卟啉及其类似化合物的应用

简要介绍了近年来卟啉及其类似化合物在医学、生物化学、材料科学、分析化学等领域的最新研究与应用。     

卟啉及其衍生物的合成研究进展

卟啉及其金属配合物由于其结构的易修饰性和性质的可调控性成为常用的超分子骨架。从卟啉环合方法和卟啉取代基修饰两个方面综述了卟啉及其衍生物的合成研究进展;以卟啉经典合成方法为基础,介绍了各类复杂结构卟啉的合成条件及适用范围。     

欧盟禁用或限制含金属染料的新情况与新型取代染料的开发

该文阐述了欧盟发布的禁用和限制含金属染料和新情况,介绍了取代禁用和限制含金属染料的新型染料.     

Phototoxic Activity and DNA Interactions of Water‐Soluble Porphyrins and Their Rhenium(I) Conjugates

In the search for alternative photosensitizers for use in photodynamic therapy (PDT), herein we describe two new water‐soluble porphyrins, a neutral fourfold‐symmetric compound and a +3‐charged tris‐methylpyridinium derivative, in which either four or one [1,4,7]‐triazacyclononane (TACN) units are connected to the porphyrin macrocycle through a hydrophilic linker; we also report their corresponding tetracationic Re^I conjugates. The in vitro (photo)toxic effects of the compounds toward the human cell lines HeLa (cervical cancer), H460M2 (non‐small‐cell lung carcinoma), and HBL‐100 (non‐tumorigenic epithelial cells) are reported. Three of the compounds are not cytotoxic in the dark up to 100 μm , and the fourfold‐symmetric couple revealed very good phototoxic indexes (PIs). The intracellular localization of all derivatives was studied in HeLa cells by confocal fluorescence microscopy. Although low nuclear localization was observed for some of them, it still prompted us to investigate their capacity to bind both quadruplex and duplex DNA; we observed significant selectivity in the tris‐methylpyridinium derivatives for G‐quadruplex interactions.     

Porphyrins and metalloporphyrins: potential hypoxic agents

Synthetic water-soluble porphyrins and their metalloporphyrin derivatives with Co(III), Cu(II), Ru(II) and Pt(II), containing various functional groups within the meso-positions of the porphyrin, were synthesised and evaluated as hypoxic agents, especially as cytotoxins and radiosensitisers. Cobalt complexes of the porphyrins containing positively charged methylpyridinium groups showed selective toxicity toward hypoxic Chinese Hamster Ovary (CHO) cells. The Co(III) complexes of the cationic and the anionic porphyrins are all weak radiosensitisers toward hypoxic cells, the highest sensitisation enhancement ratio (SER = 1.22, at 50 muM) being with a porphyrin complex containing a cis-arrangement of two nitro and two methylpyridinium meso-substituents. A copper complex of a tetracationic porphyrin showed slight radiosensitisation activity with an SER value of about 1.1. The other metalloporphyrins showed no hypoxic selectivity or radiosensitisation activity. In total, over 50 porphyrin free bases have been synthesised, of which half are water-soluble and have been metallated; thus, the chemistry is now in place for further development of water-soluble hypoxic agents.     

Porphyrins of Sakhalin crude oils

• 1.1. The quantitative distribution and the composition of porphyrins in North Sakhalin crude oil were examined. The concentration of vanadylporphyrins was shown to decrease and the content of nickel complexes in crude oils was shown to increase in southerly and westerly directions.
• 2.2. All the crude oil examined had similar vanadylporphyrin structural-group composition.
• 3.3. Sakhalin crude oils differ from those in Western Ekhabi in the relative content of porphyrin isomers most likely to be retained in ivnerted-phase chromatography (molar mass values 487, 501 and 515).

     

卟啉化学简介

本文较全面扼要地介绍了卟啉、金属卟啉的天然存在、结构、性质、合成、波谱等，并简述了它们在化学、生物学、医药等方面的应用现状     

卟啉化合物的合成

卟啉化合物广泛存在于自然界中和生命体中,对生命活动起着重要作用,卟啉化合物因其特殊的结构和生物活性,应用前景广阔。本文主要介绍卟啉化合物的合成方法,根据所采用起始反应物的不同,将卟啉的合成方法分为两大类：全合成法和半合成法,对两类合成方法给予较详细的介绍。     

