK的表面;通过X射线光电子能谱仪、水接触角测量仪、表面轮廓仪和万能材料试验机对表面处理前后的PEEK进行表征,并采用MC3T3-E1成骨细胞来评价表面修饰的PEEK的细胞相容性。结果表明,—COOH被成功地引入至PEEK表面,并且RGD肽成功地键合在等离子体羧基化的PEEK表面;丙烯酸等离子体处理和RGD肽的修饰均改善了PEEK表面的亲水性,增加了其表面的粗糙度;等离子体处理和RGD肽的修饰均未影响PEEK的拉伸强度及弯曲强度;等离子体处理和RGD肽的修饰均能改善PEEK表面成骨细胞的黏附、铺展与增殖,但RGD肽修饰的PEEK表面对于促进细胞黏附、铺展与增殖的效果明显优于等离子体羧基化的PEEK表面。     

生物大分子接枝改性丙纶非织造布研究

采用低温氧气等离子体处理聚丙烯(PP)非织造布,利用交联剂将处理后的PP非织造布与生物大分子壳聚糖或胶原蛋白进行接枝反应,探讨了接枝反应条件及改性PP非织造布的性能。结果表明:在环氧交联剂的架桥作用下,等离子体处理后的PP非织造布可接枝壳聚糖或胶原蛋白,适宜的接枝反应条件为0.1 g交联剂,45℃下12 g/L壳聚糖溶液中反应8 h,或35℃下15 g/L胶原蛋白溶液中反应6 h;经氧气等离子体处理后,PP非织造布表面引入了大量的羟基和羧基,并参与接枝反应,壳聚糖的接枝效果优于胶原蛋白;接枝改性后PP非织造布的亲水性、染色性、抗菌性及伤口愈合能力均得到提高。     

医用聚醚醚酮表面功能化的构建及抗菌性能研究进展

聚醚醚酮(PEEK)表面的生物堕性,限制了其表面与相邻骨组织的良好融合,在实际临床应用中受到限制.通过PEEK表面功能化负载抗菌性和生物活性组分,可有效提升PEEK骨科植入材料的抗菌性能和生物活性,有望拓展其临床应用领域.综述了PEEK表面功能化掺杂抗菌性组分的研究进展,包括PEEK负载抗菌药物、负载金属离子、负载抗菌...     

水润滑下偶件表面粗糙度对碳纤维增强PEEK复合材料摩擦学性能的影响

以聚醚醚酮(PEEK)复合材料为销样,316不锈钢材料为盘样,在销-盘摩擦磨损试验机上考察了水润滑条件下偶件表面粗糙度对纯PEEK及碳纤维增强PEEK复合材料摩擦学性能的影响,并用光学显微镜观察了PEEK复合材料的磨损表面形貌。结果表明,在水润滑条件下,碳纤维增强PEEK复合材料的耐磨性能明显提高,磨损率比纯PEEK的磨损率降低了4~6倍。当偶件表面粗糙度R_a处于0.08~0.09μm范围内时,PEEK复合材料可以取得较低的磨损率;当偶件表面粗糙度R_a的值过高或者过低时,摩擦磨损机理将发生改变。     

壳聚糖的改性及应用研究进展

对壳聚糖改性已成为获得性能更优良的壳聚糖聚合物的重要手段。近年来,人们通过修饰、交联、接枝等改性方法,使壳聚糖的应用性能得到大幅度的提高。着重介绍了壳聚糖在生物医药、化工材料、环境保护等领域的改性和功能提升方法,指出了壳聚糖应用中应注意的问题。     

聚醚醚酮表面接枝O-羧甲基壳聚糖及其血液相容性研究

采用紫外自引发光接枝在聚醚醚酮表面接枝聚丙烯酸,并进而以此为反应位点,通过共价键结合引入O羧甲基壳聚糖(O-CMC)。采用接触角测定仪、扫描电子显微镜、X射线光电子能谱和血小板粘附实验等对改性聚醚醚酮进行了表征。结果表明,改性聚醚醚酮表面浸润性得到提高,具有抗凝血性能。     

