白藜芦醇对兔动脉粥样硬化基质金属蛋白酶表达的影响

目的探讨白藜芦醇对实验性动脉粥样硬化兔基质金属蛋白酶(MMP)表达的影响。方法选择新西兰纯种雄性大白兔50只随机分为三组,正常对照组10只,模型组20只,白藜芦醇组20只。采用液氮冻伤术建立动脉硬化模型,造模2个月后采用液氮冻伤术激发动脉硬化斑块破裂,模后2个月及激发试验后48h后分别对三组动物测定MMP-1、9的浓度。结果模型组造模后2个月MMP-1、9的浓度分别为(50.74±5.49)ng/ml和(337.69±8.98)ng/ml,同期白藜芦醇组MMP-1、9的浓度分别为(41.33±9.58)ng/ml和(309.83±10.59)ng/ml(P<0.01),激发试验48h后模型组MMP-1、9的浓度分别为(100.35±6.58)ng/ml和(869.56±12.37)ng/ml,同期白藜芦醇组MMP-1、9的浓度分别为(61.68±11.69)ng/ml和(411.24±15.74)ng/ml(P<0.01)。结论白藜芦醇能够降低MMP-1、9的浓度,从而预防和延缓动脉硬化的发生。     

兔股骨近端骨性结构的解剖研究

目的研究兔股骨近端解剖结构及股骨头钻孔减压细胞注入的可行性。方法以20只新西兰兔为实验动物,对殴骨近端进行Micro—CT、大体测量,观察兔股骨近端骨性解剖特点。结果兔股骨近端转子窝较深,股骨颈最小直径〉4mm。结论以2mm克氏针及骨髓穿刺针可有效完成钻孔减压及细胞注入.     

输精(卵)管激光节育法

为寻求一种非手术、可复性强的输精 (卵 )管节育新法 ,对 160只雄性日本长耳白兔输精管、5 0头雌性香猪输卵管进行不同功率的激光照射试验 ,并行激光照射处组织病理学检查、雌雄动物合笼 (圈 )等相关检查。激光照射后 1年 ,兔有效节育率 10 0 %、香猪有效节育率(95 %) ,未见明显激光照射并发症。认为激光可用于输精 (卵 )管节育。     

挠曲电效应对液晶微波相位调制的影响

液晶微波调制器件的相位调制取决于液晶分子指向矢的分布。液晶指向矢的分布不仅会受基板表面处液晶分子预倾角和锚定能等因素的影响,液晶材料的挠曲电特性同样会影响液晶指向矢分布。基于液晶弹性理论和差分迭代方法,研究了挠曲电效应对平行排列向列相(PAN)液晶微波相位调制的影响,理论推导得到弱锚定PAN液晶盒的平衡态方程,数值模拟给出了不同的预倾角、锚定能和液晶材料的挠曲电特性条件下单位长度微波相移(MPSL)随电压的变化。结果表明MPSL随锚定能系数的减小而增大,A_0=A_d=5×10~(-5)J/m~2时,挠曲电效应e_(11)+e_(33)=5×10~(-11 )C/m对MPSL最大可调范围为20°,0°预倾角对MPSL最大可调范围为17°,MPSL差值最大增加均为9°;预倾角为3°时,MPSL可调范围随挠曲电系数的增大而增大,相对于忽略挠曲电效应情形,强锚定A_0=A_d=10~(-3)J/m~2条件下MPSL始终减小,弱锚定A_0=A_d=5×10~(-5)J/m~2条件下MPSL先减小后增大然后再减小,MPSL差值最大增加为9°。此项研究对液晶微波调制器件设计有一定的指导意义。     