卟啉化合物的应用与合成研究进展

卟啉化学是现代化学领域中重要的研究分支之一。概述卟啉化合物在医学、化学、生物学、材料学、能源等领域的应用;同时还介绍了卟啉化合物的合成方法。     

环糊精与卟啉键合的新型超分子

综述了环糊精与卟啉键合的新型超分子的合成及其在模拟酶催化、光电子转移、构筑多卟啉组合体等方面的应用,这对于深入了解酶催化反应、光合作用等生物过程具有重要意义。     

卟啉化合物在抗肿瘤方面的应用现状及进展

卟啉化合物的出现,在抗肿瘤方面起到了重要的作用,它可以在肿瘤前期对患者进行有效的治疗。天然的卟啉化合物,在实际的使用中,没有合成的卟啉化合物方便,加上现在的天然卟啉化合物已经不满足于现在的试验研究,所以现在也在大量的出现人工卟啉化合物。人工卟啉化合物在特性上和化学性质上和天然卟啉化合物相同,在药用方面也比天然卟啉化合物更好。     

以氢键组装的铜(Ⅱ)、锌(Ⅱ)卟啉超分子构象

考察了 5 -对 - (间羰基苯甲酸 ) -氨基苯基 - 1 0 ,1 5 ,2 0 -三苯基卟啉锌 ( )配合物 ( Zn( m-CPTPP) )、铜 ( )配合物 ( Cu( m- CPTPP) )及 ( Zn( m- CPTPP) )与 5 -对 - (对羰基苯甲酸 ) -氨基苯基 -1 0 ,1 5 ,2 0 -三苯基卟啉铜 ( ) ( Cu( p- CPTPP) )通过氢键的超分子自组装行为。上述两体系都通过氢键自组装成超分子。 Zn( m- CPTPP) - Cu( m- CPTPP)体系存在卟啉环间的π-π堆积作用     

Meso-取代卟啉及其金属配合物的合成进展

为了筛选仿生催化氧化环己烷的催化剂,通过查阅相关文献,重点概述了Meso-取代卟啉及其金属配合物的合成方法。合成卟啉的方法有Rothemund法、Adler法及其改进法、Lindsey法等,合成金属卟啉的方法有＂一步法＂和：＂两步法＂,目前,＂两步法＂被普遍使用。     

国外卟啉合成化学的研究

卟啉作为一种具有高度共轭结构的分子,国外卟啉的合成化学发展迅速.了解国外发展动态有利于国内这一方面的进一步发展.对卟啉的合成化学的研究作了文献综述.     

胡椒醛缩合卟啉化合物的合成及其光谱性能

以胡椒醛及羟基芳香醛为原料与吡咯在丙酸中回流,合成了6种卟啉化合物,其结构用1HNMR,IR,UV-V is和ESI-MS确定。与四苯基卟啉(TPP)相比,胡椒醛的引入增大了卟啉环的共轭性,使几种化合物的光学吸收波长均发生不同程度的红移,其中,Soret带最大红移11 nm;同时,胡椒醛的引入缩小了基态与激发态之间的能极差,化合物荧光发射波长发生1~5 nm的红移。     

膨体聚四氟乙烯的制备及应用

综述了膨体聚四氟乙烯（ePTFE）的几种制备方法,包括拉伸方法、成孔剂方法以及纺丝方法,详细介绍了ePTFE在化工、纺织、医学、机械与航空航天领域的应用,并对其后续的研究工作进行了展望。     

Porphyrins as Colorimetric and Photometric Biosensors in Modern Bioanalytical Systems

Advances in porphyrin chemistry have provided novel materials and exciting technologies for bioanalysis such as colorimetric sensor array (CSA), photo-electrochemical (PEC) biosensing, and nanocomposites as peroxidase mimetics for glucose detection. This review highlights selected recent advances in the construction of supramolecular assemblies based on the porphyrin macrocycle that provide recognition of various biologically important entities through the unique porphyrin properties associated with colorimetry, spectrophotometry, and photo-electrochemistry.     

Ethanolamine Production Expanded Rapidly

<正> Ethanolamine family has three members- monoethanolamine,diethanolamine andtri-ethanolamine.Monoethanolamine ismainly used in absorbing acid gases,makingantibiotics and producing syntheticdyestuffs,ethylene amine,surfactants,air refreshing agent and anti-freezingagents etc.Diethanolamine can be usedas raw material in making buffers in thepharmaceuticals industry,or as acrosslink agent in making polyurethanefoam materials.It is an important raw     

用作电子器件外壳的发泡PP制品

德国Hewlett Packard公司开发了一种专利技术,据称这种名为E-Pac的专利技术,可使PP泡沫制品(EPP)更广泛用作电子器械部件的外壳。目前购买了E-Pac专利技术的最大加工厂商是Ruch Novaplast公司,这是一家位于黑森林镇的德国塑料制品加工厂,该企业采用HewlettPackard公司的E-Pac专