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1.
马言顺  吴珊  刘文乐  张景  周湘富 《应用化工》2013,(1):171-172,175
以二乙烯基苯(DVB-55)和二缩三乙二醇二甲基丙烯酸酯(TGD)为共聚单体,以乙腈为溶剂,采用沉淀聚合法一步合成了聚(二乙烯基苯-co-二缩三乙二醇二甲基丙烯酸酯)[P(DVB-co-TGD)]微球。采用反相液相色谱模式考察了微球的色谱性能。结果表明,共聚微球表面无大孔,单分散微球数均粒径为3.5μm,比表面积为2.9 m2/g,用作固定相具有较高的柱效,碱性物质具有对称的色谱峰形。  相似文献   

2.
吴珊  胡锐  马言顺  陈璐  杨了 《化学工程师》2013,27(2):15-17,20
以二乙烯基苯(DVB)为交联剂、苯乙烯(ST)为共聚单体,采用沉淀聚合法合成了聚(苯乙烯-co-二乙烯基苯)微球[P(ST-co-DVB)]。扫描电子显微镜分析(SEM)显示微球表面无大孔结构,粒径统计分析表明粒径单分散微球的平均直径为3.2μm,FT-IR表明两种单体实现了共聚。BET分析可知比表面积为2.7m2.g-1,平均孔径为10.0nm。以碱性化合物为探针分子,采用反相液相色谱模式考察了P(ST-co-DVB)微球的色谱性能,色谱结果显示固定相具有较高的柱效和较好的色谱峰形,表明沉淀聚合法用作固定相具有较好前景。  相似文献   

3.
沉淀聚合法制备咖啡因分子印迹聚合物微球   总被引:7,自引:0,他引:7  
姚伟  高志贤  房彦军  程义勇 《化工进展》2007,26(6):869-872,877
以咖啡因为印迹分子,甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸酯为交联剂,偶氮二异丁腈为引发剂,采用沉淀聚合法在乙腈溶液中制备了针对咖啡因的分子印迹聚合物微球。对沉淀聚合中单体、引发剂、溶剂用量的比例关系进行探索,并利用平衡结合实验研究了聚合物对印迹分子的吸附性能,结果表明该印迹聚合物微球呈现出较好的结合能力。  相似文献   

4.
以二乙烯基苯为单体,采用微孔膜乳化法制备了尺寸均一的水包油乳液,在75℃下悬浮聚合20 h,制得均一的聚二乙烯基苯微球填料,粒径为14.2μm,粒径分布系数Rspan=0.71,孔径为65 nm,比表面积为160 m2/g.通过高压匀浆法将合成的微球介质高效装填不锈钢液相色谱柱(ψ4.6 mm×250 mm),使柱效达11000塔板数.利用装填的色谱柱进行多肽药物奥曲肽的分离纯化,奥曲肽从固相合成粗品中快速有效分离,纯度由42.89%提高到99.99%.  相似文献   

5.
胆固醇分子印迹聚合微球的制备及其吸附性能   总被引:1,自引:0,他引:1  
以胆固醇为模板分子、甲基丙烯酸为功能单体、乙二醇二甲基丙烯酸酯为交联剂,在甲苯-乙腈(9:1, j)混合溶剂中沉淀聚合制备了分子印迹聚合物微球. 采用平衡结合法和Scatchard模型评价了该聚合微球的结合性,考察了其吸附行为. 结果表明,胆固醇分子印迹聚合微球中形成两类不同的结合位点,得到高亲和性结合位点的离解常数和最大表观吸附量分别为0.86 mmol/L和80.4 mmol/g,低亲和性结合位点解离常数和最大表观吸附量分别为0.39 mmol/L和61.6 mmol/g. 此方法合成的分子印迹微球对胆固醇有较好的结合性能,可用于胆固醇的分析检测.  相似文献   

6.
以甲基丙烯酸为单体、二乙烯基苯为交联剂、苯胺为模板分子,利用沉淀聚合法通过改变溶剂等条件制备了单分散苯胺分子印迹聚合物微球。通过扫描电子显微镜表征微球表面形貌幵测量微球尺寸,通过纳米粒度分析仪验证微球单分散性。经气相色谱表征,该分子印迹聚合物对苯胺最大静态吸附量为12.98 mg/g,具备对苯胺分子的特异性识别能力。  相似文献   

