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Triggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non-exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H2O2) into the lethal reactive oxygen species (ROS) hydroxyl radicals (•OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor-specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H2O2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo-, ultrasound-, magnetic-, and other stimuli-response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti-cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial-based chemodynamic cancer therapy. In this review, the various nanomaterials-based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better-quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications. 相似文献
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Byungkuk Kim Eunsun Lee Yerang Kim Sanga Park Gilson Khang Dongwon Lee 《Advanced functional materials》2013,23(40):5091-5097
Cinnamaldehyde, a major active compound of cinnamon, is known to induce apoptotic cell death in numerous human cancer cells. Here, dual acid‐responsive polymeric micelle‐forming cinnamaldehyde prodrugs, poly[(3‐phenylprop‐2‐ene‐1,1‐diyl)bis(oxy)bis(ethane‐2,1‐diyl)diacrylate]‐co‐4,4’(trimethylene dipiperidine)‐co‐poly(ethylene glycol), termed PCAE copolymers, are reported. PCAE is designed to incorporate cinnamaldehyde via acid‐cleavable acetal linkages in its pH‐sensitive hydrophobic backbone and self assemble to form stable micelles which can encapsulate camptothecin (CPT). PCAE self assembles to form micelles which release CPT and cinnamaldehyde in pH‐dependent manners. PCAE micelles induce apoptotic cell death through the generation of intracellular reactive oxygen species (ROS) and exert synergistic anticancer effects with a payload of CPT in vitro and in vivo model of SW620 human colon tumor‐bearing mice. It is anticipated that dual acid‐sensitive micelle‐forming PCAE with intrinsic anticancer activities has enormous potential as novel anticancer therapeutics. 相似文献
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Jiusi Guo Zhenyu Xing Luchang Liu Yimin Sun Hongju Zhou Mingru Bai Xikui Liu Mohsen Adeli Chong Cheng Xianglong Han 《Advanced functional materials》2023,33(15):2211778
Exploration of efficient antioxidase-like reactive oxygen nanobiocatalysts (ROBCs) is a major challenge in combating oxidative stress-related diseases. Herein, the molecularly well-defined Ru-porphyrin-networks (Ru-Por-Net)-based ROBCs with ultrafast and reversible redox-centers for catalytic elimination of reactive oxygen species (ROS) are reported. Owing to the large π-conjugated networks, Ru–N coordination structures, and unique electronic and redox properties of atomic Ru sites, the Ru-Por-Net-based ROBCs exhibit exceptional catalytic ROS-scavenging activities. It is considerably more efficient than recently reported state-of-the-art anti-ROS biocatalysts. Notably, a new nucleophilic attack pathway to eliminate H2O2 and produce O2 is proposed via theoretical calculations, and the desorption of the OO* process is identified as the rate-determining step of atomic Ru centers. Cellular studies reveal that the new ROBCs can efficiently secure the survival, adhesion, spreading, and differentiation of the stem cells in high-ROS-level microenvironments. In vivo rat periodontitis treatments further demonstrate their superior anti-ROS therapeutic effects. This study provides significant insights into the crucial functions of Ru–N coordinated porphyrin-networks in catalytic ROS-scavenging and offers a new strategy to engineer high-performance antioxidase-like nanobiocatalysts for stem cell-based therapies and inflammatory diseases. 相似文献
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Ling Li Lijian Cao Xi Xiang Xizheng Wu Lang Ma Fan Chen Sujiao Cao Chong Cheng Dawei Deng Li Qiu 《Advanced functional materials》2022,32(1):2107530