纳米羟基磷灰石/聚酰胺复合材料人工肱骨头柄界面成骨的实验研究

目的:探讨纳米羟基磷灰石/聚酰胺复合材料的人工肱骨头柄界面结合能力。方法:新西兰大白兔20只,行nHA/PA人工肱骨头置换术。术后3、6、12、24周分别处死动物。标本进行X线,组织学及计算机图象分析。结果:X线观察可见各期假体柄表面周围界面模糊,密度随时间增加,各周肱骨头假体无碎裂。组织学观察术后3周,围绕假体形成的界膜组织中可见成骨细胞呈镶边状排列,大量成纤维细胞、间充质细胞、成骨细胞浸润;随着时间的延长,界膜中纤维组织逐渐由类骨质代替。骨组织结合率:3周组<6周组<12周组<24周组(P<0.05),其中12周组和24周组更高达91%、97%。结论:nHA/PA植入体柄具有一定的界面骨结合能力。     

兔声带成纤维细胞的体外分离培养、鉴定与标记

目的探讨体外培养兔声带成纤维细胞(Vocal Fold Fibroblasts,VFFs)的培养及标记方法。方法消化培养法分离、培养兔声带成纤维细胞,倒置显微镜观察其生长和形态特征,并传代、鉴定。增强型绿色荧光蛋白腺病毒载体(Ad-EGFP)标记体外培养的VFFs,取12只新西兰兔,以1×100万/0.1ml分别注入损伤模型左侧声带,观察注入VFFs的生长情况。结果兔声带成纤维细胞可以在体外原代和传代培养,具有成纤维细胞的典型形态。波形蛋白免疫荧光染色阳性,Ad-EFGP可以成功转染VFFs。将VFFs诸如声带后15d,组织学切片未发现成活细胞。结论用消化培养法可成功获得VFFs,Ad-EGFP是一种理想的示踪标记物。     

益气活血复方对兔颈总动脉球囊损伤后VCAM-1表达的影响

目的观察益气活血复方（YQHXFF）对兔颈动脉内皮损伤后血管内膜增生及血管细胞黏附分子-1（VCAM-1）表达的影响。方法将雄性新西兰白兔28只,随机分为3组,空白组给予普通饲料8周;模型组和益气活血复方组给予高脂喂养6周后,用球囊拉伤法建立兔颈总动脉内皮损伤模型,第8周末处死动物,免疫组化法检测损伤处颈总动脉组织中VCAM-1表达,HE染色观察颈动脉组织病理形态学改变。结果与模型组对比,益气活血复方可明显抑制损伤后的动脉内膜增殖反应,下调损伤局部VCAM-1的表达水平（P〈0．05）。结论益气活血复方可抑制球囊损伤后动脉内膜增殖反应,其机制可能与下调VCAM-1表达有关。     

准分子激光上皮下角膜磨镶术(LASEK)与准分子激光角膜切削术(PRK)术后兔角膜超微结构实验研究

目的:比较准分子激光上皮下角膜磨镶术(LASEK)与准分子激光角膜切削术(PRK)术后兔角膜创面愈合的情况,从组织学超微结构角度探讨角膜雾状混浊(Haze)及屈光度数回退的可能成因。方法:5 2只新西兰白兔分为8组,每只兔右眼行LASEK ,左眼行PRK。术后1天、7天及1、3、4、5、6月处死动物取角膜行透射电镜和扫描电镜观察,比较术后每一时相点角膜上皮及角膜基质愈合的动态变化过程。结果:LASEK术后角膜上皮细胞、基底膜、基质内胶原纤维和成纤维细胞的超微结构改变程度轻于PRK组。结论:术后LASEK组角膜创伤修复反应弱于PRK ,这可能是LASEK术后角膜恢复正常较早的原因。     

CO_2激光刀和线锯切骨术后移植骨愈合过程的比较

CO_2激光作用于下颌骨后的骨生物学研究甚少,现将我们的研究结果报导如下。材料与方法实验动物及器材:健康杂种狗22只,体重10～15kg。按每只动物的左右侧下颌骨进行分组,右侧下颌骨用激光切骨为实验组,左侧用线锯切骨为对照组。     