7.
以亚甲基蓝为模板分子,丙烯酰胺为功能单体,乙二醇二甲基丙烯酸酯(EGDMA)为交联剂,偶氮二异丁腈(AIBN)为引发剂,采用沉淀聚合法制备了亚甲基蓝分子印迹聚合物微球(MIP)。用扫描电镜表征了MIP的形貌,结果显示制备的MIP的粒径为1~3μm,粒径较为均匀。考察了MIP对亚甲基蓝的吸附性能,结果表明其吸附动力学过程可以用假二级吸附速率方程来描述,MIP对亚甲基蓝的最大吸附量为27.1 mg/g,吸附效果较好,可以用于染料废水中亚甲基蓝的分离富集。  相似文献   

8.
以香草醛(VAN)为模板分子,?-甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯(EGDMA)为交联剂,二甲基亚砜(DMSO)为溶剂,采用沉淀聚合法合成了香草醛分子印迹聚合物微球(MIPMs)。通过紫外光谱(UV)、傅里叶变换红外光谱仪(FT-IR)研究了模板分子与功能单体之间的相互作用和最佳配比,利用透射电子显微镜考察了聚合物微球的微观形貌;结合膜技术的优点,进一步制备了香草醛分子印迹共混膜,通过扫描电子显微镜(SEM)考察了共混膜的形态特征,并研究了分子印迹共混膜的结合性能及选择性透过能力。结果表明,MAA与VAN之间通过氢键相互作用,分子印迹共混膜对模板分子香草醛表现出高度识别性。  相似文献   

9.
宋子凡  韦俊  付曹飞  李翔  常振旗 《精细化工》2014,31(9):1057-1060
设计构建了可拆装的毛细管基微流体控制系统用于制备具有高度单分散性(CV值为3.78%)的苯乙烯(St)/二乙烯基苯(DVB)/三缩丙二醇双丙烯酸酯(TPGDA)多孔共聚物微球。所制备的单分散性多孔微球在直径250~1 550μm内通过调控分散相与连续相流量比及连续相黏度实现粒径精准可控。采用光引发聚合实现具有优良球形度微球(Max.D./Min.D.小于1.05)的快速在线制备,光引发聚合速率随着TPGDA在混合单体中质量的增加而增加。该研究提供了一种有效制备单分散性大粒径聚苯乙烯类多孔微球方法。  相似文献   

10.
以蒸馏沉淀聚合法合成了单分散的光、温度双响应中空微球:以3-(甲基丙烯酰氧)丙基三甲氧基硅烷(MPS)表面改性的Si O2球为模板、温度响应的N-异丙基丙烯酰胺(NIPAM)为单体、光响应的对二甲基丙烯酰胺偶氮苯(BMAAB)为交联剂,加入少量二乙烯基苯(DVB)助交联剂,并以偶氮二异丁腈(AIBN)为引发剂,合成以二氧化硅为核,壳层为偶氮苯交联的PNIPAM核壳微纳米粒子。再利用氢氟酸选择性刻蚀除去SiO_2内核形成具有中空结构的光/温敏的PNIPAM聚合物微球。PNIPAM中空微球具有最低的低互溶临界温度(LCST),约为32℃。使用TEM、FT-IR等手段对得到的聚合物微球的组成和结构进行了表征。接着,将荧光物质罗丹明B分子成功载入了中空微球,并验证了其光和温度的双重控制释放行为。结果表明采用蒸馏沉淀聚合法成功制备单分散的聚N-异丙基丙烯酰胺中空微球,该微球具有优异的光/温度双重控制释放行为。  相似文献   

11.
以亚甲基蓝为模板分子,丙烯酰胺为功能单体,乙二醇二甲基丙烯酸酯(EGDMA)为交联剂,偶氮二异丁腈(AIBN)为引发剂.采用沉淀聚合法制备了亚甲基蓝分子印迹聚合物微球(MIP)。用扫描电镜表征了MIP的形貌,结果显示制备的MIP的粒径为1~3μm,粒径较为均匀。考察了MIP对亚甲基蓝的吸附性能,结果表明其吸附动力学过程可以用假二级吸附速率方程来描述,MIP对亚甲基蓝的最大吸附量为27.1mg/g,吸附效果较好,可以用于染料废水中亚甲基蓝的分离富集。  相似文献   