The extensive research into developing new nanomedicines during the past few years has witnessed significant progress in diverse biomedical fields, especially for combating drug resistance in antitumor and antibacterial therapies. Recently, transition-metal-based enzymatic nanoagents (TM-EnzNAs) with catalytic production of reactive oxygen species (ROS) have been designed and intensively explored, which have become powerful nanoplatforms and exciting research frontiers in constructing next-generation nanotherapeutics to combat drug-resistant tumors and bacteria. Here, the focus is on the recent design, fundamental principles, and material chemistries in developing and applications of TM-EnzNAs. At first, the different ROS-producing mechanisms and the key factors to enhance ROS level are carefully concluded, and the analytic methods are systematically summarized. Then, the rationally engineered TM-EnzNAs via different synthetic approaches with high ROS producing efficiencies are comprehensively discussed, especially the catalytic activities, mechanisms, and structure–function relationships. After that, the representative applications of these ROS-catalytic TM-EnzNAs for antitumor and bacterial eradication are summarized in detail. Finally, the primary challenges and future perspectives have also been outlined. It is anticipated new therapeutic insights into combating drug-resistant tumors and bacteria will be provided, and significant new inspiration for designing future enzymatic nanoagents is offered. 相似文献
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Huiyuan Wang Qianqian Guo Yifan Jiang Ergang Liu Yongxing Zhao Huixin Wang Yaping Li Yongzhuo Huang 《Advanced functional materials》2013,23(48):6068-6075
The tetra‐peptide AVPI, derived from the Smac/DIABLO N‐terminal epitope, is able to trigger caspase activation and apoptotic process. However, its clinical value is greatly hampered by the nature of membrane‐impermeability. Herein, the cell‐penetrating chimeric apoptotic peptide of AVPIR8 is synthesized, of which the apoptosis‐induced AVPI is strategically blended with the cell‐penetrating sequence of octaarginine (R8). The dual‐functionalized AVPIR8 is not only potent in inducing apoptosis in tumor cells due to the cell penetration ability, but also is able to work as gene carrier for transfering the tumor suppressor p53 DNA into cells, thus constructing a co‐delivery drug system (AVPIR8/p53). Such system efficiently promotes apoptosis in cancer cells while sparing normal cells, and its antitumor activity is further significantly enhanced in combination with doxorubicin as cocktail therapy. More importantly, the anticancer efficacy of the cocktail is demonstrated to be able to arrest tumor growth in two animal tumor models (melanoma and cervical cancers), respectively. The chemotherapeutic dose in the AVPIR8/p53‐based cocktail is significantly reduced by 80%, compared to the monotherapy of doxorubicin. The present results show the promise of the co‐delivered AVPIR8/p53 as adjuvant therapy for boosting the conventional chemotherapeutics, with a unique benefit of enhanced productive treatment outcomes yet greatly reduced adverse toxicity. 相似文献
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Cell encapsulation within hydrogel droplets is transforming what is feasible in multiple fields of biomedical science such as tissue engineering and regenerative medicine, in vitro modeling, and cell-based therapies. Recent advances have allowed researchers to miniaturize material encapsulation complexes down to single-cell scales, where each complex, termed a single-cell microgel, contains only one cell surrounded by a hydrogel matrix while remaining <100 μm in size. With this achievement, studies requiring single-cell resolution are now possible, similar to those done using liquid droplet encapsulation. Of particular note, applications involving long-term in vitro cultures, modular bioinks, high-throughput screenings, and formation of 3D cellular microenvironments can be tuned independently to suit the needs of individual cells and experimental goals. In this progress report, an overview of established materials and techniques used to fabricate single-cell microgels, as well as insight into potential alternatives is provided. This focused review is concluded by discussing applications that have already benefited from single-cell microgel technologies, as well as prospective applications on the cusp of achieving important new capabilities. 相似文献