混合除草剂对小鼠睾丸超微结构的毒性影响

除草剂对农业增产优势作用有目共睹,但对环境及人身的潜在伤害关注甚少,作者现仅就生殖毒理方面进行超微结构探索。研究中共用正常成年雄性昆明小鼠20只随机分组,以麦草绝(500g／kg)和莠玄津(4g／kg)混悬除草水溶剂饲鼠,分别于18周及24周后杀死动物,切取睾丸组织进行超微结构观     

Resolution Enhancement Technology:Integrated Process Solutions using OPC

DUV lithography, using the 248 nm wavelength, is a viable manufacturing option for devices with features at 130 nm and less. Given the low kl value of the lithography, integrated process development is a necessary method for achieving acceptable process latitude. The application of assist features for rule based OPC requires the simultaneous optimization of the mask, illumination optics and the resist.Described in this paper are the details involved in optimizing each of these aspects for line and space imaging.A reference pitch is first chosen to determine how the optics will be set. The ideal sigma setting is determined by a simple geometrically derived expression. The inner and outer machine settings are determined, in turn,with the simulation of a figure of merit. The maximum value of the response surface of this FOM occurs at the optimal sigma settings. Experimental confirmation of this is shown in the paper.Assist features are used to modify the aerial image of the more isolated images on the mask. The effect that the diffraction of the scattering bars (SBs) has on the image intensity distribution is explained. Rules for determining the size and placement of SBs are also given.Resist is optimized for use with off-axis illumination and assist features. A general explanation of the material' s effect is discussed along with the affect on the through-pitch bias. The paper culminates with the showing of the lithographic results from the fully optimized system.     

Cost-effective test solutions for smart card and other integrated flash applications

From its emergence in the late 1980s as a lower cost alternative to early EEPROM technologies, flash memory has evolved to higher densities and speedsand rapidly growing acceptance in mobile applications.In the process, flash memory devices have placed increased test requirements on manufacturers. Today, as flash device test grows in importance in China, manufacturers face growing pressure for reduced cost-oftest, increased throughput and greater return on investment for test equipment. At the same time, the move to integrated flash packages for contactless smart card applications adds a significant further challenge to manufacturers seeking rapid, low-cost test.     

Theoretical analysis of the relationship between the Brillouin gain coefficient and the strain in the optical-fiber sensors

The relation between the power of the Brillouin signal and the strain is one of the bases of the distributed fiber sensors of temperature and strain. The coefficient of the Bfillouin gain can be changed by the temperature and the strain that will affect the power of the Brillouin scattering. The relation between the change of the Brillouin gain coefficient and the strain is thought to be linear by many researchers. However, it is not always linear based on the theoretical analysis and numerical simulation. Therefore, errors will be caused if the relation between the change of the Brillouin gain coefficient and the strain is regarded as to be linear approximately for measuring the temperature and the strain. For this reason, the influence of the parameters on the Brillouin gain coefficient is proposed through theoretical analysis and numerical simulation.     

An improved parallel thinning algorithm with two subiterations

The parallel thinning algorithm with two subiterations is improved in this paper. By analyzing the notions of connected components and passes, a conclusion is drawn that the number of passes and the number of eight-connected components are equal. Then the expression of the number of eight-connected components is obtained which replaces the old one in the algorithm. And a reserving condition is proposed by experiments, which alleviates the excess deletion where a diagonal line and a beeline intersect. The experimental results demonstrate that the thinned curve is almost located in the middle of the original curve connectivelv with single pixel width and the processing speed is high.     

Novel fiber-optical interferometer with miniaturized probe for in-hole measurements

Today, micro-system technology and the development of new MEMS （Micro-Electro-Mechanical Systems） are emerging rapidly. In order for this development to become a success in the long run, measurement systems have to ensure product quality. Most often, MEMS have to be tested by means of functionality or destructive tests. One reason for this is that there are no suitable systems or sensing probes available which can be used for the measurement of quasi inaccessible features like small holes or cavities. We present a measurement system that could be used for these kinds of measurements. The system combines a fiber optical, miniaturized sensing probe with low-coherence interferometry, so that absolute distance measurements with nanometer accuracy are possible.     