12.
Myong-Goo Lee 《Polymer》2002,43(15):4307-4309
A conductive monodisperse microspheres consisting of poly(ethylene glycol)dimethacrylate and methyloxycarbonyl-bicyclo[2.2.1]hepta-2,5-diene was synthesized by radiation induced polymerization. Ionic conductivity and relative dielectric constant were found to be greatly dependent on the content of poly(ethylene glycol)methacrylate in the copolymer. The diameter of the microspheres was 0.48-0.86 μm, in which the irradiation was carried out without stabilizer at a dose rate of 20 kGy/h with 60Co γ-ray.  相似文献   

13.
介绍了一种以大孔高比表面积甲基丙烯酸缩水甘油酯(GMA)与二甲基丙烯酸乙二醇酯(EGDMA)共聚交联微球[P(GMA-co-EGDMA)]为模板制备磁性复合微球的简单方法。制备过程包括Fe3+和Fe2+的浸入、OH-作用下孔内铁离子的共沉淀两步。在此过程中考察了浸泡温度、浸泡时间、共沉淀温度以及沉积次数对微球磁含量的影响,确定最佳制备工艺为50℃浸泡4 h,70℃反应1 h,如此反复4次磁含量可以达到45.24%。并通过SEM、VSM、XRD、TGA及压汞仪、激光粒度仪等手段对Fe3O4/P(GMA-co-EGDMA)的形貌、比饱和磁化强度、磁含量及孔性能进行了表征,微球的粒径范围处于100~200 μm之间,平均粒径为162 μm,比饱和磁化强度为10.92 emu·g-1,平均孔径及比表面积分别为60 nm和116 m2·g-1。  相似文献   

14.
A novel method for the separation of berberine hydrochloride has been developed. Berberine hydrochloride molecularly imprinted polymers were prepared by suspension polymerization in the aqueous phase using berberine hydrochloride as the template, methyl acrylic acid as a functional monomer, and ethylene glycol maleic rosinate acrylate (which contains a phenanthrene ring skeleton) and ethylene glycol dimethacrylate as combinatorial crosslinkers. The imprinted polymers were successfully used as a selective stationary phase in high‐performance liquid chromatography. Separation performance of the chromatographic column was determined from the selectivity (evaluated by separation factor) and sorption selectivity (evaluated by imprinting factor) of the molecularly imprinted and non‐imprinted polymers towards the template. The optimum conditions to maximize separation and imprinting factors were investigated. Acetic acid–methanol solution (0.05% v/v) was selected as the optimum mobile phase, while 0.2 mL min?1 was chosen as the optimized flow rate for selective separation of berberine hydrochloride. The highest imprinting and separation factors obtained were 1.924 and 18.52, respectively. Simultaneously, the chromatographic column backpressure was stable and showed good permeability. The chromatographic column was used to separate effectively template molecules from coptis root extract and other analogues. Such chromatographic columns with high selectivity can be used to selectively separate berberine hydrochloride from other compounds. © 2014 Society of Chemical Industry  相似文献   

15.
环氧基多孔磁性复合微球的制备及性质   总被引:1,自引:0,他引:1  
以聚醚为致孔剂,通过悬浮聚合法制备了表面带有环氧基的多孔磁性复合微球。用红外光谱(FTIR)、扫描电子显微镜(SEM)、磁强计(VSM)、压汞法等对其进行了表征,考察了分散剂质量分数对多孔磁性微球性能的影响。结果表明,该微球粒径为35~50μm,表面有不规则孔道,w(Fe3O4)≈15.8%,饱和磁化强度8.98 emu/g。水相中w(PVA)由1.5%升至3%时,微球平均粒径由130μm变为40μm,而平均孔径亦由144 nm降为39 nm。  相似文献   

16.
A new kind of molecularly imprinted polymer (MIP) microspheres for the selective extraction of kaempferol was prepared by precipitation polymerization using 4-vinylpridine (4-VP) and ethylene glycol dimethacrylate (EDMA) as functional monomer and cross-linker respectively. The synthesis conditions, such as ratios of 4-VP/EDMA and polymerization time were discussed in detail. Results showed that the 2% was the optimal concentration of co-monomers to obtain monodisperse MIP microspheres, the best ratio of 4-VP/EDMA was 1:2, and 24 h was considered as the proper polymerization time. Compared with the MIP agglomeration or coagulum particles, monodisperse MIP microspheres showed the better adsorption capacity: the saturated adsorption capacity of monodisperse MIP microspheres was 7.47 mg g?1, the adsorption equilibrium could be obtained in 30 min. Finally, the adsorption performances of the optimal MIP microspheres were evaluated by kinetic adsorption, adsorption isotherm, and selective adsorption experiments, which indicated that the adsorption mechanism were chemical single layer adsorption and the separation factor was up to 3.91 by comparing with the structure similar compound (quercetin). The MIP microspheres exhibit prospects in the kaempferol efficient and selective separation.  相似文献   