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以铁基合金粉和铝粉为原料,采用激光熔覆反应合成工艺在低碳钢基体表面制备Fe-Al合金覆层.利用扫描电镜、能谱仪、透射电镜以及X射线衍射实验方法等对熔覆合金层以及与钢基体的结合界面等进行了显微组织与相结构的分析.结果表明:采用激光熔覆反应合成Fe-Al合金工艺在1.5～2.1kW的熔覆功率范围内获得了与基体之间良好冶金结合的Fe-Al合金覆层,覆层组织致密,含少量孤立微孔隙,但无裂纹缺陷;Fe-Al覆层组织主要为细密、均匀的树枝晶,树枝主晶是固溶有一定量Cr、Ni、Si,化学成分满足Fe_3Al中Fe与Al原子配比范围的α-Fe固溶体,其中各元素的原子比Fe∶Al∶Ni∶Cr∶Si大约为55∶24∶8∶8∶5. 相似文献
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Optical waveguides in silica-on-silicon are one of the key elements in optical communications.The processes of deep etching silica waveguides using resist and metal masks in RIE plasma are investigated.The etching responses,including etching rate and selectivity as functions of variation of parameters,are modeled with a 3D neural network.A novel resist/metal combined mask that can overcome the single-layer masks’ limitations is developed for enhancing the waveguides deep etching and low-loss optical waveguides are fabricated at last. 相似文献
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本文报道了水热反应条件对BaTiO3纳米晶形成的影响,尤其是其原子尺度的表面结构。研究结果表明,Ba/Ti摩尔比较大的前驱体溶液中,易获得立方状大尺寸（～260nm）的BaTiO3纳米晶体;而采用乙二醇作为水热反应介质,可获得小尺寸弱圉聚的BaTiO3纳米晶（与纯水溶液或水-乙二醇的混合液相比较）。立方状或长方体状的BaTiO3纳米晶外表面被{100}晶面所包围,{110}晶面条纹与纳米晶体的边界相交呈45°角。在粗糙的BaTiO3纳米晶表面,常可观察到台面台阶扭折（terrace—ledge—kink）的表面结构,台面（terrace）和台阶（1edge）位于{100}晶面。由于表面结构的重构,{110}晶面通常被分解成由许多小的{100}晶面相连接而成的扭折结构。而在球状的BaTiO3纳米晶边缘,没有观察到表面台阶结构。 相似文献
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Qing Wang Wei Wang Xiaole Peng Gaoran Ge Wenhao Li Chen Zhu Xu Chen Shun Guo Ning Li Huilin Yang Yaozeng Xu Jiaxiang Bai Guoqing Pan Dechun Geng 《Advanced functional materials》2024,34(41):2406503
Intracellular oligonucleotide delivery possesses unparalleled potential for precise regulation of pathogenic gene expression and alteration of cell destiny. However, limited by its feeble resistance against humoral environment, hindered intracellular transportation, and lysosomal phagocytosis, oligonucleotide therapy remains a formidable challenge. The discovery of cationic peptides has provided innovative insights for the effective delivery of oligonucleotides, yet the stable, efficient, and convenient assembly of peptides and oligonucleotides remains an elusive goal, referred to as the “Holy Grail” challenge in the field. Addressing this challenge, it has pioneered the development of a straightforward and highly efficient engineering carrier-free covalent peptide-oligonucleotide nano-conjugates (PONs) through a mild click reaction. Notably, this PONs can realize self-assemble into nanoparticles under amphiphilic electrostatic interactions, which exhibits significant RNase resistance and surprisingly effective intracellular oligonucleotide delivery as well as lysosomal escape. Based on this strategy, a PONs named CPP-(DOPA)6-miRNA-223 is synthesized, which demonstrates rapid and effective cellular uptake, swift lysosomal escape in macrophage, remarkable accumulation in inflammatory regions and excellent therapeutic effect in an inflammatory arthritis model. Therefore, this work may provide a breakthrough for the clinical application of all oligonucleotide delivery therapies and expanding the applications in gene therapy. 相似文献
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Shengming Wu Peng Wang Jingwen Qin Yanbai Pei Yilong Wang 《Advanced functional materials》2021,31(31):2102160
Although inspiring progress has been achieved in tumor nanocatalytic therapies based on tailor-made nanozymes for converting hydrogen peroxide into reactive oxygen species (ROS) efficiently, most cytotoxic hydroxyl radicals do not spread far enough within a cell to damage the primary organelles for effective tumor therapy due to their short half-life time (≈1 µs). Developing a novel nanocatalyst platform involving longer half-life time ROS is desired. To this end, Fe3O4-Schwertmannite nanocomposites (Fe3O4-Sch) with triple-effect tumor therapy are constructed through a facile method. The Schwertmannite shell converts the •OH produced by Fe3O4 via the Fenton reaction into sulfate radicals with a longer half-life time (30 µs). Combination of dual radicals exhibits overwhelming tumor inhibition efficacy. The nanocomposites also show the multifunctionality of good photothermal efficiency (33.2%) and synergistic oxidative stress amplification upon glutathione biosynthesis (GSH) depletion by the l -buthionine sulfoximine (BSO) molecules loaded in the hollow Fe3O4 cores. The comprehensive properties of the nanoplatform including the dual-radical production, Fe3O4 nanocrystal mediated PTT, and the BSO mediated GSH depletion result in remarkable tumor inhibition both in vitro and in vivo, which may pave a way to constructing a synergic catalytic nanoplatform for efficient tumor therapy. 相似文献