Development of the readout system for waveguide multilayer optical card

Waveguide multilayer optical card （WMOC） is a novel storage device of three-dimensional optical information. An advanced readout system fitting for the WMOC is introduced in this paper. The hardware mainly consists of the light source for reading, WMOC, motorized stages addressing unit, microscope imaging unit, CCD detecting unit and PC controlling ＆ processing unit. The movement of the precision motorized stage is controlled by the computer through Visual Basic （VB） language in software. A control panel is also designed to get the layer address and the page address through which the position of the motorized stages can be changed. The WMOC readout system is easy to manage and the readout result is directly displayed on computer monitor.     

Study of waveguide coupling efficiency in hybrid silicon lasers

This paper presents a new method to increase the waveguide coupling efficiency in hybrid silicon lasers. We find that the propagation constant of the InGaAsP emitting layer can be equal to that of the Si resonant layer through improving the design size of the InP waveguide. The coupling power achieves 42% of the total power in the hybrid lasers when the thickness of the bonding layer is 100 nm. Our result is very close to 50% of the total power reported by Intel when the thickness of the thin bonding layer is less than 5 nm. Therefore, our invariable coupling power technique is simpler than Intel＇s.     

Collinear phase-matching study of terahertz-wave generation via difference frequency mixed in GaAs and Inp

The collinearly phase-matching condition of terahertz-wave generation via difference frequency mixed in GaAs and InP is theoretically studied. In collinear phase-matching, the optimum phase-matching wave hands of these two crystals are calculated. The optimum phase-matching wave bands in GaAs and lnP are 0.95-1.38μm and 0.7-0.96μm respectively. The influence of the wavelength choice of the pump wave on the coherent length in THz-wave tuning is also discussed. The influence of the temperature alteration on the phase-matching and the temperature tuning properties in GaAs crystal are calculated and analyzed. It can serve for the following experiments as a theoretical evidence and a reference as well.     

Effects of the alloy compositions on the phonon-polaritons in ternary mixed crystals

Composition dependence of bulk and surface phonon-polaritons in ternary mixed crystals are studied in the framework of the modified random-element-isodisplacement model and the Bom-Huang approximation. The numerical results for Several Ⅱ - Ⅵ and Ⅲ- Ⅴ compound systems are performed, and the polariton frequencies as functions of the compositions for ternary mixed crystals AlxGa1-xAs, GaPxAS1-x, ZnSxSe1-x, GaAsxSb1-x, GaxIn1-xP, and ZnxCd1-xS as examples are given and discussed. The results show that the dependence of the energies of two branches of bulk phonon-polaritons which have phonon-like characteristics, and surface phonon-polaritons on the compositions of ternary mixed crystals are nonlinear and different from those of the corresponding binary systems.     

New insert layer structure OLEDs

An insert layer structure organic electroluminescent device（OLED） based on a new luminescent material （Zn（salen）） is fabricated. The configuration of the device is ITO/CuPc/NPD/Zn（salen）/Liq/LiF/A1/CuPc/NPD/Zn（salen）/Liq/LiF/A1. Effective insert electrode layers comprising LiF（1nm）/Al（5 nm） are used as a single semitransparent mirror, and bilayer cathode LiF（1 nm）/A1（100 nm） is used as a reflecting mirror. The two mirrors form a Fabry-Perot microcavity and two emissive units. The maximum brightness and luminous efficiency reach 674 cd/m^2 and 2.652 cd/A, respectively, which are 2.1 and 3.7 times higher than the conventional device, respectively. The superior brightness and luminous efficiency over conventional single-unit devices are attributed to microcavity effect.