17.
Novel crosslinked hydrophobic lauryl acrylate-styrene-ethylene glycol dimethacrylate copolymer particles were synthesized with heterogeneous structures by radical suspension copolymerization with benzoyl peroxide as the initiator. Ethylene glycol dimethacrylate was used as a crosslinking agent; toluene, cyclohexanol, 1-octanol and liquid paraffin were used as porogens. The effects of the crosslinking monomer and porogens on the morphologies of the copolymer microspheres were investigated. The copolymers were characterized by FTIR, SEM and swelling in toluene. Permanent pores remained in the dried polymeric particles prepared with nonsolvating porogens at certain crosslink densities as indicated by SEM pictures. The results of swelling revealed that 1-octanol was the most effective porogen, leading to the LA-S-EGDMA copolymer particles with maximum porosity and optimized spheric morphology. Furthermore, lower crosslink density and higher porogen contents promote the formation of porous morphology.  相似文献   

18.
Narrowdisperse poly(divinylbenzene‐coN‐isopropylacrylamide) (poly(DVB‐co‐NIPAM)) functional microspheres with the diameter in the range of 630 nm and 2.58 μm were prepared by distillation–precipitation polymerization in neat acetonitrile in the absence of any stabilizer. The effect of N‐isopropylacrylamide (NIPAM) ratio in the comonomer feed on the morphology of the resultant polymer particles was investigated in detail with divinylbenzene (DVB) as crosslinker and 2,2′‐azobisisobutyronitrile (AIBN) as initiator. The monodisperse poly(DVB‐co‐NIPAM) microspheres with NIPAM fraction of 20 wt % were selected for the preparation of raspberry‐like core‐corona polymer composite by the hydrogen‐bonding self‐assembly heterocoagulation with poly(ethyleneglycol dimethacrylate‐co‐acrylic acid) [poly(EGDMA‐co‐AA)] nanospheres. Both of the functional poly(DVB‐co‐NIPAM) microspheres and the core‐corona particles were characterized with scanning electron microscopy (SEM), Fourier transform infrared spectra (FTIR), and elemental analysis (EA). © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 1350–1357, 2007  相似文献   

19.
药物载体淀粉微球的制备及表征   总被引:13,自引:0,他引:13  
选用V(环己烷)∶V(三氯甲烷)=4∶1构成混合油相,淀粉水溶液为水相,m(Span 60)∶m(Tween 60)=3∶2复配为乳化剂,N,N′-亚甲基双丙烯酰胺为预交联剂,环氧氯丙烷为交联剂,采用反相乳液聚合方法制备了淀粉微球;用粒度分析仪、扫描电镜、红外光谱等对产物进行了表征。结果表明,淀粉微球平均粒径为14.7μm,83%分布在6~30μm,球形圆整,表面光滑致密,可作为良好的药物载体和吸附剂。通过单因素实验和正交设计实验考察了制备条件对微球理化性质的影响,推导出平均粒径与主要影响因素之间的多项回归方程,以期通过优化工艺条件实现对微球制备的预测和控制。  相似文献   

20.
Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model, cholesteryl (4‐vinyl)phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as crosslinker. The base‐labile carbonate ester bond was easily hydrolyzed to leave imprinted cavities in the resulting polymers. Radioligand binding analysis, elemental analysis, and scanning electron microscopy were used to characterize the imprinted materials. Imprinted microspheres prepared from DVB crosslinker had larger and more defined spherical shape, and displayed better imprinting effect than did the EDMA‐based microparticles. For comparison, imprinted bulk polymers were also prepared in the same reaction solvent as that used in precipitation polymerization. Elemental analysis results indicated that imprinted microspheres contained more template monomer units than bulk materials. The efficiency of template removal by hydrolysis treatment for microspheres was also higher than that for bulk polymers. For DVB‐based polymers, imprinted microspheres displayed higher specific cholesterol uptake than did the corresponding bulk polymer. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 1390–1398, 2006  相似文献   

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