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用于LCD的氧化铝阻挡层的射频反应溅射沉积及其特性 总被引：6，自引：0，他引：6
用金属铝靶射频反应溅射制备了Ａｌ２Ｏ３薄膜，用作ＬＣＤ基片玻璃的钠离子阻挡层。报道了射频溅射参数对薄膜沉积速率和折射率的影响。测试结果表明，所沉积的Ａｌ２Ｏ３薄膜满足ＬＣＤ器件阻挡层的要求。 相似文献
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An effective generation of reactive oxygen species (ROS) is of interest from the perspective of environmental technology and industrial chemistry, and here piezocatalysis and photocatalysis using heterostructures based on iodide-doped BiVO4/BaTiO3 with photodeposited Ag or Cu nanoparticles (BiVO4:I/BTO-Ag or BiVO4:I/BTO-Cu) is studied. The generation rates of •OH and •O2− radicals over BiVO4:I/BTO-Ag during piezophotocatalysis are 371 and 292 µmol g−1 h−1, respectively, and significantly higher than those of sole piezocatalysis and photocatalysis. These rates are among the highest reported for the production of free radicals with the piezophototronic effect. Among the catalysts, BiVO4:I/BTO shows the highest reactivity for the production of H2O2 in piezocatalysis (with a concentration of 468 µm after 100 min of irradiation, and still constantly increasing). On BiVO4:I/BTO-Ag and BiVO4:I/BTO-Cu, it seems that redundant electrons and holes had reacted effectively with the generated H2O2 and in turn had reduced their activities; however, the amounts of H2O2 that are formed on BiVO4:I/BTO-Ag or BiVO4:I/BTO-Cu under piezophotocatalysis are superior to those of individual piezocatalysis and photocatalysis. A piezophototronic coupling via an ultrasound-mediated and piezoelectric-based polarization field and photoexcitation accounting for the enhanced photocatalytic activity of the iodine-doped heterostructures with plasmonically sized Ag or Cu nanoparticles is suggested. 相似文献
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Hua Gong Liang Cheng Jian Xiang Huan Xu Liangzhu Feng Xiaoze Shi Zhuang Liu 《Advanced functional materials》2013,23(48):6059-6067
Poly(3,4‐ethylenedioxythiophene):poly(4‐styrenesulfonate) (PEDOT:PSS) nanoparticles, after being coated with polyethylene glycol (PEG), are used as a drug carrier to load various types of aromatic therapeutic molecules, including chemotherapy drugs doxorubicin (DOX) and SN38, as well as a photodynamic agent chlorin e6 (Ce6), through π–π stacking and hydrophobic interaction. Interesting functionalities of PEDOT:PSS‐PEG as an unique versatile drug delivery platform are discovered. Firstly, for water‐insoluble drugs such as SN38, the loading on PEDOT:PSS‐PEG dramatically enhances its water solubility, while maintaining its cytotoxicity to cancer cells. Secondly, the delivery of Ce6 by PEDOT:PSS‐PEG is able to remarkably accelerate the cellular uptake of Ce6 molecules, and thus offers improved photodynamic therapeutic efficacy. Using DOX‐loaded PEDOT:PSS‐PEG as the model system, it is demonstrated that the photothermal effect of PEDOT:PSS‐PEG can be utilized to promote the delivery of this chemotherapeutic agent, achieving a combined photothermal‐ and chemotherapy with an obvious synergistic cancer killing effect. Moreover, it is also shown that multiple types of therapeutic agents could be simultaneously loaded on PEDOT:PSS‐PEG nanoparticles and delivered into cancer cells. This work highlights the great potential of NIR‐absorbing polymeric nanoparticles as multifunctional drug carriers for potential cancer combination therapy with high efficacy. 相似文献
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利用激光微束穿刺法获得抗黄萎病转基因棉花的研究 总被引：14，自引：0，他引：14
通过激光微束穿刺法 ,将 β 1,3 葡聚糖酶及几丁质酶基因双价植物表达载体 pBLGC导入棉花幼胚。转化一代棉花幼苗用蘸根法进行抗黄萎病筛选 ,将存活的苗移入病圃进行了卡那霉素(Kan 1% )抗性测定。结果表明 ,在移栽的 2 9株幼苗中 ,有 9株表现出明显的Kan抗性 ,对 9株抗Kan植株进行了PCR检测 ,结果显示 ,其中 7株表现为阳性。病圃中的T1代转基因植株在经历了黄萎病发病高峰期后 ,7株PCR阳性植株表现明显抗病 ,并已正常开花结铃 ,其他T1代植株及对照植株全部因后期发病死亡。这初步证明外源基因已整合到棉花基因组中 ,且使转基因植株对黄萎病表现出一定的抗性。 相似文献