聚丙烯酰胺接枝壳聚糖及其污水处理试验

以脱乙酰度大于90%的自制壳聚糖和丙烯酰胺为原料,以正交试验法得到丙烯酰胺接枝壳聚糖最佳反应条件为:反应温度30℃;丙烯酰胺与壳聚糖质量比6:1;反应时间3h;引发剂浓度1.5 mmol/L,红外光谱对接枝产物进行了表征,以接枝和未接枝壳聚糖对实际工业废水作絮凝处理性能的对比试验,接枝壳聚糖的COD,浊度和色度去除率分别比未接枝壳聚糖提高6.7%,2.7%和8.6%。     

Effect of dihydroxydiphenyl ether on poly(ether ether ketone)

A series of modified poly(ether ether ketone) (PEEK) polymers were synthesized by introduction of addition ether groups from dihydroxydiphenyl ether (DHDE) into the PEEK structure. The inherent viscosity of the DHDE-modified PEEK increased with reaction time at 320 °C. DSC thermograms showed the melting points of the obtained PEEK decreased with the increase of the DHDE content in the backbone. The degradation temperature (T_d) was slightly decreased by the introduction of DHDE. The crystallinity as measured via the X-ray diffraction (XRD) increases with the introduction of DHDE into the modified PEEK. The crystalline structure was identified as an orthorhombic structure with lattice constants a = 7.72 Å, b = 5.86 Å, and c = 10.24 Å. Due to the glass transition temperature (T_g) and the melting temperature (T_m) decreasing with the increase of the DHDE content in the reaction system. the processability of the resultant PEEK could be improved through this DHDE modification.     

Spherulitic growth kinetics in miscible blends of poly(ether ether ketone) and poly(ether imide)

Growths of poly(ether ether ketone) (PEEK) spherulites from both pure melt and its miscible blends with poly(ether imide) (PEI) have been studied by polarized optical microscopy. The nucleation density of PEEK spherulites was depressed upon blending with PEI, which can be attributed to the reduction in degree of supercooling arising from equilibrium melting point depression. A modified Lauritzen-Hoffman (L-H) theory was adopted to analyze the growth kinetics. Regime III-II transition was observed with the transition temperature decreasing with increasing PEI composition. Assuming free rotations of the virtual bonds in PEEK molecule, the side surface free energy of 12.0 erg/cm² was calculated from the characteristic ratio. The fold surface free energy of 188 erg/cm² and work of chain folding of 12.3 kcal/mol were then obtained from the modified L-H analysis.     

聚苯酯对聚醚醚酮结晶行为的影响

用模压法制备了聚苯酯(Ekonol)／聚醚醚酮(PEEK)复合材料，通过X射线衍射(XRD)、差示扫描量热分析(DSC)考察了PEEK的结晶行为，并测定了复合材料的熔点、结晶温度和玻璃化转变温度。结果表明：Ekonol含量的大小对PEEK的结晶行为产生了直接影响，PEEK的相对结晶度随着Ekonol含量的增加而提高；Ekonol含量小于30％时，对复合材料的熔点、结晶温度和玻璃化转变温度影响不大，但含量大于30％时，材料的结晶温度、熔融温度下降，玻璃化转变温度提高。     

Tribological properties of micron silicon carbide filled poly(ether ether ketone)

The composite of poly(ether ether ketone) (PEEK) filled with micron silicon carbide (SiC) with different filler proportions was prepared by compression molding. The friction and wear properties of the composite were investigated at ambient conditions on a block on ring machine by running a plain carbon steel (AISI 1045 steel) ring against the composite block. The morphologies of the worn composite surfaces and the transfer film on the counterpart steel ring were examined with scanning electron microscopy and electron probe microanalysis. The results showed that the friction and wear of PEEK was slightly reduced at a filler proportion of micron SiC of 2.5–5.0 wt %. Abrasive wear was dominant for the PEEK composite; this was especially so at higher filler proportion. Meanwhile, abrasion and transfer to the composite surface of the counterpart steel ring were also observed. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 2611–2615, 1999     

聚醚醚酮共混改性研究进展

综述了聚醚醚酮（PEEK）、聚醚酰亚胺（PEI）、聚四氟乙烯（PTFE）、热致液晶（TLCP）和聚醚砜（PES）等高性能工程塑料的共混改性研究进展,详细探讨了各种PEEK共混物的相容性、结晶行为、微观结构、热行为和力学性能等性能特征。PEEK与PEI在熔融和无定形状态下完全相容,常用于PEEK的结晶行为和微观结构的基础研究;与PTFE、TLCP、PES共混分别是提高PEEK的摩擦磨损性能、加工性能和热稳定性的有效手段。各种共混物的相容性好坏对其结晶行为和微观结构有重要影响,从而影响了共混物的力学性能。在此基础上,对PEEK共混改性领域进一步的研究方向和内容进行了讨论。     

Action of transfer film in improving friction and wear behaviors of iron‐ and copper‐filled poly(ether ether ketone) composites

The composites of poly(ether ether ketone) (PEEK) filled with micrometer‐sized Cu and Fe particles were prepared by compression molding. The friction and wear behaviors of the composites were examined on a pin‐on‐disc friction‐and‐wear tester by sliding PEEK‐based composites against tool steel at a sliding speed of 1.0 m s⁻¹ and a normal load of 19.6N. Optical microscopic analysis of the transfer film and of the worn pin surfaces and wear debris was performed to investigate the wear mechanisms of the composites. It was found that Cu and Fe used as filler considerably decreased the wear rate of PEEK. A thin, uniform, and tenacious transfer film was formed when Cu was used as the filler, and a nonuniform and thick transfer film was formed when Fe was used as the filler. The transfer film played a key role in increasing the wear resistance of the PEEK composites. Plastic deformation was dominant for wear of PEEK–Cu, while abrasion and adhesion were dominant for wear of PEEK–Fe. Because of the strong affinity between Fe as filler and its identical counterpart in the counterface tool steel surface, the adhesion between the PEEK–Fe composite surface and the counterface tool steel surface was thus severe. This contributed to the generation of a thicker transfer film for PEEK–Fe. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 76: 179–184, 2000     

Functionalized poly(ether ether ketone): Improved mechanical property and acellular bioactivity

Poly(ether ether ketone), PEEK, was functionalized by addition of pendant functional groups, that is, acetyl, carboxylic, acyl chloride, amide, and amine groups in the benzene ring of polymer backbone without substituting the parent (ether or ketonic) functional groups of polymer to improve the mechanical and surface adhesivity with acellular inorganic biomaterials. The functional groups of virgin PEEK and functionalized PEEK were identified by Fourier transform infrared spectroscopy and ¹³C nuclear magnetic resonance. The crystallinity was studied by X‐ray diffraction and further supported by differential scanning calorimetry (DSC) analysis. Similarly, the change in glass transition temperature was confirmed by the DSC and dynamic mechanical analysis (DMA). The improved mechanical property was also evaluated by DMA. The excellent surface adhesivity and bioactivity were revealed by acellular in vitro test using simulated body fluid. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011     

Fine poly(ether ether ketone) powders

The physical form of polymers is often important for carrying out subsequent processing operations. For example, fine powders are desirable for molding and sintering compounds because they consolidate to produce void free components. The objective of this work is to prepare fine polymeric particulates suitable for processing into fiber reinforced polymer matrix composites. Micron size particles of poly(ether ether ketone) (PEEK) were prepared by rapidly quenching solutions of these materials. PEEK pellets were dissolved at temperatures near the PEEK melting point in a mixture of terphenyls and quaterphenyls; then the solution was quenched to a temperature between the T_g and T_m (≈ 225°C) by adding a room temperature eutectic mixture of diphenyl ether and biphenyl. A supersaturated, metastable solution of PEEK resulted, causing rapid nucleation. Fine PEEK particles rapidly crystallized from this solution. The average particle size was measured using transmission electron microscopy, atomic force microscopy, and by light scattering of aqueous suspensions which had been fractionated by centrifugation. The average particle diameter was about 0.6 μm. Three dimensional photomicrographs obtained via atomic force microscopy showed some aggregates in the suspensions. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 63: 1571–1578, 1997     

聚醚醚酮纤维的发展现状与应用

综述了国内外聚醚醚酮(PEEK)纤维的研究发展现状;分析了制约我国PEEK纤维发展的原因;介绍了PEEK树脂的流变性能、纺丝技术;阐述了PEEK纤维的结构、物理化学性能及应用领域;提出我国应加大PEEK原料及其纤维的研发,实现PEEK纤维国产化。